{"id":"https://openalex.org/W2000381222","doi":"https://doi.org/10.1021/nl0345668","title":"Initiating Conformation Transitions of Individual YOYO-Intercalated DNA Molecules with Optical Trapping","display_name":"Initiating Conformation Transitions of Individual YOYO-Intercalated DNA Molecules with Optical Trapping","publication_year":2003,"publication_date":"2003-09-11","ids":{"openalex":"https://openalex.org/W2000381222","doi":"https://doi.org/10.1021/nl0345668","mag":"2000381222"},"language":"en","primary_location":{"id":"doi:10.1021/nl0345668","doi":"https://doi.org/10.1021/nl0345668","is_oa":false,"landing_page_url":"https://doi.org/10.1021/nl0345668","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071050301","display_name":"Christopher L. Kuyper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Kuyper","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, Washington 98195-1700"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, Washington 98195-1700","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005351692","display_name":"Greg P. Brewood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg P. Brewood","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, Washington 98195-1700"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, Washington 98195-1700","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035797201","display_name":"Daniel T. Chiu","orcid":"https://orcid.org/0000-0003-2964-9578","observed_orcids":["https://orcid.org/0000-0003-2964-9578"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel T. Chiu","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, Washington 98195-1700"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, Washington 98195-1700","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8043,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.67467512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"10","first_page":"1387","last_page":"1389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.37040001153945923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.37040001153945923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.3109999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.21549999713897705,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yoyo-1","display_name":"YOYO-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dna-intercalation","display_name":"DNA intercalation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dna-condensation","display_name":"DNA condensation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dna-conformational-change","display_name":"DNA conformational change","score":0.7099999785423279},{"id":"https://openalex.org/keywords/single-molecule-dna-mechanics","display_name":"single-molecule DNA mechanics","score":0.6010000109672546},{"id":"https://openalex.org/keywords/optical-trapping","display_name":"optical trapping","score":0.796999990940094},{"id":"https://openalex.org/keywords/lambda-dna","display_name":"lambda DNA","score":0.5419999957084656},{"id":"https://openalex.org/keywords/single-molecule-force-spectroscopy","display_name":"single-molecule force spectroscopy","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C142372107","wikidata":"https://www.wikidata.org/wiki/Q309871","display_name":"pUC19","level":4,"score":0.7933849692344666},{"id":"https://openalex.org/C137824038","wikidata":"https://www.wikidata.org/wiki/Q175562","display_name":"Intercalation (chemistry)","level":2,"score":0.7428373098373413},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.7357584238052368},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6884649395942688},{"id":"https://openalex.org/C2777924906","wikidata":"https://www.wikidata.org/wiki/Q34168","display_name":"Trapping","level":2,"score":0.543847382068634},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4789193868637085},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4738357961177826},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.4520074427127838},{"id":"https://openalex.org/C20198109","wikidata":"https://www.wikidata.org/wiki/Q1066633","display_name":"Optical tweezers","level":2,"score":0.4501698315143585},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.436272531747818},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4070419669151306},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3945189416408539},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3667104244232178},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.18240034580230713},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16398701071739197},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.08968314528465271},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0852404534816742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07551151514053345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/nl0345668","doi":"https://doi.org/10.1021/nl0345668","is_oa":false,"landing_page_url":"https://doi.org/10.1021/nl0345668","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1660481570","https://openalex.org/W1681122864","https://openalex.org/W1970300629","https://openalex.org/W1998606660","https://openalex.org/W2009439307","https://openalex.org/W2013635888","https://openalex.org/W2018545954","https://openalex.org/W2025560515","https://openalex.org/W2028029982","https://openalex.org/W2028930321","https://openalex.org/W2043951259","https://openalex.org/W2069759058","https://openalex.org/W2090864621","https://openalex.org/W2104672342","https://openalex.org/W4233309778"],"related_works":["https://openalex.org/W1967052828","https://openalex.org/W2743236013","https://openalex.org/W2120702604","https://openalex.org/W2097131667","https://openalex.org/W2013635888","https://openalex.org/W2027737662","https://openalex.org/W2083287927","https://openalex.org/W2584014176","https://openalex.org/W2071888020","https://openalex.org/W2035352076"],"abstract_inverted_index":{"This":[0],"letter":[1],"reports":[2],"that":[3,55],"the":[4,83],"commonly":[5],"used":[6,80],"DNA":[7,25,90],"intercalator":[8],"dye":[9],"YOYO-1":[10],"can":[11,78],"act":[12],"as":[13],"a":[14,52,65],"condensing":[15],"agent":[16],"under":[17],"moderately":[18],"acidic":[19],"pH":[20],"conditions":[21],"(pH":[22],"5.7)":[23],"for":[24],"molecules":[26,73,91],"ranging":[27],"in":[28,57],"size":[29],"from":[30,59],"\u223c2.7":[31],"kbp":[32,36],"(pUC19)":[33],"to":[34,50,61,81],"\u223c105":[35],"(T5).":[37],"With":[38],"atomic":[39],"force":[40],"microscopy,":[41],"individual":[42],"YOYO-intercalated":[43],"\u03bb-DNA":[44],"condensates":[45],"(\u223c48.5":[46],"kbp)":[47],"were":[48],"shown":[49],"exhibit":[51],"toroidal":[53],"structure":[54],"ranged":[56],"diameter":[58],"100":[60],"150":[62],"nm":[63],"with":[64,92],"maximum":[66],"height":[67],"of":[68,86],"\u223c6":[69],"nm.":[70],"Once":[71],"these":[72],"are":[74],"compacted,":[75],"optical":[76],"trapping":[77],"be":[79],"initiate":[82],"conformational":[84],"transitions":[85],"such":[87],"single,":[88],"condensed":[89],"excellent":[93],"time":[94],"resolution.":[95]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}