{"id":"https://openalex.org/W2000363237","doi":"https://doi.org/10.1093/carcin/18.4.783","title":"Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks","display_name":"Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2000363237","doi":"https://doi.org/10.1093/carcin/18.4.783","mag":"2000363237","pmid":"https://pubmed.ncbi.nlm.nih.gov/9111215"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/18.4.783","doi":"https://doi.org/10.1093/carcin/18.4.783","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/18.4.783","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067957789","display_name":"Hao Le Thi Hong","orcid":"https://orcid.org/0000-0003-2286-1461","observed_orcids":["https://orcid.org/0000-0003-2286-1461"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. Hong","raw_affiliation_strings":["Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research, Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research, Triangle Park, NC 27709, USA","institution_ids":["https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067957789"],"corresponding_institution_ids":["https://openalex.org/I4210095140"],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":0.8492,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71865291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"4","first_page":"783","last_page":"789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoprene","display_name":"isoprene","score":0.9309999942779541},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hras-mutation","display_name":"HRAS mutation","score":1.0},{"id":"https://openalex.org/keywords/1-3-butadiene","display_name":"1,3-butadiene","score":0.8410000205039978},{"id":"https://openalex.org/keywords/inhalation-carcinogenesis","display_name":"inhalation carcinogenesis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4359999895095825},{"id":"https://openalex.org/keywords/b6c3f1-mice","display_name":"B6C3F1 mice","score":0.7900000214576721},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2780959689","wikidata":"https://www.wikidata.org/wiki/Q271943","display_name":"Isoprene","level":4,"score":0.9081473350524902},{"id":"https://openalex.org/C2780915157","wikidata":"https://www.wikidata.org/wiki/Q12490552","display_name":"Harderian gland","level":2,"score":0.6529161930084229},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6258046627044678},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6192662119865417},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5673158764839172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4644045829772949},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.4216090440750122},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4169890880584717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3869168162345886},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2565091848373413},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2509305477142334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24057766795158386},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002070","descriptor_name":"Butadienes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006243","descriptor_name":"Harderian Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010420","descriptor_name":"Pentanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045782","descriptor_name":"Hemiterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/18.4.783","doi":"https://doi.org/10.1093/carcin/18.4.783","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/18.4.783","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:9111215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9111215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091542561","https://openalex.org/W2148808138","https://openalex.org/W2128816697","https://openalex.org/W2435830210","https://openalex.org/W7100213497","https://openalex.org/W2138256438","https://openalex.org/W7099786280","https://openalex.org/W2093269827","https://openalex.org/W1969962763","https://openalex.org/W1974150942"],"abstract_inverted_index":{"Isoprene":[0],"is":[1],"the":[2,65,125,211,221,231,266],"2-methyl":[3],"analog":[4],"of":[5,45,87,98,104,124,145,160,191,210,265],"1,3-butadiene,":[6],"a":[7,38],"genotoxic":[8],"and":[9,14,67,76,84,154,157,170,200,263],"carcinogenic":[10],"compound":[11],"in":[12,64,70,74,107,113,117,143,158,176,182,217,230],"rats":[13],"mice.":[15],"Male":[16],"B6C3F1":[17,166],"mice":[18,151,167],"were":[19,78,141,215],"exposed":[20,150],"to":[21,60,253,276],"0,":[22],"2200":[23,222],"or":[24,119,133,184,240],"7000":[25,232],"ppm":[26,223,233],"isoprene":[27],"by":[28,80],"inhalation":[29],"(6":[30],"h/day;":[31],"5":[32],"days/week)":[33],"for":[34],"26":[35],"weeks.":[36],"Following":[37],"26-week":[39],"recovery":[40],"period,":[41],"an":[42,244],"increased":[43],"incidence":[44],"Harderian":[46],"gland":[47],"(HG)":[48],"neoplasms":[49,115,128,147,162,219,237,256],"was":[50,58,111,228],"observed":[51],"at":[52,195,204],"both":[53],"concentrations.":[54],"The":[55,173,260],"present":[56,229],"study":[57],"designed":[59],"characterize":[61],"genetic":[62],"alterations":[63],"K-ras":[66,75,109,131,153,169,196,212,239],"H-ras":[68,77,134,205,241],"protooncogenes":[69],"HG":[71,99,121,127,146,161,178,188,218,236,255,278],"neoplasms.":[72,100,122],"Mutations":[73],"identified":[79],"single-strand":[81],"conformational":[82],"analysis":[83],"direct":[85],"sequencing":[86],"polymerase":[88],"chain":[89],"reaction":[90],"(PCR)":[91],"amplified":[92],"DNA,":[93],"isolated":[94],"from":[95,148,164,220],"paraffin-embedded":[96],"sections":[97],"A":[101],"higher":[102],"frequency":[103,262],"ras":[105,139,258,267,272],"mutations,":[106,110],"particular":[108],"detected":[112,142,216],"isoprene-induced":[114,126,177,277],"than":[116],"1,3-butadiene-induced":[118,187],"control":[120,165],"All":[123],"exhibited":[129],"activated":[130],"(60%)":[132],"(40%)":[135],"mutations.":[136,259],"In":[137],"contrast,":[138],"mutations":[140,175,214,242],"69%":[144],"1,3-butadiene":[149],"(14%":[152],"55%":[155],"H-ras)":[156],"56%":[159],"obtained":[163],"(8%":[168],"48%":[171],"H-ras).":[172],"predominant":[174],"neoplasms,":[179,189],"but":[180],"not":[181],"previously":[183],"newly":[185],"analysed":[186],"consisted":[190],"A-->T":[192],"transversions":[193,202],"(CAA-->CTA)":[194],"codon":[197,206],"61":[198,207],"(15/30)":[199],"C-->A":[201],"(CAA-->AAA)":[203],"(8/30).":[208],"Two-thirds":[209],"CTA":[213],"exposure":[224],"group":[225],"while":[226],"one-third":[227],"group.":[234],"Isoprene-induced":[235],"with":[238],"had":[243],"elevated":[245],"proliferating":[246],"cell":[247],"nuclear":[248],"antigen":[249],"(PCNA)":[250],"index,":[251],"compared":[252],"spontaneous":[254],"without":[257],"high":[261],"specificity":[264],"mutation":[268],"profile":[269],"suggest":[270],"that":[271],"protooncogene":[273],"activation":[274],"contributes":[275],"tumorigenesis.":[279]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
