{"id":"https://openalex.org/W2000418319","doi":"https://doi.org/10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.0.co;2-1","title":"Simultaneous Determination of Carbamazepine and Carbamazepine 10,11-Epoxide by Using Microcolumn HPLC: Study of Pharmacokinetics of Carbamazepine in a Volunteer","display_name":"Simultaneous Determination of Carbamazepine and Carbamazepine 10,11-Epoxide by Using Microcolumn HPLC: Study of Pharmacokinetics of Carbamazepine in a Volunteer","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2000418319","doi":"https://doi.org/10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.0.co;2-1","mag":"2000418319","pmid":"https://pubmed.ncbi.nlm.nih.gov/9051215"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.0.co;2-1","doi":"https://doi.org/10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.0.co;2-1","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.0.co;2-1","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000418319"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071666425","display_name":"Maka M. Alexishvili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102808428","display_name":"Tbilisi State University","ror":"https://ror.org/05fd1hd85","country_code":"GE","type":"education","lineage":["https://openalex.org/I102808428"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Maka M. Alexishvili","raw_affiliation_strings":["Department of Chemistry, Tbilisi State University, Republic of Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Tbilisi State University, Republic of Georgia","institution_ids":["https://openalex.org/I102808428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043748638","display_name":"Marina D. Rukhadze","orcid":"https://orcid.org/0000-0003-3654-0554","observed_orcids":["https://orcid.org/0000-0003-3654-0554"]},"institutions":[{"id":"https://openalex.org/I102808428","display_name":"Tbilisi State University","ror":"https://ror.org/05fd1hd85","country_code":"GE","type":"education","lineage":["https://openalex.org/I102808428"]}],"countries":["GE"],"is_corresponding":true,"raw_author_name":"Marina D. Rukhadze","raw_affiliation_strings":["Department of Chemistry, Tbilisi State University, Chavchavadze ave. 3, Tbilisi, 380028, Republic of Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Tbilisi State University, Chavchavadze ave. 3, Tbilisi, 380028, Republic of Georgia","institution_ids":["https://openalex.org/I102808428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021935181","display_name":"V. M. Okujava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102808428","display_name":"Tbilisi State University","ror":"https://ror.org/05fd1hd85","country_code":"GE","type":"education","lineage":["https://openalex.org/I102808428"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Vazha M. Okujava","raw_affiliation_strings":["Department of Chemistry, Tbilisi State University, Chavchavadze ave. 3, Tbilisi, 380028, Republic of Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Tbilisi State University, Chavchavadze ave. 3, Tbilisi, 380028, Republic of Georgia","institution_ids":["https://openalex.org/I102808428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043748638"],"corresponding_institution_ids":["https://openalex.org/I102808428"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":1.2047,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.71098504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"36","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":1.0},{"id":"https://openalex.org/keywords/carbamazepine-10-11-epoxide","display_name":"carbamazepine-10,11-epoxide","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9390000104904175},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.8119999766349792},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.8119999766349792},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.9610000252723694},{"id":"https://openalex.org/keywords/multiple-peaks","display_name":"multiple peaks","score":0.7429999709129333},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.8349999785423279},{"id":"https://openalex.org/keywords/one-compartment-model","display_name":"one-compartment model","score":0.753000020980835},{"id":"https://openalex.org/keywords/absorption-kinetics","display_name":"absorption kinetics","score":0.6230000257492065},{"id":"https://openalex.org/keywords/elimination-kinetics","display_name":"elimination kinetics","score":0.800000011920929},{"id":"https://openalex.org/keywords/drug-solubility","display_name":"drug solubility","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tissue-binding","display_name":"tissue binding","score":0.7540000081062317},{"id":"https://openalex.org/keywords/biotransformation","display_name":"biotransformation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/drug-redistribution","display_name":"drug redistribution","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.965684175491333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9087367653846741},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7315817475318909},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5989705324172974},{"id":"https://openalex.org/C2776768635","wikidata":"https://www.wikidata.org/wiki/Q3427301","display_name":"Volunteer","level":2,"score":0.581243634223938},{"id":"https://openalex.org/C2776920199","wikidata":"https://www.wikidata.org/wiki/Q408028","display_name":"Epoxide","level":3,"score":0.47813403606414795},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.462552011013031},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2741154432296753},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.19970369338989258},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07695084810256958},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.07012972235679626},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.03632998466491699},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.0.co;2-1","doi":"https://doi.org/10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.0.co;2-1","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.0.co;2-1","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.3.co;2-t","doi":"https://doi.org/10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.3.co;2-t","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-0801(199701)11:1<36::aid-bmc622>3.3.co;2-t","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},{"id":"pmid:9051215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9051215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical chromatography : BMC","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1995637850","https://openalex.org/W1996841433","https://openalex.org/W1999894844","https://openalex.org/W2003013811","https://openalex.org/W2059107921","https://openalex.org/W2271609064","https://openalex.org/W4253436419"],"related_works":["https://openalex.org/W2027314279","https://openalex.org/W2186633608","https://openalex.org/W2352261348","https://openalex.org/W2041872661","https://openalex.org/W4407284022","https://openalex.org/W2029830927","https://openalex.org/W2506170952","https://openalex.org/W2528217864","https://openalex.org/W167624810","https://openalex.org/W2031542311"],"abstract_inverted_index":{"A":[0],"highly-sensitive":[1],"microcolumn":[2],"HPLC":[3],"method":[4,21],"for":[5,25],"the":[6,26,52,59,65,78,86,91,99,109,119,128,131,136,154,157,173,177,183,189,199,206,209,226,235,242,248,258,261,266],"simultaneous":[7],"determination":[8],"of":[9,28,30,37,42,67,77,82,93,111,116,130,133,139,144,153,156,168,179,192,203,208,219,244,257],"carbamazepine":[10,31,43,94,193,220],"and":[11,16,39,61,74,118,141,159,229,231],"carbamazepine-10,11-epoxide":[12],"in":[13,32,58,172,215,225,234],"human":[14],"serum":[15,60,213],"saliva":[17],"is":[18,186,196,239,251],"described.":[19],"The":[20,80,166],"was":[22,106,164],"successfully":[23],"employed":[24],"study":[27],"pharmacokinetics":[29],"humans.":[33],"After":[34],"oral":[35],"administration":[36],"100":[38],"200":[40],"mg":[41],"to":[44,265],"a":[45,112],"volunteer,":[46],"multiple":[47,68,83,134,180,245],"peaks":[48,69,84,135,146,181,246],"were":[49,56,122,147],"observed":[50],"on":[51,85,162,182,247],"kinetic":[53,87,92,184,249],"curves.":[54],"They":[55],"symbathic":[57],"saliva.":[62],"This":[63,270],"indicated":[64],"presence":[66,178,243],"which":[70],"characterize":[71],"both":[72],"free":[73],"protein-bound":[75],"fractions":[76],"drug.":[79],"existence":[81],"curves":[88,185,250],"implies":[89],"that":[90,195,241],"cannot":[95],"be":[96],"described":[97],"with":[98,124,221],"one-compartment":[100,113],"linear":[101,114],"model.":[102],"Nevertheless,":[103],"each":[104],"peak":[105],"treated":[107],"within":[108],"range":[110],"model":[115],"absorption":[117,158,194],"results":[120],"obtained":[121],"compared":[123],"published":[125],"data.":[126],"For":[127],"elucidation":[129],"nature":[132],"graphical":[137],"differentiation":[138],"ascending":[140],"descending":[142],"branches":[143],"all":[145],"carried":[148],"out.":[149],"On":[150],"this":[151],"basis":[152],"dependence":[155],"elimination":[160,207],"rates":[161],"time":[163],"constrained.":[165],"analysis":[167],"experimental":[169],"data":[170],"resulted":[171],"following":[174],"conclusions:":[175],"(a)":[176],"induced":[187],"by":[188,198,255],"interrupted":[190],"character":[191],"caused":[197,253],"very":[200],"poor":[201],"solubility":[202],"carbamazepine;":[204],"(b)":[205],"drug":[210,259],"from":[211,260],"blood":[212],"occurs":[214,233],"two":[216],"phases.":[217],"Binding":[218],"tissues":[222],"takes":[223],"place":[224],"first":[227],"phase,":[228],"biotransformation":[230],"excretion":[232],"second":[236],"phase.":[237],"It":[238],"possible":[240],"partially":[252],"also":[254],"redistribution":[256],"comparatively":[262],"easily":[263],"accessible":[264,268],"less":[267],"tissues.":[269],"requires":[271],"further":[272],"investigation.":[273]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
