{"id":"https://openalex.org/W2000483769","doi":"https://doi.org/10.1016/j.febslet.2013.01.017","title":"Mechanisms of islet amyloidosis toxicity in type 2 diabetes","display_name":"Mechanisms of islet amyloidosis toxicity in type 2 diabetes","publication_year":2013,"publication_date":"2013-01-18","ids":{"openalex":"https://openalex.org/W2000483769","doi":"https://doi.org/10.1016/j.febslet.2013.01.017","mag":"2000483769","pmid":"https://pubmed.ncbi.nlm.nih.gov/23337872","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4557799"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2013.01.017","doi":"https://doi.org/10.1016/j.febslet.2013.01.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2013.01.017","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2013.01.017","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2013.01.017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065857864","display_name":"Andisheh Abedini","orcid":"https://orcid.org/0000-0002-1396-1420","observed_orcids":["https://orcid.org/0000-0002-1396-1420"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andisheh Abedini","raw_affiliation_strings":["Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Medical Center, 550 First Avenue, Smilow 906, New York, NY 10016, USA. Andisheh.Abedini@nyumc.org","Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Medical Center, 550 First Avenue, Smilow 906, New York, NY 10016, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Medical Center, 550 First Avenue, Smilow 906, New York, NY 10016, USA. Andisheh.Abedini@nyumc.org","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Medical Center, 550 First Avenue, Smilow 906, New York, NY 10016, United States","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007603996","display_name":"Ann Marie Schmidt","orcid":"https://orcid.org/0000-0001-8902-070X","observed_orcids":["https://orcid.org/0000-0001-8902-070X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Marie Schmidt","raw_affiliation_strings":["Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Medical Center, 550 First Avenue, Smilow 906, New York, NY 10016, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Medical Center, 550 First Avenue, Smilow 906, New York, NY 10016, United States","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065857864"],"corresponding_institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":{"value":3980,"currency":"USD","value_usd":3980},"fwci":3.303,"has_fulltext":true,"cited_by_count":200,"citation_normalized_percentile":{"value":0.95255126,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"587","issue":"8","first_page":"1119","last_page":"1127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.07940000295639038,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-amyloidosis","display_name":"islet amyloidosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/amylin","display_name":"amylin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8939999938011169},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/receptor-mediated-toxicity","display_name":"receptor-mediated toxicity","score":0.753000020980835},{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.6579999923706055},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C2780705028","wikidata":"https://www.wikidata.org/wiki/Q424643","display_name":"Amylin","level":4,"score":0.9447548389434814},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8301973342895508},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.7545068264007568},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6114972829818726},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6108828783035278},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.5958030819892883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5511882901191711},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5167964696884155},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5086954236030579},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4893328547477722},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47006091475486755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3032657504081726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23746660351753235},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.15163540840148926},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058287","descriptor_name":"Receptors, Islet Amyloid Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058287","descriptor_name":"Receptors, Islet Amyloid Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058287","descriptor_name":"Receptors, Islet Amyloid Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.febslet.2013.01.017","doi":"https://doi.org/10.1016/j.febslet.2013.01.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2013.01.017","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2013.01.017","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:23337872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23337872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3535962","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4557799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4557799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4557799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEBS Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.febslet.2013.01.017","doi":"https://doi.org/10.1016/j.febslet.2013.01.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2013.01.017","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2013.01.017","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7200000286102295}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2649278410","display_name":"RAGE Mediated Mechanisms of Islet Amyloid Polypeptide Cytotoxicity in Type 2 Diab","funder_award_id":"F32DK089734","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000483769.pdf","grobid_xml":"https://content.openalex.org/works/W2000483769.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W61170777","https://openalex.org/W195933567","https://openalex.org/W1487900963","https://openalex.org/W1530011783","https://openalex.org/W1557198624","https://openalex.org/W1576215380","https://openalex.org/W1587054558","https://openalex.org/W1588092320","https://openalex.org/W1641175229","https://openalex.org/W1753272189","https://openalex.org/W1963586335","https://openalex.org/W1966909071","https://openalex.org/W1968786165","https://openalex.org/W1969165181","https://openalex.org/W1971701221","https://openalex.org/W1971713572","https://openalex.org/W1974854551","https://openalex.org/W1974924674","https://openalex.org/W1976025018","https://openalex.org/W1981554609","https://openalex.org/W1982040051","https://openalex.org/W1982151034","https://openalex.org/W1982466438","https://openalex.org/W1983082230","https://openalex.org/W1988018861","https://openalex.org/W1991182327","https://openalex.org/W1991356605","https://openalex.org/W1991576961","https://openalex.org/W1992109285","https://openalex.org/W1992861325","https://openalex.org/W1994523986","https://openalex.org/W1998849703","https://openalex.org/W1999851917","https://openalex.org/W2000460252","https://openalex.org/W2007554792","https://openalex.org/W2007839917","https://openalex.org/W2009303608","https://openalex.org/W2009623261","https://openalex.org/W2009675851","https://openalex.org/W2014272598","https://openalex.org/W2015219413","https://openalex.org/W2015684005","https://openalex.org/W2016040396","https://openalex.org/W2018821716","https://openalex.org/W2019288511","https://openalex.org/W2020046808","https://openalex.org/W2024941512","https://openalex.org/W2025447674","https://openalex.org/W2025980514","https://openalex.org/W2027505632","https://openalex.org/W2028013909","https://openalex.org/W2029292770","https://openalex.org/W2030363184","https://openalex.org/W2031173385","https://openalex.org/W2033484052","https://openalex.org/W2034946303","https://openalex.org/W2036600670","https://openalex.org/W2037781436","https://openalex.org/W2038438971","https://openalex.org/W2045035507","https://openalex.org/W2046855344","https://openalex.org/W2049167261","https://openalex.org/W2052747925","https://openalex.org/W2054674509","https://openalex.org/W2056410662","https://openalex.org/W2056880208","https://openalex.org/W2057714820","https://openalex.org/W2061111679","https://openalex.org/W2065786925","https://openalex.org/W2067820229","https://openalex.org/W2068048197","https://openalex.org/W2068688814","https://openalex.org/W2070114315","https://openalex.org/W2070159057","https://openalex.org/W2073776794","https://openalex.org/W2074512420","https://openalex.org/W2079290792","https://openalex.org/W2082592680","https://openalex.org/W2084191614","https://openalex.org/W2084317099","https://openalex.org/W2089701069","https://openalex.org/W2092729668","https://openalex.org/W2093340710","https://openalex.org/W2093861673","https://openalex.org/W2094366594","https://openalex.org/W2094765619","https://openalex.org/W2096410114","https://openalex.org/W2096982461","https://openalex.org/W2097259690","https://openalex.org/W2106201112","https://openalex.org/W2106607972","https://openalex.org/W2106754968","https://openalex.org/W2111096047","https://openalex.org/W2111112233","https://openalex.org/W2111567059","https://openalex.org/W2115025731","https://openalex.org/W2120302366","https://openalex.org/W2120511656","https://openalex.org/W2121963977","https://openalex.org/W2126070572","https://openalex.org/W2128721378","https://openalex.org/W2129412868","https://openalex.org/W2129889492","https://openalex.org/W2132822308","https://openalex.org/W2137110972","https://openalex.org/W2148869006","https://openalex.org/W2149315447","https://openalex.org/W2150367899","https://openalex.org/W2153965694","https://openalex.org/W2156215695","https://openalex.org/W2159489160","https://openalex.org/W2160873224","https://openalex.org/W2165021720","https://openalex.org/W2165160052","https://openalex.org/W2165186407","https://openalex.org/W2168140551","https://openalex.org/W2168465164","https://openalex.org/W2169273342","https://openalex.org/W2169461964","https://openalex.org/W2169536198","https://openalex.org/W2326164100","https://openalex.org/W2411377367","https://openalex.org/W2414840807","https://openalex.org/W2414934891","https://openalex.org/W4211192758"],"related_works":["https://openalex.org/W1999909300","https://openalex.org/W2209022283","https://openalex.org/W2097259690","https://openalex.org/W2030900671","https://openalex.org/W4229000632","https://openalex.org/W1964172387","https://openalex.org/W2015068531","https://openalex.org/W2352043281","https://openalex.org/W2011139454","https://openalex.org/W1992861325"],"abstract_inverted_index":{"Amyloid":[0],"formation":[1],"by":[2,45],"the":[3,14,40,66,73,105,114],"neuropancreatic":[4],"hormone,":[5],"islet":[6,21,29],"amyloid":[7,64],"polypeptide":[8],"(IAPP":[9],"or":[10],"amylin),":[11],"one":[12],"of":[13,42,62,68,88,99,107,116],"most":[15],"amyloidogenic":[16],"sequences":[17],"known,":[18],"leads":[19],"to":[20,28,78],"amyloidosis":[22],"in":[23,39],"type":[24],"2":[25],"diabetes":[26,108],"and":[27,57,72,92,109],"transplant":[30],"failure.":[31],"Under":[32],"normal":[33],"conditions,":[34],"IAPP":[35,63,69,100],"plays":[36],"a":[37],"role":[38],"maintenance":[41],"energy":[43],"homeostasis":[44],"regulating":[46],"several":[47],"metabolic":[48],"parameters,":[49],"such":[50],"as":[51],"satiety,":[52],"blood":[53],"glucose":[54],"levels,":[55],"adiposity":[56],"body":[58],"weight.":[59],"The":[60],"mechanisms":[61,87],"formation,":[65],"nature":[67],"toxic":[70],"species":[71],"cellular":[74],"pathways":[75],"that":[76],"lead":[77],"pancreatic":[79],"\u03b2-cell":[80],"toxicity":[81],"are":[82,110],"not":[83],"well":[84],"characterized.":[85],"Several":[86],"toxicity,":[89],"including":[90],"receptor":[91],"non-receptor-mediated":[93],"events,":[94],"have":[95,101],"been":[96,102],"proposed.":[97],"Analogs":[98],"approved":[103],"for":[104,113],"treatment":[106,115],"under":[111],"investigation":[112],"obesity.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}