{"id":"https://openalex.org/W2000466010","doi":"https://doi.org/10.1055/s-0029-1212125","title":"Comparative effects of glimepiride and glibenclamide on blood glucose, C-peptide and insulin concentrations in the fasting and postprandial state in normal man","display_name":"Comparative effects of glimepiride and glibenclamide on blood glucose, C-peptide and insulin concentrations in the fasting and postprandial state in normal man","publication_year":2009,"publication_date":"2009-07-14","ids":{"openalex":"https://openalex.org/W2000466010","doi":"https://doi.org/10.1055/s-0029-1212125","mag":"2000466010","pmid":"https://pubmed.ncbi.nlm.nih.gov/10543411"},"language":"en","primary_location":{"id":"doi:10.1055/s-0029-1212125","doi":"https://doi.org/10.1055/s-0029-1212125","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0029-1212125","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology &amp; Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090174738","display_name":"Sotiris A. Raptis","orcid":"https://orcid.org/0000-0001-7040-966X","observed_orcids":["https://orcid.org/0000-0001-7040-966X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S. Raptis","raw_affiliation_strings":["Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001903464","display_name":"Erifili E. Hatziagelaki","orcid":"https://orcid.org/0000-0002-5038-3412","observed_orcids":["https://orcid.org/0000-0002-5038-3412"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. Hatziagelaki","raw_affiliation_strings":["Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012389412","display_name":"Georgios K. Dimitriadis","orcid":"https://orcid.org/0000-0002-6662-804X","observed_orcids":["https://orcid.org/0000-0002-6662-804X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G. Dimitriadis","raw_affiliation_strings":["Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069016628","display_name":"K. E. Draeger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K. Draeger","raw_affiliation_strings":["Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065389275","display_name":"Claudia Pfeiffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C. Pfeiffer","raw_affiliation_strings":["Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029508170","display_name":"Athanasios E. Raptis","orcid":"https://orcid.org/0000-0002-1866-8709","observed_orcids":["https://orcid.org/0000-0002-1866-8709"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Raptis","raw_affiliation_strings":["Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Evangelismos Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3954,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.67479404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"107","issue":"06","first_page":"350","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glimepiride","display_name":"glimepiride","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":1.0},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.9879999756813049},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.859000027179718},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.9129999876022339},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.871999979019165},{"id":"https://openalex.org/keywords/postprandial-hyperglycemia","display_name":"postprandial hyperglycemia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.7039999961853027},{"id":"https://openalex.org/keywords/oral-glucose-tolerance","display_name":"oral glucose tolerance","score":0.5740000009536743},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.453000009059906},{"id":"https://openalex.org/keywords/drug-comparison","display_name":"drug comparison","score":0.5619999766349792},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.35100001096725464},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.5049999952316284},{"id":"https://openalex.org/keywords/mixed-meal-tolerance-test","display_name":"mixed meal tolerance test","score":0.42800000309944153},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hypoglycemia-risk","display_name":"hypoglycemia risk","score":0.6269999742507935},{"id":"https://openalex.org/keywords/type-2-diabetes-treatment","display_name":"type 2 diabetes treatment","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2776307423","wikidata":"https://www.wikidata.org/wiki/Q425027","display_name":"Glimepiride","level":4,"score":0.9850773811340332},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.9665156006813049},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.871025025844574},{"id":"https://openalex.org/C2778854520","wikidata":"https://www.wikidata.org/wiki/Q418776","display_name":"Sulfonylurea","level":3,"score":0.7829526662826538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7077553272247314},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6484878659248352},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6256221532821655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6162465810775757},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.57090824842453},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.51031893491745},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3901347517967224},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.13122066855430603},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005502","descriptor_name":"Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0029-1212125","doi":"https://doi.org/10.1055/s-0029-1212125","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0029-1212125","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology &amp; Diabetes","raw_type":"journal-article"},{"id":"pmid:10543411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10543411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966210363","https://openalex.org/W2126650736","https://openalex.org/W2377728700","https://openalex.org/W2113230212","https://openalex.org/W2158275124","https://openalex.org/W1980585694","https://openalex.org/W2033895007","https://openalex.org/W1997847826","https://openalex.org/W2116836307","https://openalex.org/W1966349538"],"abstract_inverted_index":{"A":[0],"single-center,":[1],"randomised,":[2],"placebo-":[3],"controlled,":[4],"cross-over":[5],"study":[6],"was":[7,34,54,82,119,180,204,224],"conducted":[8],"to":[9,16,57,144,153,216],"characterize":[10],"the":[11,23,69,110,113,117,126,222,225,230,242,252,262],"new":[12],"sulfonylurea":[13,26],"glimepiride":[14,133,162,166,196,217,245,274,280,296],"and":[15,45,92,130,137,156,167,246,267,270],"compare":[17],"its":[18],"profile":[19],"of":[20,31,43,85,128,292],"action":[21,299],"with":[22],"second":[24],"generation":[25],"glibenclamide.":[27,154,164],"The":[28],"total":[29],"duration":[30],"each":[32],"experiment":[33],"5":[35],"hours.":[36],"At":[37,75],"zero":[38],"time":[39],"an":[40],"i.v.":[41,56,259],"injection":[42,70],"2":[44,98,129,194],"4":[46,131],"mg":[47,50,132,195],"glimepiride,":[48],"1":[49],"glibenclamide":[51,168,184,210,247,293],"or":[52,163,294],"placebo":[53,145],"given":[55,83],"24":[58],"healthy":[59],"volunteers.":[60],"Blood":[61],"samples":[62,94],"were":[63,95,158,232],"collected":[64,96],"for":[65,97,227],"three":[66],"hours":[67,100],"after":[68,125,161,183,193,258],"(0-3":[71,104],"hours,":[72,77],"preprandial":[73],"experiment).":[74,102],"3":[76],"a":[78,86,285],"standard":[79],"mixed":[80],"meal":[81],"(20%,":[84],"30":[87],"Kcal/Kg":[88],"Body":[89],"Weight":[90],"diet)":[91],"blood":[93,106,178,255],"more":[99],"(postprandial":[101],"Pre-prandially":[103],"hrs)":[105,177],"glucose":[107,179,256],"(expressed":[108],"as":[109],"area":[111],"under":[112],"curve":[114],"divided":[115],"by":[116],"time)":[118],"significantly":[120,181,205,234],"lower":[121,268],"(p":[122,189,207,236],"<":[123,190,208],"0.0001)":[124,191],"administration":[127],"(3.8":[134],"+/-":[135,139,147,186,198,212,219],"0.22":[136],"3.5":[138],"0.3":[140],"mM":[141],"respectively)":[142],"compared":[143,152,215],"(4.63":[146],"0.31":[148],"mM),":[149],"but":[150,229],"not":[151,159,233],"Insulin":[155],"C-peptide":[157,203,271],"different":[160,235,289],"Both":[165],"had":[169,248],"similar":[170,249],"effects":[171,250],"on":[172,251],"insulin":[173,228,269,282,298],"secretion.":[174],"Post-prandially":[175],"(3-5":[176],"higher":[182,206],"(6.54":[185],"0.8":[187],"mM)":[188],"than":[192],"(5.75":[197],"0.5":[199],"mM).":[200],"Despite":[201],"this":[202],"0.002)":[209],"(5.7":[211],"1.5":[213],"ng/ml)":[214],"(5.1":[218],"1.3":[220],"ng/ml);":[221],"trend":[223],"same":[226],"results":[231],"=":[237],"0.06)":[238],"In":[239],"conclusion,":[240],"in":[241,254],"fasting":[243],"state,":[244],"changes":[253],"levels":[257,272],"administration.":[260],"After":[261],"meal,":[263],"less":[264],"pronounced":[265],"hyperglycemia":[266],"following":[273],"(2":[275],"mg)":[276],"suggests":[277],"either":[278],"that":[279,291,295],"induces":[281],"secretion":[283],"through":[284,300],"pathway":[286],"which":[287],"is":[288],"from":[290],"facilitates":[297],"extrapancreatic":[301],"effects.":[302]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}