{"id":"https://openalex.org/W2000484406","doi":"https://doi.org/10.1167/iovs.12-9475","title":"Lactate-H + Transport Is a Significant Component of the In Vivo Corneal Endothelial Pump","display_name":"Lactate-H + Transport Is a Significant Component of the In Vivo Corneal Endothelial Pump","publication_year":2012,"publication_date":"2012-03-13","ids":{"openalex":"https://openalex.org/W2000484406","doi":"https://doi.org/10.1167/iovs.12-9475","mag":"2000484406","pmid":"https://pubmed.ncbi.nlm.nih.gov/22410572","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3995573"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.12-9475","doi":"https://doi.org/10.1167/iovs.12-9475","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.12-9475","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000484406"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3995573","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113795559","display_name":"Tracy T. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy T. Nguyen","raw_affiliation_strings":["Indiana University, School of Optometry, Bloomington, Indiana 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University, School of Optometry, Bloomington, Indiana 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081947536","display_name":"Joseph A. Bonanno","orcid":"https://orcid.org/0000-0002-3842-7646","observed_orcids":["https://orcid.org/0000-0002-3842-7646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph A. Bonanno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":1.2288,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.75999258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"53","issue":"4","first_page":"2020","last_page":"2020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.10920000076293945,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corneal-endothelium","display_name":"corneal endothelium","score":0.9539999961853027},{"id":"https://openalex.org/keywords/monocarboxylate-transporters","display_name":"monocarboxylate transporters","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mct1","display_name":"MCT1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/monocarboxylate-transporter-2","display_name":"MCT2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mct4","display_name":"MCT4","score":1.0},{"id":"https://openalex.org/keywords/corneal-hydration","display_name":"corneal hydration","score":0.6919999718666077},{"id":"https://openalex.org/keywords/corneal-edema","display_name":"corneal edema","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bicarbonate-buffering","display_name":"bicarbonate buffering","score":0.5759999752044678},{"id":"https://openalex.org/keywords/nbce1","display_name":"NBCe1","score":0.8840000033378601},{"id":"https://openalex.org/keywords/carbonic-anhydrase","display_name":"carbonic anhydrase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/proton-efflux","display_name":"proton efflux","score":0.6190000176429749},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2779533339","wikidata":"https://www.wikidata.org/wiki/Q4036893","display_name":"DIDS","level":3,"score":0.8135318756103516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7205676436424255},{"id":"https://openalex.org/C2779700409","wikidata":"https://www.wikidata.org/wiki/Q304285","display_name":"Niflumic acid","level":2,"score":0.7021452188491821},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6861745715141296},{"id":"https://openalex.org/C2777405951","wikidata":"https://www.wikidata.org/wiki/Q413690","display_name":"Acetazolamide","level":2,"score":0.6459283828735352},{"id":"https://openalex.org/C120405084","wikidata":"https://www.wikidata.org/wiki/Q285307","display_name":"Symporter","level":4,"score":0.6302899122238159},{"id":"https://openalex.org/C2781217356","wikidata":"https://www.wikidata.org/wiki/Q83426191","display_name":"Monocarboxylate transporter","level":4,"score":0.5776128768920898},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.5220670104026794},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.5017931461334229},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.42723405361175537},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.4121830463409424},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3996107578277588},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3727038502693176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36638474464416504},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.2261981964111328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20849177241325378},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.17088276147842407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11942639946937561},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.11064350605010986},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0833905041217804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07388350367546082},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099233","descriptor_name":"Monocarboxylate Transport Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004728","descriptor_name":"Endothelium, Corneal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004728","descriptor_name":"Endothelium, Corneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027501","descriptor_name":"Monocarboxylic Acid Transporters","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1167/iovs.12-9475","doi":"https://doi.org/10.1167/iovs.12-9475","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.12-9475","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2979155","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3995573","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:22410572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22410572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:3995573","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3995573/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2979155","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3995573","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1327750461","display_name":"Regulation of pHi and Fluid Flux in Corneal Endothelium","funder_award_id":"R01EY008834","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3735213561","display_name":"Lactic acid transport across the corneal endothelium","funder_award_id":"K08EY019537","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5183765871","display_name":"Core Support for Vision Research at Indiana University","funder_award_id":"P30EY019008","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G577914604","display_name":"Visual Optics and Cornea","funder_award_id":"K12EY015504","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W2258750","https://openalex.org/W25941797","https://openalex.org/W31608458","https://openalex.org/W69000070","https://openalex.org/W69418710","https://openalex.org/W95380653","https://openalex.org/W120780304","https://openalex.org/W125755836","https://openalex.org/W204053634","https://openalex.org/W1819146832","https://openalex.org/W1967623490","https://openalex.org/W1968043594","https://openalex.org/W1974514289","https://openalex.org/W1975196234","https://openalex.org/W1979075589","https://openalex.org/W1989237369","https://openalex.org/W1990669317","https://openalex.org/W1990847664","https://openalex.org/W1991659312","https://openalex.org/W1998976350","https://openalex.org/W2003681089","https://openalex.org/W2004759191","https://openalex.org/W2012289040","https://openalex.org/W2015275016","https://openalex.org/W2031485798","https://openalex.org/W2031888440","https://openalex.org/W2032268647","https://openalex.org/W2038523875","https://openalex.org/W2041120836","https://openalex.org/W2042715218","https://openalex.org/W2046871515","https://openalex.org/W2049236761","https://openalex.org/W2060497252","https://openalex.org/W2061700980","https://openalex.org/W2066398047","https://openalex.org/W2073262502","https://openalex.org/W2077058712","https://openalex.org/W2085812078","https://openalex.org/W2087402108","https://openalex.org/W2105235933","https://openalex.org/W2106532277","https://openalex.org/W2112543188","https://openalex.org/W2120035805","https://openalex.org/W2128578138","https://openalex.org/W2131995833","https://openalex.org/W2165347702","https://openalex.org/W2188576260","https://openalex.org/W2416530817","https://openalex.org/W4238605098","https://openalex.org/W4241738696"],"related_works":["https://openalex.org/W2042715218","https://openalex.org/W2029752117","https://openalex.org/W2396030882","https://openalex.org/W2093806477","https://openalex.org/W3005378015","https://openalex.org/W2318329488","https://openalex.org/W2001141138","https://openalex.org/W3049518537","https://openalex.org/W2066308918","https://openalex.org/W4403709802"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"confirm":[2],"the":[3,19,65,99,120,131,169,183,226,267],"expression":[4,44],"of":[5,45,69,171,185,249,260,266],"monocarboxylate":[6],"transporters":[7],"(MCT)":[8],"1,":[9],"2,":[10,82,216],"and":[11,16,28,53,67,71,83,87,104,116,126,160,165,206,217,228,231,245,256],"4":[12,218],"in":[13,40,61,64,92,143,149,168,176,182,201,221,254],"rabbit":[14,46,222],"CE":[15,63,223],"to":[17,80,119,130,145,233],"test":[18],"hypothesis":[20],"that":[21,107,154,258],"cellular":[22],"buffering":[23],"contributed":[24],"by":[25,50,157,161,189,240],"HCO\u2083\u207b,":[26],"NBCe1,":[27,195],"carbonic":[29],"anhydrase":[30],"(CA)":[31],"activity":[32,198],"facilitates":[33],"lactate-H\u207a":[34],"efflux":[35,262],"thereby":[36],"controlling":[37],"corneal":[38,203,211,252],"hydration":[39],"vivo.":[41],"METHODS:":[42],"MCT1-4":[43],"endothelium":[47],"was":[48,59,155,178,199,207],"examined":[49],"Western":[51],"blotting":[52],"immunofluorescence":[54],"staining.":[55],"Lactate-induced":[56],"acidification":[57],"(LIA)":[58],"measured":[60,91],"perfused":[62],"presence":[66,170,184],"absence":[68],"HCO\u2083\u207b":[70,186,243],"acetazolamide":[72],"(ACTZ)":[73],"using":[74],"tissue":[75],"treated":[76,97],"with":[77,98,111,209],"siRNA":[78,163],"specific":[79,118],"MCT1,":[81,215],"4.":[84],"Corneal":[85],"thickness":[86],"lactate":[88,148,212,261],"concentration":[89],"were":[90,108],"New":[93],"Zealand":[94],"White":[95],"rabbits":[96],"topical":[100],"CA":[101,197,246],"inhibitor":[102],"Azopt,":[103],"from":[105],"eyes":[106],"injected":[109],"intracamerally":[110],"ouabain,":[112],"disodium":[113],"4,4'-diisothiocyanatostilbene-2,2'-disulfonate":[114],"(DIDS),":[115],"shRNA":[117],"1Na\u207a:2HCO\u2083\u207b":[121],"cotransporter":[122],"NBCe1.":[123],"RESULTS:":[124],"MCT1":[125],"MCT4":[127],"are":[128,219],"localized":[129],"lateral":[132],"membrane,":[133],"while":[134],"MCT2":[135],"is":[136,238,263],"apical.":[137],"Cell":[138],"pH":[139],"measurements":[140],"showed":[141],"LIA":[142],"response":[144],"40":[146],"mM":[147],"bicarbonate":[150],"free":[151],"(BF)":[152],"Ringer's":[153],"inhibited":[156],"niflumic":[158],"acid":[159],"MCT":[162],"knockdown,":[164],"significantly":[166,180],"reduced":[167,188],"HCO\u2083\u207b.":[172],"Lactate-dependent":[173],"proton":[174],"flux":[175,237],"vitro":[177],"not":[179],"greater":[181],"or":[187,196],"ACTZ.":[190],"However,":[191],"when":[192],"active":[193,241],"transport,":[194,242],"disrupted":[200],"vivo,":[202],"edema":[204,253],"ensued":[205],"associated":[208],"significant":[210],"accumulation.":[213],"CONCLUSIONS:":[214],"expressed":[220],"on":[224],"both":[225],"apical":[227],"basolateral":[229],"surfaces":[230],"function":[232],"transport":[234,244],"lactate-H\u207a.":[235],"Lactate-H\u207a":[236],"facilitated":[239],"activity,":[247],"disruption":[248],"which":[250],"causes":[251],"vivo":[255],"indicates":[257],"facilitation":[259],"a":[264],"component":[265],"endothelial":[268],"pump.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}