{"id":"https://openalex.org/W2000338095","doi":"https://doi.org/10.1097/01.pra.0000333583.75741.8b","title":"Effectiveness of Antiepileptic Drugs for the Treatment of Bipolar Disorder: Findings from a Systematic Review","display_name":"Effectiveness of Antiepileptic Drugs for the Treatment of Bipolar Disorder: Findings from a Systematic Review","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2000338095","doi":"https://doi.org/10.1097/01.pra.0000333583.75741.8b","mag":"2000338095","pmid":"https://pubmed.ncbi.nlm.nih.gov/19034205"},"language":"en","primary_location":{"id":"doi:10.1097/01.pra.0000333583.75741.8b","doi":"https://doi.org/10.1097/01.pra.0000333583.75741.8b","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pra.0000333583.75741.8b","pdf_url":null,"source":{"id":"https://openalex.org/S156364528","display_name":"Journal of Psychiatric Practice","issn_l":"1527-4160","issn":["1527-4160","1538-1145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Practice","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042969262","display_name":"Cathy Lee Melvin","orcid":"https://orcid.org/0000-0001-7862-5631","observed_orcids":["https://orcid.org/0000-0001-7862-5631"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CATHY L. MELVIN","raw_affiliation_strings":["The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill, NC 27599-7590, USA. cathy_melvin@unc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill, NC 27599-7590, USA. cathy_melvin@unc.edu","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076285729","display_name":"Timothy S. Carey","orcid":"https://orcid.org/0000-0001-6539-5021","observed_orcids":["https://orcid.org/0000-0001-6539-5021"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TIMOTHY S. CAREY","raw_affiliation_strings":["GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","WILLIAMS: Duke University School of Medicine, Durham, NC","Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","institution_ids":["https://openalex.org/I2799886695"]},{"raw_affiliation_string":"MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"WILLIAMS: Duke University School of Medicine, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054148434","display_name":"Francine Goodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FRANCINE GOODMAN","raw_affiliation_strings":["GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","WILLIAMS: Duke University School of Medicine, Durham, NC","University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","institution_ids":["https://openalex.org/I2799886695"]},{"raw_affiliation_string":"MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"WILLIAMS: Duke University School of Medicine, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114250022","display_name":"John M. Oldham","orcid":"https://orcid.org/0000-0001-8344-3023","observed_orcids":["https://orcid.org/0000-0001-8344-3023"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN M. OLDHAM","raw_affiliation_strings":["GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","WILLIAMS: Duke University School of Medicine, Durham, NC","University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","institution_ids":["https://openalex.org/I2799886695"]},{"raw_affiliation_string":"MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"WILLIAMS: Duke University School of Medicine, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085275264","display_name":"John W Williams","orcid":"https://orcid.org/0000-0002-5267-5558","observed_orcids":["https://orcid.org/0000-0002-5267-5558"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN W. WILLIAMS","raw_affiliation_strings":["GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","WILLIAMS: Duke University School of Medicine, Durham, NC","University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","institution_ids":["https://openalex.org/I2799886695"]},{"raw_affiliation_string":"MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"WILLIAMS: Duke University School of Medicine, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086562081","display_name":"Leah M. Ranney","orcid":"https://orcid.org/0000-0001-9766-4767","observed_orcids":["https://orcid.org/0000-0001-9766-4767"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LEAH M. RANNEY","raw_affiliation_strings":["GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","WILLIAMS: Duke University School of Medicine, Durham, NC","University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GOODMAN: Veterans Health Administration Pharmacy Benefits Management Strategic Healthcare Group, Columbia, SC","institution_ids":["https://openalex.org/I2799886695"]},{"raw_affiliation_string":"MELVIN, CAREY, and RANNEY: The Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"OLDHAM: Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"WILLIAMS: Duke University School of Medicine, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4282,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.37744714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"Supplement 1","first_page":"9","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.984000027179718},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.9559999704360962},{"id":"https://openalex.org/keywords/drug-class-review","display_name":"drug class review","score":0.6970000267028809},{"id":"https://openalex.org/keywords/drug-effectiveness","display_name":"drug effectiveness","score":0.621999979019165},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.8511564135551453},{"id":"https://openalex.org/C2778567577","wikidata":"https://www.wikidata.org/wiki/Q188611","display_name":"Hypomania","level":5,"score":0.7769885063171387},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.6838210821151733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6380341649055481},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.5806302428245544},{"id":"https://openalex.org/C2776608144","wikidata":"https://www.wikidata.org/wiki/Q410352","display_name":"Gabapentin","level":3,"score":0.578519344329834},{"id":"https://openalex.org/C2781246090","wikidata":"https://www.wikidata.org/wiki/Q7836908","display_name":"Treatment of bipolar disorder","level":5,"score":0.5355192422866821},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4681399464607239},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4510948359966278},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.15871858596801758},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.pra.0000333583.75741.8b","doi":"https://doi.org/10.1097/01.pra.0000333583.75741.8b","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pra.0000333583.75741.8b","pdf_url":null,"source":{"id":"https://openalex.org/S156364528","display_name":"Journal of Psychiatric Practice","issn_l":"1527-4160","issn":["1527-4160","1538-1145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Practice","raw_type":"journal-article"},{"id":"pmid:19034205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19034205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatric practice","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W62608121","https://openalex.org/W2003490971","https://openalex.org/W2038648766","https://openalex.org/W2063347068","https://openalex.org/W2064119051","https://openalex.org/W2070662859","https://openalex.org/W2073208294","https://openalex.org/W2078403212","https://openalex.org/W2099326967","https://openalex.org/W2124969157","https://openalex.org/W2127656341","https://openalex.org/W2128861864","https://openalex.org/W2163264591","https://openalex.org/W4205319165","https://openalex.org/W4205748692","https://openalex.org/W4244474040"],"related_works":["https://openalex.org/W2039377151","https://openalex.org/W2078403212","https://openalex.org/W144891953","https://openalex.org/W1552157540","https://openalex.org/W4415241552","https://openalex.org/W2564998324","https://openalex.org/W7218231423","https://openalex.org/W3194294835","https://openalex.org/W2095679719","https://openalex.org/W1966967062"],"abstract_inverted_index":{"Bipolar":[0],"disorder":[1,39,53],"is":[2,95],"characterized":[3],"by":[4,72,129],"chronic":[5,46],"and":[6,12,14,47,133,224,239],"recurrent":[7,48],"symptoms":[8],"including":[9,161],"mania,":[10],"hypomania,":[11],"depressive":[13,62],"mixed":[15],"episodes,":[16],"with":[17,51,61],"approximately":[18],"5.7":[19],"million":[20],"Americans":[21],"over":[22],"age":[23],"18,":[24],"or":[25,74],"2.6%":[26],"of":[27,37,113,116,141,147,158,166,201,212,228,233,246,257],"the":[28,33,38,130,145,167,178,184,207,231,247,250,258],"U.S.":[29,131],"population,":[30],"suffering":[31],"from":[32,249],"illness.":[34],"The":[35,164],"prevalence":[36],"may":[40],"be":[41],"higher":[42],"due":[43],"to":[44,100,110,221,255],"its":[45,153],"nature.":[49],"Individuals":[50],"bipolar":[52,88,123,162,234,261],"often":[54],"first":[55],"present":[56],"in":[57,68,85,102,127,230,260],"general":[58],"medical":[59],"settings":[60,71],"symptomatology.":[63],"Long-term":[64],"management":[65],"typically":[66],"occurs":[67],"mental":[69,76],"health":[70,77],"psychiatrists":[73],"other":[75],"specialists.":[78],"While":[79],"there":[80],"have":[81],"been":[82,174],"major":[83],"advances":[84],"pharmacotherapy":[86],"for":[87,122,138,156,169,183],"disorder,":[89,236],"evidence-based":[90],"information":[91,106],"on":[92],"drug":[93,168,218,251],"effectiveness":[94,223],"not":[96,173],"always":[97],"easily":[98],"accessible":[99],"prescribers":[101],"daily":[103],"practice.":[104],"Available":[105],"has":[107],"sometimes":[108],"led":[109],"inappropriate":[111],"use":[112,155],"various":[114],"classes":[115],"drugs,":[117],"specifically":[118],"antiepileptic":[119],"drugs":[120],"(AEDs),":[121],"disorder.":[124,163,262],"Originally":[125],"approved":[126],"1993":[128],"Food":[132],"Drug":[134],"Administration":[135],"(FDA)":[136],"only":[137],"adjunctive":[139],"treatment":[140,157,232],"partial":[142],"complex":[143],"seizures,":[144],"manufacturer":[146,179],"gabapentin":[148],"(Neurontin),":[149],"an":[150],"AED,":[151],"promoted":[152],"off-label":[154,198],"psychiatric":[159],"disorders,":[160],"efficacy":[165],"this":[170],"indication":[171],"had":[172,177],"demonstrated,":[175],"nor":[176],"sought":[180],"FDA":[181],"approval":[182],"indication.":[185],"In":[186],"2004,":[187],"50":[188],"Attorneys":[189],"General":[190],"settled":[191],"consumer":[192],"protection":[193],"claims":[194],"regarding":[195],"alleged":[196],"deceptive":[197],"marketing":[199],"practices":[200],"Pfizer":[202],"subsidiary":[203],"Warner-Lambert.":[204],"At":[205],"about":[206],"same":[208],"time,":[209],"a":[210,217,244],"consortium":[211],"State":[213],"Medicaid":[214],"agencies":[215],"funded":[216],"class":[219,252],"review":[220,253],"compare":[222],"adverse":[225],"event":[226],"profiles":[227],"AEDs":[229,259],"mood":[235],"neuropathic":[237],"pain,":[238],"fibromyalgia.":[240],"This":[241],"article":[242],"presents":[243],"summary":[245],"findings":[248],"related":[254],"prescription":[256]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
