{"id":"https://openalex.org/W2000438077","doi":"https://doi.org/10.1074/jbc.c000289200","title":"Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing","display_name":"Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2000438077","doi":"https://doi.org/10.1074/jbc.c000289200","mag":"2000438077","pmid":"https://pubmed.ncbi.nlm.nih.gov/10880505"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.c000289200","doi":"https://doi.org/10.1074/jbc.c000289200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c000289200","pdf_url":"http://www.jbc.org/article/S0021925819612044/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000438077"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819612044/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025548879","display_name":"Baomin Li","orcid":"https://orcid.org/0000-0001-6320-4228","observed_orcids":["https://orcid.org/0000-0001-6320-4228","https://orcid.org/0000-0002-1427-2889"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baomin Li","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048816559","display_name":"Lucio Comai","orcid":"https://orcid.org/0000-0003-3109-1841","observed_orcids":["https://orcid.org/0000-0003-3109-1841"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lucio Comai","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033","From the Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"From the Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048816559"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.9673,"has_fulltext":true,"cited_by_count":210,"citation_normalized_percentile":{"value":0.98154216,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"275","issue":"37","first_page":"28349","last_page":"28352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/werner-syndrome-protein","display_name":"Werner syndrome protein","score":0.8420000076293945},{"id":"https://openalex.org/keywords/wrn","display_name":"WRN","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ku70","display_name":"Ku70","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ku80","display_name":"Ku80","score":1.0},{"id":"https://openalex.org/keywords/ku-heterodimer","display_name":"Ku heterodimer","score":0.9490000009536743},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8690000176429749},{"id":"https://openalex.org/keywords/dna-end-processing","display_name":"DNA end processing","score":0.7160000205039978},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9200000166893005},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9800000190734863},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2778090637","wikidata":"https://www.wikidata.org/wiki/Q1154619","display_name":"Werner syndrome","level":5,"score":0.8617897033691406},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.8096882104873657},{"id":"https://openalex.org/C193104389","wikidata":"https://www.wikidata.org/wiki/Q18032397","display_name":"Ku80","level":5,"score":0.7847403287887573},{"id":"https://openalex.org/C2777501222","wikidata":"https://www.wikidata.org/wiki/Q411664","display_name":"Exonuclease","level":4,"score":0.7199857831001282},{"id":"https://openalex.org/C2780919815","wikidata":"https://www.wikidata.org/wiki/Q6440930","display_name":"Ku70","level":4,"score":0.718880295753479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6478486657142639},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5478833913803101},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5064457654953003},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.4862422049045563},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.472206175327301},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4460085332393646},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.429922491312027},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.41178545355796814},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39636772871017456},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2336655557155609},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.17129120230674744},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.0916963517665863},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.06805074214935303}],"mesh":[{"descriptor_ui":"D000071657","descriptor_name":"Werner Syndrome Helicase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072200","descriptor_name":"Ku Autoantigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034961","descriptor_name":"Antigens, Nuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053484","descriptor_name":"RecQ Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.c000289200","doi":"https://doi.org/10.1074/jbc.c000289200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c000289200","pdf_url":"http://www.jbc.org/article/S0021925819612044/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10880505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10880505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.c000289200","doi":"https://doi.org/10.1074/jbc.c000289200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c000289200","pdf_url":"http://www.jbc.org/article/S0021925819612044/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320310851","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000438077.pdf","grobid_xml":"https://content.openalex.org/works/W2000438077.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W119749093","https://openalex.org/W1538603370","https://openalex.org/W1540819637","https://openalex.org/W1542472052","https://openalex.org/W1966347623","https://openalex.org/W1971708555","https://openalex.org/W1975817860","https://openalex.org/W1995702418","https://openalex.org/W2000912535","https://openalex.org/W2005573768","https://openalex.org/W2011037268","https://openalex.org/W2011320725","https://openalex.org/W2045106090","https://openalex.org/W2054689390","https://openalex.org/W2058094663","https://openalex.org/W2064310741","https://openalex.org/W2080152855","https://openalex.org/W2084712319","https://openalex.org/W2089041372","https://openalex.org/W2091660221","https://openalex.org/W2123909581","https://openalex.org/W2132000312","https://openalex.org/W2153043528","https://openalex.org/W2155835896","https://openalex.org/W2158820560","https://openalex.org/W2170970288","https://openalex.org/W2245671961","https://openalex.org/W4300564463"],"related_works":["https://openalex.org/W2117529453","https://openalex.org/W1989635566","https://openalex.org/W2116343025","https://openalex.org/W7161016132","https://openalex.org/W2005963486","https://openalex.org/W2093624810","https://openalex.org/W4300564463","https://openalex.org/W2010562095","https://openalex.org/W1971108678","https://openalex.org/W2043052441"],"abstract_inverted_index":{"Werner":[0,36],"syndrome":[1,17,37],"(WS)":[2],"is":[3,68,145],"an":[4,41],"autosomal":[5],"recessive":[6],"disease":[7],"characterized":[8],"by":[9,126,147],"premature":[10],"aging.":[11],"The":[12],"gene":[13],"responsible":[14],"for":[15],"the":[16,35,46,100,108,148,158,163,166,178],"was":[18],"recently":[19],"cloned":[20],"and":[21,115,141],"shown":[22],"to":[23,30,48,99,113,139],"encode":[24],"a":[25,73,89,117,172],"protein":[26,38],"with":[27],"strong":[28],"homology":[29,47],"DNA/RNA":[31],"helicases.":[32],"In":[33,153],"addition,":[34,154],"(WRN)":[39],"possesses":[40],"exonuclease":[42],"activity.":[43],"Based":[44],"on":[45],"helicases":[49],"it":[50],"has":[51],"been":[52],"proposed":[53],"that":[54,97,107,135,142,157],"WRN":[55,76,101,136,167,176],"functions":[56],"in":[57,77,120,177],"some":[58],"aspects":[59],"of":[60,72,75,79,151,160,165,175,180],"DNA":[61,123,128,183],"replication,":[62],"recombination,":[63],"or":[64],"repair.":[65],"However,":[66],"there":[67],"currently":[69],"no":[70],"evidence":[71],"role":[74],"any":[78],"these":[80],"processes;":[81],"therefore,":[82],"its":[83],"biological":[84],"function":[85],"remains":[86],"unknown.":[87],"Using":[88],"biochemical":[90],"approach,":[91],"we":[92,155],"have":[93],"identified":[94],"two":[95,109],"polypeptides":[96],"bind":[98],"protein.":[102],"Peptide":[103],"sequence":[104],"analysis":[105],"indicates":[106],"proteins":[110],"are":[111],"identical":[112],"Ku70":[114],"Ku80,":[116],"heterodimer":[118],"involved":[119],"double":[121,181],"strand":[122,182],"break":[124],"repair":[125,179],"non-homologous":[127],"end":[129],"joining.":[130],"Protein-protein":[131],"interaction":[132,144],"studies":[133],"reveal":[134],"binds":[137],"directly":[138],"Ku80":[140],"this":[143],"mediated":[146],"amino":[149],"terminus":[150],"WRN.":[152],"show":[156],"binding":[159],"Ku":[161],"alters":[162],"specificity":[164],"exonuclease.":[168],"These":[169],"results":[170],"suggest":[171],"potential":[173],"involvement":[174],"breaks.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}