{"id":"https://openalex.org/W2000315480","doi":"https://doi.org/10.1039/b606424h","title":"Manipulating the generation of Ca-alginate microspheres using microfluidic channels as a carrier of gold nanoparticles","display_name":"Manipulating the generation of Ca-alginate microspheres using microfluidic channels as a carrier of gold nanoparticles","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2000315480","doi":"https://doi.org/10.1039/b606424h","mag":"2000315480","pmid":"https://pubmed.ncbi.nlm.nih.gov/16804602"},"language":"en","primary_location":{"id":"doi:10.1039/b606424h","doi":"https://doi.org/10.1039/b606424h","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b606424h","pdf_url":null,"source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000315480"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018985374","display_name":"Keng\u2010Shiang Huang","orcid":"https://orcid.org/0000-0002-7751-0223","observed_orcids":["https://orcid.org/0000-0002-7751-0223"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Keng-Shiang Huang","raw_affiliation_strings":["Department of Engineering Science, National Cheng Kung University, 1 University Road, 701 Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, National Cheng Kung University, 1 University Road, 701 Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084178603","display_name":"Tzung-Heng Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzung-Heng Lai","raw_affiliation_strings":["Department of Engineering Science, National Cheng Kung University, 1 University Road, 701 Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, National Cheng Kung University, 1 University Road, 701 Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100856376","display_name":"Yu-Cheng Lin","orcid":"https://orcid.org/0009-0006-1088-9108","observed_orcids":["https://orcid.org/0009-0006-1088-9108"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yu-Cheng Lin","raw_affiliation_strings":["Department of Engineering Science, National Cheng Kung University, 1 University Road, 701 Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, National Cheng Kung University, 1 University Road, 701 Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100856376"],"corresponding_institution_ids":["https://openalex.org/I91807558"],"apc_list":null,"apc_paid":null,"fwci":10.9365,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.99099222,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"6","issue":"7","first_page":"954","last_page":"954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-alginate-microspheres","display_name":"calcium alginate microspheres","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.8309999704360962},{"id":"https://openalex.org/keywords/microfluidic-encapsulation","display_name":"microfluidic encapsulation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hydrodynamic-focusing","display_name":"hydrodynamic focusing","score":0.8600000143051147},{"id":"https://openalex.org/keywords/water-in-oil-emulsions","display_name":"water-in-oil emulsions","score":0.9769999980926514},{"id":"https://openalex.org/keywords/droplet-size-control","display_name":"droplet size control","score":0.7590000033378601},{"id":"https://openalex.org/keywords/sodium-alginate","display_name":"sodium alginate","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.8135231733322144},{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.7949857711791992},{"id":"https://openalex.org/C63662833","wikidata":"https://www.wikidata.org/wiki/Q6839341","display_name":"Microchannel","level":2,"score":0.7850466966629028},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6672109961509705},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6602818965911865},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.5996353030204773},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5987924933433533},{"id":"https://openalex.org/C2778713300","wikidata":"https://www.wikidata.org/wiki/Q2034064","display_name":"Calcium alginate","level":3,"score":0.5741252303123474},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5496776700019836},{"id":"https://openalex.org/C172120300","wikidata":"https://www.wikidata.org/wiki/Q1134348","display_name":"Volumetric flow rate","level":2,"score":0.4731777012348175},{"id":"https://openalex.org/C147831808","wikidata":"https://www.wikidata.org/wiki/Q1431442","display_name":"Microreactor","level":3,"score":0.46105945110321045},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4331441819667816},{"id":"https://openalex.org/C2993699647","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous medium","level":3,"score":0.42719462513923645},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.412601113319397},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31275689601898193},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2903221845626831},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07708099484443665},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.061017900705337524},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0534796416759491},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004655","descriptor_name":"Emulsions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/b606424h","doi":"https://doi.org/10.1039/b606424h","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b606424h","pdf_url":null,"source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},{"id":"pmid:16804602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16804602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a chip","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1971141424","https://openalex.org/W1979337987","https://openalex.org/W1981051452","https://openalex.org/W2009858479","https://openalex.org/W2014455525","https://openalex.org/W2023585844","https://openalex.org/W2042965999","https://openalex.org/W2055489543","https://openalex.org/W2057317821","https://openalex.org/W2071088782","https://openalex.org/W2098302283","https://openalex.org/W2125364971","https://openalex.org/W2139879061","https://openalex.org/W4211124701"],"related_works":["https://openalex.org/W2070394870","https://openalex.org/W2010190296","https://openalex.org/W2000177896","https://openalex.org/W2039613302","https://openalex.org/W2001047663","https://openalex.org/W2359513491","https://openalex.org/W3156145237","https://openalex.org/W2072958019","https://openalex.org/W2009888444","https://openalex.org/W2962584513"],"abstract_inverted_index":{"In":[0],"this":[1,119],"paper":[2],"the":[3,13,27,36,42,98,104,124],"manipulation":[4],"of":[5,15,29,32,49,58,97],"Ca-alginate":[6,64],"microspheres,":[7],"using":[8],"a":[9,30,56,85,127],"microfluidic":[10],"chip,":[11],"for":[12],"encapsulation":[14],"gold":[16,116],"nanoparticles":[17],"is":[18,22],"presented.":[19],"Our":[20],"strategy":[21],"based":[23],"on":[24,26,126],"hydrodynamic-focusing":[25],"forming":[28],"series":[31],"self-assembling":[33],"sphere":[34],"structures,":[35],"so-called":[37],"water-in-oil":[38],"(w/o)":[39],"emulsions,":[40,47],"in":[41,66],"cross-junction":[43],"microchannel.":[44],"These":[45],"fine":[46],"consisting":[48],"aqueous":[50],"Na-alginates,":[51],"are":[52,100],"then":[53],"dripped":[54],"into":[55],"solution":[57],"20%":[59],"calcium":[60],"salt":[61],"to":[62,81,114],"accomplish":[63],"microspheres":[65,74],"an":[67],"efficient":[68],"manner.":[69],"Experimental":[70],"data":[71],"show":[72],"that":[73],"with":[75,84],"diameters":[76],"ranging":[77],"from":[78],"50":[79],"microm":[80,83],"2000":[82],"variation":[86],"less":[87],"than":[88],"5%":[89],"were":[90],"precisely":[91],"generated.":[92],"The":[93],"size":[94],"and":[95,118],"gap":[96],"droplets":[99],"tunable":[101],"by":[102],"adjusting":[103],"relative":[105],"sheath/sample":[106],"flow":[107],"rate":[108],"ratio.":[109],"Furthermore,":[110],"we":[111],"applied":[112],"them":[113],"encapsulated":[115],"nanoparticles,":[117],"one":[120],"shot":[121],"operation":[122],"performs":[123],"'Lab":[125],"Chip'.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
