{"id":"https://openalex.org/W2000398692","doi":"https://doi.org/10.1016/j.biochi.2004.09.020","title":"The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering","display_name":"The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering","publication_year":2004,"publication_date":"2004-10-21","ids":{"openalex":"https://openalex.org/W2000398692","doi":"https://doi.org/10.1016/j.biochi.2004.09.020","mag":"2000398692","pmid":"https://pubmed.ncbi.nlm.nih.gov/15589687"},"language":"en","primary_location":{"id":"doi:10.1016/j.biochi.2004.09.020","doi":"https://doi.org/10.1016/j.biochi.2004.09.020","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biochi.2004.09.020","pdf_url":null,"source":{"id":"https://openalex.org/S75247133","display_name":"Biochimie","issn_l":"0037-9042","issn":["0037-9042","0300-9084","1638-6183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073333495","display_name":"Johnathan A. Napier","orcid":"https://orcid.org/0000-0003-3580-3607","observed_orcids":["https://orcid.org/0000-0003-3580-3607"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Johnathan A. Napier","raw_affiliation_strings":["Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK. johnathan.napier@bbsrc.ac.uk <johnathan.napier@bbsrc.ac.uk>","Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK. johnathan.napier@bbsrc.ac.uk <johnathan.napier@bbsrc.ac.uk>","institution_ids":["https://openalex.org/I2799553609"]},{"raw_affiliation_string":"Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007012556","display_name":"Fr\u00e9d\u00e9ric Beaudoin","orcid":"https://orcid.org/0000-0001-9847-3866","observed_orcids":["https://orcid.org/0000-0001-9847-3866"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Beaudoin","raw_affiliation_strings":["Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045946677","display_name":"Louise V. Michaelson","orcid":"https://orcid.org/0000-0001-5621-4495","observed_orcids":["https://orcid.org/0000-0001-5621-4495"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise V. Michaelson","raw_affiliation_strings":["Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032872461","display_name":"Olga V. Sayanova","orcid":"https://orcid.org/0000-0002-8484-2322","observed_orcids":["https://orcid.org/0000-0002-8484-2322"]},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olga Sayanova","raw_affiliation_strings":["Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK","institution_ids":["https://openalex.org/I2799553609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073333495"],"corresponding_institution_ids":["https://openalex.org/I2799553609"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.3654,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.22685185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"86","issue":"11","first_page":"785","last_page":"792"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-chain-polyunsaturated-fatty-acids","display_name":"long-chain polyunsaturated fatty acids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8769999742507935},{"id":"https://openalex.org/keywords/genetically-modified-plants","display_name":"transgenic plants","score":0.8669999837875366},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/reverse-engineering","display_name":"reverse engineering","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.5210000276565552},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.8903790712356567},{"id":"https://openalex.org/C3020382795","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Long chain","level":2,"score":0.6138188242912292},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5900148749351501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5048170685768127},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.4519091844558716},{"id":"https://openalex.org/C142796444","wikidata":"https://www.wikidata.org/wiki/Q181394","display_name":"Nutrient","level":2,"score":0.4116484820842743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3195542097091675},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23329228162765503},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.16529685258865356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14936408400535583},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.11284571886062622},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biochi.2004.09.020","doi":"https://doi.org/10.1016/j.biochi.2004.09.020","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biochi.2004.09.020","pdf_url":null,"source":{"id":"https://openalex.org/S75247133","display_name":"Biochimie","issn_l":"0037-9042","issn":["0037-9042","0300-9084","1638-6183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"journal-article"},{"id":"pmid:15589687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15589687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimie","raw_type":"Journal Article"},{"id":"pmh:oai:repository.rothamsted.ac.uk:89606","doi":null,"is_oa":false,"landing_page_url":"https://repository.rothamsted.ac.uk/item/89606/the-production-of-long-chain-polyunsaturated-fatty-acids-in-transgenic-plants-by-reverse-engineering","pdf_url":null,"source":{"id":"https://openalex.org/S4306402645","display_name":"Rothamsted Repository (Rothamsted Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799553609","host_organization_name":"Rothamsted Research","host_organization_lineage":["https://openalex.org/I2799553609"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6875},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3079645751","display_name":null,"funder_award_id":"BBS/E/C/00004156","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1941679825","https://openalex.org/W1966611297","https://openalex.org/W1972549325","https://openalex.org/W1983531379","https://openalex.org/W1984272301","https://openalex.org/W1986450487","https://openalex.org/W1990876848","https://openalex.org/W1991643570","https://openalex.org/W1996358681","https://openalex.org/W2002770328","https://openalex.org/W2007187686","https://openalex.org/W2012716766","https://openalex.org/W2022714377","https://openalex.org/W2024082478","https://openalex.org/W2026203662","https://openalex.org/W2026643194","https://openalex.org/W2029819513","https://openalex.org/W2030211358","https://openalex.org/W2032583718","https://openalex.org/W2033283286","https://openalex.org/W2046012971","https://openalex.org/W2053698594","https://openalex.org/W2057677845","https://openalex.org/W2061409430","https://openalex.org/W2063047536","https://openalex.org/W2077926859","https://openalex.org/W2081493241","https://openalex.org/W2082546405","https://openalex.org/W2085182901","https://openalex.org/W2087168928","https://openalex.org/W2088655445","https://openalex.org/W2102578839","https://openalex.org/W2102716658","https://openalex.org/W2107154530","https://openalex.org/W2109188497","https://openalex.org/W2117289446","https://openalex.org/W2117370193","https://openalex.org/W2137681900","https://openalex.org/W2140090951","https://openalex.org/W2143901058","https://openalex.org/W2174731688","https://openalex.org/W2192223169","https://openalex.org/W2403179797","https://openalex.org/W2490737437"],"related_works":["https://openalex.org/W2063325347","https://openalex.org/W1992300347","https://openalex.org/W2048546178","https://openalex.org/W2371488736","https://openalex.org/W1999842629","https://openalex.org/W7164015251","https://openalex.org/W1974234774","https://openalex.org/W2031579020","https://openalex.org/W1995273200","https://openalex.org/W2142038669"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}