{"id":"https://openalex.org/W2000477644","doi":"https://doi.org/10.1073/pnas.1012720108","title":"Identifying the cellular origin of squamous skin tumors","display_name":"Identifying the cellular origin of squamous skin tumors","publication_year":2011,"publication_date":"2011-04-18","ids":{"openalex":"https://openalex.org/W2000477644","doi":"https://doi.org/10.1073/pnas.1012720108","mag":"2000477644","pmid":"https://pubmed.ncbi.nlm.nih.gov/21502497","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088632"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1012720108","doi":"https://doi.org/10.1073/pnas.1012720108","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1012720108","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000477644"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088632","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108156867","display_name":"Ga\u00eblle Lapouge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ga\u00eblle Lapouge","raw_affiliation_strings":["Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080754752","display_name":"Khalil Kass Youssef","orcid":"https://orcid.org/0000-0002-4572-3160","observed_orcids":["https://orcid.org/0000-0002-4572-3160"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Khalil Kass Youssef","raw_affiliation_strings":["Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000964288","display_name":"Beno\u00eet Vokaer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Benoit Vokaer","raw_affiliation_strings":["Institut d'Immunologie M\u00e9dicale, Universit\u00e9 Libre de Bruxelles, B-6041 Charleroi, Belgium; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut d'Immunologie M\u00e9dicale, Universit\u00e9 Libre de Bruxelles, B-6041 Charleroi, Belgium; and","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067728030","display_name":"Youn\u00e8s Achouri","orcid":"https://orcid.org/0000-0001-7409-1441","observed_orcids":["https://orcid.org/0000-0001-7409-1441"]},"institutions":[{"id":"https://openalex.org/I4210114657","display_name":"de Duve Institute","ror":"https://ror.org/022em3k58","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210114657"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Younes Achouri","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain de Duve Institute, B-1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain de Duve Institute, B-1200 Brussels, Belgium","institution_ids":["https://openalex.org/I4210114657","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034650825","display_name":"Cindy Michaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Cindy Michaux","raw_affiliation_strings":["Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115600877","display_name":"Panagiota A. Sotiropoulou","orcid":"https://orcid.org/0000-0002-0213-7110","observed_orcids":["https://orcid.org/0000-0002-0213-7110"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Panagiota A. Sotiropoulou","raw_affiliation_strings":["Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079923302","display_name":"C\u00e9dric Blanpain","orcid":"https://orcid.org/0000-0002-4028-4322","observed_orcids":["https://orcid.org/0000-0002-4028-4322"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Blanpain","raw_affiliation_strings":["Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":37.1355,"has_fulltext":false,"cited_by_count":306,"citation_normalized_percentile":{"value":0.99960492,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"108","issue":"18","first_page":"7431","last_page":"7436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.573199987411499,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.573199987411499,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.10509999841451645,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.722000002861023},{"id":"https://openalex.org/keywords/cell-of-origin","display_name":"cell of origin","score":0.597000002861023},{"id":"https://openalex.org/keywords/papilloma","display_name":"papilloma","score":0.7179999947547913},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/p53-loss","display_name":"p53 deficiency","score":0.9419999718666077},{"id":"https://openalex.org/keywords/interfollicular-epidermis","display_name":"interfollicular epidermis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/mouse-genetics","display_name":"mouse genetics","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.820002019405365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.695264458656311},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.6872515082359314},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5617104768753052},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.5442367792129517},{"id":"https://openalex.org/C2779688582","wikidata":"https://www.wikidata.org/wiki/Q7112036","display_name":"Outer root sheath","level":3,"score":0.4921793043613434},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45808497071266174},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4320877194404602},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.41689518094062805},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38662412762641907},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2412702441215515},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18134701251983643},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.12491461634635925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12228494882583618},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08939945697784424},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.1012720108","doi":"https://doi.org/10.1073/pnas.1012720108","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1012720108","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2209897","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088632","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21502497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21502497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3088632","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3088632/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:dial.uclouvain.be:boreal:163404","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/163404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National academy of sciences of the United States of America, Vol. 108, no. 18, p. 7431-7436 (2011)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/123391","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/123391","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 108 (18","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2209897","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088632","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1520740054","https://openalex.org/W1724512254","https://openalex.org/W1885126307","https://openalex.org/W1910697241","https://openalex.org/W1973697421","https://openalex.org/W1974805319","https://openalex.org/W1976222351","https://openalex.org/W1979812265","https://openalex.org/W1981634986","https://openalex.org/W1985103299","https://openalex.org/W1985651419","https://openalex.org/W1992975936","https://openalex.org/W1999829508","https://openalex.org/W2000099020","https://openalex.org/W2011202983","https://openalex.org/W2020969391","https://openalex.org/W2021689495","https://openalex.org/W2024902613","https://openalex.org/W2036041106","https://openalex.org/W2037882440","https://openalex.org/W2038858817","https://openalex.org/W2050389860","https://openalex.org/W2059694060","https://openalex.org/W2070081201","https://openalex.org/W2074019221","https://openalex.org/W2076971256","https://openalex.org/W2079452508","https://openalex.org/W2080155427","https://openalex.org/W2080628861","https://openalex.org/W2086296240","https://openalex.org/W2088823531","https://openalex.org/W2093358903","https://openalex.org/W2095278911","https://openalex.org/W2109627278","https://openalex.org/W2113888680","https://openalex.org/W2123032512","https://openalex.org/W2124670362","https://openalex.org/W2125280450","https://openalex.org/W2127292451","https://openalex.org/W2137388149","https://openalex.org/W2145768398","https://openalex.org/W2151011478","https://openalex.org/W2161092951","https://openalex.org/W2161282017","https://openalex.org/W2165849327","https://openalex.org/W2166724005"],"related_works":["https://openalex.org/W2314598629","https://openalex.org/W2346211751","https://openalex.org/W2312671547","https://openalex.org/W1997509648","https://openalex.org/W4242777689","https://openalex.org/W1995434582","https://openalex.org/W2047926803","https://openalex.org/W1992975936","https://openalex.org/W2341262906","https://openalex.org/W2342760745"],"abstract_inverted_index":{"Squamous":[0],"cell":[1,27],"carcinoma":[2],"(SCC)":[3],"is":[4,129],"the":[5,25,30,62,133,152,181,189],"second":[6],"most":[7],"frequent":[8],"skin":[9,63,110],"cancer.":[10],"The":[11],"cellular":[12,59],"origin":[13,31],"of":[14,32,61,78,114,148,154,183,191],"SCC":[15],"remains":[16],"controversial.":[17],"Here,":[18],"we":[19,53],"used":[20],"mouse":[21],"genetics":[22],"to":[23,107,121,132,171],"determine":[24],"epidermal":[26,51,69,164],"lineages":[28,165],"at":[29],"SCC.":[33,158,193],"Using":[34],"mice":[35],"conditionally":[36],"expressing":[37],"a":[38],"constitutively":[39],"active":[40],"KRas":[41,80,185],"mutant":[42,79],"(G12D)":[43],"and":[44,65,88,94,175],"an":[45],"inducible":[46],"CRE":[47],"recombinase":[48],"in":[49,57,81,100,116,180],"different":[50,58,163],"lineages,":[52],"activated":[54],"Ras":[55,71],"signaling":[56],"compartments":[60,70],"epidermis":[64,118],"determined":[66],"from":[67],"which":[68],"activation":[72],"induces":[73],"squamous":[74,109,126],"tumor":[75,111,127,140],"formation.":[76],"Expression":[77,113],"hair":[82,134],"follicle":[83,135],"bulge":[84,167],"stem":[85],"cells":[86],"(SCs)":[87],"their":[89,101],"immediate":[90],"progeny":[91],"(hair":[92],"germ":[93],"outer":[95],"root":[96],"sheath),":[97],"but":[98],"not":[99,130],"transient":[102],"amplifying":[103],"matrix":[104],"cells,":[105],"led":[106,120],"benign":[108],"(papilloma).":[112],"KRas(G12D)":[115,144,149],"interfollicular":[117],"also":[119],"papilloma":[122,173],"formation,":[123],"demonstrating":[124],"that":[125,162,176],"initiation":[128],"restricted":[131],"lineages.":[136],"Whereas":[137],"no":[138],"malignant":[139],"was":[141],"observed":[142],"after":[143],"expression":[145,147],"alone,":[146],"combined":[150],"with":[151],"loss":[153],"p53":[155],"induced":[156],"invasive":[157,192],"Our":[159],"studies":[160],"demonstrate":[161],"including":[166],"SC":[168],"are":[169,186],"competent":[170],"initiate":[172],"formation":[174],"multiple":[177],"genetic":[178],"hits":[179],"context":[182],"oncogenic":[184],"required":[187],"for":[188],"development":[190]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":35}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
