{"id":"https://openalex.org/W2000368359","doi":"https://doi.org/10.1016/j.neo.2014.03.010","title":"SHOX2 Is a Direct miR-375 Target and a Novel Epithelial-to-Mesenchymal Transition Inducer in Breast Cancer Cells","display_name":"SHOX2 Is a Direct miR-375 Target and a Novel Epithelial-to-Mesenchymal Transition Inducer in Breast Cancer Cells","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2000368359","doi":"https://doi.org/10.1016/j.neo.2014.03.010","mag":"2000368359","pmid":"https://pubmed.ncbi.nlm.nih.gov/24746361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094831"},"language":"en","primary_location":{"id":"doi:10.1016/j.neo.2014.03.010","doi":"https://doi.org/10.1016/j.neo.2014.03.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2014.03.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558614000293/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1476558614000293/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058937668","display_name":"Sungguan Hong","orcid":"https://orcid.org/0000-0002-7144-6478","observed_orcids":["https://orcid.org/0000-0002-7144-6478"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sungguan Hong","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012803952","display_name":"Hyangsoon Noh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyangsoon Noh","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085519270","display_name":"Yong Teng","orcid":"https://orcid.org/0000-0002-1856-7289","observed_orcids":["https://orcid.org/0000-0002-1856-7289"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Teng","raw_affiliation_strings":["Cancer Center, Georgia Regents University, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057585738","display_name":"Jing Shao","orcid":"https://orcid.org/0000-0001-7573-9326","observed_orcids":["https://orcid.org/0000-0001-7573-9326"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Shao","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042240076","display_name":"Hina Rehmani","orcid":"https://orcid.org/0000-0003-2252-8976","observed_orcids":["https://orcid.org/0000-0003-2252-8976"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hina Rehmani","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University , Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051093403","display_name":"Han\u2010Fei Ding","orcid":"https://orcid.org/0000-0001-5702-3439","observed_orcids":["https://orcid.org/0000-0001-5702-3439"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han-Fei Ding","raw_affiliation_strings":["Cancer Center, Georgia Regents University, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050155862","display_name":"Zheng Dong","orcid":"https://orcid.org/0000-0003-3538-8095","observed_orcids":["https://orcid.org/0000-0003-3538-8095"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Dong","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108133583","display_name":"Shibing Su","orcid":"https://orcid.org/0000-0001-9127-7002","observed_orcids":["https://orcid.org/0000-0001-9127-7002"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-Bing Su","raw_affiliation_strings":["Research Center for Traditional Chinese Medicine Complexity System and E-institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Traditional Chinese Medicine Complexity System and E-institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061372791","display_name":"Huidong Shi","orcid":"https://orcid.org/0000-0003-1137-3390","observed_orcids":["https://orcid.org/0000-0003-1137-3390"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huidong Shi","raw_affiliation_strings":["Cancer Center, Georgia Regents University, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072202064","display_name":"Jaejik Kim","orcid":"https://orcid.org/0000-0002-5964-0876","observed_orcids":["https://orcid.org/0000-0002-5964-0876"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaejik Kim","raw_affiliation_strings":["Department of Biostatistics, Georgia Regents University, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100765273","display_name":"Shuang Huang","orcid":"https://orcid.org/0000-0002-9674-2249","observed_orcids":["https://orcid.org/0000-0002-9674-2249"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Shuang Huang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA; Research Center for Traditional Chinese Medicine Complexity System and E-institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: shuang@gru.edu","Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","Research Center for Traditional Chinese Medicine Complexity System and E-institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA; Research Center for Traditional Chinese Medicine Complexity System and E-institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: shuang@gru.edu","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210098460"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Research Center for Traditional Chinese Medicine Complexity System and E-institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100765273"],"corresponding_institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210098460"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":{"value":3530,"currency":"USD","value_usd":3530},"fwci":3.5092,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.93547733,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"16","issue":"4","first_page":"279","last_page":"290.e5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shox2","display_name":"SHOX2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-375","display_name":"miR-375","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9760000109672546},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tgf-beta-type-i-receptor","display_name":"TGF-beta type I receptor","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.875},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.7960000038146973},{"id":"https://openalex.org/keywords/tumor-microarray","display_name":"tumor microarray","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.7916880249977112},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7760599255561829},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6717588901519775},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6089363694190979},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5720245838165283},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5282615423202515},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.518552839756012},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49392348527908325},{"id":"https://openalex.org/C2778893926","wikidata":"https://www.wikidata.org/wiki/Q575849","display_name":"Twist transcription factor","level":5,"score":0.4232408106327057},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3384077847003937},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3103915750980377},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.17622950673103333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09174445271492004},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07911142706871033}],"mesh":[{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neo.2014.03.010","doi":"https://doi.org/10.1016/j.neo.2014.03.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2014.03.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558614000293/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4094831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094831","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"Text"},{"id":"pmid:24746361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24746361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0756d293bf014f40b287d04e98a20c4b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0756d293bf014f40b287d04e98a20c4b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 4, Pp 279-290.e5 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neo.2014.03.010","doi":"https://doi.org/10.1016/j.neo.2014.03.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2014.03.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558614000293/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4399999976158142,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1608837221","display_name":"Role of SHOX2 in breast tumor progression and metastasis","funder_award_id":"R01CA187152","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1705489360","display_name":null,"funder_award_id":"E03008","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G2103328663","display_name":null,"funder_award_id":"E 03008","funder_id":"https://openalex.org/F4320334955","funder_display_name":"E-Institutes of Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G4732140698","display_name":"MAPK-activated protein kinase 2 regulation of endothelial cell migration","funder_award_id":"R01HL083335","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6644248876","display_name":null,"funder_award_id":"HL083335","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334955","display_name":"E-Institutes of Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000368359.pdf","grobid_xml":"https://content.openalex.org/works/W2000368359.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1206967436","https://openalex.org/W1588961760","https://openalex.org/W1964081206","https://openalex.org/W1972383046","https://openalex.org/W1975874715","https://openalex.org/W1976324983","https://openalex.org/W1984960456","https://openalex.org/W1986936614","https://openalex.org/W1991480775","https://openalex.org/W1996628512","https://openalex.org/W2002418457","https://openalex.org/W2004102172","https://openalex.org/W2005451662","https://openalex.org/W2025355337","https://openalex.org/W2026570544","https://openalex.org/W2044073319","https://openalex.org/W2044110125","https://openalex.org/W2047061331","https://openalex.org/W2050817299","https://openalex.org/W2076583198","https://openalex.org/W2084613660","https://openalex.org/W2089737806","https://openalex.org/W2104989160","https://openalex.org/W2111548566","https://openalex.org/W2113860186","https://openalex.org/W2114639059","https://openalex.org/W2125120607","https://openalex.org/W2150380366","https://openalex.org/W2151209374","https://openalex.org/W2158062858","https://openalex.org/W2163199119","https://openalex.org/W2167691689"],"related_works":["https://openalex.org/W3196684755","https://openalex.org/W3188283582","https://openalex.org/W2332696917","https://openalex.org/W2566940970","https://openalex.org/W2595718592","https://openalex.org/W2068914230","https://openalex.org/W1994374023","https://openalex.org/W2549691860","https://openalex.org/W7099260538","https://openalex.org/W3084600513"],"abstract_inverted_index":{"MicroRNAs":[0],"have":[1],"added":[2],"a":[3,49,97,168],"new":[4],"dimension":[5],"to":[6,100],"our":[7],"understanding":[8],"of":[9,149,171],"tumorigenesis":[10],"and":[11,30,52,110,144],"associated":[12],"processes":[13],"like":[14],"epithelial-to-mesenchymal":[15],"transition":[16],"(EMT).":[17],"Here,":[18],"we":[19],"show":[20,92],"that":[21,93,122,155],"miR-375":[22,32,50],"is":[23,128],"elevated":[24],"in":[25,36,55,69,80,136,141,145,173],"epithelial-like":[26,70],"breast":[27,38,71,82,137,150,174],"cancer":[28,39,72,83,138],"cells,":[29,73,84],"ectopic":[31,118],"expression":[33,65,158],"suppresses":[34],"EMT":[35,56,68,78,89,115],"mesenchymal-like":[37,81],"cells.":[40],"We":[41,91],"identified":[42],"short":[43],"stature":[44],"homeobox":[45],"2":[46],"(SHOX2)":[47],"as":[48,87,96],"target,":[51],"miR-375-mediated":[53],"suppression":[54],"was":[57],"reversed":[58],"by":[59,117],"forced":[60],"SHOX2":[61,64,75,86,94,119,134,157,172],"expression.":[62],"Ectopic":[63],"can":[66],"induce":[67],"whereas":[74],"knockdown":[76],"diminishes":[77],"traits":[79],"demonstrating":[85],"an":[88],"inducer.":[90],"acts":[95],"transcription":[98],"factor":[99,104,125],"upregulate":[101],"transforming":[102,123],"growth":[103,124],"\u03b2":[105,126],"receptor":[106],"I":[107],"(T\u03b2R-I)":[108],"expression,":[109,120],"T\u03b2R-I":[111],"inhibitor":[112],"LY364947":[113],"abolishes":[114],"elicited":[116],"suggesting":[121],"signaling":[127],"essential":[129],"for":[130],"SHOX2-induced":[131],"EMT.":[132],"Manipulating":[133],"abundance":[135],"cells":[139],"impact":[140],"vitro":[142],"invasion":[143],"vivo":[146],"dissemination.":[147],"Analysis":[148],"tumor":[151],"microarray":[152],"database":[153],"revealed":[154],"high":[156],"significantly":[159],"correlates":[160],"with":[161],"poor":[162],"patient":[163],"survival.":[164],"Our":[165],"study":[166],"supports":[167],"critical":[169],"role":[170],"tumorigenicity.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
