{"id":"https://openalex.org/W2000443188","doi":"https://doi.org/10.3810/pgm.2009.01.1953","title":"Overview of the Gliptin Class (Dipeptidyl Peptidase-4 Inhibitors) in Clinical Practice","display_name":"Overview of the Gliptin Class (Dipeptidyl Peptidase-4 Inhibitors) in Clinical Practice","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2000443188","doi":"https://doi.org/10.3810/pgm.2009.01.1953","mag":"2000443188","pmid":"https://pubmed.ncbi.nlm.nih.gov/19179812"},"language":"en","primary_location":{"id":"doi:10.3810/pgm.2009.01.1953","doi":"https://doi.org/10.3810/pgm.2009.01.1953","is_oa":false,"landing_page_url":"https://doi.org/10.3810/pgm.2009.01.1953","pdf_url":null,"source":{"id":"https://openalex.org/S11800902","display_name":"Postgraduate Medicine","issn_l":"0032-5481","issn":["0032-5481","1941-9260"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postgraduate Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113758902","display_name":"Nancy J.V. Bohannon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nancy Bohannon","raw_affiliation_strings":["Monteagle Medical Center, San Francisco, CA, USA. sugarnancy@pol.net","Monteagle Medical Center, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monteagle Medical Center, San Francisco, CA, USA. sugarnancy@pol.net","institution_ids":[]},{"raw_affiliation_string":"Monteagle Medical Center, San Francisco, CA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113758902"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1636,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.91540465,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"121","issue":"1","first_page":"40","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7570000290870667},{"id":"https://openalex.org/keywords/glucagon-suppression","display_name":"glucagon suppression","score":0.8970000147819519},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.8059999942779541},{"id":"https://openalex.org/keywords/insulin-sensitizers","display_name":"insulin sensitizers","score":0.7620000243186951},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/sitagliptin","display_name":"sitagliptin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vildagliptin","display_name":"vildagliptin","score":1.0},{"id":"https://openalex.org/keywords/alogliptin","display_name":"alogliptin","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8330000042915344},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2776453732","wikidata":"https://www.wikidata.org/wiki/Q421042","display_name":"Vildagliptin","level":4,"score":0.9155571460723877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9046568870544434},{"id":"https://openalex.org/C2779284873","wikidata":"https://www.wikidata.org/wiki/Q419832","display_name":"Sitagliptin","level":4,"score":0.8584025502204895},{"id":"https://openalex.org/C2780012697","wikidata":"https://www.wikidata.org/wiki/Q4734170","display_name":"Alogliptin","level":5,"score":0.7637743353843689},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6658359169960022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.649787425994873},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6287734508514404},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.6248458623886108},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6126009821891785},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5889211893081665},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.5838193893432617},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.482260525226593},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.46731871366500854},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.43081676959991455},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36851978302001953}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3810/pgm.2009.01.1953","doi":"https://doi.org/10.3810/pgm.2009.01.1953","is_oa":false,"landing_page_url":"https://doi.org/10.3810/pgm.2009.01.1953","pdf_url":null,"source":{"id":"https://openalex.org/S11800902","display_name":"Postgraduate Medicine","issn_l":"0032-5481","issn":["0032-5481","1941-9260"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postgraduate Medicine","raw_type":"journal-article"},{"id":"pmid:19179812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19179812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postgraduate medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1909705449","https://openalex.org/W1969480413","https://openalex.org/W1971128106","https://openalex.org/W1977619586","https://openalex.org/W1994832750","https://openalex.org/W2004977380","https://openalex.org/W2009123354","https://openalex.org/W2036167841","https://openalex.org/W2051462052","https://openalex.org/W2059245135","https://openalex.org/W2086842286","https://openalex.org/W2089304685","https://openalex.org/W2092700428","https://openalex.org/W2106154942","https://openalex.org/W2106824929","https://openalex.org/W2113901579","https://openalex.org/W2114371597","https://openalex.org/W2115752037","https://openalex.org/W2119503252","https://openalex.org/W2141946042","https://openalex.org/W2145335273","https://openalex.org/W2171512247","https://openalex.org/W2249313904","https://openalex.org/W2325963726","https://openalex.org/W2330273698","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1988707004","https://openalex.org/W4231761993","https://openalex.org/W2011751244","https://openalex.org/W2476925298","https://openalex.org/W2492236116","https://openalex.org/W2080353308","https://openalex.org/W2123355624","https://openalex.org/W2085799548","https://openalex.org/W3032132786","https://openalex.org/W1811537425"],"abstract_inverted_index":{"Dipeptidyl":[0],"peptidase-4":[1],"inhibitors":[2,214],"(DPP-4s),":[3],"also":[4],"commonly":[5],"called":[6],"gliptins,":[7],"are":[8],"a":[9,26,104,144,200],"relatively":[10],"new":[11],"class":[12],"of":[13,18,36,55,71,95,99,147,202,211,230],"drugs":[14,122,141],"for":[15],"the":[16,34,37,53,56,69,77,81,209,212,228],"treatment":[17,229],"type":[19,189,231],"2":[20,190,232],"diabetes.":[21,233],"These":[22],"agents":[23],"work":[24],"in":[25,39,44,60,89,101,111,117,126,131,158,169,175,185,222,227],"unique":[27],"way":[28],"to":[29,41,103,128,137],"improve":[30,123],"insulin":[31,96,124,151,225],"secretion":[32,94,125],"from":[33,52,199],"Beta-cells":[35],"pancreas":[38],"response":[40,102,127],"an":[42,129],"increase":[43,130],"blood":[45,132],"sugar":[46],"and":[47,92,97,160,167,184,206,217,221],"simultaneously":[48],"decrease":[49,68],"glucagon":[50,100,112],"output":[51],"a-cells":[54],"pancreas,":[57],"which":[58],"results":[59,88],"decreased":[61],"hepatic":[62],"glucose":[63,118,162],"output.":[64],"Specifi":[65],"cally,":[66],"gliptins":[67,181],"breakdown":[70],"glucagon-like":[72],"peptide-1":[73],"(GLP-1)":[74],"such":[75,149],"that":[76,142],"circulating":[78],"levels":[79,171],"reach":[80],"high":[82],"normal":[83],"physiologic":[84],"GLP-1":[85],"range.":[86],"This":[87,195],"more":[90],"prompt":[91],"appropriate":[93,136],"suppression":[98],"carbohydrate-containing":[105],"meal":[106],"or":[107,153],"snack.":[108],"The":[109],"change":[110],"correlates":[113],"linearly":[114],"with":[115,140,187,224],"improvement":[116,168],"tolerance.":[119],"Since":[120],"these":[121],"glucose,":[133],"it":[134],"seems":[135],"pair":[138],"them":[139],"have":[143,172],"different":[145,180],"mechanism":[146],"action,":[148],"as":[150,182],"sensitizers":[152,226],"metformin.":[154],"In":[155],"fact,":[156],"improvements":[157],"fasting":[159],"postprandial":[161],"levels,":[163],"improved":[164],"beta-cell":[165],"function,":[166],"HbA1c":[170],"been":[173],"demonstrated":[174],"numerous":[176],"clinical":[177,203],"trials":[178],"using":[179],"monotherapy":[183],"combination":[186,223],"various":[188],"diabetes":[191],"medications,":[192],"including":[193],"insulin.":[194],"article":[196],"reviews":[197],"data":[198],"number":[201],"trials,":[204],"presentations,":[205],"abstracts":[207],"indicating":[208],"importance":[210],"DPP-4":[213],"sitagliptin,":[215],"vildagliptin,":[216],"alogliptin":[218],"both":[219],"alone":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
