{"id":"https://openalex.org/W2000458317","doi":"https://doi.org/10.1097/01.tp.0000069233.13409.df","title":"Human herpesvirus-6 and acute liver failure1","display_name":"Human herpesvirus-6 and acute liver failure1","publication_year":2003,"publication_date":"2003-08-15","ids":{"openalex":"https://openalex.org/W2000458317","doi":"https://doi.org/10.1097/01.tp.0000069233.13409.df","mag":"2000458317","pmid":"https://pubmed.ncbi.nlm.nih.gov/12923440"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000069233.13409.df","doi":"https://doi.org/10.1097/01.tp.0000069233.13409.df","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000069233.13409.df","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024672243","display_name":"Maiju H\u00e4rm\u00e4","orcid":"https://orcid.org/0000-0002-7369-8185","observed_orcids":["https://orcid.org/0000-0002-7369-8185"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Maiju H\u00e4rm\u00e4","raw_affiliation_strings":["Transplantation and Liver Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland","Department of Virology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation and Liver Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Virology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113435004","display_name":"Krister H\u00f6ckerstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Krister H\u00f6ckerstedt","raw_affiliation_strings":["Transplantation and Liver Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation and Liver Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110010897","display_name":"Irmeli T. Lautenschlager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Irmeli Lautenschlager","raw_affiliation_strings":["Department of Virology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland","I. Lautenschlager, M.D., Ph.D., Transplant Unit Research Laboratory, Helsinki University Central Hospital, Meilahti, P-Floor, P.O. Box 340, FIN-00029 HUS, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"I. Lautenschlager, M.D., Ph.D., Transplant Unit Research Laboratory, Helsinki University Central Hospital, Meilahti, P-Floor, P.O. Box 340, FIN-00029 HUS, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110010897"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112","https://openalex.org/I4210166427"],"apc_list":null,"apc_paid":null,"fwci":4.2465,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.94464095,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"76","issue":"3","first_page":"536","last_page":"539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.33079999685287476,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-herpesvirus-6","display_name":"human herpesvirus 6","score":0.9559999704360962},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.9760000109672546},{"id":"https://openalex.org/keywords/viral-etiology","display_name":"viral etiology","score":0.5740000009536743},{"id":"https://openalex.org/keywords/explanted-liver","display_name":"explanted liver","score":0.6819999814033508},{"id":"https://openalex.org/keywords/antigenemia","display_name":"antigenemia","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.968999981880188},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6452460885047913},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.6123716831207275},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.585686981678009},{"id":"https://openalex.org/C2777399126","wikidata":"https://www.wikidata.org/wiki/Q6974","display_name":"Human herpesvirus 6","level":5,"score":0.5207754969596863},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.49426698684692383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48981139063835144},{"id":"https://openalex.org/C128102431","wikidata":"https://www.wikidata.org/wiki/Q6005550","display_name":"Immunoperoxidase","level":4,"score":0.48764052987098694},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4817390739917755},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4817104935646057},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.468448668718338},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45709601044654846},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4111171066761017},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.3637528419494629},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.3613394498825073},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.33888110518455505},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3297156095504761},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.31919682025909424},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2373431921005249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2314819097518921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2251000702381134},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.09210142493247986},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015654","descriptor_name":"Herpesvirus 6, Human","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D019349","descriptor_name":"Roseolovirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.tp.0000069233.13409.df","doi":"https://doi.org/10.1097/01.tp.0000069233.13409.df","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000069233.13409.df","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:12923440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12923440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1786775693","https://openalex.org/W1813228732","https://openalex.org/W1985844089","https://openalex.org/W1988060050","https://openalex.org/W1994475564","https://openalex.org/W1997637668","https://openalex.org/W2032641781","https://openalex.org/W2034806350","https://openalex.org/W2038380176","https://openalex.org/W2041180747","https://openalex.org/W2064499161","https://openalex.org/W2104913286","https://openalex.org/W2112436955","https://openalex.org/W2117045214","https://openalex.org/W2120500482","https://openalex.org/W2130314269","https://openalex.org/W2132811815","https://openalex.org/W2136087694","https://openalex.org/W2143872862","https://openalex.org/W2322855468","https://openalex.org/W2332968597","https://openalex.org/W2466301127","https://openalex.org/W2468311800","https://openalex.org/W4247738120","https://openalex.org/W6719385139"],"related_works":["https://openalex.org/W2034790114","https://openalex.org/W2075554776","https://openalex.org/W1978431545","https://openalex.org/W2334612025","https://openalex.org/W2085500088","https://openalex.org/W2037175042","https://openalex.org/W4415468382","https://openalex.org/W2003860019","https://openalex.org/W1203227687","https://openalex.org/W2899994375"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"patients":[2,29,66,110,127,165,182,194,214],"with":[3,30,67,111,183,195,204],"acute":[4],"liver":[5],"failure":[6],"(ALF)":[7],"of":[8,23,113,125,137,152,162,180,193,197,228,231],"unknown":[9,114,198],"cause,":[10,115],"viral":[11,90],"infections":[12],"are":[13],"believed":[14],"to":[15,50,142],"be":[16,226],"involved.":[17],"This":[18],"study":[19],"investigates":[20],"the":[21,56,72,97,108,122,167,178,181,208,218,229],"involvement":[22],"human":[24],"herpesvirus-6":[25],"(HHV-6).":[26],"METHODS:":[27],"Thirty-two":[28],"ALF":[31,54,112,196],"who":[32],"underwent":[33],"transplantations":[34],"during":[35],"a":[36,68,211],"6-year":[37],"period":[38,75],"were":[39,82,94,175],"studied":[40],"for":[41,58,84],"viruses":[42,86,174],"in":[43,60,96,121,150,160,177,189,207,217],"biopsies":[44],"from":[45,71],"their":[46],"explanted":[47,80,170,191],"livers.":[48],"Non-A":[49],"non-E":[51],"hepatitis":[52,85],"(unknown)":[53],"was":[55,140,148,158,187,202],"reason":[57],"transplantation":[59],"15":[61,109],"patients,":[62,155],"and":[63,87,99,156,169],"another":[64],"17":[65,153,163],"known":[69],"disease":[70],"same":[73],"time":[74],"served":[76],"as":[77],"controls.":[78],"The":[79,133],"livers":[81,98,179,192],"examined":[83],"other":[88,173],"possible":[89],"agents.":[91],"HHV-6":[92,119,131,138,147,186,200,205,216,224],"antigens":[93,120,206],"demonstrated":[95,118,130],"blood":[100,168],"mononuclear":[101],"cells":[102],"by":[103],"immunoperoxidase":[104],"staining.":[105],"RESULTS:":[106],"Of":[107],"12":[116],"(80%)":[117],"liver.":[123,209,219],"Most":[124],"these":[126],"(10/12)":[128],"also":[129],"antigenemia.":[132],"predominant":[134],"histologic":[135],"finding":[136],"infection":[139],"moderate":[141],"severe":[143],"portal":[144],"lymphocytic":[145],"infiltration.":[146],"found":[149,159,176,188],"4":[151],"control":[154,164,213],"cytomegalovirus":[157],"2":[161],"(in":[166],"liver).":[171],"No":[172],"ALF.":[184,232],"CONCLUSIONS:":[185],"most":[190],"cause.":[199],"antigenemia":[201],"associated":[203],"Only":[210],"few":[212],"displayed":[215],"These":[220],"observations":[221],"indicate":[222],"that":[223],"may":[225],"one":[227],"causes":[230]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}