{"id":"https://openalex.org/W2000315424","doi":"https://doi.org/10.1016/j.jalz.2011.05.937","title":"P2\u2010048: Plasma sphingomyelin is associated with cognitive progression in Alzheimer's Disease","display_name":"P2\u2010048: Plasma sphingomyelin is associated with cognitive progression in Alzheimer's Disease","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2000315424","doi":"https://doi.org/10.1016/j.jalz.2011.05.937","mag":"2000315424"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2011.05.937","doi":"https://doi.org/10.1016/j.jalz.2011.05.937","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.937","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090710393","display_name":"Michelle M. Mielke","orcid":"https://orcid.org/0000-0001-7177-1185","observed_orcids":["https://orcid.org/0000-0001-7177-1185"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Mielke","raw_affiliation_strings":["Johns Hopkins University, Baltimore, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, Maryland, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022491794","display_name":"Norman J. Haughey","orcid":"https://orcid.org/0000-0001-5194-4122","observed_orcids":["https://orcid.org/0000-0001-5194-4122"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman Haughey","raw_affiliation_strings":["Johns Hopkins University, Baltimore, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, Maryland, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108749056","display_name":"Veera Venkata Ratnam Bandaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veera Vankata Ratnam Bandaru","raw_affiliation_strings":["Johns Hopkins University, Baltimore, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, Maryland, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068808987","display_name":"Danielle D. Weinberg","orcid":"https://orcid.org/0000-0002-9402-7911","observed_orcids":["https://orcid.org/0000-0002-9402-7911"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle Weinberg","raw_affiliation_strings":["Johns Hopkins University, Baltimore, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, Maryland, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078392820","display_name":"Noman Zaidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noman Zaidi","raw_affiliation_strings":["Baylor College of Medicine Houston Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine Houston Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045594283","display_name":"Valory Pavlik","orcid":"https://orcid.org/0000-0003-4376-3756","observed_orcids":["https://orcid.org/0000-0003-4376-3756"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valory Pavlik","raw_affiliation_strings":["Baylor College of Medicine Houston Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine Houston Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068308578","display_name":"Rachelle Smith Doody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachelle Doody","raw_affiliation_strings":["Baylor College of Medicine Houston Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine Houston Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024200262","display_name":"Constantine George Lyketsos","orcid":"https://orcid.org/0000-0003-3827-4720","observed_orcids":["https://orcid.org/0000-0003-3827-4720"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constantine Lyketsos","raw_affiliation_strings":["Johns Hopkins Medicine Baltimore Maryland United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medicine Baltimore Maryland United States","institution_ids":["https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.2201,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.61685115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"4S_Part_9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.11550000309944153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydrosphingomyelin","display_name":"dihydrosphingomyelin","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.7656980752944946},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.7096731066703796},{"id":"https://openalex.org/C2780906993","wikidata":"https://www.wikidata.org/wiki/Q5133756","display_name":"Clinical Dementia Rating","level":4,"score":0.6755144596099854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6102795004844666},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.592915415763855},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.5615191459655762},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5370079278945923},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.5285248756408691},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45079874992370605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.446085125207901},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4314728379249573},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4081260859966278},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38125061988830566},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3772946298122406},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35921818017959595},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.31769806146621704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23706501722335815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12182453274726868},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2011.05.937","doi":"https://doi.org/10.1016/j.jalz.2011.05.937","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.937","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7200000286102295,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1577773742","https://openalex.org/W1594975246","https://openalex.org/W1605199145","https://openalex.org/W1847168837","https://openalex.org/W1972686602","https://openalex.org/W1974282614","https://openalex.org/W1979556656","https://openalex.org/W1980384007","https://openalex.org/W1984142578","https://openalex.org/W1991355594","https://openalex.org/W1993868853","https://openalex.org/W1998249059","https://openalex.org/W2003919893","https://openalex.org/W2009458913","https://openalex.org/W2010120002","https://openalex.org/W2014196617","https://openalex.org/W2018954820","https://openalex.org/W2019256890","https://openalex.org/W2023794522","https://openalex.org/W2024211256","https://openalex.org/W2024719735","https://openalex.org/W2037962331","https://openalex.org/W2041442797","https://openalex.org/W2050436766","https://openalex.org/W2070596032","https://openalex.org/W2072543902","https://openalex.org/W2086379884","https://openalex.org/W2097232765","https://openalex.org/W2108474398","https://openalex.org/W2112336037","https://openalex.org/W2112768538","https://openalex.org/W2131746860","https://openalex.org/W2136250824","https://openalex.org/W2136379071","https://openalex.org/W2148744914","https://openalex.org/W2148918646","https://openalex.org/W2153742577","https://openalex.org/W2156220037","https://openalex.org/W2158721897","https://openalex.org/W2163133182","https://openalex.org/W2168568321"],"related_works":["https://openalex.org/W1703528746","https://openalex.org/W7127118644","https://openalex.org/W4406210014","https://openalex.org/W1993868853","https://openalex.org/W2129228723","https://openalex.org/W2094727315","https://openalex.org/W2075420402","https://openalex.org/W3194915506","https://openalex.org/W7100677186","https://openalex.org/W2112768538"],"abstract_inverted_index":{"Plasma":[0,91,251],"sphigolipids":[1],"have":[2,36],"been":[3,37],"shown":[4],"to":[5,184,239,283],"predict":[6,255,272],"cognitive":[7,277,289],"impairment":[8],"and":[9,27,46,82,105,115,131,148,168,207,243,291],"hippocampal":[10],"volume":[11],"loss,":[12],"but":[13,268],"there":[14,244],"is":[15],"little":[16],"research":[17],"in":[18,78,97,113],"subjects":[19],"with":[20,31,49,162,193,225,248],"Alzheimer's":[21,80,125],"disease":[22],"(AD).":[23],"Further,":[24],"only":[25],"ceramide":[26,45],"sphingomyelin":[28],"(SM)":[29],"species":[30,48],"a":[32,55,285,294],"sphingosine":[33,50,226],"(C18:0)":[34],"backbone":[35],"considered.":[38],"In":[39,151,218],"this":[40],"study":[41],"we":[42],"compared":[43,238],"plasma":[44,111,146,156,280],"SM":[47,157,224],"(C18:1)":[51],"or":[52],"sphinganine":[53,194],"(C18:0;":[54],"dihydroxy":[56],"derivative":[57],"of":[58,63,89,135,145,172,180,191,223,266],"sphingosine)":[59],"backbones":[60,195,227],"as":[61],"predictors":[62],"clinical":[64],"progression":[65,164,290],"among":[66],"AD":[67,70],"patients.":[68],"Probable":[69],"patients":[71],"(n":[72],"=":[73,201,213,232],"114)":[74],"were":[75,93,139],"followed":[76],"annually":[77],"the":[79,120,166,170,178,181,185,188,205,216,220,236,240,249],"Disease":[81,126],"Memory":[83],"Disorders":[84],"Center":[85],"at":[86,102],"Baylor":[87],"College":[88],"Medicine.":[90],"sphingolipids":[92,147],"assessed":[94],"using":[95],"ESI/MS/MS":[96],"all":[98],"patient":[99],"samples":[100],"collected":[101],"baseline.":[103],"Cross-sectional":[104],"longitudinal":[106,117,152],"regression":[107],"analyses":[108],"examined":[109],"baseline":[110],"lipids":[112],"cross-sectional":[114,141],"one-year":[116,274],"change":[118],"on":[119,165,177,204,215,235,257,276],"Mini-Mental":[121],"State":[122],"Exam":[123],"(MMSE),":[124],"Assessment":[127],"Scale-Cognitive":[128],"Subscale":[129],"(ADAS-Cog),":[130],"Clinical":[132],"Dementia":[133],"Rating-Sum":[134],"Boxes":[136],"(CDR-Sum).":[137],"There":[138],"no":[140,246],"associations":[142,174],"between":[143],"levels":[144,265],"psychometric":[149],"scores.":[150],"analyses,":[153],"higher":[154],"total":[155],"(C16:0-C24:1":[158],"combined)":[159],"was":[160,175,245],"associated":[161],"less":[163,203,234],"MMSE":[167,206],"ADAS-Cog:":[169],"strength":[171],"these":[173],"dependent":[176],"structure":[179],"backbone.":[182],"Compared":[183],"lowest":[186,241],"tertile,":[187],"highest":[189,221],"tertile":[190,222,242],"SMs":[192],"(dihydrosphingomyelins)":[196],"declined":[197],"1.5":[198],"points":[199,211,230],"(p":[200,212,231],"0.045)":[202],"increased":[208,228],"4.1":[209],"fewer":[210],"0.003)":[214],"ADAS-Cog.":[217],"contrast,":[219],"2.9":[229],"0.034)":[233],"ADAS-Cog":[237],"association":[247],"MMSE.":[250],"ceramides":[252],"did":[253],"not":[254,269],"decline":[256,275],"any":[258],"test.":[259],"These":[260],"results":[261],"suggest":[262],"that":[263],"high":[264],"SMs,":[267],"ceramides,":[270],"dose-dependently":[271],"slower":[273],"measures.":[278],"Total":[279],"dihydrosphingomyelin":[281],"appears":[282],"be":[284],"better":[286],"predictor":[287],"for":[288],"could":[292],"provide":[293],"new":[295],"treatment":[296],"target.":[297]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}