{"id":"https://openalex.org/W2000338643","doi":"https://doi.org/10.1111/j.1600-0609.2007.00928.x","title":"Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells","display_name":"Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells","publication_year":2007,"publication_date":"2007-07-21","ids":{"openalex":"https://openalex.org/W2000338643","doi":"https://doi.org/10.1111/j.1600-0609.2007.00928.x","mag":"2000338643","pmid":"https://pubmed.ncbi.nlm.nih.gov/17803679"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0609.2007.00928.x","doi":"https://doi.org/10.1111/j.1600-0609.2007.00928.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.2007.00928.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070197514","display_name":"Daniel Steinbach","orcid":"https://orcid.org/0000-0002-0276-3701","observed_orcids":["https://orcid.org/0000-0002-0276-3701"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Daniel Steinbach","raw_affiliation_strings":["University Children's Hospital Jena, Germany. Daniel@Steinba.ch","University Children's Hospital Jena, Germany","University Children's Hospital Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital Jena, Germany. Daniel@Steinba.ch","institution_ids":["https://openalex.org/I4210134900"]},{"raw_affiliation_string":"University Children's Hospital Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]},{"raw_affiliation_string":"University Children's Hospital Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086855365","display_name":"Masanori Onda","orcid":"https://orcid.org/0000-0002-6805-2152","observed_orcids":["https://orcid.org/0000-0002-6805-2152"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Onda","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042167800","display_name":"Astrid Voigt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Astrid Voigt","raw_affiliation_strings":["University Children\u2019s Hospital Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110399985","display_name":"Kristin Dawczynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kristin Dawczynski","raw_affiliation_strings":["University Children\u2019s Hospital Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054884221","display_name":"Susan Wittig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susan Wittig","raw_affiliation_strings":["University Children\u2019s Hospital Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029872582","display_name":"Raffit Hassan","orcid":"https://orcid.org/0000-0002-4012-3633","observed_orcids":["https://orcid.org/0000-0002-4012-3633"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raffit Hassan","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022487135","display_name":"Bernd Gruhn","orcid":"https://orcid.org/0000-0003-1862-0075","observed_orcids":["https://orcid.org/0000-0003-1862-0075"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Gruhn","raw_affiliation_strings":["University Children\u2019s Hospital Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children\u2019s Hospital Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056573254","display_name":"Ira H Pastan","orcid":"https://orcid.org/0000-0002-9223-0270","observed_orcids":["https://orcid.org/0000-0002-9223-0270"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira Pastan","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070197514"],"corresponding_institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I4210155144"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.2395,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.54939802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"79","issue":"4","first_page":"281","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesothelin","display_name":"mesothelin","score":1.0},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5849999785423279},{"id":"https://openalex.org/keywords/immunotoxins","display_name":"immunotoxins","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tumor-specific-antigens","display_name":"tumor-specific antigens","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.6200000047683716},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2777045440","wikidata":"https://www.wikidata.org/wiki/Q14914057","display_name":"Mesothelin","level":3,"score":0.9944775104522705},{"id":"https://openalex.org/C115085202","wikidata":"https://www.wikidata.org/wiki/Q425665","display_name":"Immunotoxin","level":4,"score":0.92097008228302},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5616015791893005},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5507909655570984},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5133718252182007},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.47099822759628296},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.44043564796447754},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4389883577823639},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.373868465423584},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25579744577407837},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2442483901977539},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1672821342945099},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.14408251643180847},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10153767466545105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05673488974571228}],"mesh":[{"descriptor_ui":"D000090204","descriptor_name":"Mesothelin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000922","descriptor_name":"Immunotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000922","descriptor_name":"Immunotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0609.2007.00928.x","doi":"https://doi.org/10.1111/j.1600-0609.2007.00928.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.2007.00928.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:17803679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17803679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1977122810","https://openalex.org/W1987305699","https://openalex.org/W1995521183","https://openalex.org/W1995837838","https://openalex.org/W2021404182","https://openalex.org/W2052428195","https://openalex.org/W2059491580","https://openalex.org/W2068778959","https://openalex.org/W2104156244","https://openalex.org/W2120353092","https://openalex.org/W2133432816","https://openalex.org/W2145463997","https://openalex.org/W2160966193","https://openalex.org/W2161930777"],"related_works":["https://openalex.org/W7127191869","https://openalex.org/W4291818111","https://openalex.org/W2911678259","https://openalex.org/W4225412270","https://openalex.org/W3095733588","https://openalex.org/W3158679424","https://openalex.org/W3088613999","https://openalex.org/W4220785729","https://openalex.org/W3213116454","https://openalex.org/W2104156244"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mesothelin":[1],"is":[2,38,44,65,117],"a":[3,39,130],"promising":[4],"candidate":[5],"for":[6],"tumor-specific":[7],"therapy":[8],"because":[9],"of":[10,25,95],"its":[11],"limited":[12],"expression":[13,19,24,94],"in":[14,20,29,48,67,106,120],"normal":[15],"tissues":[16],"and":[17,85,136],"high":[18],"several":[21],"cancers.":[22],"The":[23],"the":[26,62,93,97],"protein":[27,64],"mesothelin":[28,63,114,128],"hematological":[30],"malignancies":[31],"has":[32],"not":[33,101,118],"yet":[34],"been":[35],"analyzed.":[36],"SS1(dsFv)PE38":[37,105,116],"recombinant":[40],"anti-mesothelin":[41],"immunotoxin":[42,104],"which":[43],"undergoing":[45],"clinical":[46],"evaluation":[47],"patients":[49],"with":[50,72],"mesothelin-expressing":[51],"tumors.":[52],"METHODS":[53],"AND":[54],"RESULTS:":[55],"In":[56],"this":[57],"study":[58],"we":[59],"show":[60],"that":[61,126],"expressed":[66],"leukemic":[68],"cells":[69,112],"from":[70],"children":[71],"acute":[73],"myeloid":[74],"leukemia":[75],"(AML).":[76],"This":[77],"finding":[78],"was":[79],"confirmed":[80],"by":[81],"western":[82],"blot,":[83],"immunocytochemistry":[84],"real":[86],"time":[87],"polymerase":[88],"chain":[89],"reaction":[90],"(PCR).":[91],"Despite":[92],"mesothelin,":[96],"patient":[98],"samples":[99],"were":[100],"sensitive":[102],"to":[103],"MTT":[107],"assays.":[108],"CONCLUSIONS:":[109],"Primary":[110],"AML":[111,141],"express":[113],"but":[115],"active":[119],"killing":[121],"these":[122],"cells.":[123,142],"Other":[124],"approaches":[125],"utilize":[127],"as":[129],"target":[131],"might":[132],"be":[133,138],"more":[134],"effective":[135],"should":[137],"tested":[139],"against":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}