{"id":"https://openalex.org/W2000423768","doi":"https://doi.org/10.1634/stemcells.21-4-437","title":"Marrow Stromal Cells, Mitosis, and Neuronal Differentiation: Stem Cell and Precursor Functions","display_name":"Marrow Stromal Cells, Mitosis, and Neuronal Differentiation: Stem Cell and Precursor Functions","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2000423768","doi":"https://doi.org/10.1634/stemcells.21-4-437","mag":"2000423768","pmid":"https://pubmed.ncbi.nlm.nih.gov/12832697"},"language":"en","primary_location":{"id":"doi:10.1634/stemcells.21-4-437","doi":"https://doi.org/10.1634/stemcells.21-4-437","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.21-4-437","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000423768"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055284221","display_name":"Guillermo Mu\u00f1oz\u2010El\u00edas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Mu\u00f1oz\u2010El\u00edas","raw_affiliation_strings":["University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072549190","display_name":"Dale Woodbury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale Woodbury","raw_affiliation_strings":["University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109987219","display_name":"Ira B. Black","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ira B. Black","raw_affiliation_strings":["University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA","institution_ids":["https://openalex.org/I4405286694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109987219"],"corresponding_institution_ids":["https://openalex.org/I4405286694"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":3.2726,"has_fulltext":false,"cited_by_count":212,"citation_normalized_percentile":{"value":0.92880376,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"4","first_page":"437","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.1354999989271164,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/progenitor-cells","display_name":"progenitor cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.6819999814033508},{"id":"https://openalex.org/keywords/bromodeoxyuridine-incorporation","display_name":"bromodeoxyuridine incorporation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/dna-synthesis-inhibition","display_name":"DNA synthesis inhibition","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8668948411941528},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6483412981033325},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6453026533126831},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5798161029815674},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5759197473526001},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5582557320594788},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5477067232131958},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.48858222365379333},{"id":"https://openalex.org/C2778260397","wikidata":"https://www.wikidata.org/wiki/Q419861","display_name":"Bromodeoxyuridine","level":3,"score":0.4855656325817108},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.47638458013534546},{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.4713446795940399},{"id":"https://openalex.org/C124964019","wikidata":"https://www.wikidata.org/wiki/Q11616062","display_name":"Precursor cell","level":3,"score":0.44533565640449524},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3919874429702759},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35272306203842163},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33839839696884155},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21182656288146973},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.13092756271362305},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.13030129671096802},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10473057627677917},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1634/stemcells.21-4-437","doi":"https://doi.org/10.1634/stemcells.21-4-437","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.21-4-437","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},{"id":"pmid:12832697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12832697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6868379719","display_name":"Growth and Develoment of the Nervous System: Molecular Mechanisms","funder_award_id":"P01HD023315","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320308304","display_name":"New Jersey Commission on Spinal Cord Research","ror":"https://ror.org/03kmrjq19"},{"id":"https://openalex.org/F4320334904","display_name":"National Institute for Materials Science","ror":"https://ror.org/026v1ze26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W79768257","https://openalex.org/W336932610","https://openalex.org/W1587712169","https://openalex.org/W1599090051","https://openalex.org/W1812094318","https://openalex.org/W1965953554","https://openalex.org/W1967703106","https://openalex.org/W1970865563","https://openalex.org/W1971013937","https://openalex.org/W1972651024","https://openalex.org/W1976241604","https://openalex.org/W1976315490","https://openalex.org/W1982106546","https://openalex.org/W2001675896","https://openalex.org/W2005814409","https://openalex.org/W2005848913","https://openalex.org/W2030508161","https://openalex.org/W2043741435","https://openalex.org/W2052530372","https://openalex.org/W2071263138","https://openalex.org/W2072673889","https://openalex.org/W2079356804","https://openalex.org/W2079959192","https://openalex.org/W2080356527","https://openalex.org/W2086325450","https://openalex.org/W2095257528","https://openalex.org/W2098015360","https://openalex.org/W2108143410","https://openalex.org/W2113887763","https://openalex.org/W2132925264","https://openalex.org/W2141310245","https://openalex.org/W2144268541","https://openalex.org/W2159999899","https://openalex.org/W2165867905","https://openalex.org/W2169334227","https://openalex.org/W2403901683"],"related_works":["https://openalex.org/W1970865563","https://openalex.org/W2006986081","https://openalex.org/W2386546007","https://openalex.org/W1984562400","https://openalex.org/W2369507273","https://openalex.org/W2367623831","https://openalex.org/W2115789073","https://openalex.org/W2005848913","https://openalex.org/W2027764875","https://openalex.org/W3046734468"],"abstract_inverted_index":{"To":[0],"define":[1],"relationships":[2],"among":[3,147],"marrow":[4],"stromal":[5],"cells":[6,99,118],"(MSCs),":[7],"multipotential":[8],"progenitors,":[9,150],"committed":[10],"precursors,":[11],"and":[12,19,43,68,87,102,123,151],"derived":[13],"neurons,":[14,34],"we":[15],"examined":[16],"differentiation,":[17,94],"mitosis,":[18],"apoptosis":[20,120],"in":[21],"vitro.":[22],"Neural":[23],"induction":[24],"medium":[25],"morphologically":[26],"converted":[27],"over":[28],"70%":[29,96],"of":[30,62,85,97,117],"MSCs":[31,132],"to":[32,56],"typical":[33],"which":[35],"expressed":[36],"tau,":[37],"neuronal":[38,104],"nuclear":[39],"antigen,":[40],"neuron-specific":[41],"enolase,":[42],"TUC-4":[44],"within":[45],"24":[46],"hours.":[47],"A":[48],"subset":[49],"decreased":[50],"fibronectin":[51],"expression,":[52],"consistent":[53],"with":[54,95],"mesenchymal":[55],"neuroectodermal":[57],"conversion.":[58],"More":[59],"than":[60,115,156],"35%":[61],"differentiating":[63],"neurons":[64,137],"incorporated":[65],"bromodeoxyuridine":[66],"(BrdU)":[67],"divided,":[69],"increasing":[70],"cell":[71],"number":[72],"by":[73],"60%,":[74],"while":[75],"another":[76],"subpopulation":[77],"differentiated":[78],"without":[79,128,138],"incorporating":[80],"BrdU":[81],"or":[82],"dividing.":[83],"Inhibition":[84],"mitosis":[86],"DNA":[88],"synthesis":[89],"did":[90],"not":[91],"prevent":[92],"neural":[93],"blocked":[98],"expressing":[100],"tau":[101],"displaying":[103],"morphologies.":[105],"By":[106],"deoxynucleotidyl":[107],"transferase-mediated":[108],"dUTP-biotin":[109],"nick":[110],"end":[111],"labeling":[112],"assay,":[113],"less":[114],"1%":[116],"underwent":[119],"at":[121],"36":[122],"72":[124],"hours,":[125],"suggesting":[126,144],"differentiation":[127],"cell-selective":[129],"mechanisms.":[130],"Apparently,":[131],"may":[133],"directly":[134],"differentiate":[135],"into":[136],"passing":[139],"through":[140],"a":[141],"mitotic":[142],"stage,":[143],"that":[145],"distinctions":[146],"stem":[148],"cells,":[149],"precursors":[152],"are":[153],"more":[154],"flexible":[155],"formerly":[157],"recognized.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
