{"id":"https://openalex.org/W2000322180","doi":"https://doi.org/10.1210/en.2008-1133","title":"Impaired Bacterial Clearance in Type 3 Deiodinase-Deficient Mice Infected with Streptococcus pneumoniae","display_name":"Impaired Bacterial Clearance in Type 3 Deiodinase-Deficient Mice Infected with Streptococcus pneumoniae","publication_year":2008,"publication_date":"2008-11-26","ids":{"openalex":"https://openalex.org/W2000322180","doi":"https://doi.org/10.1210/en.2008-1133","mag":"2000322180","pmid":"https://pubmed.ncbi.nlm.nih.gov/19036878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2659279"},"language":"en","primary_location":{"id":"doi:10.1210/en.2008-1133","doi":"https://doi.org/10.1210/en.2008-1133","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2008-1133","pdf_url":"https://academic.oup.com/endo/article-pdf/150/4/1984/9008318/endo1984.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/150/4/1984/9008318/endo1984.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042061862","display_name":"Anita Boelen","orcid":"https://orcid.org/0000-0002-4994-2918","observed_orcids":["https://orcid.org/0000-0002-4994-2918"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Anita Boelen","raw_affiliation_strings":["Department of Endocrinology and Metabolism (A.B., J.K., E.F.), Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism (A.B., J.K., E.F.), Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008669331","display_name":"Joan Kwakkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joan Kwakkel","raw_affiliation_strings":["Department of Endocrinology and Metabolism (A.B., J.K., E.F.), Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism (A.B., J.K., E.F.), Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109067313","display_name":"Catharina W. Wieland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Catharina W. Wieland","raw_affiliation_strings":["Center for Infection and Immunity (C.W.W.), Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infection and Immunity (C.W.W.), Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007304489","display_name":"Donald L. St. Germain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald L. St. Germain","raw_affiliation_strings":["Department of Medicine (D.L.S.G., A.H.), Dartmouth Medical School, Lebanon, New Hampshire 03756"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (D.L.S.G., A.H.), Dartmouth Medical School, Lebanon, New Hampshire 03756","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073880325","display_name":"Eric Fliers","orcid":"https://orcid.org/0000-0001-8048-9050","observed_orcids":["https://orcid.org/0000-0001-8048-9050"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eric Fliers","raw_affiliation_strings":["Department of Endocrinology and Metabolism (A.B., J.K., E.F.), Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism (A.B., J.K., E.F.), Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030192169","display_name":"Arturo Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-6314-3987","observed_orcids":["https://orcid.org/0000-0002-6314-3987"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arturo Hernandez","raw_affiliation_strings":["Department of Medicine (D.L.S.G., A.H.), Dartmouth Medical School, Lebanon, New Hampshire 03756"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (D.L.S.G., A.H.), Dartmouth Medical School, Lebanon, New Hampshire 03756","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042061862"],"corresponding_institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.9312,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.91017675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"150","issue":"4","first_page":"1984","last_page":"1990"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-3-deiodinase","display_name":"type 3 deiodinase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bacterial-clearance","display_name":"bacterial clearance","score":0.8339999914169312},{"id":"https://openalex.org/keywords/acute-bacterial-infection","display_name":"acute bacterial infection","score":0.8199999928474426},{"id":"https://openalex.org/keywords/non-thyroidal-illness","display_name":"low T3 syndrome","score":0.8349999785423279},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.6690000295639038},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8500000238418579},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.890999972820282},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6380000114440918},{"id":"https://openalex.org/keywords/bacterial-load","display_name":"bacterial load","score":0.7409999966621399},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7680000066757202},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.7307353615760803},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.6255267858505249},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5538561940193176},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5289925336837769},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5274103879928589},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5100446343421936},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5000700950622559},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48336929082870483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46323511004447937},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.4425927400588989},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4253392517566681},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4240434765815735},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.41055479645729065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26189687848091125},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.21860715746879578},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.13946640491485596},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.08003765344619751}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1210/en.2008-1133","doi":"https://doi.org/10.1210/en.2008-1133","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2008-1133","pdf_url":"https://academic.oup.com/endo/article-pdf/150/4/1984/9008318/endo1984.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2659279","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2659279","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},{"id":"pmid:19036878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19036878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/8a6a5d53-c147-4938-87ac-7350a453db16","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/impaired-bacterial-clearance-in-type-3-deiodinase-deficient-mice-infected-with-streptococcus-pneumoniae(8a6a5d53-c147-4938-87ac-7350a453db16).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology, 150(4), 1984 - 1990. The Endocrine Society","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/f348ad98-3f98-434d-9ac9-62919b8f5061","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/f348ad98-3f98-434d-9ac9-62919b8f5061","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boelen, A, Kwakkel, J, Wieland, C W, St Germain, D L, Fliers, E & Hernandez, A 2009, 'Impaired bacterial clearance in type 3 deiodinase deficient mice infected with Streptococcus pneumoniae', Endocrinology, vol. 150, no. 4, pp. 1984-1990. https://doi.org/10.1210/en.2008-1133","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1210/en.2008-1133","doi":"https://doi.org/10.1210/en.2008-1133","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2008-1133","pdf_url":"https://academic.oup.com/endo/article-pdf/150/4/1984/9008318/endo1984.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G18328511","display_name":"The Role of the Type 3 Deiodinase in Development","funder_award_id":"R01DK054716","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3172728306","display_name":"THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERS","funder_award_id":"R37DK015070","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000864893","display_name":"Thyroid Physiology Studies of Inherited Disorders","funder_award_id":"R01DK015070","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000322180.pdf","grobid_xml":"https://content.openalex.org/works/W2000322180.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1550704138","https://openalex.org/W1972866985","https://openalex.org/W1979796052","https://openalex.org/W1987748298","https://openalex.org/W1987919249","https://openalex.org/W2005744729","https://openalex.org/W2019259772","https://openalex.org/W2029120861","https://openalex.org/W2030186159","https://openalex.org/W2030255891","https://openalex.org/W2036261582","https://openalex.org/W2044306937","https://openalex.org/W2045027601","https://openalex.org/W2046352151","https://openalex.org/W2059149560","https://openalex.org/W2062743262","https://openalex.org/W2067881527","https://openalex.org/W2068458134","https://openalex.org/W2070931075","https://openalex.org/W2071408780","https://openalex.org/W2097140043","https://openalex.org/W2101123075","https://openalex.org/W2104878795","https://openalex.org/W2106664880","https://openalex.org/W2123106811","https://openalex.org/W2130754426","https://openalex.org/W2136006969","https://openalex.org/W2136634417","https://openalex.org/W2138941595","https://openalex.org/W2144689930","https://openalex.org/W2149548143","https://openalex.org/W2165821124"],"related_works":["https://openalex.org/W2030186159","https://openalex.org/W2770024834","https://openalex.org/W2469279603","https://openalex.org/W2036261582","https://openalex.org/W4213412346","https://openalex.org/W1996632403","https://openalex.org/W2962602043","https://openalex.org/W2099194521","https://openalex.org/W2067881527","https://openalex.org/W2101123075"],"abstract_inverted_index":{"The":[0],"activation":[1],"of":[2,17,27,63,147,187,198,205,217,249],"type":[3,81],"3":[4],"deiodinase":[5],"(D3)":[6],"has":[7],"been":[8],"postulated":[9],"to":[10,68,182],"play":[11],"a":[12,24,46,109,230],"role":[13,49,62,232],"in":[14,38,53,65,92,100,108,111,115,119,139,154,165,192,212,224,235],"the":[15,54,61,66,184,188,196,203,236,245],"reduction":[16],"thyroid":[18,94],"hormone":[19,95],"levels":[20,96],"during":[21],"illness.":[22],"Using":[23],"mouse":[25],"model":[26],"acute":[28,69,239],"bacterial":[29,70,163,210,240],"infection,":[30,71,124,241],"we":[31,72],"have":[32],"recently":[33],"demonstrated":[34,160],"marked":[35],"D3":[36,64,75,178,199,234],"immunostaining":[37],"neutrophils":[39],"infiltrating":[40],"infected":[41,85,120,148],"organs.":[42],"These":[43],"observations":[44],"suggest":[45,229],"possible":[47],"additional":[48],"for":[50,233],"this":[51,193],"enzyme":[52],"innate":[55],"immune":[56],"response.":[57],"To":[58],"further":[59],"assess":[60],"response":[67],"used":[73],"null":[74],"[D3":[76],"knockout":[77],"(D3KO)]":[78],"and":[79,84,102,132,134,141,144,168,208,215],"wild":[80],"(WT)":[82],"mice":[83,149,219],"them":[86],"with":[87,171],"Streptococcus":[88],"pneumoniae.":[89],"Marked":[90],"reductions":[91],"serum":[93],"were":[97],"observed":[98],"both":[99,155],"D3KO":[101,121,140,158,218],"WT":[103,142,172,225],"mice.":[104,122,173,226],"Infection":[105],"resulted":[106],"also":[107],"decrease":[110],"liver":[112],"D1":[113],"activity":[114],"WT,":[116],"but":[117],"not":[118,180,201],"Upon":[123],"pulmonary":[125,152,206],"neutrophilic":[126],"influx":[127],"(measured":[128],"by":[129,243],"myeloperoxidase":[130],"levels)":[131],"IL-6":[133],"TNF":[135],"concentrations":[136],"increased":[137],"equally":[138],"mice,":[143],"histological":[145],"examination":[146],"showed":[150],"similar":[151],"inflammation":[153],"strains.":[156],"However,":[157],"animals":[159],"significantly":[161,221],"higher":[162,222],"load":[164],"blood,":[166,213],"lung,":[167],"spleen":[169],"compared":[170],"We":[174],"conclude":[175],"that":[176],"1)":[177],"is":[179,220],"required":[181],"generate":[183],"systemic":[185],"manifestations":[186],"nonthyroidal":[189],"illness":[190],"syndrome":[191],"model;":[194],"2)":[195],"lack":[197],"does":[200],"affect":[202],"extent":[204],"inflammation;":[207],"3)":[209],"outgrowth":[211],"spleen,":[214],"lung":[216],"than":[223],"Our":[227],"results":[228],"protective":[231],"defense":[237],"against":[238],"probably":[242],"reinforcing":[244],"microbial":[246],"killing":[247],"capacity":[248],"neutrophils.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
