{"id":"https://openalex.org/W2000467332","doi":"https://doi.org/10.1097/01.ccm.0000059997.90832.29","title":"Alveolar inflation during generation of a quasi-static pressure/volume curve in the acutely injured lung","display_name":"Alveolar inflation during generation of a quasi-static pressure/volume curve in the acutely injured lung","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W2000467332","doi":"https://doi.org/10.1097/01.ccm.0000059997.90832.29","mag":"2000467332","pmid":"https://pubmed.ncbi.nlm.nih.gov/12682483"},"language":"en","primary_location":{"id":"doi:10.1097/01.ccm.0000059997.90832.29","doi":"https://doi.org/10.1097/01.ccm.0000059997.90832.29","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0000059997.90832.29","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110570803","display_name":"Henry J. Schiller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4405257093","display_name":"Laboratoire Alexander Grothendieck","ror":"https://ror.org/04wbdez64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4405257093","https://openalex.org/I84909340"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Henry J. Schiller","raw_affiliation_strings":["Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA","(LAG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"(LAG)","institution_ids":["https://openalex.org/I4405257093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020282683","display_name":"Jay M. Steinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4405257093","display_name":"Laboratoire Alexander Grothendieck","ror":"https://ror.org/04wbdez64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4405257093","https://openalex.org/I84909340"]},{"id":"https://openalex.org/I880615350","display_name":"SUNY Cortland","ror":"https://ror.org/05a4pj207","country_code":"US","type":"education","lineage":["https://openalex.org/I880615350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Jay Steinberg","raw_affiliation_strings":["From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","and the Department of Biology, Cortland College, Cortland, NY (LAG)","(LAG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"and the Department of Biology, Cortland College, Cortland, NY (LAG)","institution_ids":["https://openalex.org/I880615350"]},{"raw_affiliation_string":"(LAG)","institution_ids":["https://openalex.org/I4405257093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089481130","display_name":"Jeffrey M. Halter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4405257093","display_name":"Laboratoire Alexander Grothendieck","ror":"https://ror.org/04wbdez64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4405257093","https://openalex.org/I84909340"]},{"id":"https://openalex.org/I880615350","display_name":"SUNY Cortland","ror":"https://ror.org/05a4pj207","country_code":"US","type":"education","lineage":["https://openalex.org/I880615350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Jeffrey Halter","raw_affiliation_strings":["From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","and the Department of Biology, Cortland College, Cortland, NY (LAG)","(LAG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"and the Department of Biology, Cortland College, Cortland, NY (LAG)","institution_ids":["https://openalex.org/I880615350"]},{"raw_affiliation_string":"(LAG)","institution_ids":["https://openalex.org/I4405257093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047296290","display_name":"Ulysse G. McCann","orcid":"https://orcid.org/0000-0002-5190-7871","observed_orcids":["https://orcid.org/0000-0002-5190-7871"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4405257093","display_name":"Laboratoire Alexander Grothendieck","ror":"https://ror.org/04wbdez64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4405257093","https://openalex.org/I84909340"]},{"id":"https://openalex.org/I880615350","display_name":"SUNY Cortland","ror":"https://ror.org/05a4pj207","country_code":"US","type":"education","lineage":["https://openalex.org/I880615350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Ulysse McCann","raw_affiliation_strings":["From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","and the Department of Biology, Cortland College, Cortland, NY (LAG)","(LAG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"and the Department of Biology, Cortland College, Cortland, NY (LAG)","institution_ids":["https://openalex.org/I880615350"]},{"raw_affiliation_string":"(LAG)","institution_ids":["https://openalex.org/I4405257093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113731250","display_name":"Monica DaSilva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4405257093","display_name":"Laboratoire Alexander Grothendieck","ror":"https://ror.org/04wbdez64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4405257093","https://openalex.org/I84909340"]},{"id":"https://openalex.org/I880615350","display_name":"SUNY Cortland","ror":"https://ror.org/05a4pj207","country_code":"US","type":"education","lineage":["https://openalex.org/I880615350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Monica DaSilva","raw_affiliation_strings":["From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","and the Department of Biology, Cortland College, Cortland, NY (LAG)","(LAG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"and the Department of Biology, Cortland College, Cortland, NY (LAG)","institution_ids":["https://openalex.org/I880615350"]},{"raw_affiliation_string":"(LAG)","institution_ids":["https://openalex.org/I4405257093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065550494","display_name":"Louis A. Gatto","orcid":"https://orcid.org/0000-0001-7658-264X","observed_orcids":["https://orcid.org/0000-0001-7658-264X"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4405257093","display_name":"Laboratoire Alexander Grothendieck","ror":"https://ror.org/04wbdez64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4405257093","https://openalex.org/I84909340"]},{"id":"https://openalex.org/I880615350","display_name":"SUNY Cortland","ror":"https://ror.org/05a4pj207","country_code":"US","type":"education","lineage":["https://openalex.org/I880615350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Louis A. Gatto","raw_affiliation_strings":["From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","and the Department of Biology, Cortland College, Cortland, NY (LAG)","(LAG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"and the Department of Biology, Cortland College, Cortland, NY (LAG)","institution_ids":["https://openalex.org/I880615350"]},{"raw_affiliation_string":"(LAG)","institution_ids":["https://openalex.org/I4405257093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017974119","display_name":"Dave Carney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4405257093","display_name":"Laboratoire Alexander Grothendieck","ror":"https://ror.org/04wbdez64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4405257093","https://openalex.org/I84909340"]},{"id":"https://openalex.org/I880615350","display_name":"SUNY Cortland","ror":"https://ror.org/05a4pj207","country_code":"US","type":"education","lineage":["https://openalex.org/I880615350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Dave Carney","raw_affiliation_strings":["From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","and the Department of Biology, Cortland College, Cortland, NY (LAG)","(LAG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"and the Department of Biology, Cortland College, Cortland, NY (LAG)","institution_ids":["https://openalex.org/I880615350"]},{"raw_affiliation_string":"(LAG)","institution_ids":["https://openalex.org/I4405257093"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011575122","display_name":"Gary F. Nieman","orcid":"https://orcid.org/0000-0002-4541-4472","observed_orcids":["https://orcid.org/0000-0002-4541-4472"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4405257093","display_name":"Laboratoire Alexander Grothendieck","ror":"https://ror.org/04wbdez64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4405257093","https://openalex.org/I84909340"]},{"id":"https://openalex.org/I880615350","display_name":"SUNY Cortland","ror":"https://ror.org/05a4pj207","country_code":"US","type":"education","lineage":["https://openalex.org/I880615350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Gary Nieman","raw_affiliation_strings":["From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","and the Department of Biology, Cortland College, Cortland, NY (LAG)","(LAG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY (HJS, JS, JH, UM, MD, DC, GN)","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"and the Department of Biology, Cortland College, Cortland, NY (LAG)","institution_ids":["https://openalex.org/I880615350"]},{"raw_affiliation_string":"(LAG)","institution_ids":["https://openalex.org/I4405257093"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7533,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.92615688,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"31","issue":"4","first_page":"1126","last_page":"1133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.7689999938011169},{"id":"https://openalex.org/keywords/alveolar-recruitment","display_name":"alveolar recruitment","score":0.7360000014305115},{"id":"https://openalex.org/keywords/alveolar-overdistension","display_name":"alveolar overdistension","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alveolar-collapse","display_name":"alveolar collapse","score":0.7369999885559082},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.7480000257492065},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.800000011920929},{"id":"https://openalex.org/keywords/alveolar-mechanics","display_name":"alveolar mechanics","score":0.671999990940094},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.5099999904632568},{"id":"https://openalex.org/keywords/lung-viscoelasticity","display_name":"lung viscoelasticity","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7888337969779968},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.6284528374671936},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.6200742125511169},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.5644281506538391},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5313233733177185},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.5279368758201599},{"id":"https://openalex.org/C2776164194","wikidata":"https://www.wikidata.org/wiki/Q2501440","display_name":"Expiration","level":3,"score":0.48203837871551514},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.46804332733154297},{"id":"https://openalex.org/C2908807708","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Alveolar Wall","level":3,"score":0.4601806402206421},{"id":"https://openalex.org/C153899047","wikidata":"https://www.wikidata.org/wiki/Q7259527","display_name":"Pulmonary gas pressures","level":3,"score":0.44508007168769836},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44261249899864197},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3794311583042145},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34616607427597046},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2483190894126892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22662264108657837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1086663007736206},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008170","descriptor_name":"Lung Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008176","descriptor_name":"Lung Volume Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011136","descriptor_name":"Polysorbates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015656","descriptor_name":"Respiratory Mechanics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.ccm.0000059997.90832.29","doi":"https://doi.org/10.1097/01.ccm.0000059997.90832.29","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0000059997.90832.29","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:12682483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12682483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1767417046","https://openalex.org/W1944977254","https://openalex.org/W1967729284","https://openalex.org/W1975626543","https://openalex.org/W2009069101","https://openalex.org/W2014047293","https://openalex.org/W2017187081","https://openalex.org/W2040937860","https://openalex.org/W2046384238","https://openalex.org/W2051675651","https://openalex.org/W2053066034","https://openalex.org/W2068656084","https://openalex.org/W2070012035","https://openalex.org/W2075789497","https://openalex.org/W2089993899","https://openalex.org/W2092786096","https://openalex.org/W2115370751","https://openalex.org/W2127670897","https://openalex.org/W2128928153","https://openalex.org/W2142789178","https://openalex.org/W2143748013","https://openalex.org/W2154615630","https://openalex.org/W2161810420","https://openalex.org/W2169525541","https://openalex.org/W2382091723","https://openalex.org/W2615932174"],"related_works":["https://openalex.org/W2092786096","https://openalex.org/W2022502929","https://openalex.org/W2043274462","https://openalex.org/W2000566162","https://openalex.org/W2077438587","https://openalex.org/W3039498649","https://openalex.org/W2005008587","https://openalex.org/W6979995018","https://openalex.org/W3061481819","https://openalex.org/W2133987523"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Lower":[1],"and":[2,26,29,113,121,137,171,231,241,257,288,303,337,354,496,565,599,649,652,660],"upper":[3],"inflection":[4,322,331,597,612,617],"points":[5],"on":[6,202],"the":[7,16,52,67,73,169,172,181,191,250,255,325,347,363,380,404,428,433,437,535,552,573,579,585,595,605,626,630,633,639,653,657,661],"quasi-static":[8,300,315,364,580],"curve":[9,57,78,317,326,635],"representing":[10],"a":[11,55,76,87,118,260,280,319,338,370,484,568],"composite":[12],"of":[13,54,69,75,91,159,174,198,362,387,530,572,632,638],"pressure/volume":[14,56,77,301,316,365,582,634],"from":[15,254,271,450],"whole":[17],"lung":[18,92,268,314,416,448,476,490,502,519,581],"are":[19,30,350],"hypothesized":[20],"to":[21,33,58,134,146,168,196,259,273,291,297,457,616,621],"represent":[22],"initial":[23],"alveolar":[24,182,203,211,248,289,305,376,389,413,420,540,553,561,574,623,641,647],"recruitment":[25],"overdistension,":[27],"respectively,":[28],"currently":[31],"utilized":[32,296],"adjust":[34],"mechanical":[35,115],"ventilation":[36,222,240],"in":[37,83,86,94,161,190,210,276,346,379,402,412,427,445,499,523,539,544,646,656],"patients":[38],"with":[39,264,279,373,415,432,447,475,483,542,559,604],"acute":[40],"respiratory":[41],"distress":[42],"syndrome.":[43],"However,":[44],"alveoli":[45,71,217,234,345,401,442,480],"have":[46],"never":[47],"been":[48],"directly":[49,577],"observed":[50],"during":[51,72,213,221,238,360],"generation":[53,74,361],"confirm":[59],"this":[60,63],"hypothesis.":[61],"In":[62,436],"study,":[64],"we":[65],"visualized":[66],"inflation":[68,385,449,503,554,607],"individual":[70,304,640],"by":[79,152,179,184,394,525,534],"direct":[80],"visualization":[81],"using":[82],"vivo":[84],"microscopy":[85],"surfactant":[88,150,392,550],"deactivation":[89,151,368,393],"model":[90],"injury":[93],"pigs.":[95,108],"DESIGN:":[96],"Prospective,":[97],"observational,":[98],"controlled":[99],"study.":[100],"SETTING:":[101],"University":[102],"research":[103],"laboratory.":[104],"SUBJECTS:":[105],"Eight":[106],"adult":[107],"INTERVENTIONS:":[109],"Pigs":[110],"were":[111,122,132,144,252,295],"anesthetized":[112],"administered":[114],"ventilation,":[116],"underwent":[117],"left":[119],"thoracotomy,":[120],"separated":[123],"into":[124],"two":[125],"groups:":[126],"control":[127,348,405,429],"pigs":[128,140],"(n":[129,141],"=":[130,142],"3)":[131],"subjected":[133,145],"surgical":[135,147],"intervention,":[136],"Tween":[138,153,160,328,395,407,434,438],"lavage":[139,154],"5)":[143],"intervention":[148],"plus":[149,644],"(1.5":[155],"mL/kg":[156],"5%":[157],"solution":[158],"saline).":[162],"The":[163,267,312,384,517],"microscope":[164],"was":[165,176,194,269,396,422,614,619],"then":[166],"attached":[167,258],"lung,":[170],"size":[173,212,220,237,358],"each":[175,388,560],"alveolus":[177,189,592],"quantified":[178],"measuring":[180],"area":[183,414,421,487,500,541],"computer":[185],"image":[186],"analysis.":[187],"Each":[188],"microscopic":[192,382],"field":[193],"assigned":[195],"one":[197,588],"three":[199,375],"types,":[200],"based":[201],"mechanics:":[204],"type":[205,215,232,352,390,440,562,589],"I,":[206],"no":[207],"visible":[208],"change":[209,219,236,357,411,538],"ventilation;":[214],"II,":[216,564],"visibly":[218,235],"but":[223,464],"do":[224,355],"not":[225,356,466,521],"totally":[226],"collapse":[227,243],"at":[228,244,333,340,594],"end":[229,245],"expiration;":[230],"III,":[233],"tidal":[239],"completely":[242],"expiration.":[246],"After":[247,549],"classification,":[249],"animals":[251],"disconnected":[253],"ventilator":[256],"super":[261],"syringe":[262],"filled":[263],"100%":[265],"oxygen.":[266],"inflated":[270],"0":[272,451],"220":[274,510],"mL":[275,452,459,489],"20-mL":[277],"increments":[278,284],"10-sec":[281],"pause":[282],"between":[283],"for":[285,629],"airway":[286,545,650],"pressure":[287],"confirmation":[290],"stabilize.":[292],"These":[293],"data":[294],"generate":[298],"both":[299],"curves":[302,576],"pressure/area":[306,547,575,642],"curves.":[307],"MEASUREMENTS":[308],"AND":[309],"MAIN":[310],"RESULTS:":[311],"normal":[313,518],"has":[318,329],"single":[320],"lower":[321],"point,":[323,608],"whereas":[324],"after":[327,391],"an":[330],"point":[332,598,613,618],"8":[334],"mm":[335,342],"Hg":[336],"second":[339,606],"24":[341],"Hg.":[343],"Normal":[344],"group":[349,408],"all":[351,374,637],"I":[353,400,419],"appreciably":[359],"curve.":[366,548,583],"Surfactant":[367],"causes":[369],"heterogenous":[371],"injury,":[372],"types":[377],"present":[378],"same":[381],"field.":[383],"pattern":[386,555],"notably":[397],"different.":[398],"Type":[399,418,478],"either":[403],"or":[406],"demonstrated":[409],"minimal":[410],"inflation.":[417,477],"significantly":[423,444],"(p":[424],"<.05)":[425],"larger":[426],"as":[430,532],"compared":[431],"group.":[435],"group,":[439],"II":[441],"increased":[443,498],"area,":[446],"(9666":[453],"+/-":[454,461,472,493,507,513],"1340":[455],"microm2)":[456,463,474,495,515],"40":[458],"(12,935":[460],"1725":[462],"did":[465],"increase":[467,522],"further":[468],"(220":[469],"mL,":[470,505,511],"14,058":[471],"1740":[473],"III":[479,590],"initially":[481],"recruited":[482,593,602],"relatively":[485],"small":[486],"(20":[488],"volume,":[491],"798":[492],"797":[494],"progressively":[497],"throughout":[501],"(120":[504],"7302":[506],"1405":[508],"microm2;":[509],"11,460":[512],"1078":[514],"CONCLUSION:":[516],"does":[520],"volume":[524],"simple":[526],"isotropic":[527],"(balloon-like)":[528],"expansion":[529],"alveoli,":[531],"evidenced":[533],"horizontal":[536],"(no":[537],"increases":[543],"pressure)":[546],"deactivation,":[551],"becomes":[556],"very":[557],"complex,":[558],"(I,":[563],"III)":[566],"displaying":[567],"distinct":[569],"pattern.":[570],"None":[571],"parallel":[578],"Of":[584],"16,":[586],"only":[587,600],"atelectatic":[591],"first":[596],"five":[601],"concomitant":[603],"suggesting":[609],"that":[610],"neither":[611],"due":[615,620],"massive":[622],"recruitment.":[624],"Thus,":[625],"components":[627],"responsible":[628],"shape":[631],"include":[636],"curves,":[643],"changes":[645],"duct":[648],"size,":[651],"elastic":[654],"forces":[655],"pulmonary":[658],"parenchyma":[659],"chest":[662],"wall.":[663]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}