{"id":"https://openalex.org/W2000430949","doi":"https://doi.org/10.1189/jlb.0703356","title":"Cognate MHC\u2013TCR interaction leads to apoptosis of antigen-presenting cells","display_name":"Cognate MHC\u2013TCR interaction leads to apoptosis of antigen-presenting cells","publication_year":2004,"publication_date":"2004-02-24","ids":{"openalex":"https://openalex.org/W2000430949","doi":"https://doi.org/10.1189/jlb.0703356","mag":"2000430949","pmid":"https://pubmed.ncbi.nlm.nih.gov/14982950"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.0703356","doi":"https://doi.org/10.1189/jlb.0703356","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0703356","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008693390","display_name":"Niclas Setterblad","orcid":"https://orcid.org/0000-0002-1899-5435","observed_orcids":["https://orcid.org/0000-0002-1899-5435"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Niclas Setterblad","raw_affiliation_strings":["INSERM U396, Institut des Cordeliers , Paris , France","INSERM U396, Institut des Cordeliers, 75006 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U396, Institut des Cordeliers , Paris , France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U396, Institut des Cordeliers, 75006 Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043664848","display_name":"Vincent Blancheteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Blancheteau","raw_affiliation_strings":["INSERM U396, Institut des Cordeliers , Paris , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U396, Institut des Cordeliers , Paris , France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013647529","display_name":"Alix Delaguillaumie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alix Delaguillaumie","raw_affiliation_strings":["INSERM U396, Institut des Cordeliers , Paris , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U396, Institut des Cordeliers , Paris , France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018736500","display_name":"Fr\u00e9d\u00e9rique Michel","orcid":"https://orcid.org/0000-0002-3524-2232","observed_orcids":["https://orcid.org/0000-0002-3524-2232"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9rique Michel","raw_affiliation_strings":["Department of Immunology, Institut Pasteur , Paris , France","Department of Immunology, Institut Pasteur, Paris, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institut Pasteur , Paris , France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Department of Immunology, Institut Pasteur, Paris, France; and","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084785290","display_name":"St\u00e9phane B\u00e9cart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane B\u00e9cart","raw_affiliation_strings":["INSERM U396, Institut des Cordeliers , Paris , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U396, Institut des Cordeliers , Paris , France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101470033","display_name":"Giovanna Lombardi","orcid":"https://orcid.org/0000-0003-4496-3215","observed_orcids":["https://orcid.org/0000-0003-4496-3215"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giovanna Lombardi","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital and University College London , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital and University College London , United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067648833","display_name":"Oreste Acuto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Oreste Acuto","raw_affiliation_strings":["Department of Immunology, Institut Pasteur , Paris , France","Department of Immunology, Institut Pasteur, Paris, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institut Pasteur , Paris , France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Department of Immunology, Institut Pasteur, Paris, France; and","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024742843","display_name":"Dominique J Charron","orcid":"https://orcid.org/0000-0001-7689-8038","observed_orcids":["https://orcid.org/0000-0001-7689-8038"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Charron","raw_affiliation_strings":["INSERM U396, Institut des Cordeliers , Paris , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U396, Institut des Cordeliers , Paris , France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089813195","display_name":"Nuala Mooney","orcid":"https://orcid.org/0000-0002-3516-6882","observed_orcids":["https://orcid.org/0000-0002-3516-6882"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nuala Mooney","raw_affiliation_strings":["INSERM U396, Institut des Cordeliers , Paris , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U396, Institut des Cordeliers , Paris , France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089813195"],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.6902,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.66584716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"75","issue":"6","first_page":"1036","last_page":"1044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.2029000073671341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.11429999768733978,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.7139999866485596},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/peptide-presentation","display_name":"peptide presentation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/t-cell-apc-interaction","display_name":"T cell-APC interaction","score":0.6230000257492065},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cytoskeletal-integrity","display_name":"cytoskeletal integrity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/phosphatidylserine-exposure","display_name":"phosphatidylserine exposure","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.996999979019165},{"id":"https://openalex.org/keywords/interleukin-2-secretion","display_name":"interleukin-2 secretion","score":0.8790000081062317},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/fas-fas-ligand","display_name":"Fas/Fas ligand","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6801520586013794},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.6103434562683105},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5883503556251526},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.5781385898590088},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5009701251983643},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49354779720306396},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4874298870563507},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.447065144777298},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.44279131293296814},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.42816779017448425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38906654715538025},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3584015369415283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07489660382270813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07172149419784546},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010718","descriptor_name":"Phosphatidylserines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1189/jlb.0703356","doi":"https://doi.org/10.1189/jlb.0703356","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0703356","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:14982950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14982950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.1267","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.1267","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jleukbio.org/content/early/2004/02/24/jlb.0703356.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.5900","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.5900","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jleukbio.org/content/75/6/1036.full.pdf","raw_type":"text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/7aeb0d95-d390-4365-bd99-ce6e75a48a62","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/7aeb0d95-d390-4365-bd99-ce6e75a48a62","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Setterbald, N, Blancheteau, V, Delaguillaumie, A, Michel, S, Becart, G, Lombardi, G, Acuto, O, Charron, D & Mooney, N 2004, 'Cognate MHC-TCR interaction leads to apoptosis of Antigen Presenting Cells', Journal of Leukocyte Biology, vol. 75, no. 6, pp. 1036 - 1044. https://doi.org/10.1189/jlb.0703356","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322646","display_name":"Fondation de France","ror":"https://ror.org/02zkxjz73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1488989767","https://openalex.org/W1520292475","https://openalex.org/W1523485804","https://openalex.org/W1548974055","https://openalex.org/W1577159905","https://openalex.org/W1584961069","https://openalex.org/W1629770860","https://openalex.org/W1782927503","https://openalex.org/W1826654473","https://openalex.org/W1844276506","https://openalex.org/W1958151369","https://openalex.org/W1969577836","https://openalex.org/W1969914430","https://openalex.org/W1974148576","https://openalex.org/W1983328041","https://openalex.org/W1988087702","https://openalex.org/W1988864413","https://openalex.org/W1989600187","https://openalex.org/W2005483507","https://openalex.org/W2007504983","https://openalex.org/W2027194054","https://openalex.org/W2033334865","https://openalex.org/W2035153917","https://openalex.org/W2046175632","https://openalex.org/W2046477202","https://openalex.org/W2057149272","https://openalex.org/W2057354555","https://openalex.org/W2073914550","https://openalex.org/W2074885149","https://openalex.org/W2076478256","https://openalex.org/W2082841258","https://openalex.org/W2088955069","https://openalex.org/W2097984152","https://openalex.org/W2099727917","https://openalex.org/W2121075882","https://openalex.org/W2122182683","https://openalex.org/W2129971278","https://openalex.org/W2133240545","https://openalex.org/W2137694849","https://openalex.org/W2147166534","https://openalex.org/W2150267414","https://openalex.org/W2158089796","https://openalex.org/W2158092895","https://openalex.org/W2159531745","https://openalex.org/W2159680966","https://openalex.org/W2160776459","https://openalex.org/W2163351493","https://openalex.org/W2237047152","https://openalex.org/W2297499700","https://openalex.org/W2414842209"],"related_works":["https://openalex.org/W2594327883","https://openalex.org/W2025857710","https://openalex.org/W2082841258","https://openalex.org/W2024434117","https://openalex.org/W2156324063","https://openalex.org/W4313331874","https://openalex.org/W2314623637","https://openalex.org/W2002917387","https://openalex.org/W2068090796","https://openalex.org/W1488989767"],"abstract_inverted_index":{"Antigen":[0,123],"presentation":[1,29,47,124],"to":[2,48,64,85,102,126,175],"T":[3,12,51,57,72,87,127,160],"lymphocytes":[4],"has":[5],"been":[6],"characterized":[7],"extensively":[8],"in":[9,66,135],"terms":[10],"of":[11,27,40,90,144],"lymphocyte":[13,58,73,88,128,161],"activation":[14,117,129],"and":[15,92,97,115,139],"eventual":[16],"cell":[17,33],"death.":[18],"In":[19,70],"contrast,":[20,71],"little":[21],"is":[22,130],"known":[23],"about":[24],"the":[25,31,38,67,136],"consequences":[26],"antigen":[28],"for":[30,120,159,169],"antigen-presenting":[32],"(APC).":[34],"We":[35,53],"have":[36,152,166],"determined":[37],"outcome":[39],"major":[41],"histocompatibility":[42],"complex":[43],"class":[44],"II-restricted":[45],"peptide":[46,83],"a":[49,142],"specific":[50,56,157],"cell.":[52],"demonstrate":[54],"that":[55],"interaction":[59,74],"with":[60,75,81,133],"peptide-presenting":[61],"APCs":[62,77,79],"led":[63],"apoptosis":[65,134],"APC":[68,93,104,121,137],"population.":[69],"nonpeptide-loaded":[76],"or":[78],"loaded":[80],"monosubstituted":[82],"failed":[84],"induce":[86],"secretion":[89],"interleukin-2":[91],"apoptosis.":[94,105,122,178],"Phosphatidylserine":[95],"externalization":[96],"mitochondrial":[98],"depolarization":[99],"were":[100,109,118],"used":[101],"evaluate":[103],"Fas/Fas":[106],"ligand":[107],"interactions":[108],"not":[110,173],"required,":[111],"but":[112],"cytoskeletal":[113],"integrity":[114],"caspase":[116],"essential":[119],"leading":[125],"therefore":[131],"coordinated":[132],"population":[138],"could":[140],"provide":[141],"mechanism":[143],"immune":[145],"response":[146],"regulation":[147],"by":[148],"eliminating":[149],"APCs,":[150,170],"which":[151,171],"fulfilled":[153],"their":[154],"role":[155],"as":[156],"ligands":[158],"activation.":[162],"This":[163],"pathway":[164],"may":[165],"particular":[167],"importance":[168],"are":[172],"sensitive":[174],"death":[176],"receptor-induced":[177]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}