{"id":"https://openalex.org/W2000409799","doi":"https://doi.org/10.4161/mabs.2.3.11802","title":"Differences in N-glycan structures found on recombinant IgA1 and IgA2 produced in murine myeloma and CHO cell lines","display_name":"Differences in N-glycan structures found on recombinant IgA1 and IgA2 produced in murine myeloma and CHO cell lines","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W2000409799","doi":"https://doi.org/10.4161/mabs.2.3.11802","mag":"2000409799","pmid":"https://pubmed.ncbi.nlm.nih.gov/20431350","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2881258"},"language":"en","primary_location":{"id":"doi:10.4161/mabs.2.3.11802","doi":"https://doi.org/10.4161/mabs.2.3.11802","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.2.3.11802","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.2.3.11802?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.2.3.11802?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086439098","display_name":"Esther M. Yoo","orcid":"https://orcid.org/0000-0001-8759-0098","observed_orcids":["https://orcid.org/0000-0001-8759-0098"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther M. Yoo","raw_affiliation_strings":["University of California, Los Angeles","Department of Microbiology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617010","display_name":"Li J. Yu","orcid":"https://orcid.org/0000-0001-5903-211X","observed_orcids":["https://orcid.org/0000-0001-5903-211X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li J. Yu","raw_affiliation_strings":["University of California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035182491","display_name":"Letitia A. Wims","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Letitia A. Wims","raw_affiliation_strings":["University of California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009201543","display_name":"David Theo Goldberg","orcid":"https://orcid.org/0000-0001-9935-0411","observed_orcids":["https://orcid.org/0000-0001-9935-0411"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Goldberg","raw_affiliation_strings":["Scripps-PARC Institute for Advanced Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps-PARC Institute for Advanced Biomedical Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113503188","display_name":"Sherie Leaver Morrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherie L. Morrison","raw_affiliation_strings":["University of California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2915,"currency":"GBP","value_usd":3575},"apc_paid":{"value":2915,"currency":"GBP","value_usd":3575},"fwci":0.7811,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.68092241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2","issue":"3","first_page":"320","last_page":"334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.3725999891757965,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0625,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-glycans","display_name":"N-glycans","score":0.7639999985694885},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.746999979019165},{"id":"https://openalex.org/keywords/cho-cell-expression-system","display_name":"CHO cell expression system","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neu5gc","display_name":"N-glycolylneuraminic acid","score":0.984000027179718},{"id":"https://openalex.org/keywords/sialylation","display_name":"sialylation","score":0.847000002861023},{"id":"https://openalex.org/keywords/monoclonal-antibody-expression","display_name":"monoclonal antibody expression","score":0.5809999704360962},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.8039693832397461},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.7800887823104858},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.7358162999153137},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7289885878562927},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.684903621673584},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6669517159461975},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6486219763755798},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.5759807229042053},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5496764779090881},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46787023544311523},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4422233998775482},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.4421873986721039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4292055368423462},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2631930708885193},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2422659993171692},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.233007550239563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07921966910362244}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/mabs.2.3.11802","doi":"https://doi.org/10.4161/mabs.2.3.11802","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.2.3.11802","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.2.3.11802?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2095784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2881258","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2881258","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2881258","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MAbs","raw_type":"Text"},{"id":"pmid:20431350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20431350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.4161/mabs.2.3.11802","doi":"https://doi.org/10.4161/mabs.2.3.11802","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.2.3.11802","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.2.3.11802?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3877609764","display_name":"GLYCOSYLATION AND ANTIBODY FUNCTION","funder_award_id":"R37AI029470","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G535917706","display_name":null,"funder_award_id":"AI51415","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G555736406","display_name":null,"funder_award_id":"AI29470","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6796219186","display_name":"MECHANISM OF ANTIBODY PROTECTION AGAINST C. NEOFORMANS","funder_award_id":"R01AI051415","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000409799.pdf","grobid_xml":"https://content.openalex.org/works/W2000409799.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W40840948","https://openalex.org/W139917636","https://openalex.org/W140302493","https://openalex.org/W1494640119","https://openalex.org/W1511743673","https://openalex.org/W1528669392","https://openalex.org/W1548459639","https://openalex.org/W1593975549","https://openalex.org/W1595328377","https://openalex.org/W1596234512","https://openalex.org/W1602390093","https://openalex.org/W1606557261","https://openalex.org/W1609910491","https://openalex.org/W1623853610","https://openalex.org/W1941487285","https://openalex.org/W1946778656","https://openalex.org/W1965998306","https://openalex.org/W1968187317","https://openalex.org/W1973283944","https://openalex.org/W1981886418","https://openalex.org/W1982131071","https://openalex.org/W1989728131","https://openalex.org/W1993024082","https://openalex.org/W2017344199","https://openalex.org/W2017515622","https://openalex.org/W2021442122","https://openalex.org/W2022564159","https://openalex.org/W2023654523","https://openalex.org/W2026103095","https://openalex.org/W2027491966","https://openalex.org/W2031807034","https://openalex.org/W2035433348","https://openalex.org/W2036610647","https://openalex.org/W2051133499","https://openalex.org/W2051666192","https://openalex.org/W2055455449","https://openalex.org/W2055507506","https://openalex.org/W2055585414","https://openalex.org/W2063353549","https://openalex.org/W2066735040","https://openalex.org/W2081935297","https://openalex.org/W2084672045","https://openalex.org/W2089574326","https://openalex.org/W2093638388","https://openalex.org/W2101160849","https://openalex.org/W2110562475","https://openalex.org/W2114571489","https://openalex.org/W2136078012","https://openalex.org/W2136482421","https://openalex.org/W2137354517","https://openalex.org/W2140035322","https://openalex.org/W2140702251","https://openalex.org/W2147483959","https://openalex.org/W2156500667","https://openalex.org/W2159768475","https://openalex.org/W2161464792","https://openalex.org/W2161622051","https://openalex.org/W7128166399"],"related_works":["https://openalex.org/W2141073877","https://openalex.org/W2613625247","https://openalex.org/W2089574326","https://openalex.org/W7110481061","https://openalex.org/W2413093586","https://openalex.org/W2991536560","https://openalex.org/W2614209313","https://openalex.org/W2133342941","https://openalex.org/W4226020346","https://openalex.org/W2055251699"],"abstract_inverted_index":{"The":[0,40],"development":[1],"and":[2,73,84,93,100,127,169,173,202],"production":[3,46,143,228],"of":[4,13,42,47,76,88,144,167,189,195,197,220,229],"recombinant":[5,24,48,81],"monoclonal":[6],"antibodies":[7,49],"is":[8,18,50,135],"well":[9],"established.":[10],"Although":[11],"most":[12],"these":[14],"are":[15,54,178],"IgGs,":[16],"there":[17],"also":[19],"great":[20],"interest":[21],"in":[22,33,90,108,116,118,151,171,180,184,200],"producing":[23],"IgAs":[25,106,149],"since":[26],"this":[27],"isotype":[28],"plays":[29],"a":[30,185],"critical":[31],"role":[32],"providing":[34],"immunologic":[35],"protection":[36],"at":[37,57],"mucosal":[38],"surfaces.":[39],"choice":[41],"expression":[43,139],"system":[44,140],"for":[45,141,212,226],"crucial":[51],"because":[52],"they":[53,120],"glycoproteins":[55,230],"containing":[56],"least":[58],"one":[59],"N-linked":[60,103],"carbohydrate.":[61],"These":[62,215],"glycans":[63,155],"have":[64,79],"been":[65],"shown":[66],"to":[67,69,97,160],"contribute":[68],"the":[70,102,122,137,142,193,218,222,227],"stability,":[71],"pharmacokinetics":[72],"biologic":[74],"function":[75],"antibodies.":[77],"We":[78],"produced":[80,107,150,199],"human":[82,145,164],"IgA1":[83,168],"all":[85],"three":[86],"allotypes":[87],"IgA2":[89,170],"murine":[91,109,133,201],"myeloma":[92,134],"CHO":[94,152,203],"cell":[95,175,224],"lines":[96,176],"systematically":[98],"characterize":[99],"compare":[101],"glycans.":[104],"Recombinant":[105],"myelomas":[110],"differ":[111],"significantly":[112,206],"from":[113],"IgA":[114],"found":[115,162],"humans":[117],"that":[119,132,156,177,209],"contain":[121],"highly":[123],"immunogenic":[124],"Galalpha(1,3)Gal":[125],"epitope":[126],"N-glycolylneuraminic":[128],"acid":[129],"residues,":[130],"indicating":[131],"not":[136],"optimal":[138],"IgA.":[146,165],"In":[147,191],"contrast,":[148],"cells":[153,204],"contained":[154],"were":[157],"more":[158],"similar":[159],"those":[161],"on":[163],"Expression":[166],"Lec2":[172],"Lec8":[174],"defective":[179],"glycan":[181],"processing":[182],"resulted":[183],"less":[186],"complex":[187],"pool":[188],"N-glycans.":[190],"addition,":[192],"level":[194],"sialylation":[196],"rIgAs":[198],"was":[205],"lower":[207],"than":[208],"previously":[210],"reported":[211],"serum":[213],"IgA1.":[214],"data":[216],"underscore":[217],"importance":[219],"choosing":[221],"appropriate":[223],"line":[225],"with":[231],"therapeutic":[232],"potential.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}