{"id":"https://openalex.org/W2000315860","doi":"https://doi.org/10.1111/codi.12543","title":"A randomised, controlled, crossover study to investigate the pharmacodynamics, pharmacokinetics and safety of 1R,2S\u2010methoxamine hydrochloride (NRL001) in healthy elderly subjects","display_name":"A randomised, controlled, crossover study to investigate the pharmacodynamics, pharmacokinetics and safety of 1R,2S\u2010methoxamine hydrochloride (NRL001) in healthy elderly subjects","publication_year":2014,"publication_date":"2014-02-05","ids":{"openalex":"https://openalex.org/W2000315860","doi":"https://doi.org/10.1111/codi.12543","mag":"2000315860","pmid":"https://pubmed.ncbi.nlm.nih.gov/24499494"},"language":"en","primary_location":{"id":"doi:10.1111/codi.12543","doi":"https://doi.org/10.1111/codi.12543","is_oa":false,"landing_page_url":"https://doi.org/10.1111/codi.12543","pdf_url":null,"source":{"id":"https://openalex.org/S91064148","display_name":"Colorectal Disease","issn_l":"1462-8910","issn":["1462-8910","1463-1318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113524657","display_name":"David Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107895","display_name":"BioKinetic Europe (United Kingdom)","ror":"https://ror.org/01hp17k95","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210107895"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Bell","raw_affiliation_strings":["BioKinetic Europe Limited Belfast UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioKinetic Europe Limited Belfast UK","institution_ids":["https://openalex.org/I4210107895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066067619","display_name":"A. Duffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107895","display_name":"BioKinetic Europe (United Kingdom)","ror":"https://ror.org/01hp17k95","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210107895"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Duffin","raw_affiliation_strings":["BioKinetic Europe Limited Belfast UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioKinetic Europe Limited Belfast UK","institution_ids":["https://openalex.org/I4210107895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110238994","display_name":"H J Gruss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. J. Gruss","raw_affiliation_strings":["Medical & Safety Services ICON Clinical Research Eastleigh UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical & Safety Services ICON Clinical Research Eastleigh UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107378891","display_name":"Claudio Pediconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141803","display_name":"Norgine (United Kingdom)","ror":"https://ror.org/046zgtw08","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136628","https://openalex.org/I4210141803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"C. Pediconi","raw_affiliation_strings":["Norgine Limited Uxbridge UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norgine Limited Uxbridge UK","institution_ids":["https://openalex.org/I4210141803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036936951","display_name":"Adam Jacobs","orcid":"https://orcid.org/0000-0003-2792-3166","observed_orcids":["https://orcid.org/0000-0003-2792-3166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Jacobs","raw_affiliation_strings":["Dianthus Medical Limited London UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dianthus Medical Limited London UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5107378891"],"corresponding_institution_ids":["https://openalex.org/I4210141803"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":1.4729,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.83322286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"s1","first_page":"27","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.3610999882221222,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.3610999882221222,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.2168000042438507,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14020","display_name":"Medical research and treatments","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suppositories","display_name":"suppositories","score":0.6299999952316284},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8709999918937683},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7329999804496765},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.959383487701416},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7247171401977539},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6741271018981934},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6594222784042358},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4988701343536377},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4754840135574341},{"id":"https://openalex.org/C2776460385","wikidata":"https://www.wikidata.org/wiki/Q420060","display_name":"Hydrochloride","level":2,"score":0.45296478271484375},{"id":"https://openalex.org/C2780745239","wikidata":"https://www.wikidata.org/wiki/Q685119","display_name":"Methoxamine","level":4,"score":0.4390376806259155},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.41493475437164307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2192537486553192},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.1265072524547577},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.11452573537826538},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.11385476589202881},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013488","descriptor_name":"Suppositories","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013488","descriptor_name":"Suppositories","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013488","descriptor_name":"Suppositories","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015716","descriptor_name":"Electrocardiography, Ambulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015716","descriptor_name":"Electrocardiography, Ambulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015716","descriptor_name":"Electrocardiography, Ambulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058646","descriptor_name":"Adrenergic alpha-1 Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/codi.12543","doi":"https://doi.org/10.1111/codi.12543","is_oa":false,"landing_page_url":"https://doi.org/10.1111/codi.12543","pdf_url":null,"source":{"id":"https://openalex.org/S91064148","display_name":"Colorectal Disease","issn_l":"1462-8910","issn":["1462-8910","1463-1318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal Disease","raw_type":"journal-article"},{"id":"pmid:24499494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24499494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332137","display_name":"Norgine","ror":"https://ror.org/02vt89g81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2005692215","https://openalex.org/W2045670186","https://openalex.org/W2117175841","https://openalex.org/W2136888129","https://openalex.org/W2141398379","https://openalex.org/W2169479533","https://openalex.org/W2226327246","https://openalex.org/W2343192899"],"related_works":["https://openalex.org/W2056868288","https://openalex.org/W2064541680","https://openalex.org/W2018887812","https://openalex.org/W2044291706","https://openalex.org/W2124465274","https://openalex.org/W2026887642","https://openalex.org/W2044561687","https://openalex.org/W4390261636","https://openalex.org/W813629418","https://openalex.org/W2012695707"],"abstract_inverted_index":{"AIMS:":[0],"This":[1,41],"study":[2,51,98],"aimed":[3],"to":[4,173,204],"assess":[5],"the":[6,192],"effects":[7],"of":[8,12,19,61,169],"a":[9,23,36,43,56,66,187],"single":[10,57],"dose":[11],"10":[13,62],"mg":[14,63],"NRL001":[15,64,119,127,137,170,182,205],"(the":[16],"1R,2S":[17],"stereoisomer":[18],"methoxamine":[20],"hydrochloride)":[21],"in":[22,35,69,103,158,175,212],"2":[24,58],"g":[25,59],"suppository":[26,60],"on":[27],"pharmacodynamic":[28],"and":[29,33,65,82,89,111,123,139,150],"pharmacokinetic":[30],"(PK)":[31],"variables,":[32],"safety,":[34],"healthy":[37,210],"elderly":[38,195],"population.":[39],"METHODS:":[40],"was":[42,183],"Phase":[44],"I,":[45],"single-centre,":[46],"randomised,":[47],"double-blind,":[48],"placebo-controlled":[49],"crossover":[50],"during":[52,191],"which":[53],"subjects":[54,94,196],"received":[55],"matching":[67],"placebo":[68,121,180],"two":[70],"separate":[71],"treatment":[72],"periods.":[73],"The":[74],"main":[75],"outcome":[76],"measures":[77],"were":[78,95,116,134,156],"Holter-,":[79],"vital":[80,108],"signs-":[81],"electrocardiogram-derived":[83],"cardiovascular":[84],"variables;":[85],"plasma":[86,128],"PK":[87],"analysis;":[88],"safety":[90,189],"assessments.":[91],"RESULTS:":[92],"Twenty-six":[93],"dosed":[96],"with":[97,120,125,165,179,186,208],"medication.":[99],"Statistically":[100],"significant":[101,132],"reductions":[102],"Holter-derived":[104],"heart":[105],"rate":[106],"(HR),":[107],"signs-derived":[109],"HR":[110,176],"diastolic":[112],"blood":[113],"pressure":[114,144],"(BP)":[115],"observed":[117,135],"comparing":[118],"treatment,":[122],"also":[124],"increasing":[126],"concentration.":[129],"No":[130],"statistically":[131],"relationships":[133],"between":[136],"concentration":[138],"systolic":[140],"BP,":[141],"mean":[142],"arterial":[143],"or":[145],"QTC":[146],"interval":[147],"(both":[148],"Bazett's":[149],"Fridericia's":[151],"correction).":[152],"Thirty-nine":[153],"adverse":[154],"events":[155],"reported":[157],"20":[159],"(76.9%)":[160],"subjects,":[161],"mostly":[162],"after":[163],"dosing":[164],"NRL001.":[166],"CONCLUSION:":[167],"Administration":[168],"suppositories":[171,206],"led":[172],"decreases":[174],"when":[177],"compared":[178,207],"data.":[181],"well":[184],"tolerated":[185],"good":[188],"profile":[190],"study.":[193],"Healthy":[194],"did":[197],"not":[198],"show":[199],"significantly":[200],"different":[201],"biological":[202],"responses":[203],"younger":[209],"volunteers":[211],"previous":[213],"studies.":[214]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}