{"id":"https://openalex.org/W2000418353","doi":"https://doi.org/10.1111/j.1365-2222.2008.03174.x","title":"Serum and monoclonal immunoglobulin E antibodies from NC/Nga mice with severe atopic\u2010like dermatitis recognize an auto\u2010antigen, histone H3","display_name":"Serum and monoclonal immunoglobulin E antibodies from NC/Nga mice with severe atopic\u2010like dermatitis recognize an auto\u2010antigen, histone H3","publication_year":2009,"publication_date":"2009-02-18","ids":{"openalex":"https://openalex.org/W2000418353","doi":"https://doi.org/10.1111/j.1365-2222.2008.03174.x","mag":"2000418353","pmid":"https://pubmed.ncbi.nlm.nih.gov/19226275"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2222.2008.03174.x","doi":"https://doi.org/10.1111/j.1365-2222.2008.03174.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.2008.03174.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2222.2008.03174.x","source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical &amp; Experimental Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2222.2008.03174.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032896772","display_name":"Takeshi Matsubara","orcid":"https://orcid.org/0000-0001-7407-2451","observed_orcids":["https://orcid.org/0000-0001-7407-2451"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Matsubara","raw_affiliation_strings":["Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111795414","display_name":"N. Aoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Aoki","raw_affiliation_strings":["Department of Life Science, Graduate School of Bioresources, Mie University, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Graduate School of Bioresources, Mie University, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002907227","display_name":"Shingo Hino","orcid":"https://orcid.org/0000-0003-2644-2301","observed_orcids":["https://orcid.org/0000-0003-2644-2301"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Hino","raw_affiliation_strings":["Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan and","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048389629","display_name":"Tetsuya Okajima","orcid":"https://orcid.org/0000-0002-3677-648X","observed_orcids":["https://orcid.org/0000-0002-3677-648X"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Okajima","raw_affiliation_strings":["Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan and","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069280614","display_name":"Daita Nadano","orcid":"https://orcid.org/0000-0003-4473-4236","observed_orcids":["https://orcid.org/0000-0003-4473-4236"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"D. Nadano","raw_affiliation_strings":["Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan and","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031625403","display_name":"Tsukasa Matsuda","orcid":"https://orcid.org/0000-0002-2914-0782","observed_orcids":["https://orcid.org/0000-0002-2914-0782"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"T. Matsuda","raw_affiliation_strings":["Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan and","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031625403"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":2.7833,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.89385475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"39","issue":"4","first_page":"579","last_page":"590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nc-nga-mice","display_name":"NC/Nga mice","score":0.9869999885559082},{"id":"https://openalex.org/keywords/serum-ige","display_name":"serum IgE","score":0.8370000123977661},{"id":"https://openalex.org/keywords/histone-h3","display_name":"histone H3","score":0.7570000290870667},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.7570000290870667},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7940000295639038},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7870000004768372},{"id":"https://openalex.org/keywords/igg1","display_name":"IgG1","score":0.5899999737739563},{"id":"https://openalex.org/keywords/igg2a","display_name":"IgG2a","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.6866684556007385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6681959629058838},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5745372176170349},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5700892210006714},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5528108477592468},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5461583733558655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5233446955680847},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.4493294060230255}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2222.2008.03174.x","doi":"https://doi.org/10.1111/j.1365-2222.2008.03174.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.2008.03174.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2222.2008.03174.x","source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical &amp; Experimental Allergy","raw_type":"journal-article"},{"id":"pmid:19226275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19226275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2222.2008.03174.x","doi":"https://doi.org/10.1111/j.1365-2222.2008.03174.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.2008.03174.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2222.2008.03174.x","source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical &amp; Experimental Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000418353.pdf","grobid_xml":"https://content.openalex.org/works/W2000418353.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W121148389","https://openalex.org/W1963771365","https://openalex.org/W1964236572","https://openalex.org/W1964847117","https://openalex.org/W1970140945","https://openalex.org/W1973070576","https://openalex.org/W1974238525","https://openalex.org/W1974241633","https://openalex.org/W1979381376","https://openalex.org/W1981527452","https://openalex.org/W1983076900","https://openalex.org/W1984366394","https://openalex.org/W1984891873","https://openalex.org/W1991195369","https://openalex.org/W1991355814","https://openalex.org/W2001574120","https://openalex.org/W2005063559","https://openalex.org/W2008795839","https://openalex.org/W2019921670","https://openalex.org/W2034775565","https://openalex.org/W2042240204","https://openalex.org/W2044766463","https://openalex.org/W2048215442","https://openalex.org/W2053613115","https://openalex.org/W2055905930","https://openalex.org/W2057369726","https://openalex.org/W2064729133","https://openalex.org/W2065861447","https://openalex.org/W2066127782","https://openalex.org/W2066973654","https://openalex.org/W2090132232","https://openalex.org/W2091714697","https://openalex.org/W2099513954","https://openalex.org/W2116424766","https://openalex.org/W2137722996","https://openalex.org/W2140856730","https://openalex.org/W2173221988","https://openalex.org/W2474991507"],"related_works":["https://openalex.org/W2137722996","https://openalex.org/W1963771365","https://openalex.org/W1981061597","https://openalex.org/W1970140945","https://openalex.org/W2044766463","https://openalex.org/W1531689223","https://openalex.org/W1983076900","https://openalex.org/W1996060937","https://openalex.org/W4234752941","https://openalex.org/W2041397127"],"abstract_inverted_index":{"BACKGROUND:":[0],"NC/Nga":[1,63,74,272],"mice":[2,75],"are":[3,52],"known":[4],"to":[5,161,283],"show":[6],"a":[7,15,25,33,228],"spontaneous":[8],"outbreak":[9],"of":[10,31,41,62,73,86,119,168,195,213,231,237,244,247,253,299],"atopic-like":[11],"dermatitis":[12,43,78,268],"accompanied":[13],"by":[14,48,166,192],"marked":[16],"elevation":[17],"in":[18,24,149,186,200,208,262,281,294],"serum":[19,35,202,287],"IgE":[20,36,50,61,88,121,171,174,205,219,223,288],"levels":[21],"when":[22],"reared":[23],"conventional":[26],"environment.":[27],"The":[28,221],"specific":[29,45,84,101,179],"effects":[30],"such":[32],"strong":[34],"response":[37],"on":[38],"the":[39,42,49,60,87,103,120,150,169,201,211,242,267,284,295],"development":[40,296],"and":[44,79,83,99,143,215,239,289,297],"antigens":[46,85,259],"recognized":[47,165],"antibodies":[51,90],"still":[53],"uncertain.":[54],"OBJECTIVE":[55],"AND":[56],"METHODS:":[57],"To":[58],"characterize":[59],"mice,":[64,188,273],"we":[65],"established":[66],"IgE-secreting":[67],"hybridoma":[68,112],"clones":[69,113,126],"from":[70,266],"spleen":[71],"cells":[72],"spontaneously":[76],"developing":[77],"identified":[80,104,160],"variable-region":[81],"genes":[82],"monoclonal":[89],"(mAbs).":[91],"Serum":[92,173],"polyclonal":[93],"IgE,":[94],"as":[95,97,175,177],"well":[96,176,226],"IgG1":[98,178],"IgG2a,":[100],"for":[102,139,180],"antigen":[105,155],"were":[106,114,183,260],"also":[107],"analysed.":[108],"RESULTS:":[109],"Four":[110],"IgE-producing":[111],"established.":[115],"Variable-region":[116],"nucleotide":[117],"sequences":[118],"mAbs":[122],"showed":[123],"that":[124],"these":[125],"did":[127],"not":[128],"necessarily":[129],"share":[130],"common":[131],"germline":[132],"gene":[133,152],"segments":[134],"(V,":[135],"D":[136],"or":[137],"J)":[138],"each":[140,232,248],"variable":[141],"region,":[142],"several":[144],"somatic":[145],"mutations":[146],"had":[147],"occurred":[148],"V":[151],"segments.":[153],"Through":[154],"screening,":[156],"histone":[157,181],"H3":[158,182,204,275],"was":[159,206],"be":[162],"an":[163],"auto-antigen":[164],"three":[167],"four":[170],"mAbs.":[172],"almost":[184],"undetectable":[185],"6-week-old":[187],"but":[189],"rapidly":[190],"increased":[191],"10-12":[193],"weeks":[194,236,252],"age.":[196,254],"This":[197],"age-dependent":[198],"increase":[199],"anti-histone":[203,274],"roughly":[207],"parallel":[209],"with":[210,227,241],"onset":[212],"dermatitis,":[214],"slightly":[216],"preceding":[217],"total":[218],"elevation.":[220],"serum-specific":[222],"level":[224],"correlated":[225],"dermatitis-severity":[229],"score":[230],"mouse":[233,249],"at":[234,279],"12-16":[235],"age,":[238],"weakly":[240],"severity":[243],"ear":[245],"erosion":[246],"over":[250],"28":[251],"Furthermore,":[255],"immunologically":[256],"detectable":[257],"histone-H3":[258],"observed":[261],"skin":[263],"tissue":[264],"sections":[265],"sites.":[269],"CONCLUSION:":[270],"In":[271],"auto-antibodies":[276],"may":[277],"contribute,":[278],"least":[280],"part,":[282],"considerably":[285],"elevated":[286],"might":[290],"play":[291],"some":[292],"roles":[293],"exacerbation":[298],"dermatitis.":[300]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
