{"id":"https://openalex.org/W2000368193","doi":"https://doi.org/10.1016/j.ijrobp.2007.08.034","title":"Synergistic Tumor-Killing Effect of Radiation and Berberine Combined Treatment in Lung Cancer: The Contribution of Autophagic Cell Death","display_name":"Synergistic Tumor-Killing Effect of Radiation and Berberine Combined Treatment in Lung Cancer: The Contribution of Autophagic Cell Death","publication_year":2008,"publication_date":"2008-01-20","ids":{"openalex":"https://openalex.org/W2000368193","doi":"https://doi.org/10.1016/j.ijrobp.2007.08.034","mag":"2000368193","pmid":"https://pubmed.ncbi.nlm.nih.gov/18207031"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2007.08.034","doi":"https://doi.org/10.1016/j.ijrobp.2007.08.034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2007.08.034","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039119278","display_name":"Pei-Ling Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129936","display_name":"Taichung Hospital","ror":"https://ror.org/03ky42c33","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210129936"]},{"id":"https://openalex.org/I4210158931","display_name":"Taichung Armed Forces General Hospital","ror":"https://ror.org/04nx04y60","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158931"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-ling Peng","raw_affiliation_strings":["Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan","Division of Gastroenterology, Armed Forces Taichung Hospital, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]},{"raw_affiliation_string":"Division of Gastroenterology, Armed Forces Taichung Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210129936","https://openalex.org/I4210158931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102713783","display_name":"Wu\u2010Hsien Kuo","orcid":"https://orcid.org/0000-0002-6147-2015","observed_orcids":["https://orcid.org/0000-0002-6147-2015"]},"institutions":[{"id":"https://openalex.org/I4210129936","display_name":"Taichung Hospital","ror":"https://ror.org/03ky42c33","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210129936"]},{"id":"https://openalex.org/I4210158931","display_name":"Taichung Armed Forces General Hospital","ror":"https://ror.org/04nx04y60","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158931"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wu-Hsien Kuo","raw_affiliation_strings":["Division of Gastroenterology, Armed Forces Taichung Hospital, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Armed Forces Taichung Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210129936","https://openalex.org/I4210158931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008525045","display_name":"Hsien\u2010Chun Tseng","orcid":"https://orcid.org/0000-0002-4742-3057","observed_orcids":["https://orcid.org/0000-0002-4742-3057"]},"institutions":[{"id":"https://openalex.org/I4210104362","display_name":"Chung Shan Medical University Hospital","ror":"https://ror.org/01abtsn51","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210104362"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsien-Chun Tseng","raw_affiliation_strings":["Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056725777","display_name":"Fen\u2010Pi Chou","orcid":"https://orcid.org/0000-0003-2731-6884","observed_orcids":["https://orcid.org/0000-0003-2731-6884"]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Fen-Pi Chou","raw_affiliation_strings":["Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056725777"],"corresponding_institution_ids":["https://openalex.org/I91279580"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":5.1355,"has_fulltext":false,"cited_by_count":141,"citation_normalized_percentile":{"value":0.95145161,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"70","issue":"2","first_page":"529","last_page":"542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":1.0},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/autophagic-cell-death","display_name":"autophagic cell death","score":0.8899999856948853},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.7160000205039978},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8880000114440918},{"id":"https://openalex.org/keywords/lewis-lung-carcinoma","display_name":"Lewis lung carcinoma","score":0.7210000157356262},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.9395669102668762},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.5862494707107544},{"id":"https://openalex.org/C2776428644","wikidata":"https://www.wikidata.org/wiki/Q2126468","display_name":"Radiosensitizer","level":3,"score":0.560163140296936},{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.5405229330062866},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5324496030807495},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.5232428908348083},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5122267603874207},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5091428160667419},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4953121244907379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4626089036464691},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.429445743560791},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3787058889865875},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3369569778442383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28909116983413696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2578815221786499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16894152760505676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10867619514465332},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000165","descriptor_name":"Acridine Orange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D024161","descriptor_name":"Collagen Type XI","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijrobp.2007.08.034","doi":"https://doi.org/10.1016/j.ijrobp.2007.08.034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2007.08.034","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},{"id":"pmid:18207031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18207031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation oncology, biology, physics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W46693493","https://openalex.org/W1498088147","https://openalex.org/W1789901929","https://openalex.org/W1911902119","https://openalex.org/W1989016316","https://openalex.org/W1999150533","https://openalex.org/W2005142336","https://openalex.org/W2020830322","https://openalex.org/W2030997110","https://openalex.org/W2033428403","https://openalex.org/W2067356165","https://openalex.org/W2067706443","https://openalex.org/W2070172183","https://openalex.org/W2075065864","https://openalex.org/W2103782088","https://openalex.org/W2121546200","https://openalex.org/W2132850522","https://openalex.org/W2141140178","https://openalex.org/W2144687501","https://openalex.org/W2145653040","https://openalex.org/W2146127756","https://openalex.org/W2146860811","https://openalex.org/W2151766741","https://openalex.org/W2152452482","https://openalex.org/W2157053804","https://openalex.org/W2161234475","https://openalex.org/W2162113821","https://openalex.org/W2167907490","https://openalex.org/W2407635548","https://openalex.org/W2416055129","https://openalex.org/W2464898134","https://openalex.org/W4252116727","https://openalex.org/W6647565378"],"related_works":["https://openalex.org/W3081032924","https://openalex.org/W2299146779","https://openalex.org/W2024898949","https://openalex.org/W1999146290","https://openalex.org/W2000036013","https://openalex.org/W2100336633","https://openalex.org/W2089459111","https://openalex.org/W7203775324","https://openalex.org/W2412950622","https://openalex.org/W4385359322"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
