{"id":"https://openalex.org/W2000355855","doi":"https://doi.org/10.1021/ac8005318","title":"Orthogonal Projections to Latent Structures Discriminant Analysis Modeling on in Situ FT-IR Spectral Imaging of Liver Tissue for Identifying Sources of Variability","display_name":"Orthogonal Projections to Latent Structures Discriminant Analysis Modeling on in Situ FT-IR Spectral Imaging of Liver Tissue for Identifying Sources of Variability","publication_year":2008,"publication_date":"2008-08-20","ids":{"openalex":"https://openalex.org/W2000355855","doi":"https://doi.org/10.1021/ac8005318","mag":"2000355855","pmid":"https://pubmed.ncbi.nlm.nih.gov/18714965"},"language":"en","primary_location":{"id":"doi:10.1021/ac8005318","doi":"https://doi.org/10.1021/ac8005318","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac8005318","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035554566","display_name":"Hans C. Stenlund","orcid":"https://orcid.org/0000-0001-9943-296X","observed_orcids":["https://orcid.org/0000-0001-9943-296X"]},"institutions":[{"id":"https://openalex.org/I4210120671","display_name":"Ume\u00e5 Plant Science Centre","ror":"https://ror.org/02ehp0f77","country_code":"SE","type":"facility","lineage":["https://openalex.org/I298625061","https://openalex.org/I4210120671","https://openalex.org/I90267481"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hans Stenlund","raw_affiliation_strings":["Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I4210120671","https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021463634","display_name":"Andr\u00e1s Gorzs\u00e1s","orcid":"https://orcid.org/0000-0002-2298-8844","observed_orcids":["https://orcid.org/0000-0002-2298-8844"]},"institutions":[{"id":"https://openalex.org/I4210120671","display_name":"Ume\u00e5 Plant Science Centre","ror":"https://ror.org/02ehp0f77","country_code":"SE","type":"facility","lineage":["https://openalex.org/I298625061","https://openalex.org/I4210120671","https://openalex.org/I90267481"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andr\u00e1s Gorzs\u00e1s","raw_affiliation_strings":["Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I4210120671","https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036143020","display_name":"Per Persson","orcid":"https://orcid.org/0000-0001-9172-3068","observed_orcids":["https://orcid.org/0000-0001-9172-3068"]},"institutions":[{"id":"https://openalex.org/I4210120671","display_name":"Ume\u00e5 Plant Science Centre","ror":"https://ror.org/02ehp0f77","country_code":"SE","type":"facility","lineage":["https://openalex.org/I298625061","https://openalex.org/I4210120671","https://openalex.org/I90267481"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Persson","raw_affiliation_strings":["Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden","External Organization - Unknown"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I4210120671","https://openalex.org/I90267481"]},{"raw_affiliation_string":"External Organization - Unknown","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002039438","display_name":"Bj\u00f6rn Sundberg","orcid":"https://orcid.org/0000-0003-1801-3873","observed_orcids":["https://orcid.org/0000-0003-1801-3873"]},"institutions":[{"id":"https://openalex.org/I4210120671","display_name":"Ume\u00e5 Plant Science Centre","ror":"https://ror.org/02ehp0f77","country_code":"SE","type":"facility","lineage":["https://openalex.org/I298625061","https://openalex.org/I4210120671","https://openalex.org/I90267481"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Sundberg","raw_affiliation_strings":["Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I4210120671","https://openalex.org/I90267481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001681126","display_name":"Johan Trygg","orcid":"https://orcid.org/0000-0003-3799-6094","observed_orcids":["https://orcid.org/0000-0003-3799-6094"]},"institutions":[{"id":"https://openalex.org/I4210120671","display_name":"Ume\u00e5 Plant Science Centre","ror":"https://ror.org/02ehp0f77","country_code":"SE","type":"facility","lineage":["https://openalex.org/I298625061","https://openalex.org/I4210120671","https://openalex.org/I90267481"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Johan Trygg","raw_affiliation_strings":["Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Life Science Cluster (CLIC), KBC, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden, and Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish Agricultural University, SE-901 83 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I4210120671","https://openalex.org/I90267481"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001681126"],"corresponding_institution_ids":["https://openalex.org/I4210120671","https://openalex.org/I90267481"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.137,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.93389961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"80","issue":"18","first_page":"6898","last_page":"6906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.2741999924182892,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opls-da","display_name":"OPLS-DA","score":0.9520000219345093},{"id":"https://openalex.org/keywords/liver-tissue","display_name":"liver tissue","score":0.7919999957084656},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5220000147819519},{"id":"https://openalex.org/keywords/source-variability","display_name":"sources of variation","score":0.621999979019165},{"id":"https://openalex.org/keywords/edge-effects","display_name":"edge effects","score":0.7570000290870667},{"id":"https://openalex.org/keywords/spectral-normalization","display_name":"spectral normalization","score":0.7440000176429749},{"id":"https://openalex.org/keywords/proteins","display_name":"proteins","score":0.5609999895095825},{"id":"https://openalex.org/keywords/lipids","display_name":"lipids","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amide-i-region","display_name":"amide I region","score":0.8379999995231628},{"id":"https://openalex.org/keywords/focal-plane-array-detector","display_name":"focal plane array detector","score":0.5680000185966492},{"id":"https://openalex.org/keywords/mouse-liver","display_name":"mouse liver","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7958551645278931},{"id":"https://openalex.org/C38660458","wikidata":"https://www.wikidata.org/wiki/Q7072834","display_name":"OPLS","level":4,"score":0.7838136553764343},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.674496591091156},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.5405352115631104},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.43785709142684937},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.4210149645805359},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.38371169567108154},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.36946749687194824},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3030042052268982},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1882774829864502},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.1867227554321289},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.12685582041740417},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119049451","wikidata":"https://www.wikidata.org/wiki/Q3318070","display_name":"Water model","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ac8005318","doi":"https://doi.org/10.1021/ac8005318","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac8005318","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:18714965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18714965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:ea1d8c3e-0623-4c2a-8535-4c3f69caade1","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/4332396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Analytical Chemistry; 80, pp 6898-6906 (2008)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1529290642","https://openalex.org/W1559442512","https://openalex.org/W1977448398","https://openalex.org/W2010365101","https://openalex.org/W2015670952","https://openalex.org/W2016090370","https://openalex.org/W2027757546","https://openalex.org/W2039692707","https://openalex.org/W2042810309","https://openalex.org/W2045125597","https://openalex.org/W2045407210","https://openalex.org/W2048778471","https://openalex.org/W2081083140","https://openalex.org/W2082784639","https://openalex.org/W2089210920","https://openalex.org/W2089468765","https://openalex.org/W2102667102","https://openalex.org/W2108488321","https://openalex.org/W2109606373","https://openalex.org/W2123727902","https://openalex.org/W2131668746","https://openalex.org/W2134130921","https://openalex.org/W2440612840"],"related_works":["https://openalex.org/W1949502573","https://openalex.org/W1894759300","https://openalex.org/W7099951244","https://openalex.org/W1973296843","https://openalex.org/W580142330","https://openalex.org/W3156549540","https://openalex.org/W3024638892","https://openalex.org/W2043880738","https://openalex.org/W2470769522","https://openalex.org/W2170047566"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"the":[3,17,75,87,132,137,162,170,183,189],"orthogonal":[4],"projections":[5],"to":[6,15,89,101,106,117,153,179,194,219],"latent":[7],"structures":[8],"discriminant":[9],"analysis":[10],"(OPLS-DA)":[11],"method":[12],"was":[13,115,151],"used":[14],"assess":[16],"in":[18,27,86,104,169,182],"situ":[19],"chemical":[20,120,133],"composition":[21],"of":[22,49,65,77,109,112,131,161,201,223,233],"two":[23,138],"different":[24,110,221],"cell":[25,94,102,139,154],"types":[26,140],"mouse":[28],"liver":[29],"samples,":[30],"hepatocytes":[31],"and":[32,122,144,165,227,229],"erythrocytes.":[33],"High":[34],"spatial":[35,63],"resolution":[36,64],"FT-IR":[37,208],"microspectroscopy":[38],"equipped":[39],"with":[40,60,83],"a":[41,61,158,180,199],"focal":[42],"plan":[43],"array":[44],"(FPA)":[45],"detector":[46],"is":[47,99],"capable":[48],"simultaneously":[50],"recording":[51],"over":[52],"4000":[53],"spectra":[54],"from":[55,96],"64":[56,58],"x":[57,69],"pixels":[59],"maximum":[62],"about":[66],"5":[67,70],"microm":[68],"microm,":[71],"which":[72],"allows":[73],"for":[74],"differentiation":[76],"individual":[78],"cells.":[79],"The":[80,147],"main":[81],"benefit":[82],"OPLS-DA":[84,114,128,214],"lies":[85],"ability":[88],"separate":[90],"predictive":[91,226],"variation":[92,97,149,164],"(between":[93],"type)":[95],"that":[98,135,150,197,213],"uncorrelated":[100,152],"type":[103,155],"order":[105],"facilitate":[107],"understanding":[108,232],"sources":[111,222],"variation.":[113],"able":[116],"differentiate":[118],"between":[119],"properties":[121,124],"physical":[123],"(e.g.,":[125],"edge":[126],"effects).":[127],"model":[129],"interpretation":[130],"features":[134],"separated":[136],"clearly":[141],"highlighted":[142],"proteins":[143],"lipids/bile":[145],"acids.":[146],"modeled":[148],"made":[156],"up":[157],"larger":[159],"portion":[160],"total":[163],"displayed":[166],"strong":[167],"variability":[168],"amide":[171],"I":[172],"region.":[173],"This":[174,211],"could":[175],"be":[176],"traced":[177],"back":[178],"gradient":[181],"high":[184],"intensity":[185,191],"(high-density)":[186],"areas":[187,192],"vs":[188],"low":[190],"(close":[193],"empty":[195],"areas)":[196],"as":[198],"result":[200],"normalization":[202],"had":[203],"an":[204,216],"adverse":[205],"effect":[206],"on":[207],"spectral":[209],"profiles.":[210],"highlights":[212],"provides":[215],"effective":[217],"solution":[218],"identify":[220],"variability,":[224],"both":[225],"uncorrelated,":[228],"also":[230],"facilitates":[231],"any":[234],"sampling,":[235],"experimental,":[236],"or":[237],"preprocessing":[238],"issues.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}