{"id":"https://openalex.org/W2000440645","doi":"https://doi.org/10.1046/j.1365-2036.2001.00973.x","title":"The pharmacokinetics of the novel promotile drug, tegaserod, are similar in healthy subjects\u2014male and female, elderly and young","display_name":"The pharmacokinetics of the novel promotile drug, tegaserod, are similar in healthy subjects\u2014male and female, elderly and young","publication_year":2001,"publication_date":"2001-07-09","ids":{"openalex":"https://openalex.org/W2000440645","doi":"https://doi.org/10.1046/j.1365-2036.2001.00973.x","mag":"2000440645","pmid":"https://pubmed.ncbi.nlm.nih.gov/11421867"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2036.2001.00973.x","doi":"https://doi.org/10.1046/j.1365-2036.2001.00973.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2036.2001.00973.x","pdf_url":null,"source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089523988","display_name":"Silke Appel\u2010Dingemanse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"S. Appel\u2010Dingemanse","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland. silke.appeldingemanse@pharma.novartis.com","Novartis Pharma AG, Basel, SWITZERLAND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland. silke.appeldingemanse@pharma.novartis.com","institution_ids":["https://openalex.org/I1283582996"]},{"raw_affiliation_string":"Novartis Pharma AG, Basel, SWITZERLAND","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009310045","display_name":"Ann D. Horowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Horowitz","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061384907","display_name":"Joelle Campestrini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092929","display_name":"Novartis (France)","ror":"https://ror.org/00geypp27","country_code":"FR","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210092929"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Campestrini","raw_affiliation_strings":["Novartis Pharma SA, Rueil-Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma SA, Rueil-Malmaison, France","institution_ids":["https://openalex.org/I4210092929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109183110","display_name":"Stuart Osborne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S. Osborne","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052635590","display_name":"James F. McLeod","orcid":"https://orcid.org/0000-0003-0285-9954","observed_orcids":["https://orcid.org/0000-0003-0285-9954"]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Mcleod","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA","institution_ids":["https://openalex.org/I4210117619"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089523988"],"corresponding_institution_ids":["https://openalex.org/I1283582996"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":3.4629,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.92171521,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"7","first_page":"937","last_page":"944"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tegaserod","display_name":"tegaserod","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9710000157356262},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.7519999742507935},{"id":"https://openalex.org/keywords/gender-effects","display_name":"gender effects","score":0.7080000042915344},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5920000076293945},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.8069999814033508},{"id":"https://openalex.org/keywords/drug-exposure","display_name":"drug exposure","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2781419993","wikidata":"https://www.wikidata.org/wiki/Q44944","display_name":"Tegaserod","level":3,"score":0.9787882566452026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8713783621788025},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8209189176559448},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.6205127239227295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46434053778648376},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40845948457717896},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.3359031081199646},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.24348148703575134},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09205913543701172}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010528","descriptor_name":"Peristalsis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2036.2001.00973.x","doi":"https://doi.org/10.1046/j.1365-2036.2001.00973.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2036.2001.00973.x","pdf_url":null,"source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:11421867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11421867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary pharmacology & therapeutics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1486363003","https://openalex.org/W1839541123","https://openalex.org/W1964572903","https://openalex.org/W1982805508","https://openalex.org/W1983989974","https://openalex.org/W1998506301","https://openalex.org/W2016335393","https://openalex.org/W2035977493","https://openalex.org/W2042828709","https://openalex.org/W2047367566","https://openalex.org/W2048437966","https://openalex.org/W2048838775","https://openalex.org/W2058278066","https://openalex.org/W2065898488","https://openalex.org/W2071327709","https://openalex.org/W2078818718","https://openalex.org/W2093095026","https://openalex.org/W2095495549","https://openalex.org/W2320941135","https://openalex.org/W3189231529","https://openalex.org/W4235690972","https://openalex.org/W4253371316"],"related_works":["https://openalex.org/W2050389538","https://openalex.org/W1982805508","https://openalex.org/W2080596408","https://openalex.org/W2363296655","https://openalex.org/W2009590288","https://openalex.org/W2417695897","https://openalex.org/W2784329301","https://openalex.org/W1988750503","https://openalex.org/W2035736822","https://openalex.org/W2314251966"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tegaserod":[1,98],"(HTF":[2],"919)":[3],"is":[4,161,170,187,198],"a":[5,40,44,126],"selective":[6],"5-HT4":[7],"receptor":[8],"partial":[9],"agonist":[10],"in":[11,102,138,144,159,174,200],"development":[12],"for":[13,93,194],"the":[14,26,33,139,145,172,175,182],"treatment":[15],"of":[16,28,36,47,56,109,130,178,185],"irritable":[17],"bowel":[18],"syndrome.":[19],"AIM:":[20],"This":[21,157],"study":[22],"aimed":[23],"to":[24,53,77,164],"assess":[25],"effect":[27,108,129],"age":[29,110,131,195],"and":[30,64,84,88,115,122,136,180],"gender":[31,112,197],"on":[32,113,132],"single-dose":[34],"pharmacokinetics":[35,82,176],"tegaserod.":[37],"METHODS:":[38],"In":[39],"parallel-group,":[41],"open-label":[42],"study,":[43],"single":[45],"dose":[46,192],"tegaserod":[48,179,186,201],"(12":[49],"mg)":[50],"was":[51,99,106,125],"administered":[52],"four":[54],"groups":[55],"healthy":[57],"young":[58,60,146],"male,":[59],"female,":[61],"elderly":[62,65,140],"male":[63],"female":[66],"subjects":[67],"(n=10":[68],"per":[69],"group).":[70],"Blood":[71],"samples":[72],"were":[73,95,141],"collected":[74],"from":[75],"0":[76],"24":[78],"h":[79],"postdose.":[80],"Non-compartmental":[81],"evaluation":[83],"statistical":[85],"analysis":[86],"(ANOVA":[87],"Wilcoxon":[89],"signed":[90],"ranks":[91],"test":[92],"tmax)":[94],"performed.":[96],"RESULTS:":[97],"well":[100],"tolerated":[101],"all":[103],"groups.":[104],"There":[105],"no":[107],"or":[111,196],"tmax":[114],"Cmax.":[116],"Gender":[117],"did":[118],"not":[119,163],"affect":[120],"AUC0-infinity":[121,135],"AUC0-tz;":[123],"there":[124],"statistically":[127],"significant":[128],"these":[133],"parameters.":[134],"AUC0-tz":[137,153],"greater":[142],"than":[143],"(AUC0-infinity":[147],"ratio":[148,154],"1.37,":[149],"P":[150],"<":[151],"0.001;":[152],"1.23,":[155],"P=0.029).":[156],"increase":[158],"exposure":[160],"judged":[162],"be":[165],"clinically":[166],"relevant":[167],"because":[168,181],"it":[169],"within":[171],"variability":[173],"parameters":[177],"dose-response":[183],"relationship":[184],"relatively":[188],"shallow.":[189],"CONCLUSIONS:":[190],"No":[191],"adjustment":[193],"recommended":[199],"therapy.":[202]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}