{"id":"https://openalex.org/W2000435338","doi":"https://doi.org/10.1074/jbc.m412327200","title":"Base Catalysis of Chromophore Formation in Arg96 and Glu222 Variants of Green Fluorescent Protein","display_name":"Base Catalysis of Chromophore Formation in Arg96 and Glu222 Variants of Green Fluorescent Protein","publication_year":2005,"publication_date":"2005-05-12","ids":{"openalex":"https://openalex.org/W2000435338","doi":"https://doi.org/10.1074/jbc.m412327200","mag":"2000435338","pmid":"https://pubmed.ncbi.nlm.nih.gov/15888441"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m412327200","doi":"https://doi.org/10.1074/jbc.m412327200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m412327200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m412327200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077468618","display_name":"Jennifer A. Sniegowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Sniegowski","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060680292","display_name":"Jason W. Lappe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason W. Lappe","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009776692","display_name":"Hetal Patel","orcid":"https://orcid.org/0009-0007-1669-9513","observed_orcids":["https://orcid.org/0009-0007-1669-9513"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hetal N. Patel","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049801936","display_name":"Holly A. Huffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly A. Huffman","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024944707","display_name":"Rebekka M. Wachter","orcid":"https://orcid.org/0000-0002-4693-4488","observed_orcids":["https://orcid.org/0000-0002-4693-4488"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebekka M. Wachter","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024944707"],"corresponding_institution_ids":["https://openalex.org/I55732556"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.9052,"has_fulltext":false,"cited_by_count":137,"citation_normalized_percentile":{"value":0.95830816,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"280","issue":"28","first_page":"26248","last_page":"26255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.03359999880194664,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"green fluorescent protein","score":0.996999979019165},{"id":"https://openalex.org/keywords/base-catalysis","display_name":"base catalysis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.6980000138282776},{"id":"https://openalex.org/keywords/site-directed-mutants","display_name":"site-directed mutants","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.858295738697052},{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.8556629419326782},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.7454533576965332},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.7119191288948059},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.5908412337303162},{"id":"https://openalex.org/C93391505","wikidata":"https://www.wikidata.org/wiki/Q658700","display_name":"Reaction rate constant","level":3,"score":0.5835959911346436},{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.5376836657524109},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4722168743610382},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.47019538283348083},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.4548417329788208},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.4282224178314209},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38289403915405273},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.32186514139175415},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1699180006980896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11038222908973694},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.11025944352149963},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m412327200","doi":"https://doi.org/10.1074/jbc.m412327200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m412327200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15888441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15888441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m412327200","doi":"https://doi.org/10.1074/jbc.m412327200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m412327200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W573383296","https://openalex.org/W588942190","https://openalex.org/W1544900705","https://openalex.org/W1974144765","https://openalex.org/W1974243596","https://openalex.org/W1976881268","https://openalex.org/W1978895054","https://openalex.org/W1980073547","https://openalex.org/W1995702879","https://openalex.org/W2001741929","https://openalex.org/W2002360833","https://openalex.org/W2006860644","https://openalex.org/W2010373880","https://openalex.org/W2015835861","https://openalex.org/W2030497718","https://openalex.org/W2030695915","https://openalex.org/W2033656921","https://openalex.org/W2035679715","https://openalex.org/W2036742051","https://openalex.org/W2042806005","https://openalex.org/W2061104342","https://openalex.org/W2067211564","https://openalex.org/W2070458959","https://openalex.org/W2081344793","https://openalex.org/W2091205925","https://openalex.org/W2110310164","https://openalex.org/W2111455017","https://openalex.org/W2123440527","https://openalex.org/W2125299258","https://openalex.org/W2127068865","https://openalex.org/W2134190459","https://openalex.org/W2150153332","https://openalex.org/W2161996750","https://openalex.org/W2167098582","https://openalex.org/W2498454769","https://openalex.org/W2499620034","https://openalex.org/W3086983054","https://openalex.org/W4233808990","https://openalex.org/W4241294442"],"related_works":["https://openalex.org/W2155974000","https://openalex.org/W2122215583","https://openalex.org/W2119825110","https://openalex.org/W2039603790","https://openalex.org/W2062538413","https://openalex.org/W2123440527","https://openalex.org/W1970887193","https://openalex.org/W2147169786","https://openalex.org/W1986584796","https://openalex.org/W2007328099"],"abstract_inverted_index":{"In":[0,56,81,108],"green":[1],"fluorescent":[2],"protein":[3,31],"(GFP),":[4],"chromophore":[5,63,182],"biosynthesis":[6],"is":[7,27,65,87,98,112],"initiated":[8],"by":[9,29,216],"a":[10,36,117,178,194],"spontaneous":[11],"main-chain":[12],"condensation":[13],"reaction.":[14],"Nucleophilic":[15],"addition":[16],"of":[17,62,103,120,134,156,171,188,193,213,230,239,248],"the":[18,23,30,45,57,60,82,85,135,148,162,186,191,201,206,211,218,224,227,231,237],"Gly67":[19,163,202],"amide":[20,164,203],"nitrogen":[21,165,204],"to":[22,35],"Ser65":[24],"carbonyl":[25],"carbon":[26],"catalyzed":[28],"fold":[32],"and":[33,50,77,114,130,160,222],"leads":[34],"heterocyclic":[37],"intermediate.":[38],"To":[39],"investigate":[40],"this":[41],"mechanism,":[42],"we":[43],"substituted":[44],"highly":[46],"conserved":[47],"residues":[48],"Arg96":[49,209],"Glu222":[51,149,189],"in":[52,158,173,184,236],"enhanced":[53],"GFP":[54,181],"(EGFP).":[55],"R96M":[58,129,159],"variant,":[59,84],"rate":[61,86],"formation":[64],"greatly":[66],"reduced":[67],"(time":[68],"constant":[69,119],"=":[70],"7.5":[71],"x":[72],"10(3)":[73],"h,":[74,94],"pH":[75,79,92,95,106],"7)":[76,96],"exhibits":[78],"dependence.":[80],"E222Q":[83,131],"also":[88],"attenuated":[89],"at":[90,105],"physiological":[91],"(32":[93],"but":[97],"accelerated":[99],"severalfold":[100],"beyond":[101],"that":[102,147,161],"EGFP":[104,110],"9-10.":[107],"contrast,":[109],"maturation":[111],"pH-independent":[113],"proceeds":[115],"with":[116,139,152,167,242],"time":[118],"1":[121],"h":[122],"(pH":[123],"7-10).":[124],"Mass":[125],"spectrometric":[126],"results":[127],"for":[128,180,245],"indicate":[132],"accumulation":[133],"pre-cyclization":[136],"state,":[137],"consistent":[138],"rate-limiting":[140],"backbone":[141],"condensation.":[142],"The":[143],"pH-rate":[144],"profile":[145],"implies":[146],"carboxylate":[150,187],"titrates":[151,166],"an":[153,168,214],"apparent":[154,169],"pK(a)":[155,170],"6.5":[157],"9.2":[172],"E222Q.":[174],"These":[175],"data":[176],"suggest":[177],"model":[179],"synthesis":[183],"which":[185],"plays":[190],"role":[192,212],"general":[195],"base,":[196],"facilitating":[197],"proton":[198],"abstraction":[199],"from":[200],"or":[205],"Tyr66":[207],"alpha-carbon.":[208],"fulfills":[210],"electrophile":[215],"lowering":[217],"respective":[219],"pK":[220],"values":[221],"stabilizing":[223],"alpha-enolate.":[225],"Modulating":[226],"base":[228],"strength":[229],"proton-abstracting":[232],"group":[233],"may":[234],"aid":[235],"design":[238],"fast-maturing":[240],"GFPs":[241],"improved":[243],"characteristics":[244],"real-time":[246],"monitoring":[247],"cellular":[249],"events.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
