{"id":"https://openalex.org/W2000331307","doi":"https://doi.org/10.1021/ml1000189","title":"Preparation and Characterization of Tetrabenazine Enantiomers against Vesicular Monoamine Transporter 2","display_name":"Preparation and Characterization of Tetrabenazine Enantiomers against Vesicular Monoamine Transporter 2","publication_year":2010,"publication_date":"2010-03-31","ids":{"openalex":"https://openalex.org/W2000331307","doi":"https://doi.org/10.1021/ml1000189","mag":"2000331307","pmid":"https://pubmed.ncbi.nlm.nih.gov/20694189","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915582"},"language":"en","primary_location":{"id":"doi:10.1021/ml1000189","doi":"https://doi.org/10.1021/ml1000189","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ml1000189","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108415774","display_name":"Qian\u2010sheng Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian-sheng Yu","raw_affiliation_strings":["Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224","Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056758372","display_name":"Weiming Luo","orcid":"https://orcid.org/0009-0002-3035-3176","observed_orcids":["https://orcid.org/0009-0002-3035-3176"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiming Luo","raw_affiliation_strings":["Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030863493","display_name":"Jeffrey R. Deschamps","orcid":"https://orcid.org/0000-0001-5845-0010","observed_orcids":["https://orcid.org/0000-0001-5845-0010"]},"institutions":[{"id":"https://openalex.org/I1288214837","display_name":"United States Naval Research Laboratory","ror":"https://ror.org/04d23a975","country_code":"US","type":"facility","lineage":["https://openalex.org/I1288214837","https://openalex.org/I1330347796","https://openalex.org/I175003984","https://openalex.org/I3130687028"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery Deschamps","raw_affiliation_strings":["Laboratory for the Structure of Matter, Department of the Navy, Naval Research Laboratory, Washington, D.C. 20375"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for the Structure of Matter, Department of the Navy, Naval Research Laboratory, Washington, D.C. 20375","institution_ids":["https://openalex.org/I1288214837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110898328","display_name":"Harold W. Holloway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold W. Holloway","raw_affiliation_strings":["Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067428741","display_name":"Theresa A. Kopajtic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Kopajtic","raw_affiliation_strings":["Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053763901","display_name":"Jonathan L. Katz","orcid":"https://orcid.org/0000-0002-1068-1159","observed_orcids":["https://orcid.org/0000-0002-1068-1159"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan L. Katz","raw_affiliation_strings":["Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111536602","display_name":"Arnold R. Brossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold Brossi","raw_affiliation_strings":["School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056649584","display_name":"Nigel H. Greig","orcid":"https://orcid.org/0000-0002-3032-1468","observed_orcids":["https://orcid.org/0000-0002-3032-1468"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nigel H. Greig","raw_affiliation_strings":["Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5056649584"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9101,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.83017422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1","issue":"3","first_page":"105","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.22509999573230743,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.22509999573230743,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.1736000031232834,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12527","display_name":"Chemistry and Stereochemistry Studies","score":0.16539999842643738,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrabenazine","display_name":"tetrabenazine","score":1.0},{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.984000027179718},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.746999979019165},{"id":"https://openalex.org/keywords/enantiomeric-resolution","display_name":"enantiomer resolution","score":0.8050000071525574},{"id":"https://openalex.org/keywords/vmat2","display_name":"vesicular monoamine transporter 2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.777999997138977},{"id":"https://openalex.org/keywords/optical-rotation","display_name":"optical rotation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hyperkinetic-movement-disorders","display_name":"hyperkinetic movement disorders","score":0.8460000157356262},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2776284327","wikidata":"https://www.wikidata.org/wiki/Q413050","display_name":"Tetrabenazine","level":3,"score":0.9292613863945007},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.761655330657959},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.6261444687843323},{"id":"https://openalex.org/C2778406628","wikidata":"https://www.wikidata.org/wiki/Q2521094","display_name":"Vesicular monoamine transporter 2","level":5,"score":0.6093507409095764},{"id":"https://openalex.org/C2776291748","wikidata":"https://www.wikidata.org/wiki/Q4105920","display_name":"Vesicular monoamine transporter","level":5,"score":0.4999713897705078},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48855122923851013},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.444791316986084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33057036995887756},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.20189297199249268},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20031434297561646},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.13316020369529724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12902897596359253},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.07312577962875366},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1021/ml1000189","doi":"https://doi.org/10.1021/ml1000189","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ml1000189","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2075245","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915582","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2915582","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915582","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"},{"id":"pmid:20694189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20694189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS medicinal chemistry letters","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:r207tv81c","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/0wcc-0a14","pdf_url":"https://doi.org/10.17615/0wcc-0a14","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Medicinal Chemistry Letters, 1(3)","raw_type":"Article"},{"id":"doi:10.17615/0wcc-0a14","doi":"https://doi.org/10.17615/0wcc-0a14","is_oa":true,"landing_page_url":"https://doi.org/10.17615/0wcc-0a14","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2075245","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915582","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5053974381","display_name":"Design And Development Of Experimental Therapeutics","funder_award_id":"Z01AG000311","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W966241985","https://openalex.org/W1635920298","https://openalex.org/W1766910547","https://openalex.org/W1966835560","https://openalex.org/W1973680024","https://openalex.org/W1984186801","https://openalex.org/W1990299071","https://openalex.org/W1996853731","https://openalex.org/W2000176513","https://openalex.org/W2005928469","https://openalex.org/W2011854027","https://openalex.org/W2019685130","https://openalex.org/W2026227625","https://openalex.org/W2038763233","https://openalex.org/W2053778058","https://openalex.org/W2063242260","https://openalex.org/W2088507974","https://openalex.org/W2090349074","https://openalex.org/W2125267782","https://openalex.org/W2166427560","https://openalex.org/W2428187695","https://openalex.org/W4239925697"],"related_works":["https://openalex.org/W2044660000","https://openalex.org/W2009777989","https://openalex.org/W4408221581","https://openalex.org/W3010217656","https://openalex.org/W2950691632","https://openalex.org/W2007766043","https://openalex.org/W2152361711","https://openalex.org/W2419415752","https://openalex.org/W2378179757","https://openalex.org/W2026227625"],"abstract_inverted_index":{"As":[0],"a":[1,38,67],"clinical":[2],"medication":[3],"for":[4,70],"the":[5,60,84,107],"treatment":[6],"of":[7,63,72,83,90,102],"hyperkinetic":[8],"movement":[9],"disorders,":[10],"in":[11,23],"conditions":[12],"such":[13],"as":[14],"Huntington's":[15],"disease,":[16],"tetrabenazine":[17],"(TBZ)":[18],"has":[19],"been":[20],"always":[21],"used":[22],"its":[24,32,75],"racemic":[25],"form.":[26],"To":[27],"establish":[28],"whether":[29],"or":[30],"not":[31],"beneficial":[33],"therapeutic":[34],"actions":[35],"are":[36],"enantiospecific,":[37],"practical":[39],"total":[40,61],"synthetic":[41],"route":[42],"was":[43],"developed":[44],"to":[45,50],"yield":[46],"each":[47,91],"enantiomeric":[48],"form":[49],"allow":[51],"their":[52,103],"chemical":[53],"and":[54,65,78,87],"pharmacological":[55],"characterization.":[56],"We":[57],"briefly":[58],"summarize":[59],"synthesis":[62],"TBZ":[64,73,92],"report":[66],"detailed":[68],"procedure":[69],"resolution":[71],"into":[74],"enantiomers,":[76],"(+)-TBZ":[77,113],"(-)-TBZ.":[79,119],"This":[80],"allowed":[81],"determination":[82],"optical":[85],"rotation":[86],"absolute":[88],"configurations":[89],"enantiomer,":[93],"based":[94],"on":[95],"X-ray":[96],"crystallographic":[97],"analysis,":[98],"together":[99],"with":[100],"characterization":[101],"inhibitory":[104],"action":[105],"at":[106],"vesicular":[108],"monoamine":[109],"transporter":[110],"2,":[111],"where":[112],"proved":[114],"three-fold":[115],"more":[116],"active":[117],"than":[118]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
