{"id":"https://openalex.org/W2000478711","doi":"https://doi.org/10.1021/ic050743r","title":"Synthesis and Relaxivity Studies of a Tetranuclear Gadolinium(III) Complex of DO3A as a Contrast-Enhancing Agent for MRI","display_name":"Synthesis and Relaxivity Studies of a Tetranuclear Gadolinium(III) Complex of DO3A as a Contrast-Enhancing Agent for MRI","publication_year":2005,"publication_date":"2005-11-12","ids":{"openalex":"https://openalex.org/W2000478711","doi":"https://doi.org/10.1021/ic050743r","mag":"2000478711","pmid":"https://pubmed.ncbi.nlm.nih.gov/16323930"},"language":"en","primary_location":{"id":"doi:10.1021/ic050743r","doi":"https://doi.org/10.1021/ic050743r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic050743r","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044114628","display_name":"Jebasingh Bhagavathsingh","orcid":"https://orcid.org/0000-0003-3405-6208","observed_orcids":["https://orcid.org/0000-0003-3405-6208"]},"institutions":[{"id":"https://openalex.org/I4405274569","display_name":"Loyola College","ror":"https://ror.org/01ypxeq73","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405274569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B. Jebasingh","raw_affiliation_strings":["Department of Chemistry, Loyola College, Chennai-600034, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Loyola College, Chennai-600034, India","institution_ids":["https://openalex.org/I4405274569"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024051009","display_name":"V. Alexander","orcid":"https://orcid.org/0000-0002-0187-4004","observed_orcids":["https://orcid.org/0000-0002-0187-4004"]},"institutions":[{"id":"https://openalex.org/I4405274569","display_name":"Loyola College","ror":"https://ror.org/01ypxeq73","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405274569"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"V. Alexander","raw_affiliation_strings":["Department of Chemistry, Loyola College, Chennai-600034, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Loyola College, Chennai-600034, India","institution_ids":["https://openalex.org/I4405274569"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024051009"],"corresponding_institution_ids":["https://openalex.org/I4405274569"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0955,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.7347745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"25","first_page":"9434","last_page":"9443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10612","display_name":"Magnetism in coordination complexes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadolinium-iii-complexes","display_name":"gadolinium(III) complexes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tetranuclear-complexes","display_name":"tetranuclear complexes","score":0.6909999847412109},{"id":"https://openalex.org/keywords/do3a-ligand","display_name":"DO3A ligand","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mri-contrast-agents","display_name":"MRI contrast agents","score":0.9929999709129333},{"id":"https://openalex.org/keywords/relaxivity","display_name":"relaxivity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ph-responsive-contrast-agents","display_name":"pH-responsive contrast agents","score":0.6909999847412109},{"id":"https://openalex.org/keywords/rotational-correlation-time","display_name":"rotational correlation time","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.9422683715820312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9279661178588867},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.920251727104187},{"id":"https://openalex.org/C2778978742","wikidata":"https://www.wikidata.org/wiki/Q6717498","display_name":"MRI contrast agent","level":3,"score":0.5458765625953674},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4608030319213867},{"id":"https://openalex.org/C2778639546","wikidata":"https://www.wikidata.org/wiki/Q7370322","display_name":"Rotational correlation time","level":3,"score":0.4356750249862671},{"id":"https://openalex.org/C73286259","wikidata":"https://www.wikidata.org/wiki/Q7310885","display_name":"Relaxometry","level":4,"score":0.4176703989505768},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4005821943283081},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.37122923135757446},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.19066104292869568},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.07135239243507385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06779012084007263},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.057386577129364014},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C83042744","wikidata":"https://www.wikidata.org/wiki/Q904043","display_name":"Spin echo","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ic050743r","doi":"https://doi.org/10.1021/ic050743r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic050743r","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:16323930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16323930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W138860627","https://openalex.org/W587636670","https://openalex.org/W619105361","https://openalex.org/W646656861","https://openalex.org/W1825789202","https://openalex.org/W1964641397","https://openalex.org/W1966075640","https://openalex.org/W1969251429","https://openalex.org/W1973438714","https://openalex.org/W1973898074","https://openalex.org/W1979645075","https://openalex.org/W1980470550","https://openalex.org/W1982007117","https://openalex.org/W1989389526","https://openalex.org/W1991214552","https://openalex.org/W1991386968","https://openalex.org/W1991441944","https://openalex.org/W1991531047","https://openalex.org/W1993638883","https://openalex.org/W1996174625","https://openalex.org/W1996950362","https://openalex.org/W1997529464","https://openalex.org/W1998715961","https://openalex.org/W1998970140","https://openalex.org/W2001228209","https://openalex.org/W2002149965","https://openalex.org/W2005292788","https://openalex.org/W2005444217","https://openalex.org/W2005582546","https://openalex.org/W2006422372","https://openalex.org/W2007457382","https://openalex.org/W2008407458","https://openalex.org/W2013486198","https://openalex.org/W2022558454","https://openalex.org/W2026419977","https://openalex.org/W2033503179","https://openalex.org/W2036479141","https://openalex.org/W2036536580","https://openalex.org/W2043638187","https://openalex.org/W2049483437","https://openalex.org/W2051227631","https://openalex.org/W2055876104","https://openalex.org/W2056547807","https://openalex.org/W2056840986","https://openalex.org/W2059679350","https://openalex.org/W2059864970","https://openalex.org/W2064294421","https://openalex.org/W2065021976","https://openalex.org/W2066608156","https://openalex.org/W2072076892","https://openalex.org/W2072952339","https://openalex.org/W2076283593","https://openalex.org/W2079366062","https://openalex.org/W2083336655","https://openalex.org/W2086834470","https://openalex.org/W2086951715","https://openalex.org/W2087633444","https://openalex.org/W2090476704","https://openalex.org/W2092687179","https://openalex.org/W2140611255","https://openalex.org/W2140613515","https://openalex.org/W2144438585","https://openalex.org/W2150620038","https://openalex.org/W2158049321","https://openalex.org/W2165884308","https://openalex.org/W2166508769","https://openalex.org/W2315743264","https://openalex.org/W2318005455","https://openalex.org/W2321419902","https://openalex.org/W2322746707","https://openalex.org/W2330056252","https://openalex.org/W2330087873","https://openalex.org/W2491058075","https://openalex.org/W2950428398","https://openalex.org/W3004893016","https://openalex.org/W3022316311","https://openalex.org/W4248052365","https://openalex.org/W4252003650","https://openalex.org/W4256703473"],"related_works":["https://openalex.org/W2554394477","https://openalex.org/W2077777841","https://openalex.org/W2346695233","https://openalex.org/W1535202229","https://openalex.org/W4206921918","https://openalex.org/W4229084034","https://openalex.org/W2009318772","https://openalex.org/W4288101650","https://openalex.org/W2046771770","https://openalex.org/W2623291708"],"abstract_inverted_index":{"A":[0],"tetranuclear":[1],"gadolinium(III)":[2],"complex,":[3],"[Gd4(H2O)8],":[4],"of":[5,26,46,55,69,75,86,136,154],"DO3A":[6],"appended":[7],"onto":[8],"the":[9,16,56,59,70,73,76,79,84,99,137,151],"pentaerythrityl":[10],"framework":[11],"was":[12],"synthesized":[13],"to":[14],"improve":[15],"water":[17,89],"proton":[18],"relaxivity":[19,25,49,54,68,101,135],"for":[20],"MRI":[21,130],"application.":[22],"The":[23,48,66,92,133],"longitudinal":[24,96],"[Gd4(H2O)8]":[27],"is":[28,40,50,62,72,139],"28.13":[29],"mM-1":[30,109,116,141],"s-1":[31,110,117,142],"(24":[32,143],"MHz,":[33,144],"35+/-0.1":[34,145],"degrees":[35,146],"C,":[36,147],"pH":[37,107,112,119,148],"5.6)":[38],"which":[39],"5.86":[41],"times":[42],"higher":[43],"than":[44],"that":[45,122,157],"[Gd(DO3A)(H2O)2].":[47],"based":[51],"on":[52],"\"molecular\"":[53],"tetramer":[57,71,138],"and":[58,83,98,105,114,150],"r1p":[60],"value":[61],"\"7":[63],"per":[64],"Gd\".":[65],"high":[67,100,106],"result":[74],"decrease":[77],"in":[78],"rotational":[80],"correlation":[81],"(tauR)":[82],"presence":[85],"eight":[87],"inner-sphere":[88],"molecules":[90],"(q=8).":[91],"complex":[93],"exhibits":[94],"pH-dependent":[95],"relaxivity,":[97],"both":[102],"at":[103,111,118],"low":[104],"(r1p=28.13":[108],"5.6":[113],"16.52":[115],"9.5)":[120],"indicates":[121],"it":[123,158],"could":[124,159],"be":[125,160],"used":[126,161],"as":[127,162],"a":[128,163],"pH-responsive":[129],"contrast":[131,165],"agent.":[132,166],"transverse":[134],"129.97":[140],"5.6),":[149],"r2p/r1p":[152],"ratio":[153],"4.6":[155],"shows":[156],"T2-weighted":[164]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
