{"id":"https://openalex.org/W2000366122","doi":"https://doi.org/10.1074/jbc.m604847200","title":"Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity","display_name":"Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity","publication_year":2006,"publication_date":"2006-09-02","ids":{"openalex":"https://openalex.org/W2000366122","doi":"https://doi.org/10.1074/jbc.m604847200","mag":"2000366122","pmid":"https://pubmed.ncbi.nlm.nih.gov/16950786"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m604847200","doi":"https://doi.org/10.1074/jbc.m604847200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m604847200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m604847200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032989576","display_name":"Hester A. Doyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hester A. Doyle","raw_affiliation_strings":["Yale University School of Medicine, New Haven, CT 06520, USA","#N#        Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"#N#        Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031106926","display_name":"Jing Zhou","orcid":"https://orcid.org/0000-0001-6601-4446","observed_orcids":["https://orcid.org/0000-0001-6601-4446"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Zhou","raw_affiliation_strings":["Yale University School of Medicine, New Haven, Connecticut 06520","#N#        Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"#N#        Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024478900","display_name":"Martin J. Wolff","orcid":"https://orcid.org/0000-0003-4391-2395","observed_orcids":["https://orcid.org/0000-0003-4391-2395"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J. Wolff","raw_affiliation_strings":["Yale University School of Medicine, New Haven, Connecticut 06520","#N#        Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"#N#        Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050301543","display_name":"Bohdan P. Harvey","orcid":"https://orcid.org/0000-0001-8193-9340","observed_orcids":["https://orcid.org/0000-0001-8193-9340"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bohdan P. Harvey","raw_affiliation_strings":["Yale University School of Medicine, New Haven, Connecticut 06520","#N#        Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"#N#        Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040814353","display_name":"Robert M. Roman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Roman","raw_affiliation_strings":["Yale University School of Medicine, New Haven, Connecticut 06520","#N#        Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"#N#        Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052828735","display_name":"Renelle J. Gee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renelle J. Gee","raw_affiliation_strings":["Yale University School of Medicine, New Haven, Connecticut 06520","#N#        Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"#N#        Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027591123","display_name":"Raymond A. Koski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond A. Koski","raw_affiliation_strings":["L2 Diagnostics, New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L2 Diagnostics, New Haven, Connecticut 06511","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075811485","display_name":"Mark J. Mamula","orcid":"https://orcid.org/0000-0003-4822-2908","observed_orcids":["https://orcid.org/0000-0003-4822-2908"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark J. Mamula","raw_affiliation_strings":["Yale University School of Medicine, New Haven, Connecticut 06520","#N#        Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"#N#        Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075811485"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1282,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.76075136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"281","issue":"43","first_page":"32676","last_page":"32683"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.5649999976158142},{"id":"https://openalex.org/keywords/melanoma-antigens","display_name":"melanoma antigens","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tyrosinase-related-protein-2","display_name":"tyrosinase-related protein 2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cd8-t-cell-cytotoxicity","display_name":"CD8+ T cell cytotoxicity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5580000281333923},{"id":"https://openalex.org/keywords/b-cell-tolerance","display_name":"B cell tolerance","score":0.6639999747276306},{"id":"https://openalex.org/keywords/tetramer-analysis","display_name":"tetramer analysis","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6828354597091675},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.5697502493858337},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48812469840049744},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45761623978614807},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4416930079460144},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.4196878969669342},{"id":"https://openalex.org/C3017602531","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Lymphocyte activation","level":4,"score":0.4184715449810028},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4108186364173889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314655065536499},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.14683985710144043},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07039004564285278},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06130802631378174}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D026581","descriptor_name":"Isoaspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026581","descriptor_name":"Isoaspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026581","descriptor_name":"Isoaspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026581","descriptor_name":"Isoaspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D026581","descriptor_name":"Isoaspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D026581","descriptor_name":"Isoaspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m604847200","doi":"https://doi.org/10.1074/jbc.m604847200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m604847200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16950786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16950786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1074/jbc.m604847200","doi":"https://doi.org/10.1074/jbc.m604847200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m604847200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1338356861","display_name":"Isoaspartyl Modified Tumor Antigens for Vaccination","funder_award_id":"1r41ca101542-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G25744439","display_name":null,"funder_award_id":"AI48120","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G449924670","display_name":null,"funder_award_id":"CA 101542","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1493376557","https://openalex.org/W1511036913","https://openalex.org/W1512161029","https://openalex.org/W1545143289","https://openalex.org/W1563736533","https://openalex.org/W1646831595","https://openalex.org/W1847190381","https://openalex.org/W1972781750","https://openalex.org/W1980694300","https://openalex.org/W1983806918","https://openalex.org/W1992699637","https://openalex.org/W1994209619","https://openalex.org/W2015101596","https://openalex.org/W2015562865","https://openalex.org/W2031745114","https://openalex.org/W2036041717","https://openalex.org/W2041651596","https://openalex.org/W2051700627","https://openalex.org/W2053884582","https://openalex.org/W2063366729","https://openalex.org/W2066172817","https://openalex.org/W2088658776","https://openalex.org/W2092237412","https://openalex.org/W2098772563","https://openalex.org/W2103840609","https://openalex.org/W2105017308","https://openalex.org/W2106511557","https://openalex.org/W2124373740","https://openalex.org/W2125757318","https://openalex.org/W2131496660","https://openalex.org/W2142501626","https://openalex.org/W2157710456","https://openalex.org/W2169840688","https://openalex.org/W2169957856","https://openalex.org/W2176699929","https://openalex.org/W2403794702","https://openalex.org/W4249733227","https://openalex.org/W4293279301"],"related_works":["https://openalex.org/W2038485621","https://openalex.org/W2374224717","https://openalex.org/W2371113788","https://openalex.org/W2389664015","https://openalex.org/W2182027563","https://openalex.org/W1969503669","https://openalex.org/W1982188555","https://openalex.org/W1998818175","https://openalex.org/W2412998269","https://openalex.org/W2383302371"],"abstract_inverted_index":{"A":[0],"hallmark":[1],"of":[2,53,79],"the":[3,7,51,62,70,92,98],"immune":[4,17,37,134],"system":[5],"is":[6,39],"ability":[8],"to":[9,14,27,57,131,136],"ignore":[10],"self-antigens.":[11],"In":[12,49],"attempts":[13],"bypass":[15],"normal":[16],"tolerance,":[18],"a":[19,44],"post-translational":[20,125],"protein":[21,66,126],"modification":[22,127],"was":[23],"introduced":[24],"into":[25],"self-antigens":[26],"break":[28],"T":[29,87,104,109],"and":[30,121],"B":[31],"cell":[32],"tolerance.":[33],"We":[34],"demonstrate":[35],"that":[36,85],"tolerance":[38],"bypassed":[40],"by":[41],"immunization":[42],"with":[43],"post-translationally":[45],"modified":[46],"melanoma":[47,63],"antigen.":[48],"particular,":[50],"conversion":[52],"an":[54,58],"aspartic":[55],"acid":[56,60],"isoaspartic":[59],"within":[61],"antigen":[64,75],"tyrosinase-related":[65],"(TRP)-2":[67],"peptide-(181-188)":[68],"makes":[69],"otherwise":[71],"immunologically":[72],"ignored":[73],"TRP-2":[74,81,94,100,115],"immunogenic.":[76],"Tetramer":[77],"analysis":[78],"iso-Asp":[80],"peptide-immunized":[82],"mice":[83],"demonstrated":[84],"CD8+":[86,103],"cells":[88,105],"not":[89],"only":[90],"recognized":[91],"isoaspartyl":[93],"peptide":[95],"but":[96],"also":[97],"native":[99],"peptide.":[101],"These":[102],"functioned":[106],"as":[107,111],"cytotoxic":[108],"lymphocytes,":[110],"they":[112],"effectively":[113],"lysed":[114],"peptide-pulsed":[116],"targets":[117],"both":[118],"in":[119,122],"vitro":[120],"vivo.":[123],"Potentially,":[124],"can":[128],"be":[129],"utilized":[130],"trigger":[132],"strong":[133],"responses":[135],"either":[137],"tumor":[138],"proteins":[139],"or":[140],"potentially":[141],"weakly":[142],"immunogenic":[143],"pathogens.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
