{"id":"https://openalex.org/W2000392530","doi":"https://doi.org/10.1016/j.lfs.2009.02.024","title":"Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase","display_name":"Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase","publication_year":2009,"publication_date":"2009-03-05","ids":{"openalex":"https://openalex.org/W2000392530","doi":"https://doi.org/10.1016/j.lfs.2009.02.024","mag":"2000392530","pmid":"https://pubmed.ncbi.nlm.nih.gov/19268478"},"language":"en","primary_location":{"id":"doi:10.1016/j.lfs.2009.02.024","doi":"https://doi.org/10.1016/j.lfs.2009.02.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2009.02.024","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035656164","display_name":"Paul Caton","orcid":"https://orcid.org/0000-0003-0902-0676","observed_orcids":["https://orcid.org/0000-0003-0902-0676"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paul W. Caton","raw_affiliation_strings":["William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom. p.w.caton@qmul.ac.uk","William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom. p.w.caton@qmul.ac.uk","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028587307","display_name":"N.K. Nayuni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nanda K. Nayuni","raw_affiliation_strings":["William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033551763","display_name":"Oliver Murch","orcid":"https://orcid.org/0000-0003-1298-5647","observed_orcids":["https://orcid.org/0000-0003-1298-5647"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver Murch","raw_affiliation_strings":["William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053167522","display_name":"Roger Corder","orcid":"https://orcid.org/0000-0003-1712-6841","observed_orcids":["https://orcid.org/0000-0003-1712-6841"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger Corder","raw_affiliation_strings":["William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035656164"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":2.0822,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.87087017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"84","issue":"21-22","first_page":"738","last_page":"744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.3463999927043915,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.3463999927043915,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.10949999839067459,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.10000000149011612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hyperlactatemia","display_name":"hyperlactatemia","score":0.902999997138977},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":1.0},{"id":"https://openalex.org/keywords/phosphoenolpyruvate-carboxykinase","display_name":"phosphoenolpyruvate carboxykinase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pck2","display_name":"PCK2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pck1","display_name":"PCK1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitochondrial-enzyme-activity","display_name":"mitochondrial enzyme activity","score":0.5289999842643738},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6949999928474426},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.953000009059906},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/endotoxic-shock","display_name":"endotoxic shock","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C143937172","wikidata":"https://www.wikidata.org/wiki/Q303568","display_name":"Phosphoenolpyruvate carboxykinase","level":3,"score":0.9540284872055054},{"id":"https://openalex.org/C2909186138","wikidata":"https://www.wikidata.org/wiki/Q1500373","display_name":"Hyperlactatemia","level":2,"score":0.8542734384536743},{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.8238153457641602},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6557602286338806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6417653560638428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5495884418487549},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.46801695227622986},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.45242607593536377},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.43123891949653625},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3945658802986145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3235182464122772},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.20459088683128357},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.12776312232017517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10525229573249817}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010729","descriptor_name":"Phosphoenolpyruvate Carboxykinase (GTP)","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lfs.2009.02.024","doi":"https://doi.org/10.1016/j.lfs.2009.02.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2009.02.024","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:19268478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19268478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W101874289","https://openalex.org/W193452758","https://openalex.org/W1493756017","https://openalex.org/W1501595810","https://openalex.org/W1507096872","https://openalex.org/W1552399680","https://openalex.org/W1766088852","https://openalex.org/W1904168380","https://openalex.org/W1944071540","https://openalex.org/W1981071038","https://openalex.org/W1990025748","https://openalex.org/W2005093820","https://openalex.org/W2006111870","https://openalex.org/W2010921020","https://openalex.org/W2021211944","https://openalex.org/W2026562309","https://openalex.org/W2029378794","https://openalex.org/W2030012034","https://openalex.org/W2045101394","https://openalex.org/W2049395132","https://openalex.org/W2079411764","https://openalex.org/W2088928331","https://openalex.org/W2100459468","https://openalex.org/W2165059553","https://openalex.org/W2167914110","https://openalex.org/W2266427190","https://openalex.org/W2283639094","https://openalex.org/W2409299514","https://openalex.org/W4230408420","https://openalex.org/W4237147490"],"related_works":["https://openalex.org/W2082049884","https://openalex.org/W1944071540","https://openalex.org/W2416372589","https://openalex.org/W2396817814","https://openalex.org/W2074499136","https://openalex.org/W2030987469","https://openalex.org/W42487677","https://openalex.org/W2054407525","https://openalex.org/W99076639","https://openalex.org/W2002518095"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}