{"id":"https://openalex.org/W2000436131","doi":"https://doi.org/10.1016/s0014-2999(01)00801-9","title":"Population pharmacokinetic\u2013pharmacodynamic modelling of S 15535, a 5-HT1A receptor agonist, using a behavioural model in rats","display_name":"Population pharmacokinetic\u2013pharmacodynamic modelling of S 15535, a 5-HT1A receptor agonist, using a behavioural model in rats","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2000436131","doi":"https://doi.org/10.1016/s0014-2999(01)00801-9","mag":"2000436131","pmid":"https://pubmed.ncbi.nlm.nih.gov/11239924"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(01)00801-9","doi":"https://doi.org/10.1016/s0014-2999(01)00801-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(01)00801-9","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081908884","display_name":"Peter Vis","orcid":"https://orcid.org/0000-0003-3701-3270","observed_orcids":["https://orcid.org/0000-0003-3701-3270"]},"institutions":[{"id":"https://openalex.org/I4210126512","display_name":"Servier (United Kingdom)","ror":"https://ror.org/02fbwdh31","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210126512","https://openalex.org/I4210135308"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Vis","raw_affiliation_strings":["Servier Research and Development Ltd, Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK. pvis@pharsight.com","Servier Research and Development Ltd, Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servier Research and Development Ltd, Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK. pvis@pharsight.com","institution_ids":["https://openalex.org/I4210126512"]},{"raw_affiliation_string":"Servier Research and Development Ltd, Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK","institution_ids":["https://openalex.org/I4210126512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081960928","display_name":"Oscar E. Della Pasqua","orcid":"https://orcid.org/0000-0002-6211-1430","observed_orcids":["https://orcid.org/0000-0002-6211-1430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oscar Della Pasqua","raw_affiliation_strings":["Leiden/Amsterdam Center for Drug Research, PO Box 9502, 2300 RA Leiden, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden/Amsterdam Center for Drug Research, PO Box 9502, 2300 RA Leiden, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000007212","display_name":"Menno R. Kruk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Menno Kruk","raw_affiliation_strings":["Leiden/Amsterdam Center for Drug Research, PO Box 9502, 2300 RA Leiden, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden/Amsterdam Center for Drug Research, PO Box 9502, 2300 RA Leiden, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056289582","display_name":"D.P. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126512","display_name":"Servier (United Kingdom)","ror":"https://ror.org/02fbwdh31","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210126512","https://openalex.org/I4210135308"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Delphine Martin","raw_affiliation_strings":["Servier Research and Development Ltd, Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servier Research and Development Ltd, Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK","institution_ids":["https://openalex.org/I4210126512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068321695","display_name":"Elisabeth Moca\u00ebr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisabeth Moca\u00ebr","raw_affiliation_strings":["Institut de Recherches Internationales Servier, 6, Place des Pl\u00e9iades, 92415 Courbevoie Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier, 6, Place des Pl\u00e9iades, 92415 Courbevoie Cedex, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033133140","display_name":"Meindert Danhof","orcid":"https://orcid.org/0000-0002-2319-6830","observed_orcids":["https://orcid.org/0000-0002-2319-6830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meindert Danhof","raw_affiliation_strings":["Leiden/Amsterdam Center for Drug Research, PO Box 9502, 2300 RA Leiden, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden/Amsterdam Center for Drug Research, PO Box 9502, 2300 RA Leiden, Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109118078","display_name":"Roeline Jochemsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roeline Jochemsen","raw_affiliation_strings":["Institut de Recherches Internationales Servier, 6, Place des Pl\u00e9iades, 92415 Courbevoie Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier, 6, Place des Pl\u00e9iades, 92415 Courbevoie Cedex, France","institution_ids":["https://openalex.org/I4405268767"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.16554548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"414","issue":"2-3","first_page":"233","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.35109999775886536,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.35109999775886536,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.32760000228881836,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.1080000028014183,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht1a-receptor-agonist","display_name":"5-HT1A receptor agonist","score":0.8629999756813049},{"id":"https://openalex.org/keywords/buspirone","display_name":"buspirone","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-modeling","display_name":"pharmacokinetic-pharmacodynamic modeling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.46700000762939453},{"id":"https://openalex.org/keywords/ultrasonic-vocalizations","display_name":"ultrasonic vocalizations","score":0.8500000238418579},{"id":"https://openalex.org/keywords/behavioural-models","display_name":"behavioural models","score":0.5360000133514404},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.8389999866485596},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.6710000038146973},{"id":"https://openalex.org/keywords/nonlinear-mixed-effects-modelling","display_name":"nonlinear mixed-effects modelling","score":0.7599999904632568},{"id":"https://openalex.org/keywords/sigmoid-emax-model","display_name":"sigmoid Emax model","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2777287423","wikidata":"https://www.wikidata.org/wiki/Q412194","display_name":"Buspirone","level":4,"score":0.7676485776901245},{"id":"https://openalex.org/C2781093953","wikidata":"https://www.wikidata.org/wiki/Q21115043","display_name":"5-HT1A receptor","level":5,"score":0.7549828886985779},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7486982345581055},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7235002517700195},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6549410820007324},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.551479160785675},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.5279071927070618},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.5116970539093018},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48503559827804565},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4845999479293823},{"id":"https://openalex.org/C38533456","wikidata":"https://www.wikidata.org/wiki/Q1671589","display_name":"Intrinsic activity","level":4,"score":0.4388194680213928},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3829483389854431},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35849320888519287},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29004621505737305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2759968936443329},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.2198413610458374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.219355970621109},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10091710090637207},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.09954589605331421},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08446076512336731},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002065","descriptor_name":"Buspirone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014828","descriptor_name":"Vocalization, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014828","descriptor_name":"Vocalization, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044263","descriptor_name":"Receptors, Serotonin, 5-HT1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(01)00801-9","doi":"https://doi.org/10.1016/s0014-2999(01)00801-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(01)00801-9","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:11239924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11239924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1517386226","https://openalex.org/W1968030314","https://openalex.org/W1970478315","https://openalex.org/W1977775413","https://openalex.org/W1993256085","https://openalex.org/W1995411470","https://openalex.org/W1999413762","https://openalex.org/W2003883797","https://openalex.org/W2017860406","https://openalex.org/W2017861141","https://openalex.org/W2023648466","https://openalex.org/W2024951267","https://openalex.org/W2029049578","https://openalex.org/W2030301770","https://openalex.org/W2035836789","https://openalex.org/W2044320697","https://openalex.org/W2057808899","https://openalex.org/W2061945417","https://openalex.org/W2061967853","https://openalex.org/W2069704104","https://openalex.org/W2082949601","https://openalex.org/W2092477001","https://openalex.org/W2094796733","https://openalex.org/W2114588857","https://openalex.org/W2137455029","https://openalex.org/W2211245678","https://openalex.org/W2263849628","https://openalex.org/W2498555957","https://openalex.org/W4285719527","https://openalex.org/W6680811468","https://openalex.org/W6723678096","https://openalex.org/W6828816813"],"related_works":["https://openalex.org/W2137455029","https://openalex.org/W2086678126","https://openalex.org/W2021042549","https://openalex.org/W1519375409","https://openalex.org/W2094796733","https://openalex.org/W2046048788","https://openalex.org/W4214839850","https://openalex.org/W2061944048","https://openalex.org/W72208687","https://openalex.org/W2023648466"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
