{"id":"https://openalex.org/W2000351678","doi":"https://doi.org/10.1016/j.pneurobio.2006.06.003","title":"Insulin signaling in the central nervous system: Learning to survive","display_name":"Insulin signaling in the central nervous system: Learning to survive","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W2000351678","doi":"https://doi.org/10.1016/j.pneurobio.2006.06.003","mag":"2000351678","pmid":"https://pubmed.ncbi.nlm.nih.gov/16916571"},"language":"en","primary_location":{"id":"doi:10.1016/j.pneurobio.2006.06.003","doi":"https://doi.org/10.1016/j.pneurobio.2006.06.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pneurobio.2006.06.003","pdf_url":null,"source":{"id":"https://openalex.org/S69289175","display_name":"Progress in Neurobiology","issn_l":"0301-0082","issn":["0301-0082","1873-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Neurobiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055467275","display_name":"Lars P. van der Heide","orcid":"https://orcid.org/0000-0003-1779-425X","observed_orcids":["https://orcid.org/0000-0003-1779-425X"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Lars P. van der Heide","raw_affiliation_strings":["Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. L.P.van_der_heide@lumc.nl","Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. L.P.van_der_heide@lumc.nl","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045529956","display_name":"Geert M. J. Ramakers","orcid":"https://orcid.org/0000-0001-7499-6996","observed_orcids":["https://orcid.org/0000-0001-7499-6996"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert M.J. Ramakers","raw_affiliation_strings":["Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064296191","display_name":"Marten P. Smidt","orcid":"https://orcid.org/0000-0002-8815-747X","observed_orcids":["https://orcid.org/0000-0002-8815-747X"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marten P. Smidt","raw_affiliation_strings":["Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055467275"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.8963,"has_fulltext":false,"cited_by_count":454,"citation_normalized_percentile":{"value":0.87869198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"79","issue":"4","first_page":"205","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.8379999995231628},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.9179999828338623},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.9190000295639038},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8610000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.9710000157356262},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9340000152587891},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8650000095367432},{"id":"https://openalex.org/keywords/synaptic-activity","display_name":"synaptic activity","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7732213735580444},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6648572087287903},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4565108120441437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3852319121360779},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33621761202812195},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12202924489974976}],"mesh":[{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.pneurobio.2006.06.003","doi":"https://doi.org/10.1016/j.pneurobio.2006.06.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pneurobio.2006.06.003","pdf_url":null,"source":{"id":"https://openalex.org/S69289175","display_name":"Progress in Neurobiology","issn_l":"0301-0082","issn":["0301-0082","1873-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Neurobiology","raw_type":"journal-article"},{"id":"pmid:16916571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16916571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in neurobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":179,"referenced_works":["https://openalex.org/W101864503","https://openalex.org/W172293654","https://openalex.org/W196897566","https://openalex.org/W1498716467","https://openalex.org/W1503984718","https://openalex.org/W1526791253","https://openalex.org/W1543788907","https://openalex.org/W1559185749","https://openalex.org/W1563190123","https://openalex.org/W1572110929","https://openalex.org/W1585751449","https://openalex.org/W1590376803","https://openalex.org/W1604789859","https://openalex.org/W1605024684","https://openalex.org/W1627446849","https://openalex.org/W1631908837","https://openalex.org/W1670642870","https://openalex.org/W1677040403","https://openalex.org/W1752384577","https://openalex.org/W1819107323","https://openalex.org/W1847398151","https://openalex.org/W1908445283","https://openalex.org/W1911968642","https://openalex.org/W1951219327","https://openalex.org/W1963240130","https://openalex.org/W1965600418","https://openalex.org/W1970537792","https://openalex.org/W1971727526","https://openalex.org/W1971855284","https://openalex.org/W1973372369","https://openalex.org/W1974790521","https://openalex.org/W1975848149","https://openalex.org/W1976048196","https://openalex.org/W1982270009","https://openalex.org/W1983587113","https://openalex.org/W1984044273","https://openalex.org/W1984567402","https://openalex.org/W1987472079","https://openalex.org/W1988531009","https://openalex.org/W1989470426","https://openalex.org/W1990264946","https://openalex.org/W1990332775","https://openalex.org/W1990861932","https://openalex.org/W1991220317","https://openalex.org/W1992431456","https://openalex.org/W1993049854","https://openalex.org/W1993870556","https://openalex.org/W1997449321","https://openalex.org/W2000283248","https://openalex.org/W2004325493","https://openalex.org/W2005481412","https://openalex.org/W2008702542","https://openalex.org/W2009133373","https://openalex.org/W2010566425","https://openalex.org/W2011430246","https://openalex.org/W2012435234","https://openalex.org/W2012542103","https://openalex.org/W2014855335","https://openalex.org/W2015227366","https://openalex.org/W2017292900","https://openalex.org/W2018981756","https://openalex.org/W2020571036","https://openalex.org/W2022513417","https://openalex.org/W2023018428","https://openalex.org/W2023812320","https://openalex.org/W2024036641","https://openalex.org/W2025786074","https://openalex.org/W2026376328","https://openalex.org/W2029503131","https://openalex.org/W2030405687","https://openalex.org/W2030893161","https://openalex.org/W2032694200","https://openalex.org/W2032983732","https://openalex.org/W2033390091","https://openalex.org/W2033890750","https://openalex.org/W2034487207","https://openalex.org/W2035825704","https://openalex.org/W2036284058","https://openalex.org/W2037341437","https://openalex.org/W2037487194","https://openalex.org/W2038492152","https://openalex.org/W2039022835","https://openalex.org/W2039193709","https://openalex.org/W2039780677","https://openalex.org/W2040644761","https://openalex.org/W2041771374","https://openalex.org/W2044371812","https://openalex.org/W2046989794","https://openalex.org/W2047509507","https://openalex.org/W2049871798","https://openalex.org/W2050490808","https://openalex.org/W2050556351","https://openalex.org/W2051993731","https://openalex.org/W2052040627","https://openalex.org/W2052550515","https://openalex.org/W2052722944","https://openalex.org/W2056891806","https://openalex.org/W2057042201","https://openalex.org/W2058473463","https://openalex.org/W2059072734","https://openalex.org/W2059571622","https://openalex.org/W2061405268","https://openalex.org/W2061738346","https://openalex.org/W2061821053","https://openalex.org/W2062010598","https://openalex.org/W2062090790","https://openalex.org/W2062856075","https://openalex.org/W2065678329","https://openalex.org/W2066376418","https://openalex.org/W2067817632","https://openalex.org/W2069527051","https://openalex.org/W2071421185","https://openalex.org/W2071456539","https://openalex.org/W2072893435","https://openalex.org/W2073008966","https://openalex.org/W2075689054","https://openalex.org/W2077378874","https://openalex.org/W2079797384","https://openalex.org/W2080592899","https://openalex.org/W2082419933","https://openalex.org/W2082660315","https://openalex.org/W2084569379","https://openalex.org/W2086190854","https://openalex.org/W2086773481","https://openalex.org/W2087443596","https://openalex.org/W2087846936","https://openalex.org/W2089688923","https://openalex.org/W2091128918","https://openalex.org/W2092340663","https://openalex.org/W2092376456","https://openalex.org/W2092821961","https://openalex.org/W2093417526","https://openalex.org/W2094597457","https://openalex.org/W2096410114","https://openalex.org/W2100390310","https://openalex.org/W2101048381","https://openalex.org/W2101741807","https://openalex.org/W2102528806","https://openalex.org/W2106607849","https://openalex.org/W2107314314","https://openalex.org/W2107447707","https://openalex.org/W2111455366","https://openalex.org/W2111546385","https://openalex.org/W2114911095","https://openalex.org/W2117639173","https://openalex.org/W2118331240","https://openalex.org/W2118977349","https://openalex.org/W2121583117","https://openalex.org/W2121999112","https://openalex.org/W2125481927","https://openalex.org/W2128134322","https://openalex.org/W2129841439","https://openalex.org/W2137210155","https://openalex.org/W2141277427","https://openalex.org/W2141567007","https://openalex.org/W2141680511","https://openalex.org/W2143034003","https://openalex.org/W2145451941","https://openalex.org/W2145521125","https://openalex.org/W2146405340","https://openalex.org/W2147114673","https://openalex.org/W2159915554","https://openalex.org/W2160611421","https://openalex.org/W2160913167","https://openalex.org/W2166036638","https://openalex.org/W2166483018","https://openalex.org/W2166766346","https://openalex.org/W2168769697","https://openalex.org/W2169294911","https://openalex.org/W2170269651","https://openalex.org/W2184359370","https://openalex.org/W2241215111","https://openalex.org/W2473043389","https://openalex.org/W3176318548","https://openalex.org/W4243167837","https://openalex.org/W4253418569","https://openalex.org/W4254481864","https://openalex.org/W6660747288","https://openalex.org/W6677738787"],"related_works":["https://openalex.org/W1994930233","https://openalex.org/W4401197909","https://openalex.org/W2054543840","https://openalex.org/W1563190123","https://openalex.org/W2084761782","https://openalex.org/W7099302423","https://openalex.org/W4674141","https://openalex.org/W2015220759","https://openalex.org/W7098938157","https://openalex.org/W1978808714"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
