{"id":"https://openalex.org/W2000447442","doi":"https://doi.org/10.1016/j.virol.2009.10.007","title":"Nucleolin/Nsr1p binds to the 3\u2032 noncoding region of the tombusvirus RNA and inhibits replication","display_name":"Nucleolin/Nsr1p binds to the 3\u2032 noncoding region of the tombusvirus RNA and inhibits replication","publication_year":2009,"publication_date":"2009-10-28","ids":{"openalex":"https://openalex.org/W2000447442","doi":"https://doi.org/10.1016/j.virol.2009.10.007","mag":"2000447442","pmid":"https://pubmed.ncbi.nlm.nih.gov/19861225","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2788044"},"language":"en","primary_location":{"id":"doi:10.1016/j.virol.2009.10.007","doi":"https://doi.org/10.1016/j.virol.2009.10.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virol.2009.10.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682209006163/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0042682209006163/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yi Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Jiang","raw_affiliation_strings":["Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025911310","display_name":"Zhenghe Li","orcid":"https://orcid.org/0000-0001-5497-2575","observed_orcids":["https://orcid.org/0000-0001-5497-2575"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenghe Li","raw_affiliation_strings":["Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090380640","display_name":"Peter D. Nagy","orcid":"https://orcid.org/0000-0003-4164-1237","observed_orcids":["https://orcid.org/0000-0003-4164-1237"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter D. Nagy","raw_affiliation_strings":["Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090380640"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":3160,"currency":"USD","value_usd":3160},"apc_paid":null,"fwci":5.6508,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.9525567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"396","issue":"1","first_page":"10","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13220","display_name":"Plant and Fungal Interactions Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleolin","display_name":"nucleolin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tombusvirus","display_name":"tombusvirus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/viral-rna-replication","display_name":"viral RNA replication","score":0.7369999885559082},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9079999923706055},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.7310000061988831},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.8080000281333923},{"id":"https://openalex.org/keywords/replication-inhibition","display_name":"replication inhibition","score":0.5989999771118164},{"id":"https://openalex.org/keywords/nicotiana-benthamiana","display_name":"Nicotiana benthamiana","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2776525860","wikidata":"https://www.wikidata.org/wiki/Q18029887","display_name":"Nucleolin","level":4,"score":0.8535969257354736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8386693596839905},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6215474009513855},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5221664905548096},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.478658527135849},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.44441407918930054},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.43624088168144226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42363616824150085},{"id":"https://openalex.org/C2777627835","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factor","level":3,"score":0.4193362891674042},{"id":"https://openalex.org/C188036394","wikidata":"https://www.wikidata.org/wiki/Q14902224","display_name":"Replication factor C","level":5,"score":0.41691720485687256},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3810686469078064},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2381685972213745},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.2228740155696869},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.2114732563495636},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.2042878270149231},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19427835941314697},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.15190982818603516},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000097796","descriptor_name":"Nucleolin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017864","descriptor_name":"Tombusvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017864","descriptor_name":"Tombusvirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.virol.2009.10.007","doi":"https://doi.org/10.1016/j.virol.2009.10.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virol.2009.10.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682209006163/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},{"id":"pmid:19861225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19861225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2031960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2788044","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2788044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2788044","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Virology","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.virol.2009.10.007","doi":"https://doi.org/10.1016/j.virol.2009.10.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virol.2009.10.007","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682209006163/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2430943795","display_name":"Suppression of viral RNA recombination by host genes","funder_award_id":"0517218","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5340688476","display_name":"Roles of host RNA binding proteins in virus replication","funder_award_id":"R21AI072170","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6300516952","display_name":"Functional role of a host metabolic enzyme in viral replication","funder_award_id":"R21AI082143","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332532","display_name":"Kentucky Tobacco Research and Development Center","ror":"https://ror.org/02k3smh20"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000447442.pdf","grobid_xml":"https://content.openalex.org/works/W2000447442.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1504404542","https://openalex.org/W1775310695","https://openalex.org/W1901396625","https://openalex.org/W1938031086","https://openalex.org/W1969941684","https://openalex.org/W1972327390","https://openalex.org/W1973731551","https://openalex.org/W1977526669","https://openalex.org/W1979558190","https://openalex.org/W1988316350","https://openalex.org/W1994715006","https://openalex.org/W1995668581","https://openalex.org/W1998949626","https://openalex.org/W2002501315","https://openalex.org/W2014011735","https://openalex.org/W2022068951","https://openalex.org/W2022687771","https://openalex.org/W2027129957","https://openalex.org/W2029452182","https://openalex.org/W2031807756","https://openalex.org/W2043312499","https://openalex.org/W2043698583","https://openalex.org/W2050062156","https://openalex.org/W2054228580","https://openalex.org/W2055046952","https://openalex.org/W2056344904","https://openalex.org/W2069389008","https://openalex.org/W2072294559","https://openalex.org/W2074422749","https://openalex.org/W2091429085","https://openalex.org/W2098707910","https://openalex.org/W2100233791","https://openalex.org/W2103920769","https://openalex.org/W2105728074","https://openalex.org/W2110533625","https://openalex.org/W2114946909","https://openalex.org/W2115977287","https://openalex.org/W2120848963","https://openalex.org/W2127228132","https://openalex.org/W2129287268","https://openalex.org/W2135479734","https://openalex.org/W2141132246","https://openalex.org/W2142913486","https://openalex.org/W2143341850","https://openalex.org/W2143353745","https://openalex.org/W2146695930","https://openalex.org/W2148445229","https://openalex.org/W2151846890","https://openalex.org/W2154427656","https://openalex.org/W2158461665","https://openalex.org/W2159289026","https://openalex.org/W2160552816","https://openalex.org/W2165858460","https://openalex.org/W2170299265"],"related_works":["https://openalex.org/W2043312499","https://openalex.org/W2029452182","https://openalex.org/W2050690072","https://openalex.org/W174714392","https://openalex.org/W2055046952","https://openalex.org/W2026262338","https://openalex.org/W2072294559","https://openalex.org/W2140809133","https://openalex.org/W7099668526","https://openalex.org/W2154427656"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}