{"id":"https://openalex.org/W2000430191","doi":"https://doi.org/10.1002/jbm.a.31355","title":"Immobilized sonic hedgehog N\u2010terminal signaling domain enhances differentiation of bone marrow\u2010derived mesenchymal stem cells","display_name":"Immobilized sonic hedgehog N\u2010terminal signaling domain enhances differentiation of bone marrow\u2010derived mesenchymal stem cells","publication_year":2007,"publication_date":"2007-06-28","ids":{"openalex":"https://openalex.org/W2000430191","doi":"https://doi.org/10.1002/jbm.a.31355","mag":"2000430191","pmid":"https://pubmed.ncbi.nlm.nih.gov/17600327"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.31355","doi":"https://doi.org/10.1002/jbm.a.31355","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.31355","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103425465","display_name":"James E. Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Ho","raw_affiliation_strings":["Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720-1762","Department of Materials Science and Engineering, University of California at Berkeley, 370 Hearst Memorial Mining Building, Berkeley, California 94720-1760","UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720-1762","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, University of California at Berkeley, 370 Hearst Memorial Mining Building, Berkeley, California 94720-1760","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eugene H. Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene H. Chung","raw_affiliation_strings":["Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720-1762","UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720-1762","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073185963","display_name":"Samuel Wall","orcid":"https://orcid.org/0000-0002-2487-703X","observed_orcids":["https://orcid.org/0000-0002-2487-703X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Wall","raw_affiliation_strings":["Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720-1762","UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720-1762","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013729741","display_name":"David V. Schaffer","orcid":"https://orcid.org/0000-0002-9625-0121","observed_orcids":["https://orcid.org/0000-0002-9625-0121"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David V. Schaffer","raw_affiliation_strings":["Department of Chemical Engineering and the Helen Wills Neuroscience Institute, University of California at Berkeley, 201 Gilman Hall, Berkeley, California 94720-1462","UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and the Helen Wills Neuroscience Institute, University of California at Berkeley, 201 Gilman Hall, Berkeley, California 94720-1462","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073133450","display_name":"Kevin E. Healy","orcid":"https://orcid.org/0000-0002-8524-3671","observed_orcids":["https://orcid.org/0000-0002-8524-3671"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin E. Healy","raw_affiliation_strings":["Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720-1762","Department of Materials Science and Engineering, University of California at Berkeley, 370 Hearst Memorial Mining Building, Berkeley, California 94720-1760","UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720-1762","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, University of California at Berkeley, 370 Hearst Memorial Mining Building, Berkeley, California 94720-1760","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"UCSF/UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073133450"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":3.3182,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.91102781,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"83A","issue":"4","first_page":"1200","last_page":"1208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/interpenetrating-polymer-networks","display_name":"interpenetrating polymer networks","score":0.890999972820282},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.8040000200271606},{"id":"https://openalex.org/keywords/bone-sialoprotein","display_name":"bone sialoprotein","score":0.972000002861023},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7490000128746033},{"id":"https://openalex.org/keywords/peri-implant-bone-formation","display_name":"peri-implant bone formation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/implant-fixation","display_name":"implant fixation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/bioinspired-surfaces","display_name":"biomimetic surfaces","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C2776432469","wikidata":"https://www.wikidata.org/wiki/Q14907671","display_name":"Bone sialoprotein","level":5,"score":0.7807576656341553},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7569373846054077},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.7125986814498901},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6695215702056885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5898005962371826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5646745562553406},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5444298386573792},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.45400261878967285},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3279725909233093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23734885454177856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23446020483970642},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.21161481738090515},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16080570220947266},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.14832201600074768},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jbm.a.31355","doi":"https://doi.org/10.1002/jbm.a.31355","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.31355","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:17600327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17600327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.433.3994","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.433.3994","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cchem.berkeley.edu/schaffer/2007 Publications/Ho_ShhN_JBMR_07.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5654152268","display_name":"Biomimetic Materials Useful for Rehabilitation","funder_award_id":"R01AR043187","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1559596935","https://openalex.org/W1698663755","https://openalex.org/W1833613269","https://openalex.org/W1944656442","https://openalex.org/W1969670678","https://openalex.org/W1971091133","https://openalex.org/W1978848392","https://openalex.org/W1979400074","https://openalex.org/W1981019430","https://openalex.org/W1990042895","https://openalex.org/W1991144688","https://openalex.org/W1991343378","https://openalex.org/W1992453786","https://openalex.org/W1997647797","https://openalex.org/W1998761473","https://openalex.org/W2000307793","https://openalex.org/W2022353978","https://openalex.org/W2023928940","https://openalex.org/W2026152104","https://openalex.org/W2047103746","https://openalex.org/W2048579089","https://openalex.org/W2049153471","https://openalex.org/W2053307967","https://openalex.org/W2054635635","https://openalex.org/W2059205089","https://openalex.org/W2065074615","https://openalex.org/W2073457192","https://openalex.org/W2076532604","https://openalex.org/W2077094332","https://openalex.org/W2081452775","https://openalex.org/W2085173237","https://openalex.org/W2087983273","https://openalex.org/W2093985074","https://openalex.org/W2095995969","https://openalex.org/W2108707301","https://openalex.org/W2111668132","https://openalex.org/W2126438640","https://openalex.org/W2149697928","https://openalex.org/W2156115560","https://openalex.org/W2158483162","https://openalex.org/W2170047575"],"related_works":["https://openalex.org/W7100685734","https://openalex.org/W2029319981","https://openalex.org/W1980567338","https://openalex.org/W4211257604","https://openalex.org/W2046972232","https://openalex.org/W6977613971","https://openalex.org/W2414386422","https://openalex.org/W2891628252","https://openalex.org/W4310530475","https://openalex.org/W1989579884"],"abstract_inverted_index":{"The":[0,88,178,199],"signaling":[1],"domain":[2],"of":[3,11,41,82,91,98,115,158,201,208,226],"Sonic":[4],"hedgehog":[5],"(Shh),":[6],"a":[7,36,68],"potent":[8],"upstream":[9],"regulator":[10],"cell":[12,127,186],"fate":[13],"that":[14],"has":[15],"been":[16],"implicated":[17],"in":[18,25,31,194,220],"osteoblast":[19,46,176,213],"differentiation":[20,40,193,207],"from":[21],"undifferentiated":[22],"mesenchymal":[23,119],"cells":[24,43,121],"its":[26],"endogenous":[27],"form,":[28],"was":[29,54,93,183],"investigated":[30],"an":[32],"immobilized":[33,58,103,197,202],"form":[34],"as":[35,100,190,192],"means":[37],"for":[38,185],"accelerating":[39],"uncommitted":[42,209],"to":[44,130,196,211,222],"the":[45,73,96,112,154,206,212,224,227],"phenotype.":[47],"A":[48],"recombinant":[49],"cysteine-modified":[50],"N-terminal":[51],"Shh":[52,203],"(mShh)":[53],"synthesized,":[55],"purified,":[56],"and":[57,84,105,145,148,165,188,215,235],"onto":[59],"interpenetrating":[60],"polymer":[61],"network":[62],"(IPN)":[63],"surfaces":[64,101,152,169],"also":[65],"grafted":[66],"with":[67,102,138,141,161,171],"bone":[69,117,142,233],"sialoprotein-derived":[70],"peptide":[71,180],"containing":[72],"Arg-Gly-Asp":[74],"(RGD)":[75],"sequence":[76],"(bsp-RGD":[77],"(15)),":[78],"at":[79],"calculated":[80],"densities":[81],"2.42":[83],"10":[85],"pmol/cm2,":[86],"respectively.":[87],"mitogenic":[89],"effect":[90,110,225],"mShh":[92,104,125,134,147],"dependent":[94],"on":[95,111,231],"mode":[97],"presentation,":[99],"bsp-RGD":[106,149,166,181],"(15)":[107,182],"had":[108],"no":[109],"growth":[113,128],"rate":[114],"rat":[116],"marrow-derived":[118],"stem":[120],"(BMSCs),":[122],"while":[123],"soluble":[124,172],"enhanced":[126,153,175],"compared":[129,160],"similar":[131],"surface":[132],"without":[133],"supplementation.":[135],"In":[136],"conjunction":[137],"media":[139],"supplemented":[140,170],"morphogenetic":[143],"protein-2":[144],"-4,":[146],"(15)-grafted":[150,167],"IPN":[151,168],"alkaline":[155],"phosphatase":[156],"activity":[157],"BMSCs":[159,210],"tissue":[162],"culture":[163],"polystyrene":[164],"mShh,":[173],"indicating":[174],"differentiation.":[177],"adhesive":[179],"necessary":[184],"attachment":[187],"proliferation,":[189],"well":[191],"response":[195],"mShh.":[198],"addition":[200],"substantially":[204],"improved":[205],"lineage,":[214],"therefore":[216],"warrants":[217],"further":[218],"testing":[219],"vivo":[221],"examine":[223],"stated":[228],"biomimetic":[229],"system":[230],"peri-implant":[232],"formation":[234],"implant":[236],"fixation.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}