{"id":"https://openalex.org/W2000384489","doi":"https://doi.org/10.1165/ajrcmb/6.3.287","title":"Changes in Neutrophil Deformability following In Vitro Smoke Exposure: Mechanism and Protection","display_name":"Changes in Neutrophil Deformability following In Vitro Smoke Exposure: Mechanism and Protection","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W2000384489","doi":"https://doi.org/10.1165/ajrcmb/6.3.287","mag":"2000384489","pmid":"https://pubmed.ncbi.nlm.nih.gov/1311595"},"language":"en","primary_location":{"id":"doi:10.1165/ajrcmb/6.3.287","doi":"https://doi.org/10.1165/ajrcmb/6.3.287","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb/6.3.287","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113683691","display_name":"Ellen Drost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"E. M. Drost","raw_affiliation_strings":["Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland","institution_ids":["https://openalex.org/I2800666604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112091603","display_name":"C. Selby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Selby","raw_affiliation_strings":["Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland","institution_ids":["https://openalex.org/I2800666604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077003861","display_name":"S Lannan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Lannan","raw_affiliation_strings":["Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland","institution_ids":["https://openalex.org/I2800666604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107392792","display_name":"Gordon D O Lowe","orcid":"https://orcid.org/0000-0001-6365-7243","observed_orcids":["https://orcid.org/0000-0001-6365-7243","https://orcid.org/0000-0001-7566-7166"]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. D. O. Lowe","raw_affiliation_strings":["Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland","institution_ids":["https://openalex.org/I2800666604"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050425677","display_name":"William MacNee","orcid":"https://orcid.org/0000-0002-3692-1448","observed_orcids":["https://orcid.org/0000-0002-3692-1448"]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. MacNee","raw_affiliation_strings":["Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Respiratory Medicine, Rayne Laboratory, Department of Medicine, City Hospital, Edinburgh, and the Department of Medicine, Royal Infirmary, Glasgow, Scotland","institution_ids":["https://openalex.org/I2800666604"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113683691"],"corresponding_institution_ids":["https://openalex.org/I2800666604"],"apc_list":null,"apc_paid":null,"fwci":2.8996,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.91820105,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6","issue":"3","first_page":"287","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.12150000035762787,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-deformability","display_name":"neutrophil deformability","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.9390000104904175},{"id":"https://openalex.org/keywords/filtration-pressure","display_name":"filtration pressure","score":0.7459999918937683},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8740000128746033},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hypochlorous-acid","display_name":"hypochlorous acid","score":0.859000027179718},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cytochalasin-b","display_name":"cytochalasin B","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cd18","display_name":"CD18","score":0.7049999833106995},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.4399999976158142},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8679999709129333},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6792767643928528},{"id":"https://openalex.org/C2780908991","wikidata":"https://www.wikidata.org/wiki/Q407318","display_name":"Hypochlorous acid","level":2,"score":0.5939798355102539},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5221264958381653},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5015900135040283},{"id":"https://openalex.org/C2779964046","wikidata":"https://www.wikidata.org/wiki/Q209286","display_name":"Dichlorofluorescein","level":3,"score":0.465027779340744},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45005369186401367},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.40458303689956665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3708241879940033},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32655805349349976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1723347306251526},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010947","descriptor_name":"Plants, Toxic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1165/ajrcmb/6.3.287","doi":"https://doi.org/10.1165/ajrcmb/6.3.287","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb/6.3.287","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:1311595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1311595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W128635731","https://openalex.org/W1563659500","https://openalex.org/W1592252967","https://openalex.org/W1685470201","https://openalex.org/W1917280457","https://openalex.org/W1942150919","https://openalex.org/W1964598295","https://openalex.org/W1974540875","https://openalex.org/W1981361599","https://openalex.org/W1988158019","https://openalex.org/W1997820336","https://openalex.org/W2005167009","https://openalex.org/W2011965985","https://openalex.org/W2026737749","https://openalex.org/W2029615573","https://openalex.org/W2030448944","https://openalex.org/W2039978832","https://openalex.org/W2045281985","https://openalex.org/W2046258570","https://openalex.org/W2053753468","https://openalex.org/W2054370905","https://openalex.org/W2056242904","https://openalex.org/W2066712278","https://openalex.org/W2068877172","https://openalex.org/W2075970765","https://openalex.org/W2103334964","https://openalex.org/W2120940234","https://openalex.org/W2129039579","https://openalex.org/W2149861814","https://openalex.org/W2154563160","https://openalex.org/W2174292224","https://openalex.org/W2175612159","https://openalex.org/W2182102990","https://openalex.org/W2182425168","https://openalex.org/W2285903967","https://openalex.org/W2321320809","https://openalex.org/W2343553122","https://openalex.org/W2399263021","https://openalex.org/W2404188520","https://openalex.org/W2416965567","https://openalex.org/W2466250687","https://openalex.org/W2499112909","https://openalex.org/W2921152334"],"related_works":["https://openalex.org/W2027258163","https://openalex.org/W143696843","https://openalex.org/W3023571075","https://openalex.org/W2018703531","https://openalex.org/W2075970765","https://openalex.org/W2023862388","https://openalex.org/W2596661914","https://openalex.org/W1992707269","https://openalex.org/W2010078496","https://openalex.org/W7065525280"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"demonstrated":[3,71],"a":[4,26,79,209,220],"reduction":[5,60,80,136],"in":[6,17,61,74,81,106,137,145,149,159,257],"the":[7,36,48,56,59,89,93,100,129,135,157,169,172,184,200,204,213,224,237,252,255],"deformability":[8,195],"of":[9,35,51,58,92,125,171,186,203,212,254],"neutrophils,":[10,245],"exposed":[11,45],"to":[12,23,33,47,116,223,227],"whole":[13],"particulate":[14],"cigarette":[15,52],"smoke":[16,53,108,141,147,191,262],"vitro,":[18],"by":[19,154,163,168,241],"measuring":[20],"their":[21],"ability":[22],"filter":[24],"through":[25,196],"micropore":[27],"membrane":[28],"with":[29,85,219],"pore":[30],"dimensions":[31],"similar":[32],"those":[34],"average":[37],"pulmonary":[38],"capillary":[39],"segment.":[40],"In":[41],"this":[42,229],"study,":[43],"we":[44],"neutrophils":[46,67,70],"vapor":[49],"phase":[50],"and":[54,68,77,99,110,132,181],"investigated":[55],"mechanism":[57,253],"neutrophil":[62,194,231],"filterability.":[63],"Although":[64],"both":[65],"stimulated":[66,242],"smoke-exposed":[69,119,187,244],"an":[72,197],"increase":[73,158,256],"filtration":[75,160,238,258],"pressures,":[76,161],"thus":[78],"cell":[82,138],"deformability,":[83],"compared":[84],"control":[86],"untreated":[87],"cells,":[88,188],"spontaneous":[90],"release":[91],"reactive":[94],"oxygen":[95],"intermediates":[96],"hydrogen":[97],"peroxide":[98],"superoxide":[101],"anion":[102],"was":[103,112,152,250],"depressed":[104],"following":[105,140,261],"vitro":[107,146],"exposure":[109],"there":[111],"no":[113,216],"shape":[114],"change":[115,193],"suggest":[117],"that":[118,144,190,247],"cells":[120],"were":[121],"activated.":[122],"The":[123,176],"presence":[124],"erythrocytes,":[126],"plasma,":[127],"or":[128,243],"antioxidants":[130],"albumin":[131],"glutathione":[133],"prevented":[134],"filterability":[139,185],"exposure,":[142,148],"suggesting":[143,189,246],"our":[150],"system,":[151],"mediated":[153],"oxidants.":[155],"Indeed,":[156],"produced":[162],"smoke,":[164],"could":[165],"be":[166],"mimicked":[167],"addition":[170],"oxidant":[173],"hypochlorous":[174],"acid.":[175],"cytoskeletal":[177],"inhibitors":[178],"cytochalasin":[179],"B":[180],"D":[182],"improved":[183],"may":[192],"effect":[198],"on":[199],"actin":[201],"component":[202],"cytoskeleton.":[205],"By":[206],"contrast,":[207],"colchicine,":[208],"specific":[210],"inhibitor":[211],"microtubules,":[214],"had":[215],"effect.":[217],"Preincubation":[218],"monoclonal":[221],"antibody":[222],"CD18":[225],"antigen,":[226],"block":[228],"major":[230],"adhesive":[232],"glycoprotein,":[233],"did":[234],"not":[235,251],"alter":[236],"pressure":[239],"developed":[240],"increased":[248],"adhesivity":[249],"pressures":[259],"observed":[260],"exposure.(ABSTRACT":[263],"TRUNCATED":[264],"AT":[265],"250":[266],"WORDS)":[267]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
