{"id":"https://openalex.org/W2000483459","doi":"https://doi.org/10.1021/bi00209a018","title":"Evaluation of electrostatic and hydrophobic effects on the interaction of mitochondrial signal sequences with phospholipid bilayers","display_name":"Evaluation of electrostatic and hydrophobic effects on the interaction of mitochondrial signal sequences with phospholipid bilayers","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2000483459","doi":"https://doi.org/10.1021/bi00209a018","mag":"2000483459","pmid":"https://pubmed.ncbi.nlm.nih.gov/7947692"},"language":"en","primary_location":{"id":"doi:10.1021/bi00209a018","doi":"https://doi.org/10.1021/bi00209a018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00209a018","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100364881","display_name":"Yi Wang","orcid":"https://orcid.org/0000-0001-6082-8721","observed_orcids":["https://orcid.org/0000-0001-6082-8721","https://orcid.org/0009-0001-8465-0080"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Wang","raw_affiliation_strings":["Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012958448","display_name":"Henry Weiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Weiner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8856,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.70960038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"33","issue":"43","first_page":"12860","last_page":"12867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.3043999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-protein-import","display_name":"mitochondrial protein import","score":0.8130000233650208},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.722000002861023},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phospholipid-bilayers","display_name":"phospholipid bilayers","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cardiolipin","display_name":"cardiolipin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cox-iv","display_name":"cytochrome c oxidase subunit IV","score":0.9570000171661377},{"id":"https://openalex.org/keywords/membrane-binding-affinity","display_name":"membrane affinity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/negatively-charged-membranes","display_name":"negatively charged membranes","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.6859188079833984},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.573128342628479},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.546040415763855},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.5386810898780823},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5315335392951965},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.42850828170776367},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3210141658782959},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.28061771392822266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27717500925064087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11876234412193298},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.08606371283531189},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002308","descriptor_name":"Cardiolipins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004563","descriptor_name":"Electrochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021382","descriptor_name":"Protein Sorting Signals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021382","descriptor_name":"Protein Sorting Signals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00209a018","doi":"https://doi.org/10.1021/bi00209a018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00209a018","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:7947692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7947692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2297022949","display_name":null,"funder_award_id":"AA00038","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G574410073","display_name":"CEREBRAL BLOOD FLOW AND ENERGY METABOLISM IN THE CAT","funder_award_id":"1z01aa000038-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6158531442","display_name":null,"funder_award_id":"AA-05812","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W9772524","https://openalex.org/W38281283","https://openalex.org/W46424856","https://openalex.org/W60529302","https://openalex.org/W60978187","https://openalex.org/W130559879","https://openalex.org/W328114118","https://openalex.org/W335703571","https://openalex.org/W1493220182","https://openalex.org/W1539508304","https://openalex.org/W1543378549","https://openalex.org/W1553241112","https://openalex.org/W1554636519","https://openalex.org/W1568600151","https://openalex.org/W1573941143","https://openalex.org/W1588568344","https://openalex.org/W1598299012","https://openalex.org/W1601890477","https://openalex.org/W1603900493","https://openalex.org/W1825654208","https://openalex.org/W1927159013","https://openalex.org/W1966583952","https://openalex.org/W1974185809","https://openalex.org/W1980751552","https://openalex.org/W1987037622","https://openalex.org/W1994616607","https://openalex.org/W1996406766","https://openalex.org/W2007195150","https://openalex.org/W2008274778","https://openalex.org/W2026582002","https://openalex.org/W2026598193","https://openalex.org/W2026726092","https://openalex.org/W2038214413","https://openalex.org/W2038435919","https://openalex.org/W2042182746","https://openalex.org/W2055776228","https://openalex.org/W2068698588","https://openalex.org/W2076027325","https://openalex.org/W2093229658","https://openalex.org/W2101011253","https://openalex.org/W2126662679","https://openalex.org/W2137502370","https://openalex.org/W2160736797","https://openalex.org/W2178996695","https://openalex.org/W2282535718"],"related_works":["https://openalex.org/W2093029025","https://openalex.org/W2055776228","https://openalex.org/W1604838976","https://openalex.org/W2038973909","https://openalex.org/W3018346633","https://openalex.org/W7033577527","https://openalex.org/W60978187","https://openalex.org/W2155140287","https://openalex.org/W2063837406","https://openalex.org/W2064375944"],"abstract_inverted_index":{"The":[0,21,29,101],"information":[1],"that":[2,47,216],"directs":[3],"a":[4,18,48,56,125,174,178,197,210,220,229,239],"nuclear-coded":[5],"protein":[6],"to":[7,36,58,89,184,243],"be":[8,59],"imported":[9],"into":[10],"mitochondria":[11],"resides":[12],"in":[13,61],"an":[14,39],"N-terminal":[15],"extension,":[16],"called":[17],"signal":[19,82,110,137,175,249],"sequence.":[20,213],"primary":[22],"sequences":[23,83,250],"of":[24,79,93,108,118,135,139,156,207,236,247],"all":[25],"known":[26],"ones":[27],"differ.":[28],"only":[30],"common":[31],"feature":[32],"is":[33,116],"their":[34],"ability":[35],"theoretically":[37],"form":[38],"amphiphilic,":[40],"positively":[41],"charged,":[42],"alpha-helix.":[43],"We":[44],"previously":[45],"showed":[46,196],"short":[49],"stable":[50],"helical":[51],"segment":[52],"was":[53,241],"required":[54],"for":[55,182,201,259,265],"peptide":[57],"functional":[60],"import":[62],"[Wang,":[63],"Y.,":[64],"&":[65],"Weiner,":[66],"H.":[67],"(1993)":[68],"J.":[69],"Biol.":[70],"Chem.":[71],"268,":[72],"4759-4765].":[73],"Here":[74],"we":[75],"investigate":[76],"the":[77,91,99,109,129,133,136,147,152,165,185,202,234,245],"interaction":[78,246,258,264],"three":[80,102,119],"altered":[81],"with":[84,98,224,251],"phospholipid":[85,254],"membranes":[86,203,225,255],"containing":[87],"cardiolipin":[88],"ascertain":[90],"importance":[92],"electrostatic":[94,231,257],"and":[95,161,193,204,262],"hydrophobic":[96,222,263],"interactions":[97],"membrane.":[100],"already":[103],"described":[104],"peptides":[105],"were":[106,205],"derivatives":[107],"sequence":[111,138],"from":[112],"aldehyde":[113],"dehydrogenase,":[114],"which":[115,170],"composed":[117],"segments,":[120],"two":[121],"helices":[122],"separated":[123],"by":[124,132,151],"linker.":[126],"ANCN":[127,192,227],"had":[128,146,164,177,228],"C-helix":[130],"replaced":[131,150],"N-helix":[134],"cytochrome":[140,157],"c":[141],"oxidase":[142,158],"subunit":[143,159],"IV,":[144,160],"ANCC":[145],"C-terminal":[148,153],"helix":[149],"random":[154],"coil":[155],"linker":[162,166,194,217],"deleted":[163,195,218],"region":[167],"deleted.":[168],"ANCC,":[169],"functioned":[171],"poorly":[172],"as":[173,209],"sequence,":[176],"very":[179],"low":[180],"affinity":[181,200],"binding":[183,261],"negatively":[186,252],"charged":[187,253],"membranes.":[188],"In":[189],"contrast,":[190],"both":[191],"relatively":[198],"high":[199],"capable":[206],"functioning":[208],"good":[211],"leader":[212],"It":[214],"appears":[215],"possessed":[219],"stronger":[221],"effect":[223],"while":[226],"higher":[230],"interaction.":[232],"On":[233],"basic":[235],"these":[237],"studies,":[238],"model":[240],"proposed":[242],"describe":[244],"mitochondrial":[248],"involving":[256],"initial":[260],"insertion.(ABSTRACT":[266],"TRUNCATED":[267],"AT":[268],"250":[269],"WORDS)":[270]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}