{"id":"https://openalex.org/W2000400976","doi":"https://doi.org/10.1021/bi00094a020","title":"Transcriptional regulation of the Xenopus laevis B.beta. fibrinogen subunit gene by glucocorticoids and hepatocyte nuclear factor 1: Analysis by transfection into primary liver cells","display_name":"Transcriptional regulation of the Xenopus laevis B.beta. fibrinogen subunit gene by glucocorticoids and hepatocyte nuclear factor 1: Analysis by transfection into primary liver cells","publication_year":1993,"publication_date":"1993-01-26","ids":{"openalex":"https://openalex.org/W2000400976","doi":"https://doi.org/10.1021/bi00094a020","mag":"2000400976","pmid":"https://pubmed.ncbi.nlm.nih.gov/8218230"},"language":"en","primary_location":{"id":"doi:10.1021/bi00094a020","doi":"https://doi.org/10.1021/bi00094a020","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00094a020","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038949267","display_name":"Lewis Rowland Roberts","orcid":"https://orcid.org/0000-0001-7885-8574","observed_orcids":["https://orcid.org/0000-0001-7885-8574"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis R. Roberts","raw_affiliation_strings":["Department of Physiology, University of Missouri School of Medicine, Columbia 65212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Missouri School of Medicine, Columbia 65212","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089092205","display_name":"LaNita A. Nichols","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LaNita A. Nichols","raw_affiliation_strings":["University of Missouri ***"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri ***","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111713135","display_name":"Len\u00e9 J. Holland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lene J. Holland","raw_affiliation_strings":["University of Missouri ***"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri ***","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2104,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.5155786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"32","issue":"43","first_page":"11627","last_page":"11637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.15139999985694885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.1348000019788742,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-response-element","display_name":"glucocorticoid response element","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hnf1","display_name":"HNF1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.7770000100135803},{"id":"https://openalex.org/keywords/acute-phase-response","display_name":"acute phase response","score":0.8999999761581421},{"id":"https://openalex.org/keywords/fibrinogen-gene","display_name":"fibrinogen gene","score":0.6010000109672546},{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/liver-parenchymal-cells","display_name":"liver parenchymal cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/promoter-analysis","display_name":"promoter analysis","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.6762704849243164},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6560163497924805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6458804607391357},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6424278616905212},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.5206736326217651},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.520241379737854},{"id":"https://openalex.org/C51445715","wikidata":"https://www.wikidata.org/wiki/Q410477","display_name":"Hormone response element","level":5,"score":0.49031856656074524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4837096333503723},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.46865788102149963},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.46450871229171753},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11138841509819031},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.06633317470550537},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005345","descriptor_name":"Fibrinopeptide B","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005345","descriptor_name":"Fibrinopeptide B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051537","descriptor_name":"Hepatocyte Nuclear Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051539","descriptor_name":"Hepatocyte Nuclear Factor 1-beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00094a020","doi":"https://doi.org/10.1021/bi00094a020","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00094a020","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:8218230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8218230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","score":0.4699999988079071,"display_name":"Life on land"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1927288202","display_name":null,"funder_award_id":"R01-HL39095","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3598630083","display_name":"COORDINATE HORMONAL REGULATION OF THE FIBRINOGEN GENES","funder_award_id":"5r01hl039095-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4499334211","display_name":null,"funder_award_id":"DK-25295","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7567427","display_name":"CORE CENTER--DIABETES AND ENDOCRINOLOGY","funder_award_id":"P30DK025295","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W46282188","https://openalex.org/W100376596","https://openalex.org/W123775848","https://openalex.org/W152758573","https://openalex.org/W204319588","https://openalex.org/W1454601853","https://openalex.org/W1520825376","https://openalex.org/W1541596961","https://openalex.org/W1559932979","https://openalex.org/W1574588787","https://openalex.org/W1585759343","https://openalex.org/W1601407886","https://openalex.org/W1890568935","https://openalex.org/W1900380445","https://openalex.org/W1939119178","https://openalex.org/W1968056160","https://openalex.org/W1976890364","https://openalex.org/W1980485056","https://openalex.org/W1997403350","https://openalex.org/W1998280478","https://openalex.org/W2001971013","https://openalex.org/W2004563262","https://openalex.org/W2006434949","https://openalex.org/W2027807422","https://openalex.org/W2031635601","https://openalex.org/W2035602674","https://openalex.org/W2039304335","https://openalex.org/W2041781038","https://openalex.org/W2049672602","https://openalex.org/W2055234379","https://openalex.org/W2055654988","https://openalex.org/W2056799965","https://openalex.org/W2060903877","https://openalex.org/W2062923310","https://openalex.org/W2066883428","https://openalex.org/W2068392981","https://openalex.org/W2071525868","https://openalex.org/W2073709405","https://openalex.org/W2075193060","https://openalex.org/W2077326676","https://openalex.org/W2080132636","https://openalex.org/W2085641449","https://openalex.org/W2087288778","https://openalex.org/W2093091064","https://openalex.org/W2097794242","https://openalex.org/W2099591248","https://openalex.org/W2099876496","https://openalex.org/W2100837269","https://openalex.org/W2112152786","https://openalex.org/W2125244583","https://openalex.org/W2129767309","https://openalex.org/W2135075343","https://openalex.org/W2170017199","https://openalex.org/W2180559065","https://openalex.org/W2341297973","https://openalex.org/W2409578345","https://openalex.org/W2419527889"],"related_works":["https://openalex.org/W2170017199","https://openalex.org/W1574588787","https://openalex.org/W2018499187","https://openalex.org/W1507917202","https://openalex.org/W4324114016","https://openalex.org/W4248190808","https://openalex.org/W2144086369","https://openalex.org/W2078001389","https://openalex.org/W2341297973","https://openalex.org/W2031635601"],"abstract_inverted_index":{"The":[0,256],"blood-clotting":[1],"protein":[2],"fibrinogen":[3,34,59,85,358],"is":[4,36,72],"composed":[5],"of":[6,22,27,32,56,115,151,166,203,208,223,251,303,352,355],"three":[7],"subunits,":[8],"designated":[9],"A":[10,98,232],"alpha,":[11],"B":[12,106,154,359],"beta,":[13],"and":[14,112,319,340],"gamma,":[15],"which":[16],"are":[17,349],"encoded":[18],"by":[19,42,87,142,300,307],"a":[20,176,220,261,269,291,294,301,331],"family":[21],"related":[23],"genes.":[24],"As":[25],"part":[26],"the":[28,33,40,46,66,73,84,104,116,122,148,152,179,209,224,229,246,249,252,265,287,320,346,356],"acute-phase":[29],"response,":[30,51],"expression":[31,137],"genes":[35,86],"coordinately":[37],"regulated":[38],"in":[39,75,244,286,290,363],"liver":[41,91,133,367],"glucocorticoids.":[43],"To":[44],"understand":[45],"factors":[47],"underlying":[48],"this":[49,127,196,214,317],"hormonal":[50],"we":[52,328],"have":[53,329],"examined":[54],"control":[55,354],"transcription":[57,109,271,321],"from":[58,65,325,365],"gene":[60,108,362],"fragments":[61,159],"transfected":[62,130],"into":[63,89,131],"hepatocytes":[64],"frog":[67],"Xenopus":[68,105,357],"laevis.":[69],"This":[70,173],"analysis":[71],"first":[74],"any":[76],"species":[77],"to":[78,121,147,188,200,239,264,281,334,345],"define":[79],"transcriptional":[80,149,353],"regulatory":[81,257],"elements":[82],"for":[83,268,336],"transfection":[88,99],"primary":[90,132],"cells,":[92,135],"rather":[93],"than":[94],"liver-derived":[95],"cell":[96],"lines.":[97],"vector":[100],"was":[101,129,138,217,241,309],"constructed":[102],"containing":[103,228,293],"beta":[107,155,360],"start":[110],"site":[111,267,318,343],"1293":[113],"bp":[114],"5'":[117],"flanking":[118],"sequence":[119,168,177,262],"linked":[120],"firefly":[123],"luciferase":[124,136],"gene.":[125,157],"When":[126],"construct":[128,292],"parenchymal":[134],"induced":[139],"approximately":[140],"14-fold":[141],"glucocorticoids,":[143],"an":[144,341],"increase":[145],"similar":[146,263],"stimulation":[150,306],"endogenous":[153],"subunit":[156,361],"DNA":[158],"with":[160,213,219],"as":[161,163],"little":[162],"284":[164],"bases":[165,186],"upstream":[167],"retained":[169],"full":[170,337],"hormone":[171,211],"responsiveness.":[172],"region":[174,258],"contains":[175],"resembling":[178],"canonical":[180],"glucocorticoid":[181,204,226,338],"response":[182],"element":[183],"(GRE)":[184],"at":[185,236,278],"-148":[187],"-162.":[189],"Deletions":[190],"or":[191,248],"specific":[192,314],"point":[193,284],"mutations":[194,285],"eliminating":[195],"putative":[197],"GRE":[198,216,235,332],"led":[199],"complete":[201],"loss":[202],"inducibility.":[205],"Physical":[206],"association":[207],"steroid":[210],"receptor":[212,227],"functional":[215],"demonstrated":[218],"truncated":[221],"form":[222],"rat":[225],"DNA-binding":[230],"domain.":[231],"second":[233],"possible":[234],"positions":[237,279],"-526":[238],"-540":[240],"not":[242],"hormone-responsive,":[243],"either":[245],"presence":[247],"absence":[250],"more":[253],"proximal":[254],"GRE.":[255],"also":[259],"has":[260],"binding":[266],"liver-specific":[270],"factor,":[272],"hepatocyte":[273],"nuclear":[274],"factor":[275,302,322],"1":[276],"(HNF-1),":[277],"-120":[280],"-132.":[282],"Specific":[283],"HNF-1-binding":[288],"site,":[289],"wild-type":[295],"GRE,":[296],"reduced":[297],"promoter":[298,347],"activity":[299],"10,":[304],"while":[305],"glucocorticoids":[308],"retained.":[310],"Binding":[311],"studies":[312],"confirmed":[313],"interaction":[315],"between":[316],"HNF-1":[323,342],"alpha":[324],"mouse.":[326],"Thus,":[327],"identified":[330],"sufficient":[333],"account":[335],"inducibility":[339],"close":[344],"that":[348],"major":[350],"determinants":[351],"cells":[364],"normal":[366],"tissue.":[368]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}