{"id":"https://openalex.org/W2000329625","doi":"https://doi.org/10.1002/cne.20305","title":"Variable effects of chronic subcutaneous administration of rotenone on striatal histology","display_name":"Variable effects of chronic subcutaneous administration of rotenone on striatal histology","publication_year":2004,"publication_date":"2004-09-21","ids":{"openalex":"https://openalex.org/W2000329625","doi":"https://doi.org/10.1002/cne.20305","mag":"2000329625","pmid":"https://pubmed.ncbi.nlm.nih.gov/15384065"},"language":"en","primary_location":{"id":"doi:10.1002/cne.20305","doi":"https://doi.org/10.1002/cne.20305","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.20305","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015405111","display_name":"Chunni Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunni Zhu","raw_affiliation_strings":["Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769, USA","Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095\u20101769"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095\u20101769","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070293947","display_name":"Patrick Vourc\u2019h","orcid":"https://orcid.org/0000-0001-7960-8139","observed_orcids":["https://orcid.org/0000-0001-7960-8139"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Vourc'h","raw_affiliation_strings":["Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063328073","display_name":"Pierre\u2010Olivier Fernagut","orcid":"https://orcid.org/0000-0002-7737-5439","observed_orcids":["https://orcid.org/0000-0002-7737-5439"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre\u2010Olivier Fernagut","raw_affiliation_strings":["Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060876856","display_name":"Sheila M. Fleming","orcid":"https://orcid.org/0000-0001-7090-8274","observed_orcids":["https://orcid.org/0000-0001-7090-8274"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila M. Fleming","raw_affiliation_strings":["Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016930417","display_name":"Sanja La\u0107an","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanja Lacan","raw_affiliation_strings":["Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028370859","display_name":"Cheryl D. DiCarlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl D. Dicarlo","raw_affiliation_strings":["United States Army Medical Research Detachment, Brooks City-Base, Texas 78235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Army Medical Research Detachment, Brooks City-Base, Texas 78235","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023320226","display_name":"Ronald L. Seaman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald L. Seaman","raw_affiliation_strings":["McKesson BioServices at United States Army Medical Research Detachment, Brooks City-Base, Texas 78235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKesson BioServices at United States Army Medical Research Detachment, Brooks City-Base, Texas 78235","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016647522","display_name":"Marie\u2010Fran\u00e7oise Chesselet","orcid":"https://orcid.org/0000-0002-1202-1226","observed_orcids":["https://orcid.org/0000-0002-1202-1226"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marie\u2010Fran\u00e7oise Chesselet","raw_affiliation_strings":["Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1769","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016647522"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":5.7304,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.95996683,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"478","issue":"4","first_page":"418","last_page":"426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.8849999904632568},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8949999809265137},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.7039999961853027},{"id":"https://openalex.org/keywords/vmat2","display_name":"vesicular monoamine transporter 2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.972000002861023},{"id":"https://openalex.org/keywords/mitochondrial-complex-i-inhibitors","display_name":"mitochondrial complex I inhibitors","score":0.8479999899864197},{"id":"https://openalex.org/keywords/dopaminergic-terminals","display_name":"dopaminergic terminals","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2778389096","wikidata":"https://www.wikidata.org/wiki/Q412388","display_name":"Rotenone","level":3,"score":0.839181661605835},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.8011078834533691},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7705460786819458},{"id":"https://openalex.org/C2781100881","wikidata":"https://www.wikidata.org/wiki/Q21123811","display_name":"NeuN","level":3,"score":0.6586638689041138},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.6135843992233276},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5218397974967957},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4852173626422882},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47070810198783875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44716936349868774},{"id":"https://openalex.org/C37753355","wikidata":"https://www.wikidata.org/wiki/Q911877","display_name":"Nissl body","level":3,"score":0.43697723746299744},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4236338138580322},{"id":"https://openalex.org/C2778406628","wikidata":"https://www.wikidata.org/wiki/Q2521094","display_name":"Vesicular monoamine transporter 2","level":5,"score":0.4182935655117035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.363158643245697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3442070484161377},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.29552608728408813},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.23473986983299255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22692030668258667},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.16714775562286377},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.14012062549591064},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09824147820472717}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012402","descriptor_name":"Rotenone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012402","descriptor_name":"Rotenone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cne.20305","doi":"https://doi.org/10.1002/cne.20305","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.20305","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"pmid:15384065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15384065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3435046825","display_name":"Center for Gene-Environment Studies in Parkinson Disease","funder_award_id":"U54ES012078","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320338294","display_name":"Air Force Research Laboratory","ror":"https://ror.org/02e2egq70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1504584187","https://openalex.org/W1554017667","https://openalex.org/W1584829548","https://openalex.org/W1974898145","https://openalex.org/W2005773839","https://openalex.org/W2009807412","https://openalex.org/W2013819259","https://openalex.org/W2017083493","https://openalex.org/W2021899761","https://openalex.org/W2025130486","https://openalex.org/W2026674234","https://openalex.org/W2041112741","https://openalex.org/W2041631487","https://openalex.org/W2048033372","https://openalex.org/W2059718548","https://openalex.org/W2062251719","https://openalex.org/W2066430727","https://openalex.org/W2073351779","https://openalex.org/W2074533002","https://openalex.org/W2077526594","https://openalex.org/W2081355012","https://openalex.org/W2093870730","https://openalex.org/W2109759840","https://openalex.org/W2111405228","https://openalex.org/W2115524468","https://openalex.org/W2121272065","https://openalex.org/W2122956388","https://openalex.org/W2155395884","https://openalex.org/W2169788168","https://openalex.org/W2742934657"],"related_works":["https://openalex.org/W2017083493","https://openalex.org/W2013847035","https://openalex.org/W3216717223","https://openalex.org/W2078131628","https://openalex.org/W2153112824","https://openalex.org/W2001421590","https://openalex.org/W2279397902","https://openalex.org/W2005773839","https://openalex.org/W2384262638","https://openalex.org/W2000604066"],"abstract_inverted_index":{"When":[0],"infused":[1],"in":[2,45,88,99,114,127,144,157,165,176,188,208,231],"rats,":[3],"rotenone,":[4],"a":[5,94,120,232,242],"mitochondrial":[6],"complex":[7],"I":[8],"inhibitor,":[9],"induces":[10],"alterations":[11,41],"that":[12,106],"resemble":[13],"the":[14,23,28,40,46,50,100,107,145,158,177,189,192,195,237],"histological":[15],"changes":[16],"of":[17,22,30,52,56,68,76,83,97,122,139,149,194,214,217,234,239,244],"Parkinson's":[18,245],"disease,":[19],"particularly":[20],"degeneration":[21],"nigrostriatal":[24],"dopaminergic":[25],"system.":[26],"However,":[27,135,175],"specificity":[29],"rotenone":[31,44,57,218,240],"effects":[32],"has":[33],"been":[34],"challenged":[35],"recently.":[36],"We":[37],"have":[38],"re-examined":[39],"caused":[42],"by":[43,202],"substantia":[47,146],"nigra":[48],"and":[49,81,151,154,191,204,228],"striatum":[51,159],"rats":[53],"after":[54],"infusion":[55,213],"(2":[58],"mg/kg":[59],"per":[60],"day":[61],"s.c.)":[62],"for":[63],"21":[64],"days.":[65],"Three":[66],"patterns":[67],"striatal":[69,123,162,223],"tyrosine-hydroxylase":[70],"immunoreactivity":[71],"(TH-IR)":[72],"were":[73],"observed:":[74],"46%":[75,82],"animals":[77,84,128,166],"showed":[78,85,105,160],"no":[79,136,161],"reduction,":[80],"diffuse":[86,130,172],"reduction":[87,230],"TH-IR,":[89,117],"whereas":[90],"one":[91],"animal":[92,178],"presented":[93],"focal":[95,180],"loss":[96,121,138,164,185],"TH-IR":[98,133,140,170,173,181,227],"striatum.":[101],"Confocal":[102],"microscopy":[103],"analysis":[104],"vesicular":[108],"monoamine":[109],"transporter":[110],"(VMAT2)":[111],"was":[112,142,186],"decreased":[113],"parallel":[115],"with":[116,129,167,179,198],"strongly":[118],"suggesting":[119],"DA":[124],"nerve":[125],"terminals":[126],"or":[131,171],"central":[132],"loss.":[134],"significant":[137,222],"neurons":[141],"observed":[143],"nigra.":[147],"Analysis":[148],"NeuN":[150],"DARPP-32":[152],"immunoreactivity,":[153],"Nissl":[155],"staining,":[156],"neuronal":[163,184,224],"either":[168],"preserved":[169],"reduction.":[174],"loss,":[182,225],"severe":[183],"evident":[187],"center":[190],"periphery":[193],"striatum,":[196],"together":[197],"microglial":[199],"activation":[200],"detected":[201],"OX-6":[203],"OX-42":[205],"staining.":[206],"Thus,":[207],"most":[209],"cases,":[210],"chronic":[211],"subcutaneous":[212],"low":[215],"doses":[216],"does":[219],"not":[220],"induce":[221],"despite":[226],"VMAT-IR":[229],"subset":[233],"animals,":[235],"supporting":[236],"use":[238],"as":[241],"model":[243],"disease":[246],"under":[247],"carefully":[248],"controlled":[249],"experimental":[250],"conditions.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}