{"id":"https://openalex.org/W2000403281","doi":"https://doi.org/10.1113/jphysiol.1977.sp011969","title":"Effects of calcium and calcium\u2010chelating agents on the inward and outward current in the membrane of mollusc neurones","display_name":"Effects of calcium and calcium\u2010chelating agents on the inward and outward current in the membrane of mollusc neurones","publication_year":1977,"publication_date":"1977-09-01","ids":{"openalex":"https://openalex.org/W2000403281","doi":"https://doi.org/10.1113/jphysiol.1977.sp011969","mag":"2000403281","pmid":"https://pubmed.ncbi.nlm.nih.gov/409839","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1353532"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1977.sp011969","doi":"https://doi.org/10.1113/jphysiol.1977.sp011969","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1977.sp011969","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000403281"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1353532/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108443304","display_name":"Platon G. Kostyuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. G. Kostyuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035007018","display_name":"Oleg Krishtal","orcid":"https://orcid.org/0000-0003-3342-9930","observed_orcids":["https://orcid.org/0000-0003-3342-9930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. A. Krishtal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":4.9176,"has_fulltext":false,"cited_by_count":272,"citation_normalized_percentile":{"value":0.96612226,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"270","issue":"3","first_page":"569","last_page":"580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inward-calcium-current","display_name":"calcium inward current","score":0.8109999895095825},{"id":"https://openalex.org/keywords/inward-sodium-current","display_name":"sodium inward current","score":0.8790000081062317},{"id":"https://openalex.org/keywords/calcium-chelating-agents","display_name":"calcium chelating agents","score":0.8500000238418579},{"id":"https://openalex.org/keywords/egta","display_name":"EGTA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/edta","display_name":"EDTA","score":1.0},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7319999933242798},{"id":"https://openalex.org/keywords/helix-pomatia","display_name":"Helix pomatia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/divalent-cation-block","display_name":"divalent cation block","score":0.6019999980926514},{"id":"https://openalex.org/keywords/membrane-conductance","display_name":"membrane conductance","score":0.43799999356269836},{"id":"https://openalex.org/keywords/reversal-potential","display_name":"reversal potential","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.935680627822876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.769787073135376},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6813479661941528},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6662457585334778},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6397560238838196},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.6083559393882751},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.5929757356643677},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5598334670066833},{"id":"https://openalex.org/C2777959311","wikidata":"https://www.wikidata.org/wiki/Q245314","display_name":"Helix pomatia","level":3,"score":0.5183526277542114},{"id":"https://openalex.org/C121932024","wikidata":"https://www.wikidata.org/wiki/Q5159376","display_name":"Conductance","level":2,"score":0.42560291290283203},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.42065536975860596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26819396018981934},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.214176207780838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08853206038475037},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.06503280997276306},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012908","descriptor_name":"Snails","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1977.sp011969","doi":"https://doi.org/10.1113/jphysiol.1977.sp011969","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1977.sp011969","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:409839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/409839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1353532","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1353532/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1353532","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1353532/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2038060314","https://openalex.org/W2054609636","https://openalex.org/W2081299190","https://openalex.org/W2086341327","https://openalex.org/W2097141992","https://openalex.org/W2101204667","https://openalex.org/W2125809122","https://openalex.org/W2133400919","https://openalex.org/W2148071508"],"related_works":["https://openalex.org/W2410425768","https://openalex.org/W2148071508","https://openalex.org/W2081992116","https://openalex.org/W2076825161","https://openalex.org/W2008313132","https://openalex.org/W1975360971","https://openalex.org/W2127006674","https://openalex.org/W2092128480","https://openalex.org/W2011653733","https://openalex.org/W1979246811"],"abstract_inverted_index":{"1.":[0],"Effects":[1],"of":[2,36,45,74,83,90,110,122,136,154,158,189,215],"internal":[3,210,216],"and":[4,7,11,29,59,126,143,193],"external":[5,95],"Ca":[6,48,58,123,150,201,218],"Ca-chelating":[8],"agents,":[9],"EGTA":[10,39,53,97,155],"EDTA":[12],"on":[13,42,57,170],"transmembrane":[14],"ionic":[15],"currents":[16,62],"were":[17,139],"studied":[18],"in":[19,93,148,151,180],"isolated,":[20],"internally":[21,37],"dialysed":[22],"neurones":[23],"from":[24],"the":[25,43,66,81,88,94,108,128,152,159,171],"molluscs,":[26],"Helix":[27],"pomatia":[28],"Limnea":[30],"stagnalis.2.":[31],"The":[32,176],"possible":[33],"pharmacological":[34],"effect":[35,56,169,224],"applied":[38,102],"was":[40,225],"investigated":[41],"background":[44],"constant":[46],"free":[47,85,217],"concentration":[49],"(5.3":[50],"x":[51,213,235],"10(-9)M).":[52],"had":[54],"no":[55],"Na":[60,114,227],"inward":[61,115,124,202,228],"but":[63],"considerably":[64],"depressed":[65],"delayed":[67,172],"K":[68,173],"outward":[69,174],"current.":[70,175],"No":[71],"effective":[72],"removal":[73],"this":[75,181],"action":[76],"could":[77,183,230],"be":[78,184,231],"achieved":[79],"by":[80],"elevation":[82],"intracellular":[84,149,237],"Ca.3.":[86],"In":[87],"absence":[89,153],"divalent":[91],"cations":[92],"medium,":[96],"(as":[98],"well":[99],"as":[100,186],"EDTA)":[101],"either":[103],"intra-":[104],"or":[105],"extracellularly":[106],"caused":[107],"appearance":[109],"a":[111,187,194],"very":[112],"large":[113],"current":[116,125,182,203,229],"with":[117,127,161,233],"kinetics":[118],"similar":[119],"to":[120,196,209],"those":[121],"reversal":[129],"potential":[130],"around":[131],"10":[132],"mV.":[133],"Effective":[134],"concentrations":[135],"chelating":[137],"agents":[138],"0.1":[140],"mM":[141,145],"(extracellular)":[142],"1.0":[144],"(intracellular).4.":[146],"Increase":[147],"(by":[156],"dialysis":[157],"cell":[160],"Ca-saturated":[162],"solutions)":[163],"did":[164],"not":[165],"produce":[166],"any":[167],"significant":[168],"small":[177],"change":[178],"observed":[179],"evaluated":[185],"depression":[188],"maximum":[190],"slope":[191],"conductance":[192],"shift":[195],"more":[197],"negative":[198],"membrane":[199],"potential.5.":[200],"has":[204],"been":[205],"found":[206],"extremely":[207],"sensitive":[208],"Ca.":[211,238],"5.8":[212],"10(-8)M":[214],"produced":[219],"its":[220],"complete":[221],"depression.":[222],"This":[223],"reversible.":[226],"inhibited":[232],"3.5":[234],"10(-7)M":[236]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
