{"id":"https://openalex.org/W2000317817","doi":"https://doi.org/10.1093/carcin/8.11.1753","title":"Ionizing radiation enhances malignant progression of mouse skin tumors","display_name":"Ionizing radiation enhances malignant progression of mouse skin tumors","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2000317817","doi":"https://doi.org/10.1093/carcin/8.11.1753","mag":"2000317817","pmid":"https://pubmed.ncbi.nlm.nih.gov/3664970"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/8.11.1753","doi":"https://doi.org/10.1093/carcin/8.11.1753","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/8.11.1753","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112800382","display_name":"Deborah R. Jaffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah R. Jaffe","raw_affiliation_strings":["Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson 85724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson 85724","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032752677","display_name":"Jeffrey F. Williamson","orcid":"https://orcid.org/0000-0001-8559-2436","observed_orcids":["https://orcid.org/0000-0001-8559-2436"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey F. Williamson","raw_affiliation_strings":["Department of Radiation Oncology, University of Arizona Health Sciences Center Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Arizona Health Sciences Center Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110035695","display_name":"G. Tim Bowden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Tim Bowden","raw_affiliation_strings":["Department of Radiation Oncology, University of Arizona Health Sciences Center Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Arizona Health Sciences Center Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":1.2985,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.7782652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"11","first_page":"1753","last_page":"1755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.3091000020503998,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/malignant-progression","display_name":"malignant progression","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.5299999713897705},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/n-methyl-n-nitro-n-nitrosoguanidine","display_name":"N-methyl-N'-nitro-N-nitrosoguanidine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/electron-irradiation","display_name":"electron irradiation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/fractionated-irradiation","display_name":"fractionated irradiation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/cd-1-mice","display_name":"ICR mice","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.892931342124939},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6768172979354858},{"id":"https://openalex.org/C2780625556","wikidata":"https://www.wikidata.org/wiki/Q12263499","display_name":"Methylnitronitrosoguanidine","level":4,"score":0.5862010717391968},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5057437419891357},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5055978298187256},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.49431538581848145},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.3849990963935852},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3847164213657379},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36497050523757935},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36421313881874084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34387820959091187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23864981532096863},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09946712851524353},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000096","descriptor_name":"Acetone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003043","descriptor_name":"Cocarcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008769","descriptor_name":"Methylnitronitrosoguanidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/8.11.1753","doi":"https://doi.org/10.1093/carcin/8.11.1753","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/8.11.1753","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:3664970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3664970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1602298124","display_name":null,"funder_award_id":"CA42239","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2159449340","display_name":null,"funder_award_id":"CA 23074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W764383926","https://openalex.org/W2044347535","https://openalex.org/W2313207782","https://openalex.org/W70838477","https://openalex.org/W2108264324","https://openalex.org/W4244130245","https://openalex.org/W1979966666","https://openalex.org/W326150343","https://openalex.org/W1973093013","https://openalex.org/W4230780450"],"abstract_inverted_index":{"Chemical":[0],"carcinogenesis":[1],"in":[2,27,42,138,158],"mouse":[3,47],"skin":[4,48],"has":[5],"been":[6],"divided":[7],"into":[8],"the":[9,43,69,126,139,152,162],"process":[10],"of":[11,46,67,86,95,100,128,135,141,164],"initiation,":[12],"promotion":[13,60],"and":[14,154],"progression.":[15],"Recently":[16],"we":[17,34],"have":[18],"shown":[19],"that":[20,151],"ionizing":[21,40,112,148],"radiation":[22,41,113,124,149],"acts":[23],"as":[24],"an":[25,136],"initiator":[26],"this":[28,32,159],"model":[29],"system.":[30],"In":[31],"paper":[33],"describe":[35],"a":[36,78,93],"three-stage":[37],"experiment":[38],"using":[39],"third":[44],"stage":[45],"carcinogenesis.":[49],"CD-1":[50],"mice":[51],"were":[52,71],"initiated":[53],"with":[54,61,73,111,115,121],"N-methyl-N'-nitro-N-nitrosoguanidine":[55],"(MNNG)":[56],"followed":[57],"by":[58],"biweekly":[59],"12-O-tetradecanoylphorbol-13-acetate":[62],"(TPA).":[63],"After":[64],"20":[65],"weeks":[66],"promotion,":[68],"animals":[70,109,119],"treated":[72,110,120],"either":[74],"acetone,":[75],"TPA":[76],"(twice":[77],"week":[79],"for":[80,108,117],"2":[81],"weeks)":[82],"or":[83],"eight":[84],"fractions":[85],"1":[87],"MeV":[88],"electrons":[89],"(1":[90],"Gy/fraction":[91],"over":[92],"period":[94],"10":[96],"days).":[97],"The":[98,133],"conversion":[99],"papillomas":[101,143],"to":[102,147],"squamous":[103],"cell":[104],"carcinomas":[105,130],"was":[106],"80%":[107],"compared":[114],"25%":[116],"tumor-bearing":[118],"TPA.":[122],"Ionizing":[123],"increased":[125],"number":[127,140],"cumulative":[129,142],"per":[131,144],"group.":[132],"lack":[134],"increase":[137],"group":[145],"due":[146],"suggests":[150],"dose":[153],"fractionation":[155],"protocol":[156],"used":[157],"study":[160],"enhanced":[161],"progression":[163],"pre-existing":[165],"papillomas.":[166]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}