{"id":"https://openalex.org/W2000455772","doi":"https://doi.org/10.1128/aac.36.4.769","title":"Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation","display_name":"Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W2000455772","doi":"https://doi.org/10.1128/aac.36.4.769","mag":"2000455772","pmid":"https://pubmed.ncbi.nlm.nih.gov/1323953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/189400"},"language":"en","primary_location":{"id":"doi:10.1128/aac.36.4.769","doi":"https://doi.org/10.1128/aac.36.4.769","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.36.4.769","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/189400","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101458467","display_name":"Yan A. Su","orcid":"https://orcid.org/0000-0001-5502-5043","observed_orcids":["https://orcid.org/0000-0001-5502-5043"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y A Su","raw_affiliation_strings":["Department of Biologic Science, School of Dentistry, University of Michigan, Ann Arbor 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic Science, School of Dentistry, University of Michigan, Ann Arbor 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P He","raw_affiliation_strings":["Department of Biologic Science, School of Dentistry, University of Michigan, Ann Arbor 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic Science, School of Dentistry, University of Michigan, Ann Arbor 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070922478","display_name":"Don B. Clewell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D B Clewell","raw_affiliation_strings":["Department of Biologic Science, School of Dentistry, University of Michigan, Ann Arbor 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic Science, School of Dentistry, University of Michigan, Ann Arbor 48109","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":2.7016,"has_fulltext":false,"cited_by_count":141,"citation_normalized_percentile":{"value":0.89857199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"36","issue":"4","first_page":"769","last_page":"778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.288100004196167,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tn916","display_name":"Tn916","score":0.8370000123977661},{"id":"https://openalex.org/keywords/conjugative-transposons","display_name":"conjugative transposons","score":0.9309999942779541},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tetracycline-resistance","display_name":"tetracycline resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/transcriptional-attenuation","display_name":"transcriptional attenuation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/leader-peptide","display_name":"leader peptide","score":0.4129999876022339},{"id":"https://openalex.org/keywords/inverted-repeats","display_name":"inverted repeats","score":0.9240000247955322},{"id":"https://openalex.org/keywords/read-through-transcription","display_name":"read-through transcription","score":0.7519999742507935},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.7757911682128906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6578682065010071},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.5912925601005554},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.5876438617706299},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.5428919196128845},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.523465096950531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49866390228271484},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.4828948974609375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4433678984642029},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.36714595556259155},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2943956255912781},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23654139041900635},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0637885332107544},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013753","descriptor_name":"Tetracycline Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.36.4.769","doi":"https://doi.org/10.1128/aac.36.4.769","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.36.4.769","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:189400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/189400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:1323953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1323953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:189400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/189400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3079321552","display_name":null,"funder_award_id":"AI-10318","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5921595140","display_name":"CONJUGATIVE TRANSPOSON TN 916","funder_award_id":"R01AI010318","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W328595349","https://openalex.org/W1513717105","https://openalex.org/W1524056894","https://openalex.org/W1537838130","https://openalex.org/W1540797945","https://openalex.org/W1809960271","https://openalex.org/W1863028894","https://openalex.org/W1898485134","https://openalex.org/W1930118811","https://openalex.org/W1937357034","https://openalex.org/W1939323737","https://openalex.org/W1967476071","https://openalex.org/W1967995998","https://openalex.org/W1974251842","https://openalex.org/W1990911027","https://openalex.org/W1997207030","https://openalex.org/W2015148841","https://openalex.org/W2038472317","https://openalex.org/W2041972620","https://openalex.org/W2051035062","https://openalex.org/W2059158191","https://openalex.org/W2060273986","https://openalex.org/W2063450941","https://openalex.org/W2082883567","https://openalex.org/W2086269772","https://openalex.org/W2086955288","https://openalex.org/W2087431924","https://openalex.org/W2093436462","https://openalex.org/W2100256775","https://openalex.org/W2110058166","https://openalex.org/W2111435319","https://openalex.org/W2112588210","https://openalex.org/W2123668439","https://openalex.org/W2144634347","https://openalex.org/W2146660930","https://openalex.org/W2152845055","https://openalex.org/W2156518357","https://openalex.org/W2167164082","https://openalex.org/W2332949416","https://openalex.org/W2748101318","https://openalex.org/W4242994810","https://openalex.org/W4253739381"],"related_works":["https://openalex.org/W2124111522","https://openalex.org/W3149440267","https://openalex.org/W1972454096","https://openalex.org/W137314750","https://openalex.org/W1605832044","https://openalex.org/W4223475913","https://openalex.org/W165073713","https://openalex.org/W2669376687","https://openalex.org/W2146311481","https://openalex.org/W2018227990"],"abstract_inverted_index":{"The":[0],"nucleotide":[1],"sequence":[2],"of":[3,14,30,50,58,84,90,104,116,127],"the":[4,78,82,95,100,114,125,132],"tetracycline":[5,107],"resistance":[6,101],"determinant":[7],"tet(M),":[8,59],"located":[9],"on":[10,124],"conjugative":[11],"transposon":[12],"Tn916":[13],"Enterococcus":[15],"faecalis,":[16],"was":[17,54],"determined":[18],"and":[19,46],"found":[20,73],"to":[21,42,75,106],"encode":[22],"a":[23,27,43,48,66,91,110],"72,486-dalton":[24],"protein":[25],"exhibiting":[26],"high":[28],"degree":[29],"homology":[31],"with":[32],"other":[33],"tet(M)":[34,85,117],"determinants.":[35],"A":[36,135],"short":[37],"open":[38],"reading":[39],"frame":[40],"corresponding":[41],"28-amino-acid":[44],"peptide":[45],"containing":[47],"number":[49],"inverted":[51],"repeat":[52],"sequences":[53],"noted":[55],"immediately":[56],"upstream":[57,96,133],"suggesting":[60,137],"that":[61,81],"regulation":[62],"might":[63,141],"occur":[64],"by":[65],"mechanism":[67],"involving":[68],"transcriptional":[69,129,139],"attenuation.":[70],"Transcription":[71],"analyses":[72],"this":[74,119,144],"indeed":[76],"be":[77,122],"case,":[79],"showing":[80],"expression":[83],"resulted":[86,108],"from":[87,131],"an":[88],"extension":[89],"small":[92],"transcript":[93],"representing":[94],"leader":[97],"region":[98],"into":[99],"determinant.":[102],"Exposure":[103],"cells":[105],"in":[109,113,143],"significant":[111],"increase":[112,120],"amount":[115],"transcription;":[118],"could":[121],"explained":[123],"basis":[126],"increased":[128],"read-through":[130],"transcript.":[134],"model":[136],"how":[138],"attenuation":[140],"operate":[142],"system":[145],"is":[146],"presented.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
