{"id":"https://openalex.org/W2000333606","doi":"https://doi.org/10.1016/j.dnarep.2015.04.014","title":"Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response","display_name":"Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response","publication_year":2015,"publication_date":"2015-05-02","ids":{"openalex":"https://openalex.org/W2000333606","doi":"https://doi.org/10.1016/j.dnarep.2015.04.014","mag":"2000333606","pmid":"https://pubmed.ncbi.nlm.nih.gov/25956864"},"language":"en","primary_location":{"id":"doi:10.1016/j.dnarep.2015.04.014","doi":"https://doi.org/10.1016/j.dnarep.2015.04.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2015.04.014","pdf_url":null,"source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033495224","display_name":"Xiao-Feng Zheng","orcid":"https://orcid.org/0000-0001-8769-4604","observed_orcids":["https://orcid.org/0000-0001-8769-4604"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Feng Zheng","raw_affiliation_strings":["Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073057863","display_name":"Peter Kalev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kalev","raw_affiliation_strings":["Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004787236","display_name":"Dipanjan Chowdhury","orcid":"https://orcid.org/0000-0001-5645-3752","observed_orcids":["https://orcid.org/0000-0001-5645-3752"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipanjan Chowdhury","raw_affiliation_strings":["Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: dipanjan_chowdhury@dfci.harvard.edu","Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: dipanjan_chowdhury@dfci.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":0.3556,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.29610204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"32","issue":null,"first_page":"58","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.39579999446868896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase","display_name":"protein phosphatase","score":1.0},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dna-repair-proteins","display_name":"DNA repair proteins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.8633911609649658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.807487964630127},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.7935510873794556},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7426146268844604},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7335271835327148},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6573953628540039},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5401247143745422},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5332092046737671},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.5000698566436768},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4784793555736542},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4022969603538513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3038982152938843}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.dnarep.2015.04.014","doi":"https://doi.org/10.1016/j.dnarep.2015.04.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2015.04.014","pdf_url":null,"source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},{"id":"pmid:25956864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25956864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA repair","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306206","display_name":"Mary Kay Foundation","ror":"https://ror.org/05snapr15"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1553367038","https://openalex.org/W1578456308","https://openalex.org/W1902644656","https://openalex.org/W1931308484","https://openalex.org/W1958731645","https://openalex.org/W1964764218","https://openalex.org/W1967491579","https://openalex.org/W1970038285","https://openalex.org/W1970266506","https://openalex.org/W1971936302","https://openalex.org/W1972180308","https://openalex.org/W1972236331","https://openalex.org/W1972305190","https://openalex.org/W1974706661","https://openalex.org/W1977126501","https://openalex.org/W1979385111","https://openalex.org/W1980246358","https://openalex.org/W1981834531","https://openalex.org/W1983711411","https://openalex.org/W1987005978","https://openalex.org/W1987079136","https://openalex.org/W1988052396","https://openalex.org/W1995885252","https://openalex.org/W1996286498","https://openalex.org/W2000383933","https://openalex.org/W2001680897","https://openalex.org/W2003752349","https://openalex.org/W2003847336","https://openalex.org/W2010643113","https://openalex.org/W2010898393","https://openalex.org/W2012870736","https://openalex.org/W2019292967","https://openalex.org/W2019394964","https://openalex.org/W2022811243","https://openalex.org/W2024781225","https://openalex.org/W2030674755","https://openalex.org/W2031203839","https://openalex.org/W2033160262","https://openalex.org/W2033172828","https://openalex.org/W2040392790","https://openalex.org/W2043027414","https://openalex.org/W2047261627","https://openalex.org/W2048839078","https://openalex.org/W2050987046","https://openalex.org/W2052553543","https://openalex.org/W2053577515","https://openalex.org/W2059493608","https://openalex.org/W2062520229","https://openalex.org/W2063767314","https://openalex.org/W2074483662","https://openalex.org/W2076248918","https://openalex.org/W2079204151","https://openalex.org/W2080992989","https://openalex.org/W2082447947","https://openalex.org/W2083431317","https://openalex.org/W2083731894","https://openalex.org/W2097360161","https://openalex.org/W2097483662","https://openalex.org/W2097805947","https://openalex.org/W2098550464","https://openalex.org/W2098855741","https://openalex.org/W2103972950","https://openalex.org/W2104064820","https://openalex.org/W2104191744","https://openalex.org/W2104994400","https://openalex.org/W2105073128","https://openalex.org/W2107836354","https://openalex.org/W2110297856","https://openalex.org/W2112651502","https://openalex.org/W2116341402","https://openalex.org/W2117602431","https://openalex.org/W2120943086","https://openalex.org/W2122543263","https://openalex.org/W2129248613","https://openalex.org/W2141575449","https://openalex.org/W2146204567","https://openalex.org/W2150308609","https://openalex.org/W2151026121","https://openalex.org/W2157899948","https://openalex.org/W2160256607","https://openalex.org/W2161608278","https://openalex.org/W2163377650","https://openalex.org/W2317712623","https://openalex.org/W2324138891","https://openalex.org/W4240389520"],"related_works":["https://openalex.org/W1987079136","https://openalex.org/W2104507462","https://openalex.org/W7135826685","https://openalex.org/W2160286655","https://openalex.org/W3000550156","https://openalex.org/W2033348271","https://openalex.org/W2399319271","https://openalex.org/W2918464022","https://openalex.org/W7160994852","https://openalex.org/W1991693699"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
