{"id":"https://openalex.org/W2000451365","doi":"https://doi.org/10.3109/02713688109001848","title":"Characterization of cyclic AMP-mediated wound closure of the rabbit corneal epithelium","display_name":"Characterization of cyclic AMP-mediated wound closure of the rabbit corneal epithelium","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2000451365","doi":"https://doi.org/10.3109/02713688109001848","mag":"2000451365","pmid":"https://pubmed.ncbi.nlm.nih.gov/6277568"},"language":"en","primary_location":{"id":"doi:10.3109/02713688109001848","doi":"https://doi.org/10.3109/02713688109001848","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02713688109001848","pdf_url":null,"source":{"id":"https://openalex.org/S74941265","display_name":"Current Eye Research","issn_l":"0271-3683","issn":["0271-3683","1460-2202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008793352","display_name":"Marcia M. Jumblatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcia M. Jumblatt","raw_affiliation_strings":["Eye Research Institute of Retina Foundation School, Boston, MA, 02114, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA","Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA","Eye Research Institute of Retina Foundation School, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Research Institute of Retina Foundation School, Boston, MA, 02114, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Eye Research Institute of Retina Foundation School, Boston, MA, 02114, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113573946","display_name":"Arthur H. Neufeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur H. Neufeld","raw_affiliation_strings":["Eye Research Institute of Retina Foundation School, Boston, MA, 02114, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA","Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA","Eye Research Institute of Retina Foundation School, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Research Institute of Retina Foundation School, Boston, MA, 02114, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Eye Research Institute of Retina Foundation School, Boston, MA, 02114, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":1.7572,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.84705752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"4","first_page":"189","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.9089999794960022},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.9079999923706055},{"id":"https://openalex.org/keywords/wound-closure","display_name":"wound closure","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.7839999794960022},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.7760000228881836},{"id":"https://openalex.org/keywords/timolol","display_name":"timolol","score":1.0},{"id":"https://openalex.org/keywords/glycogen-storage-disease","display_name":"glycogen storage disease","score":0.5519999861717224},{"id":"https://openalex.org/keywords/corneal-epithelial-defects","display_name":"corneal epithelial defects","score":0.7419999837875366},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.6100043058395386},{"id":"https://openalex.org/C2778179392","wikidata":"https://www.wikidata.org/wiki/Q5732068","display_name":"Heptanol","level":4,"score":0.5526245832443237},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.5388085842132568},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.5199236273765564},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.49181392788887024},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.46004465222358704},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.42095476388931274},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4002556800842285},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3442147970199585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34339937567710876},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32742947340011597},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.2892783582210541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26624417304992676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21914342045783997},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.21250417828559875},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.10215738415718079},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02713688109001848","doi":"https://doi.org/10.3109/02713688109001848","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02713688109001848","pdf_url":null,"source":{"id":"https://openalex.org/S74941265","display_name":"Current Eye Research","issn_l":"0271-3683","issn":["0271-3683","1460-2202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Eye Research","raw_type":"journal-article"},{"id":"pmid:6277568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6277568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current eye research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.550000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W121072848","https://openalex.org/W168602288","https://openalex.org/W198132779","https://openalex.org/W287566307","https://openalex.org/W1428637608","https://openalex.org/W1518896112","https://openalex.org/W1775749144","https://openalex.org/W2000264418","https://openalex.org/W2023601764","https://openalex.org/W2031841677","https://openalex.org/W2062545457","https://openalex.org/W2074420838","https://openalex.org/W2176789797","https://openalex.org/W2411738355"],"related_works":["https://openalex.org/W287566307","https://openalex.org/W2074420838","https://openalex.org/W3008865033","https://openalex.org/W47011055","https://openalex.org/W2095463703","https://openalex.org/W2006565170","https://openalex.org/W1965693937","https://openalex.org/W2785341071","https://openalex.org/W30904264","https://openalex.org/W2089345041"],"abstract_inverted_index":{"Cholera":[0],"toxin":[1],"(CTX)-stimulated":[2],"synthesis":[3],"of":[4,14,17,43,77,105],"adenosine":[5],"3\u2032,":[6],"5\u2032":[7],"monophosphate":[8],"(cyclic":[9],"AMP)":[10],"enhances":[11],"the":[12,41,75,84,89,96],"rate":[13,42,76],"wound":[15,44,78],"closure":[16,45,79,100],"a":[18,81,93],"7-mm-diameter":[19],"corneal":[20],"epithelial":[21],"defect":[22],"following":[23,46],"heptanol":[24,54],"debridement":[25,55],"but":[26,56],"not":[27,39,59,92,102],"after":[28,53],"mechanical":[29],"scraping.":[30],"Pretreatment":[31],"with":[32],"topical":[33,36],"epinephrine":[34],"or":[35],"timolol":[37],"does":[38],"alter":[40],"either":[47],"trauma.":[48],"Corneal":[49],"glycogen":[50,106],"levels":[51],"decrease":[52],"glycogenosis":[57],"is":[58,91,101],"influenced":[60],"by":[61],"compounds":[62],"which":[63],"increase":[64],"intracellular":[65],"cyclic":[66,72],"AMP":[67,73],"levels.":[68],"We":[69],"postulate":[70],"that":[71],"increases":[74],"towards":[80],"maximum;":[82],"however,":[83],"first":[85],"messenger":[86],"for":[87,98],"activating":[88],"pathway":[90],"catecholamine":[94],"and":[95],"mechanism":[97],"enhancing":[99],"via":[103],"mobilization":[104],"stores.":[107]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}