{"id":"https://openalex.org/W2000328498","doi":"https://doi.org/10.1016/j.mce.2008.10.008","title":"Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction","display_name":"Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction","publication_year":2008,"publication_date":"2008-10-20","ids":{"openalex":"https://openalex.org/W2000328498","doi":"https://doi.org/10.1016/j.mce.2008.10.008","mag":"2000328498","pmid":"https://pubmed.ncbi.nlm.nih.gov/19007848"},"language":"en","primary_location":{"id":"doi:10.1016/j.mce.2008.10.008","doi":"https://doi.org/10.1016/j.mce.2008.10.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mce.2008.10.008","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045605464","display_name":"Katharina Ronacher","orcid":"https://orcid.org/0000-0002-6371-1462","observed_orcids":["https://orcid.org/0000-0002-6371-1462"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Katharina Ronacher","raw_affiliation_strings":["Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006553837","display_name":"Katie Hadley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Katie Hadley","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch 7700, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch 7700, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067887867","display_name":"Chanel Avenant","orcid":"https://orcid.org/0000-0002-2114-1473","observed_orcids":["https://orcid.org/0000-0002-2114-1473"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Chanel Avenant","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch 7700, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch 7700, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030743556","display_name":"Elisabeth Stubsrud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Elisabeth Stubsrud","raw_affiliation_strings":["Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018945206","display_name":"S. Stoney Simons","orcid":"https://orcid.org/0000-0001-5219-5696","observed_orcids":["https://orcid.org/0000-0001-5219-5696"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Stoney Simons","raw_affiliation_strings":["Steroid Hormones Section, Bldg. 10, Room 8N-307B, NIDDK/CEB, National Institutes of Health, Bethesda, MD, 20892-1772, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steroid Hormones Section, Bldg. 10, Room 8N-307B, NIDDK/CEB, National Institutes of Health, Bethesda, MD, 20892-1772, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040777054","display_name":"Ann Louw","orcid":"https://orcid.org/0000-0002-1021-6732","observed_orcids":["https://orcid.org/0000-0002-1021-6732"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Ann Louw","raw_affiliation_strings":["Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058466834","display_name":"Janet Patricia Hapgood","orcid":"https://orcid.org/0000-0002-4414-4861","observed_orcids":["https://orcid.org/0000-0002-4414-4861"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Janet P. Hapgood","raw_affiliation_strings":["Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa","institution_ids":["https://openalex.org/I26092322"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058466834"],"corresponding_institution_ids":["https://openalex.org/I26092322"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":5.3226,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.96228798,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"299","issue":"2","first_page":"219","last_page":"231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":1.0},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/transrepression","display_name":"transrepression","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.8700000047683716},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/smrt","display_name":"SMRT","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ncor","display_name":"NCoR","score":0.8109999895095825},{"id":"https://openalex.org/keywords/glucocorticoid-response-element","display_name":"glucocorticoid response element","score":0.8009999990463257},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7300000190734863},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cofactor-recruitment","display_name":"cofactor recruitment","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C59300778","wikidata":"https://www.wikidata.org/wiki/Q7835354","display_name":"Transrepression","level":5,"score":0.9621775150299072},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.9389681816101074},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.7167573571205139},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5647380948066711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5094628930091858},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4753301441669464},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.44873058795928955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3570253252983093},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3484411835670471},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33802229166030884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2752130329608917},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.22266170382499695},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1589835286140442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13812223076820374},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06948313117027283}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mce.2008.10.008","doi":"https://doi.org/10.1016/j.mce.2008.10.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mce.2008.10.008","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},{"id":"pmid:19007848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19007848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1835342283","https://openalex.org/W1965567094","https://openalex.org/W1965978465","https://openalex.org/W1969117611","https://openalex.org/W1969500227","https://openalex.org/W1971509596","https://openalex.org/W1974312109","https://openalex.org/W1985425337","https://openalex.org/W1988261104","https://openalex.org/W1989150626","https://openalex.org/W1999378087","https://openalex.org/W2004857981","https://openalex.org/W2008781112","https://openalex.org/W2011119018","https://openalex.org/W2020916965","https://openalex.org/W2021789739","https://openalex.org/W2026022568","https://openalex.org/W2027398944","https://openalex.org/W2031849324","https://openalex.org/W2032146477","https://openalex.org/W2039274765","https://openalex.org/W2042764034","https://openalex.org/W2043382313","https://openalex.org/W2053427642","https://openalex.org/W2053492909","https://openalex.org/W2061674718","https://openalex.org/W2061895411","https://openalex.org/W2076234060","https://openalex.org/W2076764916","https://openalex.org/W2079067885","https://openalex.org/W2083670053","https://openalex.org/W2089554403","https://openalex.org/W2090456077","https://openalex.org/W2091256192","https://openalex.org/W2092368286","https://openalex.org/W2094884232","https://openalex.org/W2095060581","https://openalex.org/W2108244474","https://openalex.org/W2119259534","https://openalex.org/W2119963782","https://openalex.org/W2122502036","https://openalex.org/W2126496338","https://openalex.org/W2131967029","https://openalex.org/W2132581983","https://openalex.org/W2132709184","https://openalex.org/W2135268524","https://openalex.org/W2136179374","https://openalex.org/W2137658990","https://openalex.org/W2139031643","https://openalex.org/W2140459477","https://openalex.org/W2145429468","https://openalex.org/W2150691073","https://openalex.org/W2156005057","https://openalex.org/W2163486940","https://openalex.org/W2171643283","https://openalex.org/W4234630338"],"related_works":["https://openalex.org/W2040492624","https://openalex.org/W1965567094","https://openalex.org/W2072655840","https://openalex.org/W2085976882","https://openalex.org/W2083670053","https://openalex.org/W656021468","https://openalex.org/W1997498452","https://openalex.org/W2054306576","https://openalex.org/W2069452057","https://openalex.org/W1964520567"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}