{"id":"https://openalex.org/W2000470430","doi":"https://doi.org/10.1152/ajpheart.00678.2002","title":"CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin","display_name":"CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2000470430","doi":"https://doi.org/10.1152/ajpheart.00678.2002","mag":"2000470430","pmid":"https://pubmed.ncbi.nlm.nih.gov/12969895"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00678.2002","doi":"https://doi.org/10.1152/ajpheart.00678.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00678.2002","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100403563","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0003-2712-1251","observed_orcids":["https://orcid.org/0000-0003-2712-1251"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005137599","display_name":"Jun-Ichi Kaide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Ichi Kaide","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047806485","display_name":"Liming Yang","orcid":"https://orcid.org/0000-0002-0376-8184","observed_orcids":["https://orcid.org/0000-0002-0376-8184"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LiMing Yang","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103386325","display_name":"Houli Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Houli Jiang","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054918999","display_name":"Shuo Quan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuo Quan","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103536279","display_name":"Rowena Kemp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rowena Kemp","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040163785","display_name":"Weiying Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiying Gong","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077043354","display_name":"Michael Balazy","orcid":"https://orcid.org/0000-0003-0218-8820","observed_orcids":["https://orcid.org/0000-0003-0218-8820"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Balazy","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053981602","display_name":"Nader G. Abraham","orcid":"https://orcid.org/0000-0001-8983-1959","observed_orcids":["https://orcid.org/0000-0001-8983-1959"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nader G. Abraham","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031314322","display_name":"Alberto Nasjletti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alberto Nasjletti","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":null,"apc_paid":null,"fwci":1.3053,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.76523682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"286","issue":"1","first_page":"H137","last_page":"H144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-hypoxia","display_name":"acute hypoxia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/pulmonary-vasoconstriction","display_name":"pulmonary vasoconstriction","score":0.9359999895095825},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/heme-oxygenase-2","display_name":"heme oxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/endothelin-receptor-blockade","display_name":"endothelin receptor blockade","score":0.5450000166893005},{"id":"https://openalex.org/keywords/pulmonary-artery-pressure","display_name":"pulmonary artery pressure","score":0.718999981880188},{"id":"https://openalex.org/keywords/chromium-mesoporphyrin","display_name":"chromium mesoporphyrin","score":0.828000009059906},{"id":"https://openalex.org/keywords/antisense-oligodeoxynucleotides","display_name":"antisense oligodeoxynucleotides","score":0.921999990940094},{"id":"https://openalex.org/keywords/endothelium","display_name":"endothelium","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C29323129","wikidata":"https://www.wikidata.org/wiki/Q3504897","display_name":"Hypoxic pulmonary vasoconstriction","level":3,"score":0.730445921421051},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6980706453323364},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.5796941518783569},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.5767883062362671},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.5501585006713867},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5017750263214111},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47940608859062195},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.4675534963607788},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45459699630737305},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4311331808567047},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39955055713653564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3556044399738312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12261101603507996},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.11191174387931824},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017466","descriptor_name":"Receptors, Endothelin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017466","descriptor_name":"Receptors, Endothelin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017466","descriptor_name":"Receptors, Endothelin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.00678.2002","doi":"https://doi.org/10.1152/ajpheart.00678.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00678.2002","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:12969895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12969895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.699999988079071,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2170044055","display_name":"HORMONAL REGULATION OF BLOOD PRESSURE","funder_award_id":"P01HL034300","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2346056350","display_name":"Heme Oxygenase Regulation of Eicosanoid Biosynthesis","funder_award_id":"R01DK056601","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2482593692","display_name":null,"funder_award_id":"HL 34300","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G553195937","display_name":null,"funder_award_id":"HL-18579","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G59825344","display_name":null,"funder_award_id":"DK56601","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W285469281","https://openalex.org/W1526317775","https://openalex.org/W1931804684","https://openalex.org/W1967207824","https://openalex.org/W1970445852","https://openalex.org/W1972746041","https://openalex.org/W1975903221","https://openalex.org/W1983214838","https://openalex.org/W1997967233","https://openalex.org/W2014434817","https://openalex.org/W2025115124","https://openalex.org/W2037447701","https://openalex.org/W2055863052","https://openalex.org/W2056881064","https://openalex.org/W2062188620","https://openalex.org/W2082349610","https://openalex.org/W2087516645","https://openalex.org/W2099382071","https://openalex.org/W2101035566","https://openalex.org/W2111141380","https://openalex.org/W2111496692","https://openalex.org/W2113158482","https://openalex.org/W2122524013","https://openalex.org/W2131173683","https://openalex.org/W2134360290","https://openalex.org/W2143955152","https://openalex.org/W2154271176","https://openalex.org/W2166085728","https://openalex.org/W2170431734","https://openalex.org/W2184358523","https://openalex.org/W2186766433","https://openalex.org/W2274482651","https://openalex.org/W2313400759","https://openalex.org/W2320516100","https://openalex.org/W2330224437","https://openalex.org/W2333316790","https://openalex.org/W2341747697","https://openalex.org/W2408804735","https://openalex.org/W2410047918","https://openalex.org/W2411779599","https://openalex.org/W2430902355"],"related_works":["https://openalex.org/W4232219875","https://openalex.org/W2393824044","https://openalex.org/W1964915258","https://openalex.org/W2113158482","https://openalex.org/W2055863052","https://openalex.org/W1983214838","https://openalex.org/W2246965587","https://openalex.org/W2374678992","https://openalex.org/W2001907298","https://openalex.org/W2274482651"],"abstract_inverted_index":{"Pulmonary":[0],"intralobar":[1,118],"arteries":[2],"express":[3],"heme":[4],"oxygenase":[5],"(HO)-1":[6],"and":[7,9,76,102,184,214],"-2":[8],"release":[10],"carbon":[11],"monoxide":[12],"(CO)":[13],"during":[14,121],"incubation":[15,122],"in":[16,29,50,98,116,123,132,178],"Krebs":[17],"buffer.":[18],"Acute":[19,53],"hypoxia":[20,54,169],"elicits":[21],"isometric":[22],"tension":[23],"development":[24],"(0.77":[25],"+/-":[26],"0.06":[27],"mN/mm)":[28],"pulmonary":[30,59,72,117,157,175,207],"vascular":[31,74,212],"rings":[32],"treated":[33,83],"with":[34,65,84,108,148,182],"15":[35],"micromol/l":[36],"chromium":[37],"mesoporphyrin":[38],"(CrMP),":[39],"an":[40],"inhibitor":[41],"of":[42,58,81,156,174,199],"HO-dependent":[43],"CO":[44,77,95],"synthesis,":[45],"but":[46],"has":[47],"no":[48],"effect":[49],"untreated":[51],"vessels.":[52],"also":[55,127],"induces":[56],"contraction":[57,80],"vessels":[60,82],"taken":[61],"from":[62],"rats":[63,179],"injected":[64],"HO-2":[66,73],"antisense":[67],"oligodeoxynucleotides":[68],"(ODN),":[69],"which":[70,138],"decrease":[71],"expression":[75],"release.":[78],"Hypoxia-induced":[79],"CrMP":[85,112,126,149,183],"is":[86,139],"attenuated":[87],"(P":[88],"<":[89],"0.05)":[90],"by":[91,94,103,141,161,209],"endothelium":[92],"removal,":[93],"(1-100":[96],"micromol/l)":[97],"the":[99,133,154,185],"bathing":[100],"buffer,":[101],"endothelin-1":[104],"(ET-1)":[105],"receptor":[106,187],"blockade":[107],"L-754142":[109],"(10":[110],"micromol/l).":[111],"increases":[113],"ET-1":[114,186,211],"levels":[115,213],"arteries,":[119],"particularly":[120],"hypooxygenated":[124],"media.":[125],"causes":[128],"a":[129,163,197],"leftward":[130],"shift":[131],"concentration-response":[134],"curve":[135],"to":[136],"ET-1,":[137],"offset":[140],"exogenous":[142],"CO.":[143],"In":[144],"anesthetized":[145],"rats,":[146],"pretreatment":[147],"(40":[150],"micromol/kg":[151],"iv)":[152],"intensifies":[153],"elevation":[155],"artery":[158],"pressure":[159,177],"elicited":[160],"breathing":[162],"hypoxic":[164],"gas":[165],"mixture.":[166],"However,":[167],"acute":[168],"does":[170],"not":[171],"elicit":[172],"augmentation":[173],"arterial":[176],"pretreated":[180],"concurrently":[181],"antagonist":[188],"L-745142":[189],"(15":[190],"mg/kg":[191],"iv).":[192],"These":[193],"data":[194],"suggest":[195],"that":[196],"product":[198],"HO":[200],"activity,":[201],"most":[202],"likely":[203],"CO,":[204],"inhibits":[205],"hypoxia-induced":[206],"vasoconstriction":[208],"reducing":[210],"sensitivity.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
