{"id":"https://openalex.org/W2000458653","doi":"https://doi.org/10.2174/09298673113206660263","title":"Enantiospecific Synthesis of Heterocycles Linked to Purines: Different Apoptosis Modulation of Enantiomers in Breast Cancer Cells","display_name":"Enantiospecific Synthesis of Heterocycles Linked to Purines: Different Apoptosis Modulation of Enantiomers in Breast Cancer Cells","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2000458653","doi":"https://doi.org/10.2174/09298673113206660263","mag":"2000458653","pmid":"https://pubmed.ncbi.nlm.nih.gov/24059234"},"language":"en","primary_location":{"id":"doi:10.2174/09298673113206660263","doi":"https://doi.org/10.2174/09298673113206660263","is_oa":false,"landing_page_url":"https://doi.org/10.2174/09298673113206660263","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006674189","display_name":"Mar\u00eda Eugenia Garc\u00eda-Rubi\u00f1o","orcid":"https://orcid.org/0000-0002-4008-6326","observed_orcids":["https://orcid.org/0000-0002-4008-6326"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Garc\u00eda-Rubi\u00f1o","raw_affiliation_strings":["Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain. jmcampos@ugr.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain. jmcampos@ugr.es","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010021696","display_name":"Ana Conejo\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0001-5776-7315","observed_orcids":["https://orcid.org/0000-0001-5776-7315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Conejo-Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078653959","display_name":"Mar\u00eda C. N\u00fa\u00f1ez","orcid":"https://orcid.org/0009-0002-0771-5351","observed_orcids":["https://orcid.org/0009-0002-0771-5351","https://orcid.org/0009-0000-5789-7558"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M. N\u00fa\u00f1ez","raw_affiliation_strings":["Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107845691","display_name":"Esther Carrasco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Carrasco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010158129","display_name":"Mar\u00eda \u00c1ngel Garc\u00eda","orcid":"https://orcid.org/0000-0003-2003-3769","observed_orcids":["https://orcid.org/0000-0003-2003-3769"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M. Garc\u00eda","raw_affiliation_strings":["Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091147103","display_name":"Duane Choquesillo\u2010Lazarte","orcid":"https://orcid.org/0000-0002-7077-8972","observed_orcids":["https://orcid.org/0000-0002-7077-8972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Choquesillo-Lazarte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091451539","display_name":"Juan Manuel Garc\u0131\u0301a-Ruiz","orcid":"https://orcid.org/0000-0002-4743-8718","observed_orcids":["https://orcid.org/0000-0002-4743-8718"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J. Garc\u00eda-Ruiz","raw_affiliation_strings":["Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111926265","display_name":"M.\u00c1. Gallo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M. Gallo","raw_affiliation_strings":["Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073290586","display_name":"Juan Antonio Marchal","orcid":"https://orcid.org/0000-0002-4996-8261","observed_orcids":["https://orcid.org/0000-0002-4996-8261"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J. Marchal","raw_affiliation_strings":["Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"last","author":{"id":null,"display_name":"J. Campos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J. Campos","raw_affiliation_strings":["Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Farmac\u00e9utica y Org\u00e1nica, Facultad de Farmacia, c/ Campus de Cartuja, s/n, 18071 Granada, Spain.,Spain","institution_ids":["https://openalex.org/I173304897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010158129","https://openalex.org/A5073290586","https://openalex.org/A5078653959","https://openalex.org/A5091451539","https://openalex.org/A5111926265"],"corresponding_institution_ids":["https://openalex.org/I173304897"],"apc_list":null,"apc_paid":null,"fwci":0.9093,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.6991683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"38","first_page":"4924","last_page":"4934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enantiospecific-synthesis","display_name":"enantiospecific synthesis","score":0.902999997138977},{"id":"https://openalex.org/keywords/mitsunobu-reaction","display_name":"Mitsunobu reaction","score":0.9670000076293945},{"id":"https://openalex.org/keywords/microwave-assisted-synthesis","display_name":"microwave-assisted synthesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/homochiral-compounds","display_name":"homochiral compounds","score":0.8090000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6079999804496765},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8370000123977661},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8399999737739563},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9800000190734863},{"id":"https://openalex.org/keywords/caspase-2","display_name":"caspase-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antitumour-activity","display_name":"antitumour activity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/racemate","display_name":"racemic mixtures","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.6614297032356262},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6038146018981934},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5821542143821716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5342544317245483},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.514891505241394},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.46475449204444885},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45859968662261963},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3834581971168518},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2794873118400574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2602934241294861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25514698028564453},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020717","descriptor_name":"Eukaryotic Initiation Factor-2B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/09298673113206660263","doi":"https://doi.org/10.2174/09298673113206660263","is_oa":false,"landing_page_url":"https://doi.org/10.2174/09298673113206660263","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:24059234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24059234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051646567","https://openalex.org/W2088752611","https://openalex.org/W2105313436","https://openalex.org/W2128990379","https://openalex.org/W2022280383","https://openalex.org/W2015879712","https://openalex.org/W2016677969","https://openalex.org/W3209195451","https://openalex.org/W4367301300","https://openalex.org/W1497206371"],"abstract_inverted_index":{"The":[0,88,109],"issue":[1],"of":[2,16,37,91,117,123,189],"chiral":[3],"drug":[4,39],"is":[5,46,94],"now":[6],"a":[7,67,161,177],"major":[8],"theme":[9],"in":[10,41,133,199],"the":[11,31,35,76,85,97,101,124,166,173,187],"design,":[12],"discovery":[13],"and":[14,34,57,59,100,120,156,176],"development":[15],"new":[17],"drugs.":[18],"It":[19],"has":[20],"been":[21],"shown":[22],"for":[23],"many":[24],"pharmaceuticals":[25],"that":[26,164,180],"only":[27],"one":[28],"enantiomer":[29],"contains":[30],"desired":[32],"activity,":[33],"synthesis":[36],"such":[38],"molecules":[40],"their":[42],"optically":[43],"pure":[44],"form":[45],"becoming":[47],"increasingly":[48],"important.":[49],"Mitsunobu":[50],"reaction":[51],"was":[52],"carried":[53],"out":[54],"between":[55,140],"(R)-":[56],"(S)-3,4-dihydro-2H-1,5-benzoxathiepin-3-ol":[58],"purines":[60],"under":[61],"microwave":[62],"irradiation.":[63],"A":[64],"contraction":[65],"into":[66],"six-membered":[68],"ring":[69],"takes":[70],"place":[71],"with":[72,78,143],"concomitant":[73],"inversion":[74],"at":[75],"stereocentre":[77],"excellent":[79],"enatiomeric":[80],"excesses":[81],"giving":[82],"rise":[83],"to":[84,146],"homochiral":[86,112,130,162],"9-(2,3-dihydro-1,4-benzoxathiin-3-ylmethyl)-9H-purines.":[87],"anti-tumour":[89],"activity":[90],"all":[92],"enantiomers":[93,142,155],"reported":[95],"against":[96],"caspase-3-deficient":[98],"MCF-7":[99,174],"wild":[102],"type":[103],"SKBR-3":[104,200],"human":[105],"breast":[106],"cancer":[107],"cells.":[108,201],"most":[110],"active":[111],"compound":[113,179],"displays":[114],"an":[115],"IC50":[116],"1.85":[118],"\u03bcM":[119],"induces":[121,181],"inhibition":[122],"translation":[125],"initiation":[126],"factor":[127],"eIF2\u03b1.":[128],"All":[129],"compounds":[131,198],"included":[132],"this":[134],"study":[135],"show":[136],"different":[137],"apoptotic":[138,152,170],"effects":[139],"both":[141],"levels":[144],"up":[145],"99%.":[147],"We":[148,158],"have":[149,159],"analyzed":[150],"caspase-mediated":[151],"pathways":[153],"on":[154,172],"racemates.":[157],"found":[160],"derivative":[163],"activates":[165],"canonical":[167],"intrinsic":[168],"caspase-8/caspase-3":[169],"pathway":[171],"cells,":[175],"racemic":[178],"caspase-2":[182],"activation.":[183],"Moreover,":[184],"we":[185],"demonstrate":[186],"involvement":[188],"caspase":[190],"activation":[191],"during":[192],"cell":[193],"death":[194],"induced":[195],"by":[196],"these":[197]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}