{"id":"https://openalex.org/W2000337400","doi":"https://doi.org/10.1006/frne.1995.1012","title":"Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases","display_name":"Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2000337400","doi":"https://doi.org/10.1006/frne.1995.1012","mag":"2000337400","pmid":"https://pubmed.ncbi.nlm.nih.gov/8557169"},"language":"en","primary_location":{"id":"doi:10.1006/frne.1995.1012","doi":"https://doi.org/10.1006/frne.1995.1012","is_oa":false,"landing_page_url":"https://doi.org/10.1006/frne.1995.1012","pdf_url":null,"source":{"id":"https://openalex.org/S178650970","display_name":"Frontiers in Neuroendocrinology","issn_l":"0091-3022","issn":["0091-3022","1095-6808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073351964","display_name":"Yves Rouill\u00e9","orcid":"https://orcid.org/0000-0003-0788-9271","observed_orcids":["https://orcid.org/0000-0003-0788-9271"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yves Rouill\u00e9","raw_affiliation_strings":["Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050710903","display_name":"Stephen J. Duguay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Duguay","raw_affiliation_strings":["The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004635365","display_name":"Kaare Lund","orcid":"https://orcid.org/0000-0002-3520-7744","observed_orcids":["https://orcid.org/0000-0002-3520-7744"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaare Lund","raw_affiliation_strings":["The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042982582","display_name":"Machi Furuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Machi Furuta","raw_affiliation_strings":["The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114012564","display_name":"Qiuming Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiuming Gong","raw_affiliation_strings":["The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029592041","display_name":"Gregory M. Lipkind","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Lipkind","raw_affiliation_strings":["The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013510084","display_name":"Anthony A. Oliva","orcid":"https://orcid.org/0000-0002-3099-2421","observed_orcids":["https://orcid.org/0000-0002-3099-2421"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony A. Oliva","raw_affiliation_strings":["The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080725730","display_name":"Shu Jin Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Jin Chan","raw_affiliation_strings":["The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109965485","display_name":"Donald F. Steiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald F. Steiner","raw_affiliation_strings":["The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4800,"currency":"USD","value_usd":4800},"apc_paid":null,"fwci":7.8576,"has_fulltext":false,"cited_by_count":348,"citation_normalized_percentile":{"value":0.98439737,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"16","issue":"4","first_page":"322","last_page":"361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proprotein-convertases","display_name":"proprotein convertases","score":0.9800000190734863},{"id":"https://openalex.org/keywords/subtilisin-like-protease","display_name":"subtilisin-like protease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/prohormone-processing","display_name":"prohormone processing","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neuropeptide-synthesis","display_name":"neuropeptide biosynthesis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/furin","display_name":"furin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pc2","display_name":"PC2","score":0.6759999990463257},{"id":"https://openalex.org/keywords/calcium-dependent-protease","display_name":"calcium-dependent protease","score":0.6169999837875366},{"id":"https://openalex.org/keywords/proopiomelanocortin","display_name":"proopiomelanocortin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/proinsulin","display_name":"proinsulin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/proglucagon","display_name":"proglucagon","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carboxypeptidase-e","display_name":"carboxypeptidase E","score":0.9959999918937683},{"id":"https://openalex.org/keywords/regulated-secretory-pathway","display_name":"regulated secretory pathway","score":0.7160000205039978},{"id":"https://openalex.org/keywords/constitutive-secretory-pathway","display_name":"constitutive secretory pathway","score":0.8159999847412109},{"id":"https://openalex.org/keywords/trans-golgi-network","display_name":"trans-Golgi network","score":0.6869999766349792},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.5429999828338623},{"id":"https://openalex.org/keywords/enzyme-evolution","display_name":"enzyme evolution","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2908627167","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein Convertases","level":5,"score":0.9491673111915588},{"id":"https://openalex.org/C2779811187","wikidata":"https://www.wikidata.org/wiki/Q423655","display_name":"Subtilisin","level":3,"score":0.7924264669418335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5303424596786499},{"id":"https://openalex.org/C2778824825","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein convertase","level":5,"score":0.5282237529754639},{"id":"https://openalex.org/C2778849439","wikidata":"https://www.wikidata.org/wiki/Q6397985","display_name":"Kexin","level":5,"score":0.5255441069602966},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.46701034903526306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45697009563446045},{"id":"https://openalex.org/C3019223276","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Proteolytic enzymes","level":3,"score":0.4394931495189667},{"id":"https://openalex.org/C2777265534","wikidata":"https://www.wikidata.org/wiki/Q14916427","display_name":"Furin","level":3,"score":0.4336507320404053},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1564231514930725},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.06821423768997192},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.06021282076835632},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013381","descriptor_name":"Subtilisins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/frne.1995.1012","doi":"https://doi.org/10.1006/frne.1995.1012","is_oa":false,"landing_page_url":"https://doi.org/10.1006/frne.1995.1012","pdf_url":null,"source":{"id":"https://openalex.org/S178650970","display_name":"Frontiers in Neuroendocrinology","issn_l":"0091-3022","issn":["0091-3022","1095-6808"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:8557169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8557169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroendocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2807054497","display_name":null,"funder_award_id":"DK 20595","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3394385110","display_name":null,"funder_award_id":"DK13914","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2902246034","https://openalex.org/W2022527113","https://openalex.org/W8567896","https://openalex.org/W2292427237","https://openalex.org/W2030897168","https://openalex.org/W2432175231","https://openalex.org/W2080054596","https://openalex.org/W1885047062","https://openalex.org/W1985917733","https://openalex.org/W1512050447"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}