{"id":"https://openalex.org/W2000388690","doi":"https://doi.org/10.1002/ajim.22012","title":"GSTM1 and GSTP1 gene variants and the effect of air pollutants on lung function measures in South African children","display_name":"GSTM1 and GSTP1 gene variants and the effect of air pollutants on lung function measures in South African children","publication_year":2012,"publication_date":"2012-01-06","ids":{"openalex":"https://openalex.org/W2000388690","doi":"https://doi.org/10.1002/ajim.22012","mag":"2000388690","pmid":"https://pubmed.ncbi.nlm.nih.gov/22228263","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3414676"},"language":"en","primary_location":{"id":"doi:10.1002/ajim.22012","doi":"https://doi.org/10.1002/ajim.22012","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajim.22012","pdf_url":null,"source":{"id":"https://openalex.org/S109435702","display_name":"American Journal of Industrial Medicine","issn_l":"0271-3586","issn":["0271-3586","1097-0274"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Industrial Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000388690"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3414676","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011813250","display_name":"Poovendhree Reddy","orcid":"https://orcid.org/0000-0003-0197-8951","observed_orcids":["https://orcid.org/0000-0003-0197-8951"]},"institutions":[{"id":"https://openalex.org/I177181097","display_name":"Durban University of Technology","ror":"https://ror.org/0303y7a51","country_code":"ZA","type":"education","lineage":["https://openalex.org/I177181097"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Poovendhree Reddy","raw_affiliation_strings":["Department of Occupational and Environmental Health, University of KwaZulu-Natal, Durban, South Africa. poovier@dut.ac.za","Department of Community Health Studies, Durban University of Technology, P.O. Box 1334, Durban 4000, South Africa","Department of Occupational and Environmental Health, University of KwaZulu\u2010Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational and Environmental Health, University of KwaZulu-Natal, Durban, South Africa. poovier@dut.ac.za","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"Department of Community Health Studies, Durban University of Technology, P.O. Box 1334, Durban 4000, South Africa","institution_ids":["https://openalex.org/I177181097"]},{"raw_affiliation_string":"Department of Occupational and Environmental Health, University of KwaZulu\u2010Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089960536","display_name":"Rajen Nithiseelan Naidoo","orcid":"https://orcid.org/0000-0002-2318-4004","observed_orcids":["https://orcid.org/0000-0002-2318-4004"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Rajen N. Naidoo","raw_affiliation_strings":["Department of Occupational and Environmental Health, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational and Environmental Health, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090067059","display_name":"Thomas G. Robins","orcid":"https://orcid.org/0000-0003-3230-5143","observed_orcids":["https://orcid.org/0000-0003-3230-5143"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas G. Robins","raw_affiliation_strings":["Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051141125","display_name":"Graciela B. Mentz","orcid":"https://orcid.org/0000-0003-0501-3516","observed_orcids":["https://orcid.org/0000-0003-0501-3516"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graciela Mentz","raw_affiliation_strings":["Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387042","display_name":"Huiling Li","orcid":"https://orcid.org/0000-0001-9025-436X","observed_orcids":["https://orcid.org/0000-0001-9025-436X","https://orcid.org/0009-0000-4258-3054","https://orcid.org/0009-0002-2815-7598","https://orcid.org/0009-0008-8146-0207"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiling Li","raw_affiliation_strings":["Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, North Carolina,USA","Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, North Carolina,USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"raw_affiliation_string":"Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046527955","display_name":"Stephanie J. London","orcid":"https://orcid.org/0000-0003-4911-5290","observed_orcids":["https://orcid.org/0000-0003-4911-5290"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie J. London","raw_affiliation_strings":["Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052172551","display_name":"Stuart Batterman","orcid":"https://orcid.org/0000-0001-9894-5325","observed_orcids":["https://orcid.org/0000-0001-9894-5325"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Batterman","raw_affiliation_strings":["Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011813250"],"corresponding_institution_ids":["https://openalex.org/I177181097","https://openalex.org/I95023434"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.5699,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.77744776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"55","issue":"12","first_page":"1078","last_page":"1086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gstp1-ile105val-polymorphism","display_name":"GSTP1 Ile105Val polymorphism","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glutathione-s-transferase-genes","display_name":"glutathione S-transferase genes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.6579999923706055},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fev1-variability","display_name":"FEV1 variability","score":0.9120000004768372},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.7950000166893005},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.43700000643730164},{"id":"https://openalex.org/keywords/pm10","display_name":"PM10","score":0.7089999914169312},{"id":"https://openalex.org/keywords/sulfur-dioxide","display_name":"sulfur dioxide","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nitrogen-dioxide","display_name":"nitrogen dioxide","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7720000147819519},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7120000123977661},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5019999742507935},{"id":"https://openalex.org/keywords/south-africa","display_name":"South Africa","score":0.597000002861023},{"id":"https://openalex.org/keywords/durban","display_name":"Durban","score":0.9409999847412109},{"id":"https://openalex.org/keywords/african-children","display_name":"African children","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2780122483","wikidata":"https://www.wikidata.org/wiki/Q18026593","display_name":"GSTP1","level":4,"score":0.925618588924408},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7302858829498291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7196211218833923},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6719042062759399},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.49208778142929077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4866083860397339},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4723029136657715},{"id":"https://openalex.org/C2776907368","wikidata":"https://www.wikidata.org/wiki/Q307302","display_name":"Glutathione S-transferase","level":4,"score":0.44640445709228516},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41341355443000793},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3321189284324646},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32787972688674927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22405096888542175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1651495099067688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10484716296195984},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09653991460800171}],"mesh":[{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004784","descriptor_name":"Environmental Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051549","descriptor_name":"Glutathione S-Transferase pi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/ajim.22012","doi":"https://doi.org/10.1002/ajim.22012","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajim.22012","pdf_url":null,"source":{"id":"https://openalex.org/S109435702","display_name":"American Journal of Industrial Medicine","issn_l":"0271-3586","issn":["0271-3586","1097-0274"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Industrial Medicine","raw_type":"journal-article"},{"id":"pmid:22228263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22228263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of industrial medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2829432","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3414676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3414676","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3414676/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Ind Med","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/94468","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/94468","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2829432","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3414676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1542366308","display_name":"A Regional Southern African Program in Environmental & Occupational Health","funder_award_id":"D43TW000812","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G5812725563","display_name":"Genetic And Environmental Factors In Childhood Respiratory Health","funder_award_id":"Z01ES049019","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8038390384","display_name":"Genetic Analyses For Epidemiologic Studies Of Respiratory Disease","funder_award_id":"Z01ES025045","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000914956","display_name":"Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)","funder_award_id":"P30ES017885","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320309965","display_name":"Durban University of Technology","ror":"https://ror.org/0303y7a51"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000388690.pdf","grobid_xml":"https://content.openalex.org/works/W2000388690.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1557004738","https://openalex.org/W1698280398","https://openalex.org/W1973063537","https://openalex.org/W1987396961","https://openalex.org/W2000416469","https://openalex.org/W2005266450","https://openalex.org/W2016504119","https://openalex.org/W2033051199","https://openalex.org/W2059410642","https://openalex.org/W2070661470","https://openalex.org/W2076143421","https://openalex.org/W2076691186","https://openalex.org/W2079855907","https://openalex.org/W2082942401","https://openalex.org/W2101306218","https://openalex.org/W2103354423","https://openalex.org/W2106245415","https://openalex.org/W2109865874","https://openalex.org/W2113612251","https://openalex.org/W2117138142","https://openalex.org/W2120971774","https://openalex.org/W2126848032","https://openalex.org/W2135432052","https://openalex.org/W2140993050","https://openalex.org/W2157427270","https://openalex.org/W2467957237","https://openalex.org/W2477595020","https://openalex.org/W2604596332","https://openalex.org/W2607459644"],"related_works":["https://openalex.org/W2442373628","https://openalex.org/W2005119113","https://openalex.org/W1590570054","https://openalex.org/W2019671306","https://openalex.org/W2082942401","https://openalex.org/W2384100142","https://openalex.org/W2111641945","https://openalex.org/W3178827888","https://openalex.org/W2047490826","https://openalex.org/W2159898934"],"abstract_inverted_index":{"BACKGROUND:":[0],"Several":[1],"genes":[2,20],"are":[3],"associated":[4,216,231,343],"with":[5,184,217,233,344],"an":[6,77,337],"increased":[7,267],"susceptibility":[8],"to":[9,36,60,205,292,318,335,340],"asthma,":[10,186],"which":[11,31],"may":[12,32],"be":[13],"exacerbated":[14],"by":[15,41],"ambient":[16,65,316],"air":[17,42,66],"pollution.":[18],"These":[19],"include":[21],"GSTM1":[22,96,157,209],"(glutathione-S-transferase":[23,28],"M1":[24],"gene)":[25],"and":[26,71,101,116,160,187,198,266,320,322],"GSTP1":[27,102,164,211,254,310,346],"P1":[29],"gene),":[30],"modulate":[33],"the":[34,50,151,156,163,257,295,309,313,345],"response":[35,339],"epithelial":[37],"oxidative":[38,341],"changes":[39],"caused":[40],"pollutant":[43],"exposure.":[44],"This":[45],"study":[46],"evaluated":[47],"fluctuations":[48],"in":[49,54,58,132,143,182,240,243],"forced":[51],"expiratory":[52],"volume":[53],"one":[55],"second":[56],"(FEV(1))":[57],"relation":[59],"lagged":[61,276],"daily":[62,138],"averages":[63],"of":[64,84,87,145,175,193,259,287,315],"pollutants":[67,289],"(SO(2),":[68],"NO(2),":[69,114],"NO,":[70,115],"PM(10))":[72],"while":[73],"considering":[74],"genotype":[75,159,255,311],"as":[76],"effect":[78,258],"modifier.":[79],"METHODS:":[80],"A":[81,270,325],"longitudinal":[82],"cohort":[83],"129":[85],"schoolchildren":[86],"African":[88,306],"descent":[89],"from":[90],"Durban,":[91],"South":[92,305],"Africa":[93],"was":[94,129,228,273],"assessed.":[95],"(null":[97],"vs.":[98],"present":[99],"genotype)":[100],"(Ile105Val;":[103],"AA":[104],"\u2192":[105],"AG/GG)":[106],"genotypes":[107,212],"were":[108,118,136,201,214,290],"determined":[109],"using":[110,124],"standard":[111],"techniques.":[112],"SO(2),":[113],"PM(10)":[117,197,265,319],"measured":[119],"continuously":[120],"over":[121,139],"a":[122,140,188],"year":[123],"validated":[125],"methods.":[126],"The":[127,253],"outcome":[128],"intraday":[130,219,241],"variability":[131,227,242],"FEV(1)":[133,218,226,268],".":[134],"Data":[135],"collected":[137],"3-week":[141],"period":[142],"each":[144],"four":[146],"seasons":[147],"(2004-2005).":[148],"RESULTS:":[149],"Among":[150,302],"children":[152,171,307],"tested,":[153],"27%":[154],"had":[155],"null":[158],"81%":[161],"carried":[162],"G":[165,296],"allele.":[166],"Approximately":[167],"26":[168],"out":[169],"104":[170],"(25%)":[172],"showed":[173],"evidence":[174],"bronchial":[176],"hyperreactivity,":[177],"13%":[178],"reported":[179,191],"having":[180],"symptoms":[181,192],"keeping":[183],"persistent":[185],"further":[189],"25%":[190],"mild":[194],"intermittent":[195],"asthma.":[196],"SO(2)":[199,279,321],"levels":[200],"moderately":[202],"high":[203],"relative":[204],"international":[206],"guidelines.":[207],"Neither":[208],"nor":[210],"alone":[213],"significantly":[215,230],"variability.":[220,269],"In":[221],"models":[222],"not":[223],"including":[224],"genotype,":[225],"statistically":[229],"only":[232],"NO(2)":[234],"for":[235,275,298,328],"5-day":[236],"lags":[237],"(%":[238],"change":[239],"FEV1":[244],"per":[245],"interquartile":[246],"range":[247],"=":[248],"1.59,":[249],"CI":[250],"0.58,":[251],"2.61).":[252],"modified":[256,312],"3":[260,277],"days":[261],"prior":[262],"24-hr":[263],"average":[264],"similar":[271],"pattern":[272],"observed":[274,330],"day":[278],"exposure":[280],"(P":[281],"interaction":[282],"<":[283],"0.05).":[284],"Adverse":[285],"effects":[286,314,331],"these":[288,329],"limited":[291],"individuals":[293],"carrying":[294],"allele":[297],"this":[299,303],"polymorphism.":[300],"CONCLUSION:":[301],"indigenous":[304],"cohort,":[308],"exposures":[317],"lung":[323],"function.":[324],"plausible":[326],"mechanism":[327],"is":[332],"decreased":[333],"capacity":[334],"mount":[336],"effective":[338],"stress":[342],"AG":[347],"+":[348],"GG":[349],"genotype.":[350]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
