{"id":"https://openalex.org/W2000354010","doi":"https://doi.org/10.1186/1471-2199-10-26","title":"Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila","display_name":"Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila","publication_year":2009,"publication_date":"2009-03-26","ids":{"openalex":"https://openalex.org/W2000354010","doi":"https://doi.org/10.1186/1471-2199-10-26","mag":"2000354010","pmid":"https://pubmed.ncbi.nlm.nih.gov/19323841","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2676286"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2199-10-26","doi":"https://doi.org/10.1186/1471-2199-10-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2199-10-26","pdf_url":"https://bmcmolbiol.biomedcentral.com/counter/pdf/10.1186/1471-2199-10-26","source":{"id":"https://openalex.org/S73477903","display_name":"BMC Molecular Biology","issn_l":"1471-2199","issn":["1471-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bmcmolbiol.biomedcentral.com/counter/pdf/10.1186/1471-2199-10-26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015121912","display_name":"Sebastian Kurscheid","orcid":"https://orcid.org/0000-0002-4887-7480","observed_orcids":["https://orcid.org/0000-0002-4887-7480"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I4210120434","display_name":"Cooperative Research Centre for Beef Genetic Technologies","ror":"https://ror.org/032s9tg47","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210120434"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sebastian Kurscheid","raw_affiliation_strings":["Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia. skurscheid@ccg.murdoch.edu.au","Centre for Comparative Genomics (CCG), Murdoch University, , Australia","Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia. skurscheid@ccg.murdoch.edu.au","institution_ids":["https://openalex.org/I4210120434"]},{"raw_affiliation_string":"Centre for Comparative Genomics (CCG), Murdoch University, , Australia","institution_ids":["https://openalex.org/I176790772"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia","institution_ids":["https://openalex.org/I4210120434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028527931","display_name":"Ala E. Tabor","orcid":"https://orcid.org/0000-0001-7147-1078","observed_orcids":["https://orcid.org/0000-0001-7147-1078"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I4210120434","display_name":"Cooperative Research Centre for Beef Genetic Technologies","ror":"https://ror.org/032s9tg47","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210120434"]},{"id":"https://openalex.org/I4210164589","display_name":"Department of Primary Industries","ror":"https://ror.org/05s5aag36","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801244131","https://openalex.org/I4210164589"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Ala E Lew-Tabor","raw_affiliation_strings":["Centre for Comparative Genomics (CCG), Murdoch University, Perth Western Australia, 6150, Australia","Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","Department of Primary Industries and Fisheries, Emerging Technologies, Locked Mail Bag No. 4, Moorooka, 4105, Queensland, Australia","Centre for Comparative Genomics (CCG), Murdoch University, Australia","Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Comparative Genomics (CCG), Murdoch University, Perth Western Australia, 6150, Australia","institution_ids":["https://openalex.org/I176790772"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","institution_ids":["https://openalex.org/I4210120434"]},{"raw_affiliation_string":"Department of Primary Industries and Fisheries, Emerging Technologies, Locked Mail Bag No. 4, Moorooka, 4105, Queensland, Australia","institution_ids":["https://openalex.org/I4210164589"]},{"raw_affiliation_string":"Centre for Comparative Genomics (CCG), Murdoch University, Australia","institution_ids":["https://openalex.org/I176790772"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia","institution_ids":["https://openalex.org/I4210120434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038589898","display_name":"Manuel Rodriguez-Valle","orcid":"https://orcid.org/0000-0003-2304-8085","observed_orcids":["https://orcid.org/0000-0003-2304-8085","https://orcid.org/0000-0003-0502-9040"]},"institutions":[{"id":"https://openalex.org/I4210120434","display_name":"Cooperative Research Centre for Beef Genetic Technologies","ror":"https://ror.org/032s9tg47","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210120434"]},{"id":"https://openalex.org/I4210164589","display_name":"Department of Primary Industries","ror":"https://ror.org/05s5aag36","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801244131","https://openalex.org/I4210164589"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Manuel Rodriguez Valle","raw_affiliation_strings":["Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","Department of Primary Industries and Fisheries, Emerging Technologies, Locked Mail Bag No. 4, Moorooka, 4105, Queensland, Australia","Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","institution_ids":["https://openalex.org/I4210120434"]},{"raw_affiliation_string":"Department of Primary Industries and Fisheries, Emerging Technologies, Locked Mail Bag No. 4, Moorooka, 4105, Queensland, Australia","institution_ids":["https://openalex.org/I4210164589"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia","institution_ids":["https://openalex.org/I4210120434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044486625","display_name":"Anthea G. Bruyeres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120434","display_name":"Cooperative Research Centre for Beef Genetic Technologies","ror":"https://ror.org/032s9tg47","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210120434"]},{"id":"https://openalex.org/I4210164589","display_name":"Department of Primary Industries","ror":"https://ror.org/05s5aag36","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801244131","https://openalex.org/I4210164589"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthea G Bruyeres","raw_affiliation_strings":["Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","Department of Primary Industries and Fisheries, Emerging Technologies, Locked Mail Bag No. 4, Moorooka, 4105, Queensland, Australia","Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","institution_ids":["https://openalex.org/I4210120434"]},{"raw_affiliation_string":"Department of Primary Industries and Fisheries, Emerging Technologies, Locked Mail Bag No. 4, Moorooka, 4105, Queensland, Australia","institution_ids":["https://openalex.org/I4210164589"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia","institution_ids":["https://openalex.org/I4210120434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110192082","display_name":"Vivienne J. Doogan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120434","display_name":"Cooperative Research Centre for Beef Genetic Technologies","ror":"https://ror.org/032s9tg47","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210120434"]},{"id":"https://openalex.org/I4210164589","display_name":"Department of Primary Industries","ror":"https://ror.org/05s5aag36","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801244131","https://openalex.org/I4210164589"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Vivienne J Doogan","raw_affiliation_strings":["Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","Department of Primary Industries and Fisheries, Emerging Technologies, Locked Mail Bag No. 4, Moorooka, 4105, Queensland, Australia","Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","institution_ids":["https://openalex.org/I4210120434"]},{"raw_affiliation_string":"Department of Primary Industries and Fisheries, Emerging Technologies, Locked Mail Bag No. 4, Moorooka, 4105, Queensland, Australia","institution_ids":["https://openalex.org/I4210164589"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia","institution_ids":["https://openalex.org/I4210120434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089410308","display_name":"Ulrike G. Munderloh","orcid":"https://orcid.org/0000-0001-7935-2874","observed_orcids":["https://orcid.org/0000-0001-7935-2874"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulrike G Munderloh","raw_affiliation_strings":["Department of Entomology, University of Minnesota, St Paul, Minnesota, 55108, USA","Department of Entomology, University of Minnesota, St Paul, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomology, University of Minnesota, St Paul, Minnesota, 55108, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Entomology, University of Minnesota, St Paul, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113848802","display_name":"Felix David Guerrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210120434","display_name":"Cooperative Research Centre for Beef Genetic Technologies","ror":"https://ror.org/032s9tg47","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210120434"]},{"id":"https://openalex.org/I4210143518","display_name":"Knipling-Bushland U.S. Livestock Insects Research Laboratory","ror":"https://ror.org/0432sks47","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210143518","https://openalex.org/I4210145274"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Felix D Guerrero","raw_affiliation_strings":["Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","USDA-ARS, Knipling Bushland US Livestock Insect Research Laboratory, 2700 Fredericksburg Road, Kerrville, TX, 78028, USA","Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia","USDA-ARS, Knipling Bushland US Livestock Insect Research Laboratory, Kerrville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","institution_ids":["https://openalex.org/I4210120434"]},{"raw_affiliation_string":"USDA-ARS, Knipling Bushland US Livestock Insect Research Laboratory, 2700 Fredericksburg Road, Kerrville, TX, 78028, USA","institution_ids":["https://openalex.org/I4210143518"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia","institution_ids":["https://openalex.org/I4210120434"]},{"raw_affiliation_string":"USDA-ARS, Knipling Bushland US Livestock Insect Research Laboratory, Kerrville, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210143518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042291484","display_name":"Roberto A. Barrero","orcid":"https://orcid.org/0000-0002-7735-665X","observed_orcids":["https://orcid.org/0000-0002-7735-665X"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Roberto A Barrero","raw_affiliation_strings":["Centre for Comparative Genomics (CCG), Murdoch University, Perth Western Australia, 6150, Australia","Centre for Comparative Genomics (CCG), Murdoch University, , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Comparative Genomics (CCG), Murdoch University, Perth Western Australia, 6150, Australia","institution_ids":["https://openalex.org/I176790772"]},{"raw_affiliation_string":"Centre for Comparative Genomics (CCG), Murdoch University, , Australia","institution_ids":["https://openalex.org/I176790772"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044207304","display_name":"M. Bellgard","orcid":"https://orcid.org/0000-0002-6303-9469","observed_orcids":["https://orcid.org/0000-0002-6303-9469"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I4210120434","display_name":"Cooperative Research Centre for Beef Genetic Technologies","ror":"https://ror.org/032s9tg47","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210120434"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew I Bellgard","raw_affiliation_strings":["Centre for Comparative Genomics (CCG), Murdoch University, Perth Western Australia, 6150, Australia","Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","Centre for Comparative Genomics (CCG), Murdoch University, , Australia","Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Comparative Genomics (CCG), Murdoch University, Perth Western Australia, 6150, Australia","institution_ids":["https://openalex.org/I176790772"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia","institution_ids":["https://openalex.org/I4210120434"]},{"raw_affiliation_string":"Centre for Comparative Genomics (CCG), Murdoch University, , Australia","institution_ids":["https://openalex.org/I176790772"]},{"raw_affiliation_string":"Cooperative Research Centre for Beef Genetic Technologies, Armidale, Australia","institution_ids":["https://openalex.org/I4210120434"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5028527931"],"corresponding_institution_ids":["https://openalex.org/I176790772","https://openalex.org/I4210120434","https://openalex.org/I4210164589"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":5.093,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.95967385,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.03840000182390213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ticks","display_name":"ticks","score":0.4000000059604645},{"id":"https://openalex.org/keywords/rhipicephalus-microplus","display_name":"Rhipicephalus microplus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ixodes-scapularis","display_name":"Ixodes scapularis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dicer","display_name":"Dicer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/argonaute-2","display_name":"Argonaute 2","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fmrp","display_name":"FMRP","score":0.7979999780654907},{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dsrna-uptake","display_name":"dsRNA uptake","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tick-cell-culture","display_name":"tick cell culture","score":0.4690000116825104},{"id":"https://openalex.org/keywords/loss-of-function-screen","display_name":"loss-of-function screen","score":0.6600000262260437},{"id":"https://openalex.org/keywords/drosophila-homolog","display_name":"Drosophila homolog","score":0.8399999737739563},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.6650000214576721},{"id":"https://openalex.org/keywords/oviposition","display_name":"oviposition","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cattle-ticks","display_name":"cattle ticks","score":0.48899999260902405},{"id":"https://openalex.org/keywords/ectoparasites","display_name":"ectoparasites","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9468750953674316},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.9122203588485718},{"id":"https://openalex.org/C2781453105","wikidata":"https://www.wikidata.org/wiki/Q1497962","display_name":"Ixodes scapularis","level":4,"score":0.6139225959777832},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5621011257171631},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.5572858452796936},{"id":"https://openalex.org/C2779620486","wikidata":"https://www.wikidata.org/wiki/Q10304508","display_name":"Tick","level":2,"score":0.5152647495269775},{"id":"https://openalex.org/C149034497","wikidata":"https://www.wikidata.org/wiki/Q1384835","display_name":"Expressed sequence tag","level":4,"score":0.48955926299095154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4791780710220337},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4578378200531006},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.4513975977897644},{"id":"https://openalex.org/C2776566753","wikidata":"https://www.wikidata.org/wiki/Q2040501","display_name":"Rhipicephalus","level":3,"score":0.42504486441612244},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.31226491928100586},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.25935620069503784},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.24358725547790527},{"id":"https://openalex.org/C2776127032","wikidata":"https://www.wikidata.org/wiki/Q1429304","display_name":"Ixodidae","level":3,"score":0.10119384527206421}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010063","descriptor_name":"Ovum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034743","descriptor_name":"RNA-Induced Silencing Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039642","descriptor_name":"Eukaryotic Initiation Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048494","descriptor_name":"Rhipicephalus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048494","descriptor_name":"Rhipicephalus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1186/1471-2199-10-26","doi":"https://doi.org/10.1186/1471-2199-10-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2199-10-26","pdf_url":"https://bmcmolbiol.biomedcentral.com/counter/pdf/10.1186/1471-2199-10-26","source":{"id":"https://openalex.org/S73477903","display_name":"BMC Molecular Biology","issn_l":"1471-2199","issn":["1471-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Molecular Biology","raw_type":"journal-article"},{"id":"pmid:19323841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19323841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2676286","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2676286/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Mol Biol","raw_type":"Text"},{"id":"pmh:oai:alma.61MUN_INST:11136285990007891","doi":null,"is_oa":true,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Evidence-of-a-tick-RNAi-pathway/991005544117307891","pdf_url":"https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12136285980007891/13136773620007891","source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:eprints.qut.edu.au:125439","doi":null,"is_oa":true,"landing_page_url":"https://eprints.qut.edu.au/125439/1/31999267.pdf","pdf_url":"https://eprints.qut.edu.au/125439/1/31999267.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Molecular Biology","raw_type":"Contribution to Journal"},{"id":"pmh:oai:eprints.qut.edu.au:217468","doi":null,"is_oa":true,"landing_page_url":"https://eprints.qut.edu.au/217468/1/31999267.pdf","pdf_url":"https://eprints.qut.edu.au/217468/1/31999267.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Molecular Biology","raw_type":"Contribution to Journal"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/270664","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/270664","pdf_url":"http://hdl.handle.net/11343/270664","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:4900","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.murdoch.edu.au/id/eprint/4900/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7bef5461272745a3b4a2a95d584f8007","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7bef5461272745a3b4a2a95d584f8007","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Molecular Biology, Vol 10, Iss 1, p 26 (2009)","raw_type":"article"},{"id":"pmh:oai:era.daf.qld.gov.au:11595","doi":null,"is_oa":false,"landing_page_url":"http://era.daf.qld.gov.au/id/eprint/11595/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402393","display_name":"Queensland Department of Agriculture and Fisheries archive of scientific and research publications (Queensland Department of Agriculture and Fisheries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801244131","host_organization_name":"Queensland Government","host_organization_lineage":["https://openalex.org/I2801244131"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2199-10-26","doi":"https://doi.org/10.1186/1471-2199-10-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2199-10-26","pdf_url":"https://bmcmolbiol.biomedcentral.com/counter/pdf/10.1186/1471-2199-10-26","source":{"id":"https://openalex.org/S73477903","display_name":"BMC Molecular Biology","issn_l":"1471-2199","issn":["1471-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000354010.pdf","grobid_xml":"https://content.openalex.org/works/W2000354010.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1521518663","https://openalex.org/W1631037284","https://openalex.org/W1647075334","https://openalex.org/W1658308609","https://openalex.org/W1731647989","https://openalex.org/W1911112328","https://openalex.org/W1963828768","https://openalex.org/W1974482866","https://openalex.org/W1975060999","https://openalex.org/W1976342457","https://openalex.org/W1976679748","https://openalex.org/W1989454102","https://openalex.org/W1994709452","https://openalex.org/W2009945615","https://openalex.org/W2015178362","https://openalex.org/W2016589137","https://openalex.org/W2016838288","https://openalex.org/W2017733353","https://openalex.org/W2020850118","https://openalex.org/W2022366078","https://openalex.org/W2024725357","https://openalex.org/W2037880918","https://openalex.org/W2042176182","https://openalex.org/W2042931566","https://openalex.org/W2043244089","https://openalex.org/W2048975878","https://openalex.org/W2051529436","https://openalex.org/W2053781748","https://openalex.org/W2057558367","https://openalex.org/W2063225499","https://openalex.org/W2067044289","https://openalex.org/W2070564266","https://openalex.org/W2074106269","https://openalex.org/W2077293902","https://openalex.org/W2083144347","https://openalex.org/W2089988218","https://openalex.org/W2096590736","https://openalex.org/W2101252757","https://openalex.org/W2101543035","https://openalex.org/W2101728241","https://openalex.org/W2106882534","https://openalex.org/W2107277218","https://openalex.org/W2108787198","https://openalex.org/W2109425890","https://openalex.org/W2110429095","https://openalex.org/W2113150125","https://openalex.org/W2113668592","https://openalex.org/W2115171772","https://openalex.org/W2115228628","https://openalex.org/W2117648777","https://openalex.org/W2117991391","https://openalex.org/W2119195082","https://openalex.org/W2120805065","https://openalex.org/W2121360715","https://openalex.org/W2124791602","https://openalex.org/W2128140591","https://openalex.org/W2131957545","https://openalex.org/W2132767295","https://openalex.org/W2134038772","https://openalex.org/W2138708625","https://openalex.org/W2139122866","https://openalex.org/W2141652419","https://openalex.org/W2145043911","https://openalex.org/W2146138017","https://openalex.org/W2146839338","https://openalex.org/W2151831732","https://openalex.org/W2154166273","https://openalex.org/W2158714788","https://openalex.org/W2162824156","https://openalex.org/W2166676855","https://openalex.org/W2168051144","https://openalex.org/W2171893553","https://openalex.org/W2242059436","https://openalex.org/W2325725818","https://openalex.org/W2592546660","https://openalex.org/W4301056550"],"related_works":["https://openalex.org/W6940056052","https://openalex.org/W6976737415","https://openalex.org/W6939267720","https://openalex.org/W2069766019","https://openalex.org/W2109425890","https://openalex.org/W4303962291","https://openalex.org/W4380079620","https://openalex.org/W3046797909","https://openalex.org/W2367610513","https://openalex.org/W2216370044"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,23],"Arthropods":[2,238],"are":[3],"a":[4,115,217],"diverse":[5],"group":[6],"of":[7,34,44,236],"organisms":[8],"including":[9,114],"Chelicerata":[10],"(ticks,":[11],"mites,":[12],"spiders),":[13],"Crustacea":[14],"(crabs,":[15],"shrimps),":[16],"and":[17,57,69,77,96,122,129,136,166,210],"Insecta":[18],"(flies,":[19],"mosquitoes,":[20],"beetles,":[21],"silkworm).":[22],"cattle":[24,35,37],"tick,":[25],"Rhipicephalus":[26],"(Boophilus)":[27],"microplus,":[28],"is":[29],"an":[30,177],"economically":[31],"significant":[32,192],"ectoparasite":[33],"affecting":[36],"industries":[38],"world":[39],"wide.":[40],"With":[41],"the":[42,48],"availability":[43],"sequence":[45],"reads":[46,100],"from":[47,234],"first":[49],"Chelicerate":[50],"genome":[51,99],"project":[52],"(the":[53],"Ixodes":[54],"scapularis":[55,98],"tick)":[56],"extensive":[58],"R.":[59,93,141,162,222],"microplus":[60,94,142,163],"ESTs,":[61],"we":[62],"investigated":[63],"evidence":[64],"for":[65,155],"putative":[66,116],"RNAi":[67,103,112,156,186,219,230],"proteins":[68,105,113,150,207],"studied":[70],"RNA":[71,124,126],"interference":[72],"in":[73,106,133,159,169,182,208,221],"tick":[74,117,229],"cell":[75,86,153,180],"cultures":[76],"adult":[78],"female":[79,167],"ticks":[80,168,209],"targeting":[81],"Drosophila":[82],"homologues":[83,131],"with":[84,144,152,174,212],"known":[85],"viability":[87,154,181],"phenotype.":[88],"RESULTS:":[89],"We":[90,138,202],"screened":[91],"13,643":[92],"ESTs":[95,143],"I.":[97],"to":[101,147],"identify":[102],"related":[104],"ticks.":[107],"Our":[108,224],"analysis":[109],"identified":[110,204],"31":[111],"Dicer,":[118],"RISC":[119],"associated":[120,151,173],"(Ago-2":[121],"FMRp),":[123],"dependent":[125],"polymerase":[127],"(EGO-1)":[128],"23":[130],"implicated":[132],"dsRNA":[134],"uptake":[135],"processing.":[137],"selected":[139],"10":[140],">80%":[145],"similarity":[146],"D.":[148],"melanogaster":[149],"functional":[157,218],"screens":[158],"both":[160],"BME26":[161],"embryonic":[164],"cells":[165],"vivo.":[170],"Only":[171],"genes":[172,190],"proteasomes":[175],"had":[176,191],"effect":[178],"on":[179],"vitro.":[183],"In":[184],"vivo":[185],"showed":[187],"that":[188,228,235],"9":[189],"effects":[193],"either":[194],"causing":[195],"lethality":[196],"or":[197],"impairing":[198],"egg":[199],"laying.":[200],"CONCLUSION:":[201],"have":[203],"key":[205],"RNAi-related":[206],"along":[211],"our":[213],"loss-of-function":[214],"studies":[215,226],"support":[216],"pathway":[220],"microplus.":[223],"preliminary":[225],"indicate":[227],"pathways":[231],"may":[232],"differ":[233],"other":[237],"such":[239],"as":[240],"insects.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}